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NO832292L - Modifiserte merkede nukleotider og polynukleotider samt deres fremstilling, anvendelse og paavisning - Google Patents

Modifiserte merkede nukleotider og polynukleotider samt deres fremstilling, anvendelse og paavisning

Info

Publication number
NO832292L
NO832292L NO832292A NO832292A NO832292L NO 832292 L NO832292 L NO 832292L NO 832292 A NO832292 A NO 832292A NO 832292 A NO832292 A NO 832292A NO 832292 L NO832292 L NO 832292L
Authority
NO
Norway
Prior art keywords
attached
compound
sig
nucleotide
component
Prior art date
Application number
NO832292A
Other languages
English (en)
Norwegian (no)
Inventor
Dean Engelhardt
Elazar Rabbani
Stanley Kline
Jannis G Stavrianopoulos
Dollie Kirtikar
Original Assignee
Enzo Biochem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23546604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO832292(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Enzo Biochem Inc filed Critical Enzo Biochem Inc
Publication of NO832292L publication Critical patent/NO832292L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/06—Peptides being immobilised on, or in, an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO832292A 1982-06-23 1983-06-23 Modifiserte merkede nukleotider og polynukleotider samt deres fremstilling, anvendelse og paavisning NO832292L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39144082A 1982-06-23 1982-06-23

Publications (1)

Publication Number Publication Date
NO832292L true NO832292L (no) 1983-12-27

Family

ID=23546604

Family Applications (1)

Application Number Title Priority Date Filing Date
NO832292A NO832292L (no) 1982-06-23 1983-06-23 Modifiserte merkede nukleotider og polynukleotider samt deres fremstilling, anvendelse og paavisning

Country Status (11)

Country Link
US (2) US6992180B1 (es)
EP (7) EP0302175A3 (es)
JP (4) JP2625095B2 (es)
AT (3) ATE119164T1 (es)
AU (2) AU585199B2 (es)
CA (1) CA1223831A (es)
DE (3) DE3382782T2 (es)
DK (1) DK291183A (es)
ES (4) ES8700270A1 (es)
IL (1) IL69051A (es)
NO (1) NO832292L (es)

Families Citing this family (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1309672C (en) * 1983-01-27 1992-11-03 Jannis G. Stavrianopoulos Methods and structures employing non-radioactive chemically-labeled polynucleotide probes
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
FR2540122B1 (fr) * 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
CA1254525A (en) * 1983-04-13 1989-05-23 Christine L. Brakel Kit for terminally chemically labeling dna
ES8600404A1 (es) * 1983-05-02 1985-10-01 Enzo Biochem Inc Un metodo para detectar una secuencia seleccionada de acido nucleico en un material biologico.
CA1228811A (en) 1983-05-05 1987-11-03 Robert G. Pergolizzi Assay method utilizing polynucleotide sequences
ATE78301T1 (de) * 1983-05-31 1992-08-15 Orgenics Ltd Molekulare genetische sonde und verfahren zu ihrer herstellung, testmethode und satz in denen diese molekulare genetische sonde gebraucht wird.
CA1338856C (en) * 1983-07-05 1997-01-21 Jannis Stavrianopoulos In vivo labelling of polynucleotide sequences
IL73578A (en) * 1983-12-12 1989-09-28 Miles Lab Method and reagent for the detection of polynucleotide sequence in sample of dna or rna by using a nucleic acid probe and contact of duplexes with immobilizing antibody
US4777129A (en) * 1983-12-12 1988-10-11 Molecular Diagnostics, Inc. Nucleic acid probe detectable by specific nucleic acid binding protein
EP0146039A3 (en) * 1983-12-12 1986-08-27 Miles Inc. Hybridization assay with immobilization of hybrids by antihybrid binding
US4724202A (en) * 1983-12-12 1988-02-09 Molecular Diagnostics, Inc. Use of non-hybridizable nucleic acids for the detection of nucleic acid hybridization
EP0144914A3 (en) * 1983-12-12 1986-08-13 Miles Inc. Hybridization assay employing labeled pairs of hybrid binding reagents
USRE43096E1 (en) 1984-01-16 2012-01-10 California Institute Of Technology Tagged extendable primers and extension products
US4707440A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4748111A (en) * 1984-03-12 1988-05-31 Molecular Diagnostics, Inc. Nucleic acid-protein conjugate used in immunoassay
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
US4766064A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay employing polyether and diagnostic kit
US4670380A (en) * 1984-05-23 1987-06-02 Molecular Diagnostics, Inc. Assays utilizing labeled nucleic acid probes
CA1264451A (en) * 1984-05-23 1990-01-16 Nanibhushan Dattagupta Nucleic acid probe coupled to radioactive label
US4957858A (en) * 1986-04-16 1990-09-18 The Salk Instute For Biological Studies Replicative RNA reporter systems
IL71947A (en) * 1984-05-29 1987-10-30 Yeda Research And Dev Comp Ltd Enzyme hydrazides and method for detection and determination of glycoconjugates
FR2565996B1 (fr) * 1984-06-15 1988-01-22 Inst Nat Sante Rech Med Acides nucleiques marques chimiquement, leur utilisation et necessaire pour sa mise en oeuvre
DE3431536A1 (de) * 1984-08-28 1986-03-13 Boehringer Mannheim Gmbh, 6800 Mannheim Derivatisierte nucleinsaeure-sequenz, verfahren zu deren herstellung sowie deren verwendung zum nachweis von nucleinsaeuren
US4692509A (en) * 1984-11-27 1987-09-08 Molecular Diagnostics, Inc. Radioactive labeling of proteins with nucleosides or nucleotides
US4670379A (en) * 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
ATE43348T1 (de) * 1985-01-24 1989-06-15 Neopharmed Spa Acylierte cytidin-diphosphat-choline, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
ATE48850T1 (de) * 1985-03-21 1990-01-15 Molecular Diagnostics Inc Spezifische jodierung von nukleinsaeure.
US4767699A (en) * 1985-05-02 1988-08-30 Allied Corporation Diagnostic reagent, kit and method employing polynucleotide displacement, separation, enzymatic cleavage and adenosine phosphate detection
US5273882A (en) * 1985-06-13 1993-12-28 Amgen Method and kit for performing nucleic acid hybridization assays
JPS622164A (ja) * 1985-06-25 1987-01-08 シスカ・ダイアグノステイツクス・インコ−ポレ−テツド Ｎ４−（置換アミノ）シチジンを含む核酸プロ−ブ
US4780405A (en) * 1985-06-25 1988-10-25 Siska Diagnostics, Inc. Carbonic anhydrase inhibitor-tagged nucleic acid probes
US4833251A (en) * 1985-06-25 1989-05-23 Siska Diagnostics, Inc. Compounds for tagging nucleic acid probes
CA1295559C (en) * 1985-08-13 1992-02-11 Jannis Stavrianopoulos Method for labeling polynucleotide sequences
JP2509574B2 (ja) * 1985-08-15 1996-06-19 アモコ・コーポレーション 標識付けした核酸
JP3293820B2 (ja) * 1985-12-13 2002-06-17 エンゾ− バイオケム インコ−ポレイテツド 標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物
JPS638396A (ja) * 1986-06-30 1988-01-14 Wakunaga Pharmaceut Co Ltd ポリ標識化オリゴヌクレオチド誘導体
US6013772A (en) * 1986-08-13 2000-01-11 Bayer Corporation Antibody preparations specifically binding to unique determinants of CEA antigens or fragments thereof and use of the antibody preparations in immunoassays
GB8621337D0 (en) * 1986-09-04 1986-10-15 Agricultural Genetics Co Non-radioactive nucleic acid hybridization probes
SE454781B (sv) * 1986-10-17 1988-05-30 Wallac Oy Hybridiseringsforfarande for detektion av polynukleotidsekvens
AU619170B2 (en) * 1987-01-09 1992-01-23 Abbott Laboratories Diagnostic assays using nucleic acid probes
US5227474A (en) * 1987-02-13 1993-07-13 Abbott Laboratories Bifunctional chelating agents
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
AU622104B2 (en) * 1987-03-11 1992-04-02 Sangtec Molecular Diagnostics Ab Method of assaying of nucleic acids, a reagent combination and kit therefore
FI891524A7 (fi) * 1987-07-31 1989-03-30 Gen Probe Inc Polynukleotidien määritys, jolloin käytetään oligonukleotideja estämää n ei-toivotut sivureaktiot
GB2209754A (en) * 1987-09-17 1989-05-24 Thomas Lee Mattson Polyaldehydic polynucleotides in use as probes,their preparation and use
US5021567A (en) * 1987-09-24 1991-06-04 Abbott Laboratories 8-hydroxyquinoline chelating agents
US5245026A (en) * 1987-09-24 1993-09-14 Abbott Laboratories Metal containing 8-hydroxyquinoline chelating agents
ATE192465T1 (de) * 1987-10-28 2000-05-15 Florey Howard Inst Oligonucleotid-polyamid konjugate
US5525465A (en) * 1987-10-28 1996-06-11 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates and methods of production and applications of the same
US4886741A (en) * 1987-12-09 1989-12-12 Microprobe Corporation Use of volume exclusion agents for the enhancement of in situ hybridization
US5109124A (en) * 1988-06-01 1992-04-28 Biogen, Inc. Nucleic acid probe linked to a label having a terminal cysteine
US5047523A (en) * 1988-08-02 1991-09-10 Ortho Diagnostic Systems Inc. Nucleic acid probe for detection of neisseria gonorrhoea
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5858652A (en) * 1988-08-30 1999-01-12 Abbott Laboratories Detection and amplification of target nucleic acid sequences
JPH04502107A (ja) * 1988-12-07 1992-04-16 ザ・ジェネラル・ホスピタル・コーポレーション 挿入を有するかまたは欠失に相当するｄｎａの豊富化およびクローニングの方法
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
GR1000347B (el) * 1988-12-21 1992-06-25 Ortho Diagnostic Systems Inc Μεθοδος παραγωγης νουκλεοτιδικων ανιχνευτων χρησιμοποιωντας ενα συμπληρωμα γεφυρωσεως.
US5998135A (en) 1989-02-24 1999-12-07 Enzo Diagnostics, Inc. Energy transfer hybridization assay using intercalators and lanthanide metals
DE69028725T2 (de) * 1989-02-28 1997-03-13 Canon Kk Partiell doppelsträngiges Oligonukleotid und Verfahren zu seiner Bildung
CA2012982A1 (en) * 1989-03-27 1990-09-27 Frank W. Hobbs Process for rapid nucleic acid detection by incorporating a reporter moiety into amplified target nucleic acid
DE3916871A1 (de) * 1989-05-24 1990-11-29 Boehringer Mannheim Gmbh Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsaeuren
EP0407816A3 (en) * 1989-07-14 1993-01-27 Abbott Laboratories Base modified nucleosides
DE4020529A1 (de) * 1989-09-12 1991-03-21 Roxana Vasiloiu Multifunktionelle(s) enzym(e) mit nucleosid-didesoxyribosyltransferase(n) und/oder nucleoside-desoxyribosyltransferasen(n) und/oder kinease- und/oder reduktase- und/oder desaminase- und/oder polymerase-aktivitaet
EP0422861B1 (en) * 1989-10-13 2000-05-17 Zeneca Limited Probes
WO1993024511A1 (en) * 1992-05-29 1993-12-09 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
WO1991011533A1 (en) * 1990-01-26 1991-08-08 E.I. Du Pont De Nemours And Company Method for isolating primer extension products from template-directed dna polymerase reactions
WO1991014696A1 (en) * 1990-03-29 1991-10-03 Gilead Sciences, Inc. Oligonucleotide-transport agent disulfide conjugates
US5677440A (en) * 1990-07-16 1997-10-14 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
US5612199A (en) * 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5292938A (en) * 1992-04-13 1994-03-08 Associated Universities, Inc. Synthesis of 4-substituted-trans-1, 2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging
CA2141450A1 (en) * 1992-07-31 1994-02-17 Maureen Laney Method for introducing defined sequences at the 3' end of polynucleotides
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5616464A (en) * 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5767259A (en) * 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US6294323B1 (en) 1993-04-14 2001-09-25 Behringwerke Ag Self initiating single primer amplification of nucleic acids
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5446137B1 (en) * 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
CA2140081C (en) * 1994-01-13 2008-04-01 Dean L. Engelhardt Process, construct and conjugate for producing multiple nucleic acid copies
US5731153A (en) * 1996-08-26 1998-03-24 The Regents Of The University Of California Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions
US5783387A (en) * 1995-02-06 1998-07-21 The Regents Of The University Of California Method for identifying and quantifying nucleic acid sequence aberrations
US5616465A (en) 1995-08-09 1997-04-01 The Regents Of The University Of California Detection and isolation of nucleic acid sequences using competitive hybridization probes
US6027879A (en) * 1995-08-09 2000-02-22 The Regents Of The University Of California Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe
CA2279675A1 (en) 1995-12-15 1997-06-16 Enzo Therapeutics, Inc. Property effecting and/or property exhibiting constructs for localizing a nucleic acid construct within a cell for therapeutic and diagnostic uses
GB9602028D0 (en) 1996-02-01 1996-04-03 Amersham Int Plc Nucleoside analogues
WO1997039008A1 (en) * 1996-04-12 1997-10-23 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
EP0917533A2 (en) * 1996-07-03 1999-05-26 President And Fellows Of Harvard College Oligonucleotide linker and techniques involving immobilized and linked oligonucleotides
EP0941314A1 (fr) 1996-08-02 1999-09-15 Bio Merieux Procede d'amplification d'une sequence d'un acide nucleique cible
EP2341058A3 (en) * 1997-09-12 2011-11-23 Exiqon A/S Oligonucleotide Analogues
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
FR2780059B1 (fr) 1998-06-17 2002-10-11 Bio Merieux Procede de marquage d'un acide ribonucleique et fragments d'arn marques ainsi obtenus
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
DE19850594A1 (de) * 1998-11-03 2000-05-04 Biochip Technologies Gmbh Verfahren zur Markierung von Nukleinsäuren
US6613516B1 (en) 1999-10-30 2003-09-02 Affymetrix, Inc. Preparation of nucleic acid samples
US6902891B2 (en) 1999-12-17 2005-06-07 Bio Merieux Process for labeling a nucleic acid
US6489114B2 (en) 1999-12-17 2002-12-03 Bio Merieux Process for labeling a ribonucleic acid, and labeled RNA fragments which are obtained thereby
EP1156832A1 (en) 1999-12-28 2001-11-28 Transgene S.A. Use of lithium (li?+ ) for the preparation of a composition for transfection of a polynucleotide into a cell and compositions useful in gene therapy
CA2412567A1 (en) * 2000-06-07 2001-12-13 Li-Cor, Inc. Charge-switch nucleotides
US7338805B2 (en) 2001-05-04 2008-03-04 Bio Merieux Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
US7060441B2 (en) 2001-05-04 2006-06-13 Biomerieux Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
FR2827304B1 (fr) * 2001-07-16 2004-05-21 Commissariat Energie Atomique Procede et support d'analyse biologique utilisant des oligonucleotides comportant un marqueur activable enzymatiquement
US20070136825A1 (en) 2001-09-18 2007-06-14 Wolf-Bernd Frommer Fusion proteins useful for detecting analytes
JP4898431B2 (ja) 2003-04-29 2012-03-14 ザ ジェネラル ホスピタル コーポレイション 複数薬物の持続放出のための方法およびデバイス
EP1944318B1 (en) 2003-07-21 2011-03-02 Transgene S.A. Multifunctional cytokines
US7459021B2 (en) 2003-09-03 2008-12-02 Shmuel Bukshpan Methods and apparatus for rapid crystallization of biomolecules
JP3615752B1 (ja) 2003-11-18 2005-02-02 淳 高橋 細径樹脂捩じりブラシ
US6991911B2 (en) 2003-12-15 2006-01-31 Dade Behring Inc. Assay for entactogens
US7022492B2 (en) 2003-12-15 2006-04-04 Dade Behring Inc. Ecstasy haptens and immunogens
FR2868071B1 (fr) 2004-03-26 2006-06-09 Biomerieux Sa Reactifs de marquage, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
CA2580881A1 (en) 2004-09-21 2006-03-30 Nascacell Technologies Ag Use of microproteins as tryptase inhibitors
US7541144B2 (en) * 2005-01-31 2009-06-02 Agilent Technologies, Inc. RNA labeling method
ATE468406T1 (de) 2005-02-02 2010-06-15 Univ Bayreuth Esterasen zur überwachung der proteinbiosynthese in vitro
FR2886735B1 (fr) 2005-06-01 2015-09-11 Biomerieux Sa Procede de marquage ou de traitement d'un echantillon biologique contenant des molecules biologiques d'interet, notamment des acides nucleiques
US8076064B2 (en) * 2005-07-09 2011-12-13 Agilent Technologies, Inc. Method of treatment of RNA sample
US7718365B2 (en) * 2005-07-09 2010-05-18 Agilent Technologies, Inc. Microarray analysis of RNA
US7544471B2 (en) * 2005-07-30 2009-06-09 Agilent Technologies, Inc. Preparing RNA from a wax-embedded tissue specimen
CN101321775B (zh) 2005-10-03 2012-05-23 大学健康网络 用于治疗疟疾的odcase抑制剂
US7700289B2 (en) * 2006-04-03 2010-04-20 Agilent Technologies, Inc. Method for labeling RNA
US20080038686A1 (en) * 2006-04-18 2008-02-14 Shigemi Nagai Methods and kits for early stage caries detection
US8647119B1 (en) 2006-04-18 2014-02-11 President And Fellows Of Harvard College Methods and kits with fluorescent probes for caries detection
CN101460619B (zh) 2006-06-06 2012-07-25 松下电器产业株式会社 核苷酸链的修饰方法
US7772390B1 (en) 2006-07-18 2010-08-10 The Regents Of The University Of California Lipid mediated nucleic acid synthesis
US20080091005A1 (en) * 2006-07-20 2008-04-17 Visigen Biotechnologies, Inc. Modified nucleotides, methods for making and using same
AR065076A1 (es) 2007-01-30 2009-05-13 Transgene Sa Vacuna contra el papilomavirus
FR2917090B1 (fr) 2007-06-11 2012-06-15 Biomerieux Sa Reactifs de marquage portant des fonctions diazo et nitro, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
JP5248610B2 (ja) 2007-08-24 2013-07-31 ユーリウス−マクシミリアンス−ウニベルジテート ヴュルツブルク β１−アドレナリン作動性レセプター抗体を阻害する変異体二重環化レセプターペプチド
FR2934595B1 (fr) 2008-07-29 2013-04-05 Biomerieux Sa Reactifs de marquage ayant un noyau pyridine portant une fonction diazomethyle, procedes de synthese de tels reactifs et procedes de detection de molecules biologiques
GB0815968D0 (en) * 2008-09-03 2008-10-08 Angeletti P Ist Richerche Bio Antiviral agents
US20120087870A1 (en) 2008-12-19 2012-04-12 Hentges Francois Novel caviidae allergens and uses thereof
US20110312872A1 (en) 2008-12-22 2011-12-22 Universität Regensburg Norrin in the treatment of diseases associated with an increased tgf-beta activity
MX2011008542A (es) 2009-02-13 2011-09-01 Novartis Ag Molecula de acido nucleico de un racimo biosintetico que codifica sintasas peptidicas no ribosomales y usos de la misma.
DE102010018878B4 (de) 2009-04-30 2013-09-26 Julius-Maximilians-Universität Würzburg Neue Zell-Linie zur Fluoreszenz-basierten Detektion von funktionell aktiven Antikörpern und Autoantikörpern gegen den Beta1-adrenergen Rezeptor
US9393299B2 (en) 2009-08-07 2016-07-19 Transgene S.A. Composition for treating HBV infection
EP2470203A1 (en) 2009-08-26 2012-07-04 Medizinische Hochschule Hannover Means and methods for producing artificial capsular polysaccharides of neisseria meningitidis
CA2780827A1 (en) * 2009-12-31 2011-07-07 Ventana Medical Systems, Inc. Methods for producing uniquely specific nucleic acid probes
EP2566964B1 (en) 2010-05-07 2016-10-19 Centre National De La Recherche Scientifique Ucp1 (thermogenin) - inducing agents for use in the treatment of a disorder of the energy homeostasis
JP5894581B2 (ja) 2010-05-21 2016-03-30 ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン 骨障害及び／又は心血管障害の治療又は診断に使用する組成物
US8795664B2 (en) 2010-06-04 2014-08-05 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Monoclonal antibodies targeting amyloid beta oligomers
RU2012157399A (ru) 2010-06-18 2014-07-27 КсайберСайенс ГмбХ Пептиды в качестве активных агентов для стабилизации биологических барьеров
CN103339507A (zh) 2010-08-26 2013-10-02 霍夫曼-拉罗奇有限公司 DCC第五纤连蛋白III型域的重组Fc融合蛋白
FR2968302B1 (fr) 2010-12-06 2012-11-30 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
WO2012095841A1 (en) 2011-01-10 2012-07-19 State Of Israel, Ministry Of Agriculture And Rural Development, A.R.O. - Volcani Center Improved tomato plants
WO2012113779A1 (en) 2011-02-21 2012-08-30 Medizinische Universität Wien Means and methods for treating a disease or disorder related to lymphangiogenesis or preventing metastasis
EP2522689A1 (en) 2011-05-13 2012-11-14 Universität Bayreuth Non-viral transfection systems
EP2523002A1 (en) 2011-05-13 2012-11-14 Universität Bayreuth Utilization of magnetic nanoparticles as intracellular pull-down system
WO2013017656A1 (en) 2011-08-02 2013-02-07 Medizinische Universität Wien Antagonists of ribonucleases for treating obesity
WO2013024173A1 (en) 2011-08-17 2013-02-21 Technische Universität München Computer implemented method for identifying regulatory regions or regulatory variations
RU2014129918A (ru) 2011-12-22 2016-02-10 Медицинише Универзитет Виен Циклотиды в качестве иммунодепрессантов
EP2626066A1 (en) 2012-02-10 2013-08-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Combination therapy comprising selective VEGFR-2 inhibitors and MEK inhibitors
CN104520312B (zh) 2012-02-29 2017-12-19 先正达参股股份有限公司 种子活力的调节
AU2013285537B2 (en) 2012-07-02 2017-10-12 Medizinische Universitat Wien Complement split product C4d for the treatment of inflammatory conditions
CA2875603A1 (en) 2012-07-04 2014-01-09 Wintershall Holding GmbH Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
EP2695950A1 (en) 2012-08-10 2014-02-12 Blackfield AG Markers for responsiveness to an inhibitor of the fibroblast growth factor receptor
EP2895626B1 (en) * 2012-09-12 2019-12-18 The Regents of The University of California Accurate genome sequencing of single cells by single-stranded amplification and sequencing
EP2708241A1 (en) 2012-09-12 2014-03-19 Netris Pharma Recombinant Fc-fusion protein of the two Immunoglobulin domains of UNC5
EP2708231A1 (en) 2012-09-12 2014-03-19 Netris Pharma Combined treatment with netrin-1 interfering drug and chemotherapeutic drug
US10203338B2 (en) 2013-05-14 2019-02-12 Siemens Healthcare Diagnostics Inc. Stabilized liquid formulations containing receptors
US12064484B2 (en) 2013-06-28 2024-08-20 Ethris Gmbh Compositions for introducing RNA into cells
WO2015022326A1 (en) 2013-08-12 2015-02-19 Xiber Science Gmbh Peptides as active agents for treating primary graft dysfunction
JP6745220B2 (ja) 2013-09-16 2020-08-26 ツェーエムエム−フォルシュングスツェントルム フュア モレクラレ メディツィン ゲーエムベーハー 骨髄性悪性腫瘍の診断のための突然変異体カルレチクリン
CN105764491A (zh) 2013-12-09 2016-07-13 度瑞公司 药物活性剂复合物、聚合物复合物，以及包括其的组合物和方法
EP3104873B1 (en) 2014-02-13 2019-09-04 Technische Universität München Fgf-8 for use in treating diseases or disorders of energy homeostasis
KR20160121584A (ko) 2014-02-26 2016-10-19 에트리스 게엠베하 Rna의 위장 투여용 조성물
WO2015158898A2 (en) 2014-04-17 2015-10-22 Medizinische Hochschule Hannover Means and methods for producing neisseria meningitidis capsular polysaccharides of low dispersity
WO2016050819A1 (en) 2014-09-30 2016-04-07 Basf Se Method for preparing an acrylamide solution having a low acrylic acid concentration
KR20170066471A (ko) 2014-09-30 2017-06-14 바스프 에스이 낮은 아크릴산 농도를 갖는 아크릴아미드 수용액의 제조 방법
KR102775925B1 (ko) 2014-09-30 2025-03-04 바스프 에스이 적은 아크릴산을 갖는 아미드 화합물의 제조를 위한 수단 및 방법
EP3034539A1 (en) 2014-12-19 2016-06-22 Ethris GmbH Compositions for introducing nucleic acid into cells
EP3225694A1 (en) 2016-03-29 2017-10-04 Basf Se Method for the production of acrylamide by defined addition of the biocatalyst
EP3225693A1 (en) 2016-03-29 2017-10-04 Basf Se Method for preparing aqueous acrylamide solutions
EP3436594A1 (en) 2016-03-29 2019-02-06 Basf Se Process for producing a polyacrylamide solution with increased viscosity
WO2017178193A1 (en) 2016-04-14 2017-10-19 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method for the identification of random polynucleotide or polypeptide sequences with biological activity
US20190144574A1 (en) 2016-04-26 2019-05-16 Basf Se Method for preparing an aqueous polyacrylamide solution
WO2017186685A1 (en) 2016-04-26 2017-11-02 Basf Se Method for preparing an aqueous polyacrylamide solution
CA3022178A1 (en) 2016-04-26 2017-11-02 Basf Se Method for preparing an aqueous polyacrylamide solution
MA45496A (fr) 2016-06-17 2019-04-24 Hoffmann La Roche Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
WO2018185222A1 (en) 2017-04-05 2018-10-11 Acib Gmbh - Austrian Centre Of Industrial Biotechnology Aminoacyl trna synthetases and orthogonal trnas
EP3658176A1 (en) 2017-07-26 2020-06-03 Medizinische Universität Wien Superactive mutant thymidine kinase for use in cancer therapy
IL272566B2 (en) 2017-10-16 2024-07-01 Hoffmann La Roche NUCLEIC ACID MOLECULE FOR REDUCTION OF PAPD5 AND PAPD7 mRNA FOR TREATING HEPATITIS B INFECTION
US11603374B2 (en) * 2018-01-18 2023-03-14 Array Biopharma Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
BR112020021054A2 (pt) 2018-04-25 2021-02-17 Ethris Gmbh composição, processo para a preparação de uma composição, e, composições sólida e para uso
EP3807415A1 (en) 2018-06-13 2021-04-21 Engenes Biotech GmbH Methionine analogue synthesis
CR20210179A (es) 2018-07-03 2022-05-23 Hoffmann La Roche OLIGONUCLEÓTIDOS PARA MODULAR LA EXPRESIÓN DE TAU (Divisional 2021-0058)
EP3844270B1 (en) 2018-08-31 2023-07-12 Leibniz-Institut für Pflanzenbiochemie (IPB) Calcium dependent protein kinase constructs and uses thereof
CA3103175A1 (en) 2018-09-11 2020-03-19 Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) Microrna inhibitors for use in treating metabolic diseases
US12404605B2 (en) 2018-10-05 2025-09-02 MultiplexDX, s.r.o. Method for diagnosing diseases using multiplex fluorescence and sequencing
RU2734941C2 (ru) * 2018-12-19 2020-10-26 Общество с ограниченной ответственностью "ИБМХ-ЭкоБиоФарм" (ООО "ИБМХ-ЭкоБиоФарм") Способ получения модифицированных комбинаторных ДНК библиотек методом твердофазной реакции удлинения праймера на ПЭТ-микрочастицах
EP4031658A1 (en) 2019-08-07 2022-07-27 DB Biotech, AS Improved horseradish peroxidase polypeptides
EP4025303A1 (en) 2019-09-04 2022-07-13 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Herv inhibitors for use in treating tauopathies
EP4028528A1 (en) 2019-09-11 2022-07-20 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Bactericidal phage vectors
US20220403426A1 (en) 2019-11-05 2022-12-22 Basf Se Method of storing a biocatalyst
KR20220155367A (ko) 2020-03-20 2022-11-22 메디치니쉐 유니베르지테트 빈 MS 치료를 위한 카파 오피오이드 수용체(kappa opioid receptor) 리간드와 조합된 사이클로타이드(cyclotide)
WO2021224269A2 (en) 2020-05-04 2021-11-11 MultiplexDX, s.r.o. Means and methods for detecting novel coronavirus (sars-cov-2)
WO2022003142A1 (en) 2020-07-03 2022-01-06 Engenes Biotech Gmbh PYRROLYSYL-tRNA SYNTHETASE VARIANTS AND USES THEREOF
AU2021338589B2 (en) * 2020-09-11 2025-09-04 Illumina Singapore Pte. Ltd. Detecting nucleic acids using sugar-lectin couplings
IL301543A (en) 2020-09-24 2023-05-01 Medigene Immunotherapies Gmbh Prame specific t cell receptors and uses thereof
EP4119581A1 (en) 2021-07-14 2023-01-18 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Novel fab dimers
EP4215042A1 (en) 2022-01-21 2023-07-26 Max-Delbrück-Centrum für Molekulare Medizin A non-human mammal comprising in its genome at least two human leukocyte antigen (hla) class i alleles, methods of making such mammal and uses thereof
EP4299753A1 (en) 2022-06-29 2024-01-03 enGenes Biotech GmbH Method for producing extrachromosomal nucleic acids
JP2025522719A (ja) 2022-06-29 2025-07-17 武田薬品工業株式会社 染色体外核酸を産生させるための方法
CN119923403A (zh) 2022-08-31 2025-05-02 帝斯曼知识产权资产管理有限公司 青春双歧杆菌菌株、其用于降解淀粉和调节非人类哺乳动物中的肠道菌群的方法和用途
WO2024089180A1 (en) 2022-10-26 2024-05-02 Eximmium Biotechnologies Gmbh Method to determine extracellular vesicle recovery
EP4626449A1 (en) 2022-11-28 2025-10-08 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Acinetobacter baumannii phages
WO2024180222A1 (en) 2023-03-02 2024-09-06 Universitaet Des Saarlandes Methods for producing l-pipecolic acid
WO2025079025A1 (en) 2023-10-13 2025-04-17 Takeda Pharmaceutical Company Limited Ides-rapamycin conjugate in aav gene therapy
WO2025104216A1 (en) 2023-11-15 2025-05-22 Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Bacteriophage compositions
WO2025114609A1 (en) 2023-12-01 2025-06-05 MultiplexDX, s.r.o. Method for predicting the efficacy of an antibody-drug-conjugate (adc) using multiplex fluorescence in situ hybridization (fish) and multiplex sequencing
WO2025242868A1 (en) 2024-05-23 2025-11-27 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Phage composition

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617886A1 (de) 1967-03-06 1971-01-28 Dr Med Karl Theurer Verfahren zur Herstellung von Arzneimitteln mit selektivem Tropismus gegen Krebs und bestimmte Organe
DE1814134A1 (de) 1968-12-12 1970-09-10 Theurer Dr Med Karl Zusatzverfahren zur Herstellung von arzneimitteln mit selektivem Tropismus
US3906031A (en) 1971-03-15 1975-09-16 Research Corp Novel 9-fluorenylmethoxycarbonyl compounds
US4124702A (en) 1971-07-06 1978-11-07 Merck & Co., Inc. Polynucleotides active as inducers of interferon production in living animal cells
US3931397A (en) 1971-11-05 1976-01-06 Beecham Group Limited Biologically active material
US3960840A (en) * 1972-12-29 1976-06-01 University Of Illinois Foundaton Fluorescent derivatives of adenine-containing compounds
JPS49126395A (es) 1973-04-04 1974-12-03
US4038480A (en) 1973-09-17 1977-07-26 Icn Pharmaceuticals, Inc. 6-aminocarbonyl purine 3',5'-cyclic nucleotides
GB1446536A (en) 1975-02-21 1976-08-18 Yeda Res & Dev Pharmaceutically active compositions
US4230797A (en) * 1975-04-28 1980-10-28 Miles Laboratories, Inc. Heterogenous specific binding assay employing a coenzyme as label
IN142734B (es) * 1975-04-28 1977-08-20 Miles Lab
US4119521A (en) 1977-04-25 1978-10-10 Stephen Turner Fluorescent derivatives of activated polysaccharides
JPS53133283A (en) 1977-04-25 1978-11-20 Agency Of Ind Science & Technol High polymers bonded to adenine nucleotide derivatives
SU659573A1 (ru) 1977-05-31 1979-04-30 Институт биологической физики АН СССР Спин-меченые производные олигорибонуклеотидов как спиновые зонды дл исследовани механизма действи ферментов и способ их получени
US4847240A (en) 1978-01-16 1989-07-11 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US4151065A (en) 1978-01-30 1979-04-24 The Regents Of The University Of California Horizontal slab gel electrophoresis
FR2422956A1 (fr) * 1978-04-13 1979-11-09 Pasteur Institut Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede
US4213893A (en) 1978-10-12 1980-07-22 Miles Laboratories, Inc. Flavin adenine dinucleotide-labeled conjugates for use in specific binding assays
IL57571A (en) * 1978-06-22 1983-03-31 Miles Lab Flavin adenine dinucleotide-labeled conjugates and their use in a homogeneous immunoassay method for determining haptens
JPS5519239A (en) 1978-07-28 1980-02-09 Green Cross Corp:The Interferon-producing attractant
DE2841414C2 (de) 1978-09-22 1980-04-03 Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig Verfahren zur Herstellung von an Makromoleküle gebundenen, ein Adeninringsystem enthaltenden Koenzymen
US4305922A (en) * 1978-10-04 1981-12-15 University Patents, Inc. Labeling proteins with 99m-Tc by ligand exchange
JPS5564599A (en) 1978-11-08 1980-05-15 Unitika Ltd Adenosine triphosphate derivative
US4224408A (en) * 1978-11-22 1980-09-23 Abbott Laboratories Deoxyribonucleic acid synthesis using binding protein
US4260737A (en) * 1979-03-16 1981-04-07 University Patents, Inc. Radioiodine labeling during protein synthesis
EP0024464B1 (en) * 1979-08-29 1982-05-12 Nihon Medi-Physics Co., Ltd. 2-oxopropionaldehyde bis(thiosemicarbazone)derivatives and their production and use
US4318846A (en) 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4259232A (en) 1979-10-23 1981-03-31 Miles Laboratories, Inc. Flavin adenine dinucleotide-labeled protein and polypeptide conjugates
US4310662A (en) * 1979-12-26 1982-01-12 Genentech, Inc. Nucleosidic phosphorylating agent and methods
US4255566A (en) * 1980-02-19 1981-03-10 Miles Laboratories Flavin adenine dinucleotide derivatives and labeled conjugates prepared therefrom
US4500707A (en) 1980-02-29 1985-02-19 University Patents, Inc. Nucleosides useful in the preparation of polynucleotides
US4293310A (en) 1980-03-14 1981-10-06 University Of Pittsburgh Photoelectrochemical immunoassay
US4421735A (en) * 1980-04-17 1983-12-20 The Massachusetts General Hospital Radiolabeled diagnostic compositions and method for making the same
JPS5711999A (en) 1980-06-26 1982-01-21 Chugai Pharmaceut Co Ltd Novel adenosine phosphate compound containing introduced iodine and its preparation
JPS5742632A (en) 1980-08-29 1982-03-10 Takeshi Sasaki Double-chain dna bonded to d-glutamic acid-d-lysine copolymer, its preparation and medicine containing the same
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
DE3152738C2 (de) 1981-02-23 1986-06-19 Institut botaniki AN Kazachskoj SSR, Alma-Ata K}vette für die photometrische Abtastung von Gelsa{ulen
US4668777A (en) 1981-03-27 1987-05-26 University Patents, Inc. Phosphoramidite nucleoside compounds
US4415732A (en) 1981-03-27 1983-11-15 University Patents, Inc. Phosphoramidite compounds and processes
CA1194862A (en) * 1981-03-30 1985-10-08 Jemo Kang Method for making chromogenic and/or fluorogenic substrates for use in monitoring catalytic or enzymatic activity
US4378458A (en) * 1981-03-30 1983-03-29 Baker Instruments Corporation Novel chromogenic and/or fluorogenic substrates for monitoring catalytic or enzymatic activity
US4529796A (en) * 1981-03-30 1985-07-16 Baker Instruments Corporation Method for making chromogenic and/or fluorogenic substrates for use in monitoring catalytic or enzymatic activity
US4708935A (en) 1981-04-10 1987-11-24 Research Corporation (2-5')-Oligo (3'-deoxyadenylate) and derivatives thereof
CA1219824A (en) * 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4401796A (en) 1981-04-30 1983-08-30 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4373071A (en) 1981-04-30 1983-02-08 City Of Hope Research Institute Solid-phase synthesis of polynucleotides
US4375401A (en) 1981-05-20 1983-03-01 Nicholas Catsimpoolas Electrophoresis system
CA1205028A (en) 1981-07-01 1986-05-27 Jerald C. Hinshaw Fluorescent chelates and labeled specific binding reagents prepared therefrom
CA1180647A (en) 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
US4460772A (en) 1981-08-27 1984-07-17 Miles Laboratories, Inc. 6-[N-(ω-Carboxyalkyl)amino]-1,3-dimethyl-5-formamidouracils
FR2519005B1 (fr) * 1981-12-29 1985-10-25 Pasteur Institut Fragments d'adn marques a l'une au moins de leurs extremites par des ribonucleotides modifies reconnaissables par des molecules affines et procede pour realiser une analyse de tels fragments d'adn
FR2519004B1 (fr) * 1981-12-29 1985-09-27 Pasteur Institut Acide adenosine 5'-triphosphorique modifie et procede de dosage de substances biologiques susceptibles de fixer des produits de degradation de l'acide adenosine 5'-triphosphorique
CA1222691A (en) * 1981-12-29 1987-06-09 Wilhelmus T. Goedemans Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
DE3381518D1 (de) * 1982-01-22 1990-06-07 Cetus Corp Verfahren zur charakterisierung von hla und die darin benutzten cdns-testmittel.
EP0090789A1 (en) 1982-03-26 1983-10-05 Monsanto Company Chemical DNA synthesis
US4474948A (en) 1982-04-08 1984-10-02 Biosearch Benzazolides and their employment in phosphite ester oligonucleotide synthesis processes
US4490472A (en) * 1982-06-17 1984-12-25 Imreg, Inc. Sensitive tests for malignancies based on DNA detection
US5241060A (en) * 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US5260433A (en) * 1982-06-23 1993-11-09 Enzo Diagnostics, Inc. Saccharide specific binding system labeled nucleotides
US4880918A (en) 1982-07-13 1989-11-14 Eliezer Rapaport Arrest and killing of tumor cells by adenosine 5-diphosphate and adenosine-5-triphosphate
JPS5927900A (ja) 1982-08-09 1984-02-14 Wakunaga Seiyaku Kk 固定化オリゴヌクレオチド
JPS5944648A (ja) 1982-09-07 1984-03-13 Sansou Seisakusho:Kk デオキシリボ核酸の塩基配列決定方法
JPS59126252A (ja) 1983-01-08 1984-07-20 Fuji Photo Film Co Ltd Ｄｎａもしくはｄｎａ部分分解物の塩基配列決定法
US4605735A (en) 1983-02-14 1986-08-12 Wakunaga Seiyaku Kabushiki Kaisha Oligonucleotide derivatives
US4948882A (en) * 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US4517338A (en) 1983-06-20 1985-05-14 Chiron Corporation Multiple reactor system and method for polynucleotide synthesis
US4483964A (en) 1983-06-20 1984-11-20 Chiron Corporation Reactor system and method for polynucleotide synthesis
US4598049A (en) 1983-08-31 1986-07-01 Systec Inc. General purpose gene synthesizer
JPS5993100A (ja) 1983-10-31 1984-05-29 Wakunaga Seiyaku Kk オリゴヌクレオチド誘導体
JPS6096610A (ja) 1983-10-31 1985-05-30 Agency Of Ind Science & Technol ニコチンアミド−アデニン−ジヌクレオチドホスフエ−トを結合した高分子物質
US5118802A (en) 1983-12-20 1992-06-02 California Institute Of Technology DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
CA1244786A (en) 1983-12-20 1988-11-15 Lloyd M. Smith Synthesis of amino-derivitized oligonucleotides
US5118800A (en) 1983-12-20 1992-06-02 California Institute Of Technology Oligonucleotides possessing a primary amino group in the terminal nucleotide
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US5015733A (en) 1983-12-20 1991-05-14 California Institute Of Technology Nucleosides possessing blocked aliphatic amino groups
US5171534A (en) 1984-01-16 1992-12-15 California Institute Of Technology Automated DNA sequencing technique
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
JPH0610665B2 (ja) 1984-02-01 1994-02-09 株式会社日立製作所 核酸の塩基配列決定装置
JPS60169495A (ja) 1984-02-15 1985-09-02 Takeda Chem Ind Ltd 変性されたｄνａおよびその用途
JPS60242368A (ja) 1984-05-16 1985-12-02 Hitachi Ltd 核酸塩基配列決定方法
FR2568254B1 (fr) 1984-07-25 1988-04-29 Centre Nat Rech Scient Application d'oligonucleotides lies a un agent intercalant, notamment a titre de medicament
JPS61103824A (ja) 1984-10-27 1986-05-22 Nippon Kayaku Co Ltd ポリリボイノシン酸・ポリリボシチヂル酸・ポリ−レ−リジン複合体の注射用製剤の新規調製法
US4828979A (en) 1984-11-08 1989-05-09 Life Technologies, Inc. Nucleotide analogs for nucleic acid labeling and detection
US4833251A (en) 1985-06-25 1989-05-23 Siska Diagnostics, Inc. Compounds for tagging nucleic acid probes
US5258538A (en) 1985-08-26 1993-11-02 Applied Biosystems, Inc. 2,3-disubstituted-1,3,2-oxazaphosphacycloalkanes as nucleic acid linking agents
US4757141A (en) 1985-08-26 1988-07-12 Applied Biosystems, Incorporated Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
US4868105A (en) 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US5212059A (en) 1988-01-11 1993-05-18 Microprobe Corporation Oligonucleotide probes for the detection of periodontal pathogens
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5811232A (en) 1989-12-04 1998-09-22 Isis Pharmaceuticals, Inc. Oligonucleotides for Papillomavirus
US5874564A (en) 1990-03-21 1999-02-23 Isis Pharmaceuticals, Inc. Reagents and methods for modulating gene expression through RNA mimicry
BR9106258A (pt) 1990-03-21 1993-04-06 Isis Pharmaceuticals Inc Processos para modular a expressao de um gene,para tratar uma doenca,um animal ou uma infeccao e para interferir com a funcao ou replicacao de um virus e oligonucleotideo ou analogo de oligonucleotideo
US5665710A (en) 1990-04-30 1997-09-09 Georgetown University Method of making liposomal oligodeoxynucleotide compositions
US5166195A (en) 1990-05-11 1992-11-24 Isis Pharmaceuticals, Inc. Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
ATE154246T1 (de) 1990-07-27 1997-06-15 Isis Pharmaceuticals Inc Nuklease resistente, pyrimidin modifizierte oligonukleotide, die die gen-expression detektieren und modulieren
KR970005273B1 (ko) 1990-08-16 1997-04-15 아이시스 파마슈티칼스, 인코포레이티드 거대세포 바이러스 감염의 효과를 완화시키기 위한 올리고뉴클레오티드
US5162654A (en) 1991-02-01 1992-11-10 Wisconsin Alumni Research Foundation Detection apparatus for electrophoretic gels
US5242906A (en) 1991-04-22 1993-09-07 University Of North Carolina At Chapel Hill Antisense oligonucleotides against Epstein-Barr virus
ES2092056T3 (es) 1991-09-23 1996-11-16 Pfizer Procedimiento para detectar arnm y adn especificos en celulas.
US5652094A (en) 1992-01-31 1997-07-29 University Of Montreal Nucleozymes
US5643780A (en) 1992-04-03 1997-07-01 Isis Pharmaceuticals, Inc. Compositions and methods for modulating RNA activity through modification of the 5' cap structure of RNA
US6303297B1 (en) 1992-07-17 2001-10-16 Incyte Pharmaceuticals, Inc. Database for storage and analysis of full-length sequences
US5541311A (en) 1992-12-07 1996-07-30 Third Wave Technologies, Inc. Nucleic acid encoding synthesis-deficient thermostable DNA polymerase
JPH0793370A (ja) 1993-09-27 1995-04-07 Hitachi Device Eng Co Ltd 遺伝子データベース検索システム
US5980096A (en) 1995-01-17 1999-11-09 Intertech Ventures, Ltd. Computer-based system, methods and graphical interface for information storage, modeling and stimulation of complex systems
DE19508366C2 (de) 1995-03-10 1998-01-29 Evotec Biosystems Gmbh Verfahren zum direkten Nachweisen weniger Nucleinsäurestränge
DE69637518D1 (de) 1995-12-22 2008-06-19 Dade Behring Marburg Gmbh Homogene vervielfältigung und nachweis von nukleinsäuren
CA2262776C (en) 1996-08-02 2005-03-08 Jim A. Wright Antitumor antisense sequences directed against r1 and r2 components of ribonucleotide reductase
US6189013B1 (en) 1996-12-12 2001-02-13 Incyte Genomics, Inc. Project-based full length biomolecular sequence database
US5953727A (en) 1996-10-10 1999-09-14 Incyte Pharmaceuticals, Inc. Project-based full-length biomolecular sequence database
TW520297B (en) 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
US5966712A (en) 1996-12-12 1999-10-12 Incyte Pharmaceuticals, Inc. Database and system for storing, comparing and displaying genomic information
EP1007737A4 (en) 1997-07-25 2002-07-03 Affymetrix Inc SYSTEM FOR OBTAINING A POLYMORPHISM DATABASE $ i ()

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ES8700270A1 (es) 1986-09-16
DE3382782T2 (de) 1995-10-19
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AU585199B2 (en) 1989-06-15
JP2625095B2 (ja) 1997-06-25
ES8802257A1 (es) 1988-04-16
DE3382626T2 (de) 1993-05-06
IL69051A0 (en) 1983-10-31
EP0302175A3 (en) 1990-10-31
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JP3170235B2 (ja) 2001-05-28
EP0097373B1 (en) 1992-10-07
JPH06234787A (ja) 1994-08-23
DE3382822T2 (de) 1998-11-19
EP0285057A3 (en) 1990-10-31
AU4149389A (en) 1990-01-04
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DK291183D0 (da) 1983-06-23
DE3382822D1 (de) 1998-06-04
AU1617983A (en) 1984-01-05
US8097405B1 (en) 2012-01-17
EP0285950A3 (en) 1990-11-07
DK291183A (da) 1983-12-24
ATE165605T1 (de) 1998-05-15
EP0097373A2 (en) 1984-01-04
EP0097373A3 (en) 1984-06-06
ATE119164T1 (de) 1995-03-15
EP0285950A2 (en) 1988-10-12
ES8700324A1 (es) 1986-10-01
ATE81342T1 (de) 1992-10-15
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EP0618228A1 (en) 1994-10-05
IL69051A (en) 1988-02-29
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EP0285058A3 (en) 1990-09-26
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EP0286898A2 (en) 1988-10-19
ES547320A0 (es) 1986-03-16
EP0285057A2 (en) 1988-10-05
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EP0302175A2 (en) 1989-02-08
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