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NO810851L - Fremgangsmaate for fremstilling av aspartam (kunstig soetningsmiddel) - Google Patents

Fremgangsmaate for fremstilling av aspartam (kunstig soetningsmiddel)

Info

Publication number
NO810851L
NO810851L NO810851A NO810851A NO810851L NO 810851 L NO810851 L NO 810851L NO 810851 A NO810851 A NO 810851A NO 810851 A NO810851 A NO 810851A NO 810851 L NO810851 L NO 810851L
Authority
NO
Norway
Prior art keywords
phe
asp
procedure
preparation
dipeptide
Prior art date
Application number
NO810851A
Other languages
English (en)
Inventor
Chander Prakash Bahl
Janine Estelle Rose
Thomas James White
Original Assignee
Cetus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Corp filed Critical Cetus Corp
Publication of NO810851L publication Critical patent/NO810851L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

Fremgangsmåte for fremstilling av :. det kunstige sotningsmiddel aspartam, som er et dipeptid med formel Asp-Phe-Me, 1 ved hjelp av en klonet mikroorganisme, '..' r. DNA som koder for et stort stabilt peptid bestående av den repeterende aminosyresekvens (Asp-Phe) ,innfores i en klonebefordrer som i sin tur innfores i en passende verts-mikroorganisme. Verts-mikroorganismen dyrkes og det store peptid inneholdende den gjentagende Asp-Phe-sekvens hostes derfra. Den fri karboksylgruppe av det store peptid benzyleres og hydrolyseres deretter til benzyl Asp-Phe-dipeptider. Dette dipeptid metyleres og debenzyleres deretter til å danne aspartam.
NO810851A 1980-03-14 1981-03-12 Fremgangsmaate for fremstilling av aspartam (kunstig soetningsmiddel) NO810851L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13046280A 1980-03-14 1980-03-14

Publications (1)

Publication Number Publication Date
NO810851L true NO810851L (no) 1981-09-15

Family

ID=22444802

Family Applications (1)

Application Number Title Priority Date Filing Date
NO810851A NO810851L (no) 1980-03-14 1981-03-12 Fremgangsmaate for fremstilling av aspartam (kunstig soetningsmiddel)

Country Status (7)

Country Link
EP (1) EP0036258A3 (no)
JP (1) JPS56140897A (no)
AU (1) AU6800481A (no)
DK (1) DK114681A (no)
FI (1) FI810777A7 (no)
IL (1) IL62343A0 (no)
NO (1) NO810851L (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK17881A (da) * 1980-01-30 1981-07-31 Searle & Co Syntetisk gen
ZA824218B (en) 1981-06-29 1983-04-27 Cetus Corp Plasmid for producing human insulin
DE3326520A1 (de) * 1983-07-22 1985-01-31 Hubert Prof. Dr. 2000 Hamburg Köster Verfahren zur definierten verknuepfung doppelhelikaler dna-fragmente mittels einer linker-dna sowie als linker-dna geeignete oligonucletide
WO1985001746A1 (en) * 1983-10-11 1985-04-25 Beatrice Companies, Inc. The manufacture and expression of genes for thaumatin
GB2153363B (en) * 1983-12-07 1988-05-05 Univ Manchester Method of preparation of cloning vector
CA1213537A (en) * 1984-05-01 1986-11-04 Canadian Patents And Development Limited - Societe Canadienne Des Brevets Et D'exploitation Limitee Polypeptide expression method
WO1988005082A1 (en) * 1987-01-07 1988-07-14 Allied Corporation Microbial production of peptide oligomers
DE69629460T2 (de) * 1995-04-11 2004-06-24 Merck & Co., Inc. Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden
JPH10136992A (ja) * 1996-11-07 1998-05-26 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法
RU2012129311A (ru) 2012-07-11 2014-01-20 Закрытое акционерное общество " Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Днк, кодирующая дипептид-синтезирующий фермер (варианты), бактерия рода escherichia и способ получения дипептидов с ее использованием

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3492131A (en) * 1966-04-18 1970-01-27 Searle & Co Peptide sweetening agents
IL55891A (en) * 1977-11-08 1983-10-31 Genentech Inc Synthetic dna,process for preparing it,recombinant microbial cloning vehicle containing such dna and products therefrom
GB2068971B (en) * 1980-01-30 1983-06-08 Searle & Co Recombinant dna techniques

Also Published As

Publication number Publication date
EP0036258A3 (en) 1982-02-10
FI810777L (fi) 1981-09-15
EP0036258A2 (en) 1981-09-23
FI810777A7 (fi) 1981-09-15
IL62343A0 (en) 1981-05-20
JPS56140897A (en) 1981-11-04
DK114681A (da) 1981-09-15
AU6800481A (en) 1981-09-17

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