NO803041L - Fremgangsmaate ved fremstilling av nb-kvartaere derivater av ajmalin og isoajmalin samt mellomprodukter for fremstilling av disse - Google Patents
Fremgangsmaate ved fremstilling av nb-kvartaere derivater av ajmalin og isoajmalin samt mellomprodukter for fremstilling av disseInfo
- Publication number
- NO803041L NO803041L NO803041A NO803041A NO803041L NO 803041 L NO803041 L NO 803041L NO 803041 A NO803041 A NO 803041A NO 803041 A NO803041 A NO 803041A NO 803041 L NO803041 L NO 803041L
- Authority
- NO
- Norway
- Prior art keywords
- isoajmalin
- ajmalin
- procedure
- manufacture
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 2
- CJDRUOGAGYHKKD-RQBLFBSQSA-N 1pon08459r Chemical class CN([C@H]1[C@@]2(C[C@@]3([H])[C@@H]([C@@H](O)N42)CC)[H])C2=CC=CC=C2[C@]11C[C@@]4([H])[C@H]3[C@H]1O CJDRUOGAGYHKKD-RQBLFBSQSA-N 0.000 title 1
- CJDRUOGAGYHKKD-UHFFFAOYSA-N Iso-ajmalin Natural products CN1C2=CC=CC=C2C2(C(C34)O)C1C1CC3C(CC)C(O)N1C4C2 CJDRUOGAGYHKKD-UHFFFAOYSA-N 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002908 adrenolytic effect Effects 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000962 organic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792941529 DE2941529A1 (de) | 1979-10-13 | 1979-10-13 | N(pfeil abwaerts)b(pfeil abwaerts) -quartaere derivate von ajmalin und isoajmalin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO803041L true NO803041L (no) | 1981-04-14 |
| NO156325B NO156325B (no) | 1987-05-25 |
| NO156325C NO156325C (no) | 1987-09-02 |
Family
ID=6083411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO803041A NO156325C (no) | 1979-10-13 | 1980-10-10 | Analogifremgangsmte ved fremstilling av terapeutisk aktive nb-kvartre derivater av ajmalin og isoajmalin. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4554274A (no) |
| EP (1) | EP0029115B1 (no) |
| JP (1) | JPS5681585A (no) |
| AT (1) | ATE9349T1 (no) |
| AU (1) | AU538949B2 (no) |
| CA (1) | CA1147329A (no) |
| DD (1) | DD153552A5 (no) |
| DE (2) | DE2941529A1 (no) |
| DK (1) | DK430580A (no) |
| ES (1) | ES495650A0 (no) |
| FI (1) | FI68624C (no) |
| GR (1) | GR70710B (no) |
| HU (1) | HU184840B (no) |
| IE (1) | IE50203B1 (no) |
| IL (1) | IL61253A (no) |
| NO (1) | NO156325C (no) |
| NZ (1) | NZ195220A (no) |
| PH (1) | PH15938A (no) |
| PT (1) | PT71894B (no) |
| SU (1) | SU963470A3 (no) |
| ZA (1) | ZA806167B (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2941531A1 (de) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 10-bromsandwicin und 10-bromisosandwicin, verfahren zu deren herstellung und deren verwendung |
| DE3442452A1 (de) * | 1984-11-22 | 1986-05-22 | Kali-Chemie Pharma Gmbh, 3000 Hannover | Neue n(pfeil abwaerts)b(pfeil abwaerts)-quartaere dibromderivate von ajmalin, isoajmalin, sandwicin und isosandwicin sowie diese derivate enthaltende pharmazeutische zubereitungen und zwischenprodukte und verfahren zu ihrer herstellung |
| RU2296765C1 (ru) * | 2005-10-13 | 2007-04-10 | Государственное образовательное учреждение высшего профессионального образования САНКТ-ПЕТЕРБУРГСКАЯ ГОСУДАРСТВЕННАЯ ХИМИКО-ФАРМАЦЕВТИЧЕСКАЯ АКАДЕМИЯ (ГОУ ВПО СПХФА Росздрава) | Способ получения солей n4-пропилаймалиния с карбоновыми кислотами, стабильный раствор n4-пропилаймалиния гидромалоната и способ его получения |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1196207B (de) * | 1962-12-17 | 1965-07-08 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen quartaeren Ajmaliniumsalzen |
-
1979
- 1979-10-13 DE DE19792941529 patent/DE2941529A1/de not_active Withdrawn
-
1980
- 1980-09-30 FI FI803086A patent/FI68624C/fi not_active IP Right Cessation
- 1980-10-02 SU SU802983702A patent/SU963470A3/ru active
- 1980-10-06 ZA ZA00806167A patent/ZA806167B/xx unknown
- 1980-10-06 ES ES495650A patent/ES495650A0/es active Granted
- 1980-10-07 IE IE2077/80A patent/IE50203B1/en unknown
- 1980-10-09 DD DD80224435A patent/DD153552A5/de unknown
- 1980-10-09 PT PT71894A patent/PT71894B/pt unknown
- 1980-10-10 AT AT80106150T patent/ATE9349T1/de not_active IP Right Cessation
- 1980-10-10 CA CA000362115A patent/CA1147329A/en not_active Expired
- 1980-10-10 EP EP80106150A patent/EP0029115B1/de not_active Expired
- 1980-10-10 IL IL61253A patent/IL61253A/xx unknown
- 1980-10-10 NZ NZ195220A patent/NZ195220A/xx unknown
- 1980-10-10 DE DE8080106150T patent/DE3069166D1/de not_active Expired
- 1980-10-10 DK DK430580A patent/DK430580A/da not_active Application Discontinuation
- 1980-10-10 HU HU802471A patent/HU184840B/hu not_active IP Right Cessation
- 1980-10-10 NO NO803041A patent/NO156325C/no unknown
- 1980-10-11 GR GR63126A patent/GR70710B/el unknown
- 1980-10-13 AU AU63205/80A patent/AU538949B2/en not_active Ceased
- 1980-10-13 JP JP14215780A patent/JPS5681585A/ja active Granted
- 1980-10-13 PH PH24716A patent/PH15938A/en unknown
-
1984
- 1984-05-31 US US06/615,757 patent/US4554274A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA806167B (en) | 1981-09-30 |
| IE50203B1 (en) | 1986-03-05 |
| IL61253A0 (en) | 1980-12-31 |
| JPS5681585A (en) | 1981-07-03 |
| DK430580A (da) | 1981-04-14 |
| ES8106523A1 (es) | 1981-07-01 |
| SU963470A3 (ru) | 1982-09-30 |
| EP0029115B1 (de) | 1984-09-12 |
| DD153552A5 (de) | 1982-01-13 |
| DE3069166D1 (en) | 1984-10-18 |
| AU6320580A (en) | 1981-04-16 |
| NZ195220A (en) | 1983-12-16 |
| CA1147329A (en) | 1983-05-31 |
| PH15938A (en) | 1983-04-29 |
| JPS6241598B2 (no) | 1987-09-03 |
| HU184840B (en) | 1984-10-29 |
| FI68624B (fi) | 1985-06-28 |
| IE802077L (en) | 1980-04-13 |
| US4554274A (en) | 1985-11-19 |
| NO156325C (no) | 1987-09-02 |
| NO156325B (no) | 1987-05-25 |
| PT71894B (en) | 1981-08-31 |
| AU538949B2 (en) | 1984-09-06 |
| ATE9349T1 (de) | 1984-09-15 |
| DE2941529A1 (de) | 1981-04-23 |
| GR70710B (no) | 1983-01-07 |
| FI68624C (fi) | 1985-10-10 |
| FI803086A7 (fi) | 1981-04-14 |
| PT71894A (en) | 1980-11-01 |
| IL61253A (en) | 1983-10-31 |
| ES495650A0 (es) | 1981-07-01 |
| EP0029115A1 (de) | 1981-05-27 |
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