NO333364B1 - Vandig injeksjonslosning omfattende en LHRH-antagonist samt en fremgangsmate for fremstilling - Google Patents

Vandig injeksjonslosning omfattende en LHRH-antagonist samt en fremgangsmate for fremstilling Download PDF

Info

Publication number: NO333364B1
Authority: NO; Norway
Prior art keywords: lhrh antagonist; gluconic acid; solution; polysorbate; mannitol
Prior art date: 2001-11-26

Application number

NO20042449A

Other languages

English (en)

Norwegian (no)

Other versions

NO20042449L (no

Inventor

Juergen Engel

Horst Bauer

Werner Sarlikiotis

Matthias Rischer

Frank Guethlein

Dominique Di Stefano

Original Assignee

Zentaris Ivf Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-26

Filing date

2004-06-11

Publication date

2013-05-13

2004-06-11 Application filed by Zentaris Ivf Gmbh filed Critical Zentaris Ivf Gmbh

2004-06-11 Publication of NO20042449L publication Critical patent/NO20042449L/no

2013-05-13 Publication of NO333364B1 publication Critical patent/NO333364B1/no

Links

229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 title claims abstract description 38
239000002474 gonadorelin antagonist Substances 0.000 title claims abstract description 32
239000000243 solution Substances 0.000 title claims abstract description 31
238000002347 injection Methods 0.000 title claims abstract description 25
239000007924 injection Substances 0.000 title claims abstract description 25
238000000034 method Methods 0.000 title description 4
239000004094 surface-active agent Substances 0.000 claims abstract description 14
108700008462 cetrorelix Proteins 0.000 claims abstract description 10
SBNPWPIBESPSIF-MHWMIDJBSA-N cetrorelix Chemical compound C([C@@H](C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 SBNPWPIBESPSIF-MHWMIDJBSA-N 0.000 claims abstract description 10
229960003230 cetrorelix Drugs 0.000 claims abstract description 9
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 13
229930195725 Mannitol Natural products 0.000 claims description 13
239000000594 mannitol Substances 0.000 claims description 13
235000010355 mannitol Nutrition 0.000 claims description 13
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 13
229920000053 polysorbate 80 Polymers 0.000 claims description 13
RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 11
PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 claims description 11
RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 11
235000012208 gluconic acid Nutrition 0.000 claims description 11
239000000174 gluconic acid Substances 0.000 claims description 11
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 10
229940068968 polysorbate 80 Drugs 0.000 claims description 10
239000003795 chemical substances by application Substances 0.000 claims description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
NOENHWMKHNSHGX-IZOOSHNJSA-N (2s)-1-[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-(ca Chemical compound C([C@H](C(=O)N[C@H](CCCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 NOENHWMKHNSHGX-IZOOSHNJSA-N 0.000 claims description 6
KATZUZNTRINHDT-HALMFYTRSA-N (2s)-1-[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]-methylamino]-3-(4-hydroxyphenyl)propanoyl]amino Chemical compound C([C@@H](C(=O)N[C@H](CCCCNC(N)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 KATZUZNTRINHDT-HALMFYTRSA-N 0.000 claims description 6
108010070670 antarelix Proteins 0.000 claims description 6
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GJNXBNATEDXMAK-PFLSVRRQSA-N ganirelix Chemical compound C([C@@H](C(=O)N[C@H](CCCCN=C(NCC)NCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN=C(NCC)NCC)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 GJNXBNATEDXMAK-PFLSVRRQSA-N 0.000 claims description 6
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108010023617 abarelix Proteins 0.000 claims description 5
229960002184 abarelix Drugs 0.000 claims description 5
AIWRTTMUVOZGPW-HSPKUQOVSA-N abarelix Chemical compound C([C@@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 AIWRTTMUVOZGPW-HSPKUQOVSA-N 0.000 claims description 5
239000008215 water for injection Substances 0.000 claims description 4
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims description 3
108700012941 GNRH1 Proteins 0.000 claims description 2
239000012047 saturated solution Substances 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 1
238000004220 aggregation Methods 0.000 abstract description 7
230000002776 aggregation Effects 0.000 abstract description 7
239000002253 acid Substances 0.000 abstract description 3
239000000945 filler Substances 0.000 abstract description 2
238000004128 high performance liquid chromatography Methods 0.000 description 4
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238000003860 storage Methods 0.000 description 3
239000000126 substance Substances 0.000 description 3
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000000654 additive Substances 0.000 description 2
239000000556 agonist Substances 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000009472 formulation Methods 0.000 description 2
230000007774 longterm Effects 0.000 description 2
230000002611 ovarian Effects 0.000 description 2
230000000638 stimulation Effects 0.000 description 2
CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
108010037003 Buserelin Proteins 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
102000006771 Gonadotropins Human genes 0.000 description 1
108010086677 Gonadotropins Proteins 0.000 description 1
108010069236 Goserelin Proteins 0.000 description 1
BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 1
101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
108010000817 Leuprolide Proteins 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
102100024028 Progonadoliberin-1 Human genes 0.000 description 1
206010060862 Prostate cancer Diseases 0.000 description 1
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 description 1
108010050144 Triptorelin Pamoate Proteins 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229960002719 buserelin Drugs 0.000 description 1
CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
229940112106 cetrotide Drugs 0.000 description 1
230000006957 competitive inhibition Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000004720 fertilization Effects 0.000 description 1
239000006260 foam Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 description 1
239000002622 gonadotropin Substances 0.000 description 1
229940035638 gonadotropin-releasing hormone Drugs 0.000 description 1
229960002913 goserelin Drugs 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 1
229960004338 leuprorelin Drugs 0.000 description 1
210000000287 oocyte Anatomy 0.000 description 1
229940070805 p-chloro-m-cresol Drugs 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
201000001514 prostate carcinoma Diseases 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000028327 secretion Effects 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
229960004824 triptorelin Drugs 0.000 description 1
VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Reproductive Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Diabetes (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Manufacturing Of Micro-Capsules (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

NO20042449A 2001-11-26 2004-06-11 Vandig injeksjonslosning omfattende en LHRH-antagonist samt en fremgangsmate for fremstilling NO333364B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10157628A DE10157628A1 (de)	2001-11-26	2001-11-26	Injektionslösung eines LHRH-Antagonisten
PCT/EP2002/012798 WO2003045419A1 (de)	2001-11-26	2002-11-15	Injektionslösung eines lhrh-antagonisten

Publications (2)

Publication Number	Publication Date
NO20042449L NO20042449L (no)	2004-06-11
NO333364B1 true NO333364B1 (no)	2013-05-13

Family

ID=7706799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20042449A NO333364B1 (no)	2001-11-26	2004-06-11	Vandig injeksjonslosning omfattende en LHRH-antagonist samt en fremgangsmate for fremstilling

Country Status (32)

Country	Link
EP (1)	EP1448221B1 (is)
JP (1)	JP4343693B2 (is)
KR (1)	KR100936636B1 (is)
CN (1)	CN100404068C (is)
AR (1)	AR037424A1 (is)
AT (1)	ATE350050T1 (is)
AU (1)	AU2002365504B2 (is)
BR (1)	BRPI0214412B8 (is)
CO (1)	CO5580793A2 (is)
CY (1)	CY1106401T1 (is)
DE (2)	DE10157628A1 (is)
DK (1)	DK1448221T3 (is)
EA (1)	EA010787B1 (is)
ES (1)	ES2276970T3 (is)
GE (1)	GEP20063861B (is)
HR (1)	HRP20040587B1 (is)
HU (1)	HU230992B1 (is)
IL (2)	IL161894A0 (is)
IS (1)	IS2725B (is)
ME (1)	ME00499B (is)
MX (1)	MXPA04005018A (is)
NO (1)	NO333364B1 (is)
NZ (1)	NZ533712A (is)
PL (1)	PL206199B1 (is)
PT (1)	PT1448221E (is)
RS (1)	RS51408B (is)
RU (1)	RU2322969C2 (is)
SI (1)	SI1448221T1 (is)
TW (1)	TWI312283B (is)
UA (1)	UA81612C2 (is)
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BRPI0710503A2 (pt)	2006-04-07	2011-08-16	Merrion Res Iii Ltd	uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral
JP5671451B2 (ja)	2008-05-07	2015-02-18	メリオン・リサーチ・Ｉｉｉ・リミテッド	ＧｎＲＨ関連化合物の組成物および調製プロセス
WO2011120033A1 (en)	2010-03-26	2011-09-29	Merrion Research Iii Limited	Pharmaceutical compositions of selective factor xa inhibitors for oral administration
JP2014501784A (ja)	2011-01-07	2014-01-23	メリオン・リサーチ・Ｉｉｉ・リミテッド	経口投与用の鉄の医薬組成物
CN103690560B (zh) *	2013-12-17	2016-08-17	辽宁海思科制药有限公司	一种转化糖电解质注射液药物组合物及其制备方法
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Also Published As

Publication number	Publication date
NO20042449L (no)	2004-06-11
IS7251A (is)	2004-05-06
EP1448221B1 (de)	2007-01-03
KR20040058312A (ko)	2004-07-03
HU230992B1 (hu)	2019-08-28
IS2725B (is)	2011-03-15
HRP20040587B1 (en)	2008-01-31
PL206199B1 (pl)	2010-07-30
JP4343693B2 (ja)	2009-10-14
CY1106401T1 (el)	2011-10-12
TW200300352A (en)	2003-06-01
IL161894A (en)	2014-05-28
ES2276970T3 (es)	2007-07-01
AU2002365504B2 (en)	2007-06-28
CN1592630A (zh)	2005-03-09
UA81612C2 (ru)	2008-01-25
ZA200404051B (en)	2005-05-25
RU2004119821A (ru)	2005-04-20
PT1448221E (pt)	2007-03-30
CN100404068C (zh)	2008-07-23
GEP20063861B (en)	2006-06-26
CO5580793A2 (es)	2005-11-30
AU2002365504A1 (en)	2003-06-10
HRP20040587A2 (en)	2004-10-31
NZ533712A (en)	2006-01-27
EA010787B1 (ru)	2008-10-30
HK1073078A1 (zh)	2005-09-23
SI1448221T1 (sl)	2007-06-30
JP2005510544A (ja)	2005-04-21
BR0214412A (pt)	2004-09-14
BRPI0214412B8 (pt)	2021-05-25
DE50209193D1 (de)	2007-02-15
RS44904A (sr)	2006-10-27
EA200400742A1 (ru)	2004-12-30
AR037424A1 (es)	2004-11-10
KR100936636B1 (ko)	2010-01-14
BRPI0214412B1 (pt)	2016-01-05
DK1448221T3 (da)	2007-03-19
HUP0401986A2 (hu)	2005-01-28
RS51408B (sr)	2011-02-28
IL161894A0 (en)	2005-11-20
ATE350050T1 (de)	2007-01-15
RU2322969C2 (ru)	2008-04-27
ME00499B (me)	2011-10-10
MXPA04005018A (es)	2004-08-11
EP1448221A1 (de)	2004-08-25
WO2003045419A1 (de)	2003-06-05
TWI312283B (en)	2009-07-21
HUP0401986A3 (en)	2012-09-28
PL369548A1 (en)	2005-05-02
DE10157628A1 (de)	2003-06-12

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