NO323933B1 - Stabil ikke-vandig formulering av en peptidforbindelse, fremgangsmate for fremstilling av denne og anvendelse av formuleringen til fremstillig av medikament. - Google Patents

Stabil ikke-vandig formulering av en peptidforbindelse, fremgangsmate for fremstilling av denne og anvendelse av formuleringen til fremstillig av medikament. Download PDF

Info

Publication number: NO323933B1
Authority: NO; Norway
Prior art keywords: leuprolide; formulation; formulations; peptide compound; aqueous
Prior art date: 1996-07-03

Application number

NO19986209A

Other languages

English (en)

Norwegian (no)

Other versions

NO986209L (no

NO986209D0 (no

Inventor

Jeremy Corwin Wright

Cynthia L Stevenson

Steven J Prestrelski

Sally Tao

Joe Leonard

James B Eckenhoff

Original Assignee

Alza Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-03

Filing date

1998-12-30

Publication date

2007-07-23

1998-12-30 Application filed by Alza Corp filed Critical Alza Corp

1998-12-30 Publication of NO986209L publication Critical patent/NO986209L/no

1998-12-30 Publication of NO986209D0 publication Critical patent/NO986209D0/no

2007-07-23 Publication of NO323933B1 publication Critical patent/NO323933B1/no

Links

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CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 description 1
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BLCLNMBMMGCOAS-UHFFFAOYSA-N n-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amin Chemical compound C1CCC(C(=O)NNC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 BLCLNMBMMGCOAS-UHFFFAOYSA-N 0.000 description 1
PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 description 1
229910052757 nitrogen Chemical group 0.000 description 1
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150000007530 organic bases Chemical class 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
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NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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238000007920 subcutaneous administration Methods 0.000 description 1
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239000012730 sustained-release form Substances 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
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238000003260 vortexing Methods 0.000 description 1
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NXSIJWJXMWBCBX-NWKQFZAZSA-N α-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 NXSIJWJXMWBCBX-NWKQFZAZSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oil, Petroleum & Natural Gas (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

NO19986209A 1996-07-03 1998-12-30 Stabil ikke-vandig formulering av en peptidforbindelse, fremgangsmate for fremstilling av denne og anvendelse av formuleringen til fremstillig av medikament. NO323933B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US2112996P	1996-07-03	1996-07-03
PCT/US1997/010815 WO1998000152A1 (en)	1996-07-03	1997-07-01	Non-aqueous protic peptide formulations

Publications (3)

Publication Number	Publication Date
NO986209L NO986209L (no)	1998-12-30
NO986209D0 NO986209D0 (no)	1998-12-30
NO323933B1 true NO323933B1 (no)	2007-07-23

Family

ID=21802501

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19986209A NO323933B1 (no)	1996-07-03	1998-12-30	Stabil ikke-vandig formulering av en peptidforbindelse, fremgangsmate for fremstilling av denne og anvendelse av formuleringen til fremstillig av medikament.

Country Status (27)

Country	Link
EP (1)	EP0909175B1 (id)
JP (3)	JP2001504802A (id)
CN (1)	CN1231256C (id)
AR (1)	AR008060A1 (id)
AT (1)	ATE241997T1 (id)
AU (1)	AU737664B2 (id)
BR (1)	BR9710130A (id)
CA (1)	CA2259403A1 (id)
CO (1)	CO4890854A1 (id)
CZ (1)	CZ433898A3 (id)
DE (1)	DE69722620T2 (id)
DK (1)	DK0909175T3 (id)
ES (1)	ES2201306T3 (id)
HU (1)	HUP9903942A3 (id)
ID (1)	ID19165A (id)
IL (1)	IL127769A (id)
MY (1)	MY121684A (id)
NO (1)	NO323933B1 (id)
NZ (1)	NZ333580A (id)
PL (1)	PL189402B1 (id)
PT (1)	PT909175E (id)
RO (1)	RO119862B1 (id)
RU (1)	RU2203085C2 (id)
SK (1)	SK284490B6 (id)
TW (1)	TW491703B (id)
WO (1)	WO1998000152A1 (id)
ZA (1)	ZA975942B (id)

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ES2763404T3 (es)	2010-08-11	2020-05-28	Ironwood Pharmaceuticals Inc	Formulaciones estables de linaclotida
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JP6312592B2 (ja)	2011-08-17	2018-04-18	アイアンウッドファーマシューティカルズインコーポレイテッド	消化器疾患の治療
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US9956287B2 (en)	2013-02-06	2018-05-01	Perosphere Inc.	Stable glucagon formulations
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US4897256A (en) *	1986-11-25	1990-01-30	Abbott Laboratories	LHRH analog formulations
JP2851627B2 (ja) *	1987-10-15	1999-01-27	シンテックス（ユー・エス・エイ）インコーポレイテッド	粉末形態ポリプペチド類の経鼻投与
US4980163A (en) *	1989-03-01	1990-12-25	Public Health Research Institute Of The City Of New York	Novel bacteriocin compositions for use as enhanced broad range bactericides and methods of preventing and treating microbial infection
US5158761A (en) *	1989-04-05	1992-10-27	Toko Yakuhin Kogyo Kabushiki Kaisha	Spray gel base and spray gel preparation using thereof
IT1237197B (it) *	1989-11-16	1993-05-26	Sclavo Spa	Formulazioni farmaceutiche anidre e forme di dosaggio per la somministrazione rettale di calcitonina.
RU2008354C1 (ru) *	1991-03-13	1994-02-28	Данилевич Василий Николаевич	Способ хранения препарата протеиназ
AU5018693A (en) *	1992-09-21	1994-04-12	Upjohn Company, The	Sustained-release protein formulations
ATE197550T1 (de) *	1993-02-23	2000-12-15	Genentech Inc	Stabilisierung von mit organischen lösungsmittel behandelten polypeptiden mit einem hilfsstoff
US5955430A (en) *	1993-09-24	1999-09-21	University Of Southern California	Use of angiotensin II fragments and analogs thereof in tissue repair
JP3597233B2 (ja) *	1993-10-21	2004-12-02	久光製薬株式会社	経鼻組成物及びそれを含有する経鼻製剤
EP0909175B1 (en) *	1996-07-03	2003-06-04	Alza Corporation	Non-aqueous protic peptide formulations

1997
- 1997-07-01 EP EP97930181A patent/EP0909175B1/en not_active Expired - Lifetime
- 1997-07-01 CA CA002259403A patent/CA2259403A1/en not_active Abandoned
- 1997-07-01 BR BR9710130A patent/BR9710130A/pt not_active Application Discontinuation
- 1997-07-01 AU AU34073/97A patent/AU737664B2/en not_active Ceased
- 1997-07-01 IL IL127769A patent/IL127769A/en not_active IP Right Cessation
- 1997-07-01 HU HU9903942A patent/HUP9903942A3/hu unknown
- 1997-07-01 RO RO98-01769A patent/RO119862B1/ro unknown
- 1997-07-01 AT AT97930181T patent/ATE241997T1/de active
- 1997-07-01 ES ES97930181T patent/ES2201306T3/es not_active Expired - Lifetime
- 1997-07-01 CZ CZ984338A patent/CZ433898A3/cs unknown
- 1997-07-01 DE DE69722620T patent/DE69722620T2/de not_active Expired - Lifetime
- 1997-07-01 PT PT97930181T patent/PT909175E/pt unknown
- 1997-07-01 RU RU99102540/14A patent/RU2203085C2/ru not_active IP Right Cessation
- 1997-07-01 JP JP50421898A patent/JP2001504802A/ja not_active Withdrawn
- 1997-07-01 SK SK1799-98A patent/SK284490B6/sk not_active IP Right Cessation
- 1997-07-01 PL PL97330869A patent/PL189402B1/pl not_active IP Right Cessation
- 1997-07-01 WO PCT/US1997/010815 patent/WO1998000152A1/en not_active Ceased
- 1997-07-01 CN CNB971960534A patent/CN1231256C/zh not_active Expired - Fee Related
- 1997-07-01 DK DK97930181T patent/DK0909175T3/da active
- 1997-07-01 NZ NZ333580A patent/NZ333580A/en not_active IP Right Cessation
- 1997-07-02 AR ARP970102967A patent/AR008060A1/es unknown
- 1997-07-03 ZA ZA9705942A patent/ZA975942B/xx unknown
- 1997-07-03 MY MYPI97003024A patent/MY121684A/en unknown
- 1997-07-03 CO CO97037097A patent/CO4890854A1/es unknown
- 1997-07-03 ID IDP972315A patent/ID19165A/id unknown
- 1997-08-22 TW TW086109392A patent/TW491703B/zh not_active IP Right Cessation
1998
- 1998-12-30 NO NO19986209A patent/NO323933B1/no not_active IP Right Cessation
2008
- 2008-04-23 JP JP2008112307A patent/JP2008195739A/ja active Pending
2009
- 2009-10-05 JP JP2009231256A patent/JP2010043105A/ja active Pending

Also Published As

Publication number	Publication date
SK284490B6 (sk)	2005-05-05
ID19165A (id)	1998-06-28
CN1224356A (zh)	1999-07-28
RU2203085C2 (ru)	2003-04-27
PT909175E (pt)	2003-10-31
AR008060A1 (es)	1999-12-09
EP0909175B1 (en)	2003-06-04
CO4890854A1 (es)	2000-02-28
RO119862B1 (ro)	2005-05-30
DE69722620D1 (de)	2003-07-10
MY121684A (en)	2006-02-28
JP2001504802A (ja)	2001-04-10
AU3407397A (en)	1998-01-21
PL330869A1 (en)	1999-06-07
JP2010043105A (ja)	2010-02-25
EP0909175A1 (en)	1999-04-21
WO1998000152A1 (en)	1998-01-08
DK0909175T3 (da)	2003-09-29
CA2259403A1 (en)	1998-01-08
HUP9903942A3 (en)	2000-07-28
ES2201306T3 (es)	2004-03-16
IL127769A (en)	2006-10-31
NO986209L (no)	1998-12-30
CZ433898A3 (cs)	1999-04-14
ATE241997T1 (de)	2003-06-15
IL127769A0 (en)	1999-10-28
BR9710130A (pt)	1999-08-10
TW491703B (en)	2002-06-21
SK179998A3 (en)	1999-05-07
JP2008195739A (ja)	2008-08-28
ZA975942B (en)	1998-04-16
CN1231256C (zh)	2005-12-14
DE69722620T2 (de)	2004-04-29
HUP9903942A2 (hu)	2000-04-28
AU737664B2 (en)	2001-08-30
PL189402B1 (pl)	2005-08-31
NZ333580A (en)	2000-06-23
NO986209D0 (no)	1998-12-30

Publication	Publication Date	Title
EP0909175B1 (en)	2003-06-04	Non-aqueous protic peptide formulations
EP0909177B1 (en)	2004-02-11	Aqueous formulations of peptides
EP1208846B1 (en)	2004-04-07	Non-aqueous polar aprotic peptide formulations comprising LHRH-related compounds
US5981489A (en)	1999-11-09	Non-aqueous protic peptide formulations
AU2004242540B2 (en)	2007-12-13	Aqueous formulations of peptides
KR100594519B1 (ko)	2007-03-02	비수성양성자성펩티드제제
AU775395B2 (en)	2004-07-29	Non-aqueous polar aprotic peptide formulations
HK1124244A (en)	2009-07-10	Non-aqueous polar aprotic peptide formulations

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