NO328509B1 - 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat omfattende disse og anvendelse derav for fremstilling av et medikament - Google Patents

6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat omfattende disse og anvendelse derav for fremstilling av et medikament Download PDF

Info

Publication number: NO328509B1
Authority: NO; Norway
Prior art keywords: amino; cyclopentylpurine; trans; aminocyclohexyl; piperidinylamino
Prior art date: 1998-02-26

Application number

NO20004280A

Other languages

English (en)

Norwegian (no)

Other versions

NO20004280D0 (no

NO20004280L (no

Inventor

Jennifer Ann Dumont

Alan Joseph Bitonti

David Roger Borcherding

Harry Randall Munson

Patrick Wai-Kwok Shum

Norton Paul Peet

Original Assignee

Aventisub Ii Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-26

Filing date

2000-08-25

Publication date

2010-03-08

2000-08-25 Application filed by Aventisub Ii Inc filed Critical Aventisub Ii Inc

2000-08-25 Publication of NO20004280D0 publication Critical patent/NO20004280D0/no

2000-10-25 Publication of NO20004280L publication Critical patent/NO20004280L/no

2010-03-08 Publication of NO328509B1 publication Critical patent/NO328509B1/no

Links

-1 6,9-disubstituted 2- [trans- (4-aminocyclohexyl) amino] purines Chemical class 0.000 title claims description 265
238000002360 preparation method Methods 0.000 title claims description 114
239000003814 drug Substances 0.000 title claims description 7
239000008194 pharmaceutical composition Substances 0.000 title 1
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 789
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 528
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 91
125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims description 54
229910052739 hydrogen Inorganic materials 0.000 claims description 51
239000001257 hydrogen Substances 0.000 claims description 51
150000001875 compounds Chemical class 0.000 claims description 48
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 45
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 39
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 35
150000002431 hydrogen Chemical class 0.000 claims description 35
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 34
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 33
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 32
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
201000010099 disease Diseases 0.000 claims description 26
125000000217 alkyl group Chemical group 0.000 claims description 22
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
125000003386 piperidinyl group Chemical group 0.000 claims description 21
238000011282 treatment Methods 0.000 claims description 17
125000001041 indolyl group Chemical group 0.000 claims description 16
125000001624 naphthyl group Chemical group 0.000 claims description 16
210000002569 neuron Anatomy 0.000 claims description 15
230000006907 apoptotic process Effects 0.000 claims description 13
125000001424 substituent group Chemical group 0.000 claims description 12
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 11
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 11
239000000203 mixture Substances 0.000 claims description 11
239000002246 antineoplastic agent Substances 0.000 claims description 10
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 10
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 10
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 10
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
150000003839 salts Chemical class 0.000 claims description 9
CPHXLFKIUVVIOQ-UHFFFAOYSA-N 2-(trifluoromethoxy)benzaldehyde Chemical group FC(F)(F)OC1=CC=CC=C1C=O CPHXLFKIUVVIOQ-UHFFFAOYSA-N 0.000 claims description 8
125000002774 3,4-dimethoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C(OC([H])([H])[H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims description 8
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
125000006308 propyl amino group Chemical group 0.000 claims description 8
125000002769 thiazolinyl group Chemical group 0.000 claims description 8
DWCUFHSZFVHEQY-MCXZQIONSA-N Cl.Cl.CCCCCCCCCCCCNc1nc(N[C@H]2CC[C@H](N)CC2)nc2n(cnc12)C1CCCC1 Chemical group Cl.Cl.CCCCCCCCCCCCNc1nc(N[C@H]2CC[C@H](N)CC2)nc2n(cnc12)C1CCCC1 DWCUFHSZFVHEQY-MCXZQIONSA-N 0.000 claims description 7
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 7
230000003287 optical effect Effects 0.000 claims description 7
125000000719 pyrrolidinyl group Chemical group 0.000 claims description 7
229940034982 antineoplastic agent Drugs 0.000 claims description 6
229940079593 drug Drugs 0.000 claims description 6
150000004677 hydrates Chemical class 0.000 claims description 6
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HOXNEOGOBNKIKM-VAJGKAQFSA-N Cl.Cl.COCCOCCCNc1nc(N[C@H]2CC[C@H](N)CC2)nc2n(cnc12)C1CCCC1 Chemical compound Cl.Cl.COCCOCCCNc1nc(N[C@H]2CC[C@H](N)CC2)nc2n(cnc12)C1CCCC1 HOXNEOGOBNKIKM-VAJGKAQFSA-N 0.000 claims description 5
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20004280A 1998-02-26 2000-08-25 6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat omfattende disse og anvendelse derav for fremstilling av et medikament NO328509B1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US3097598A	1998-02-26	1998-02-26
US13510998P	1998-02-26	1998-02-26
US09/247,053 US6479487B1 (en)	1998-02-26	1999-02-09	6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
PCT/US1999/003450 WO1999043675A1 (en)	1998-02-26	1999-02-18	6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

Publications (3)

Publication Number	Publication Date
NO20004280D0 NO20004280D0 (no)	2000-08-25
NO20004280L NO20004280L (no)	2000-10-25
NO328509B1 true NO328509B1 (no)	2010-03-08

Family

ID=27363758

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20004280A NO328509B1 (no)	1998-02-26	2000-08-25	6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat omfattende disse og anvendelse derav for fremstilling av et medikament

Country Status (17)

Country	Link
US (1)	US6479487B1 (et)
EP (1)	EP1056744B1 (et)
JP (1)	JP2002504552A (et)
CN (1)	CN1143858C (et)
AP (1)	AP1054A (et)
AU (1)	AU747151B2 (et)
BR (1)	BR9909256A (et)
CA (1)	CA2320474C (et)
EE (1)	EE04815B1 (et)
HU (1)	HUP0100889A3 (et)
IL (1)	IL138043A0 (et)
NO (1)	NO328509B1 (et)
PL (1)	PL194174B1 (et)
SK (1)	SK12902000A3 (et)
TR (1)	TR200002463T2 (et)
WO (1)	WO1999043675A1 (et)
ZA (1)	ZA991551B (et)

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1999
- 1999-02-09 US US09/247,053 patent/US6479487B1/en not_active Expired - Fee Related
- 1999-02-18 EP EP99908220A patent/EP1056744B1/en not_active Expired - Lifetime
- 1999-02-18 BR BR9909256-5A patent/BR9909256A/pt not_active Application Discontinuation
- 1999-02-18 HU HU0100889A patent/HUP0100889A3/hu unknown
- 1999-02-18 AP APAP/P/2000/001922A patent/AP1054A/en active
- 1999-02-18 EE EEP200000489A patent/EE04815B1/et not_active IP Right Cessation
- 1999-02-18 SK SK1290-2000A patent/SK12902000A3/sk unknown
- 1999-02-18 CN CNB998033979A patent/CN1143858C/zh not_active Expired - Fee Related
- 1999-02-18 PL PL99342604A patent/PL194174B1/pl not_active IP Right Cessation
- 1999-02-18 WO PCT/US1999/003450 patent/WO1999043675A1/en not_active Ceased
- 1999-02-18 IL IL13804399A patent/IL138043A0/xx not_active IP Right Cessation
- 1999-02-18 AU AU27709/99A patent/AU747151B2/en not_active Ceased
- 1999-02-18 CA CA002320474A patent/CA2320474C/en not_active Expired - Fee Related
- 1999-02-18 JP JP2000533430A patent/JP2002504552A/ja active Pending
- 1999-02-18 TR TR2000/02463T patent/TR200002463T2/xx unknown
- 1999-02-25 ZA ZA9901551A patent/ZA991551B/xx unknown
2000
- 2000-08-25 NO NO20004280A patent/NO328509B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP2002504552A (ja)	2002-02-12
AP1054A (en)	2002-04-01
WO1999043675A1 (en)	1999-09-02
AU2770999A (en)	1999-09-15
SK12902000A3 (sk)	2001-04-09
BR9909256A (pt)	2000-11-28
TR200002463T2 (tr)	2000-12-21
CN1292789A (zh)	2001-04-25
CN1143858C (zh)	2004-03-31
HUP0100889A2 (hu)	2002-01-28
NO20004280D0 (no)	2000-08-25
PL194174B1 (pl)	2007-05-31
PL342604A1 (en)	2001-06-18
CA2320474A1 (en)	1999-09-02
US6479487B1 (en)	2002-11-12
AP2000001922A0 (en)	2000-09-30
EE200000489A (et)	2002-04-15
AU747151B2 (en)	2002-05-09
NO20004280L (no)	2000-10-25
EP1056744B1 (en)	2003-10-22
IL138043A0 (en)	2001-10-31
ZA991551B (en)	1999-08-26
CA2320474C (en)	2005-05-10
HUP0100889A3 (en)	2003-07-28
EE04815B1 (et)	2007-04-16
EP1056744A1 (en)	2000-12-06

Publication	Publication Date	Title
NO328509B1 (no)	2010-03-08	6,9-disubstituerte 2-[trans-(4-aminocykloheksyl)amino]puriner, farmasoytisk preparat omfattende disse og anvendelse derav for fremstilling av et medikament
US6413974B1 (en)	2002-07-02	6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
AU748178B2 (en)	2002-05-30	6,9-disubstituted 2-(trans-(4- aminocyclohexyl) amino)purines
AU2002239388B2 (en)	2006-05-25	Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
AU2002239388A1 (en)	2002-08-08	Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
US6642231B2 (en)	2003-11-04	6,9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
US20030069259A1 (en)	2003-04-10	Acyl and sulfonyl derivatives of 6,9-disubstituted 2-(trans-1,4-diaminocyclohexyl)-purines and their use as antiproliferative agents
ES2207182T3 (es)	2004-05-16	2-(trans-(4- aminociclohexil) amino) purinas 6,9-disustituidas.
CZ20003104A3 (cs)	2001-01-17	6,9-Disubstituované 2-[trans-(4- aminocyklohexyl)amino]-puriny, farmaceutické prostředky obsahující tyto sloučeniny a použití
MXPA00008377A (en)	2002-07-25	6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines
HK1030949B (en)	2004-03-19	6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino]purines
HK1030948B (en)	2004-12-10	6,9-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
MXPA00008376A (en)	2002-07-25	6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines

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