NO328178B1 - Anvendelse av farnesyl proteintransferaseinhibitorer for fremstilling av en farmasoytisk sammensetning med in vivo radiosensibiliserende egenskaper - Google Patents

Anvendelse av farnesyl proteintransferaseinhibitorer for fremstilling av en farmasoytisk sammensetning med in vivo radiosensibiliserende egenskaper Download PDF

Info

Publication number: NO328178B1
Authority: NO; Norway
Prior art keywords: 6alkyl; alkyl; hydrogen; formula; methyl
Prior art date: 1998-07-06

Application number

NO20010082A

Other languages

English (en)

Norwegian (no)

Other versions

NO20010082D0 (no

NO20010082L (no

Inventor

Robert Franciscus Van Ginckel

Wim Joanna Floren

David William End

Walter Boudewijn Leopold Wouters

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-06

Filing date

2001-01-05

Publication date

2009-12-28

2001-01-05 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2001-01-05 Publication of NO20010082D0 publication Critical patent/NO20010082D0/no

2001-01-05 Publication of NO20010082L publication Critical patent/NO20010082L/no

2009-12-28 Publication of NO328178B1 publication Critical patent/NO328178B1/no

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

NO20010082A 1998-07-06 2001-01-05 Anvendelse av farnesyl proteintransferaseinhibitorer for fremstilling av en farmasoytisk sammensetning med in vivo radiosensibiliserende egenskaper NO328178B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP98202257		1998-07-06
EP98204330		1998-12-18
PCT/EP1999/004545 WO2000001411A1 (en)	1998-07-06	1999-06-30	Farnesyl protein transferase inhibitors with in vivo radiosensitizing properties

Publications (3)

Publication Number	Publication Date
NO20010082D0 NO20010082D0 (no)	2001-01-05
NO20010082L NO20010082L (no)	2001-01-05
NO328178B1 true NO328178B1 (no)	2009-12-28

Family

ID=26150503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20010082A NO328178B1 (no)	1998-07-06	2001-01-05	Anvendelse av farnesyl proteintransferaseinhibitorer for fremstilling av en farmasoytisk sammensetning med in vivo radiosensibiliserende egenskaper

Country Status (30)

Country	Link
US (1)	US6545020B1 (pt)
EP (1)	EP1094839B1 (pt)
JP (1)	JP4530537B2 (pt)
KR (1)	KR100591603B1 (pt)
CN (1)	CN1152716C (pt)
AP (1)	AP1599A (pt)
AT (1)	ATE238811T1 (pt)
AU (1)	AU762423B2 (pt)
BG (1)	BG64941B1 (pt)
BR (1)	BR9911861A (pt)
CA (1)	CA2336624C (pt)
CZ (1)	CZ300968B6 (pt)
DE (1)	DE69907461T2 (pt)
DK (1)	DK1094839T3 (pt)
EA (1)	EA003877B1 (pt)
EE (1)	EE04582B1 (pt)
ES (1)	ES2199579T3 (pt)
HR (1)	HRP20000903A2 (pt)
HU (1)	HU229076B1 (pt)
ID (1)	ID26987A (pt)
IL (2)	IL140721A0 (pt)
MY (1)	MY126519A (pt)
NO (1)	NO328178B1 (pt)
PL (1)	PL193464B1 (pt)
PT (1)	PT1094839E (pt)
SI (1)	SI1094839T1 (pt)
SK (1)	SK284723B6 (pt)
TR (1)	TR200003879T2 (pt)
TW (1)	TW586937B (pt)
WO (1)	WO2000001411A1 (pt)

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JP4974437B2 (ja)	2000-09-25	2012-07-11	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害する６−［（置換フェニル）メチル］−キノリンおよびキナゾリン誘導体
US7196094B2 (en)	2000-09-25	2007-03-27	Janssen Pharmaceutica, N.V.	Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives
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JP4348080B2 (ja)	2000-11-21	2009-10-21	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	ファルネシルトランスフェラーゼを阻害するベンゾ複素環誘導体
ES2260316T3 (es)	2000-12-27	2006-11-01	Janssen Pharmaceutica N.V.	Derivados de quinazolina y quinolina 4-sustituidos que inhiben la farnesil transferasa.
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CA2469275C (en)	2001-12-19	2011-09-06	Janssen Pharmaceutica N.V.	1,8-annelated quinoline derivatives substituted with carbon-linked triazoles as farnesyl transferase inhibitors
AU2003223970B2 (en)	2002-03-22	2008-03-06	Janssen Pharmaceutica N.V.	Benzylimidazolyl substituted 2-quinoline and quinazoline derivatives for use as farnesyl transferase inhibitors
EP1497295B1 (en)	2002-04-15	2006-08-16	Janssen Pharmaceutica N.V.	Farnesyl transferase inhibiting tricyclic quinazoline derivatives substituted with carbon-linked imidazoles or triazoles
US7517890B2 (en)	2003-11-20	2009-04-14	Children's Hospital Medical Center	GTPase inhibitors and methods of use
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WO2005089502A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
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US20050272722A1 (en) *	2004-03-18	2005-12-08	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20070293539A1 (en) *	2004-03-18	2007-12-20	Lansbury Peter T	Methods for the treatment of synucleinopathies
WO2005089518A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Uch-l1 expression and cancer therapy
WO2005089504A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US20060194821A1 (en) *	2005-02-18	2006-08-31	The Brigham And Women's Hospital, Inc.	Compounds inhibiting the aggregation of superoxide dismutase-1
EP1920048A4 (en)	2005-07-29	2009-12-09	Childrens Hosp Medical Center	GTASE INHIBITORS AND USE METHOD AND CRYSTAL STRUCTURE OF RAC-1 GTASE
EP2545919A1 (en)	2005-12-23	2013-01-16	Link Medicine Corporation	Treatment of synucleinopathies
WO2008147788A1 (en) *	2007-05-23	2008-12-04	Allergan, Inc.	Therapeutic ((phenyl)imidazolyl)methylquinolinyl compounds
US8232402B2 (en) *	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2138844B1 (en)	2008-06-26	2012-04-25	SpheroTec GmbH	Method for testing the response of cells to exposures with therapeutics
US20110060005A1 (en) *	2008-11-13	2011-03-10	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20100331363A1 (en) *	2008-11-13	2010-12-30	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
JP2012508768A (ja) *	2008-11-13	2012-04-12	リンク・メディスン・コーポレーション	アザキノリノン誘導体及びその使用
US9980942B2 (en)	2012-05-02	2018-05-29	Children's Hospital Medical Center	Rejuvenation of precursor cells
MY189505A (en)	2012-10-16	2022-02-16	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of roryt
PE20151203A1 (es)	2012-10-16	2015-08-31	Janssen Pharmaceutica Nv	MODULADORES DE QUINOLINILO UNIDOS A FENILO DE ROR-GAMMA-t
HK1213250A1 (zh)	2012-10-16	2016-06-30	Janssen Pharmaceutica, N.V.	RORγT的雜芳基連接的喹啉基調節劑
US9328095B2 (en)	2013-10-15	2016-05-03	Janssen Pharmaceutica Nv	Heteroaryl linked quinolinyl modulators of RORgammat
US9403816B2 (en)	2013-10-15	2016-08-02	Janssen Pharmaceutica Nv	Phenyl linked quinolinyl modulators of RORγt
US9284308B2 (en)	2013-10-15	2016-03-15	Janssen Pharmaceutica Nv	Methylene linked quinolinyl modulators of RORγt
AU2014334619A1 (en)	2013-10-15	2016-04-21	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORyt
US10555941B2 (en)	2013-10-15	2020-02-11	Janssen Pharmaceutica Nv	Alkyl linked quinolinyl modulators of RORγt
US9221804B2 (en)	2013-10-15	2015-12-29	Janssen Pharmaceutica Nv	Secondary alcohol quinolinyl modulators of RORγt
CA2927182A1 (en)	2013-10-15	2015-04-23	Janssen Pharmaceutica Nv	Quinolinyl modulators of ror.gamma.t
US10028503B2 (en)	2014-06-18	2018-07-24	Children's Hospital Medical Center	Platelet storage methods and compositions for same
TWI621437B (zh)	2015-08-17	2018-04-21	庫拉腫瘤技術股份有限公司	以法呢基轉移酶（farnesyltransferase）抑制劑治療癌症病患之方法
US20190119758A1 (en)	2016-04-22	2019-04-25	Kura Oncology, Inc.	Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
LT3534885T (lt)	2016-11-03	2021-07-12	Kura Oncology, Inc.	Farneziltransferazės inhibitoriai, skirti naudoti vėžio gydymui
US9956215B1 (en)	2017-02-21	2018-05-01	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2018156609A1 (en)	2017-02-21	2018-08-30	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US10806730B2 (en)	2017-08-07	2020-10-20	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
CN111182899A (zh)	2017-08-07	2020-05-19	库拉肿瘤学公司	使用法尼基转移酶抑制剂治疗癌症的方法
WO2019113269A1 (en)	2017-12-08	2019-06-13	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
TW202031259A (zh)	2018-11-01	2020-09-01	美商庫拉腫瘤技術股份有限公司	以法尼基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
WO2020180663A1 (en)	2019-03-01	2020-09-10	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US20220143006A1 (en)	2019-03-15	2022-05-12	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
KR20210144778A (ko)	2019-03-29	2021-11-30	쿠라 온콜로지, 인크.	파르네실트랜스퍼라제 억제제를 사용한 편평 세포 암종의 치료 방법
TW202102218A (zh)	2019-04-01	2021-01-16	美商庫拉腫瘤技術股份有限公司	以法呢基(farnesyl)轉移酶抑制劑治療癌症的方法
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PL193464B1 (pl)	1998-07-06	2007-02-28	Janssen Pharmaceutica Nv	Zastosowanie inhibitora białkowej transferazy farnezylowej
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1999
- 1999-06-30 PL PL99347979A patent/PL193464B1/pl unknown
- 1999-06-30 HR HR20000903A patent/HRP20000903A2/hr not_active Application Discontinuation
- 1999-06-30 SK SK1986-2000A patent/SK284723B6/sk not_active IP Right Cessation
- 1999-06-30 CN CNB998082678A patent/CN1152716C/zh not_active Expired - Lifetime
- 1999-06-30 SI SI9930332T patent/SI1094839T1/xx unknown
- 1999-06-30 KR KR1020007014066A patent/KR100591603B1/ko not_active Expired - Lifetime
- 1999-06-30 CA CA002336624A patent/CA2336624C/en not_active Expired - Lifetime
- 1999-06-30 WO PCT/EP1999/004545 patent/WO2000001411A1/en not_active Ceased
- 1999-06-30 DK DK99931229T patent/DK1094839T3/da active
- 1999-06-30 DE DE69907461T patent/DE69907461T2/de not_active Expired - Lifetime
- 1999-06-30 EA EA200100111A patent/EA003877B1/ru not_active IP Right Cessation
- 1999-06-30 ES ES99931229T patent/ES2199579T3/es not_active Expired - Lifetime
- 1999-06-30 EE EEP200000794A patent/EE04582B1/xx unknown
- 1999-06-30 AP APAP/P/2001/002057A patent/AP1599A/en active
- 1999-06-30 AT AT99931229T patent/ATE238811T1/de active
- 1999-06-30 HU HU0103689A patent/HU229076B1/hu unknown
- 1999-06-30 US US09/743,130 patent/US6545020B1/en not_active Expired - Lifetime
- 1999-06-30 BR BR9911861-0A patent/BR9911861A/pt not_active Application Discontinuation
- 1999-06-30 JP JP2000557857A patent/JP4530537B2/ja not_active Expired - Lifetime
- 1999-06-30 IL IL14072199A patent/IL140721A0/xx active IP Right Grant
- 1999-06-30 PT PT99931229T patent/PT1094839E/pt unknown
- 1999-06-30 AU AU47805/99A patent/AU762423B2/en not_active Expired
- 1999-06-30 CZ CZ20004777A patent/CZ300968B6/cs not_active IP Right Cessation
- 1999-06-30 TR TR2000/03879T patent/TR200003879T2/xx unknown
- 1999-06-30 ID IDW20010020A patent/ID26987A/id unknown
- 1999-06-30 EP EP99931229A patent/EP1094839B1/en not_active Expired - Lifetime
- 1999-07-01 MY MYPI99002794A patent/MY126519A/en unknown
- 1999-07-05 TW TW088111346A patent/TW586937B/zh not_active IP Right Cessation
2001
- 2001-01-03 BG BG105108A patent/BG64941B1/bg unknown
- 2001-01-04 IL IL140721A patent/IL140721A/en not_active IP Right Cessation
- 2001-01-05 NO NO20010082A patent/NO328178B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR9911861A (pt)	2001-03-20
EE04582B1 (et)	2006-02-15
WO2000001411A1 (en)	2000-01-13
MY126519A (en)	2006-10-31
SK19862000A3 (sk)	2001-12-03
TW586937B (en)	2004-05-11
NO20010082D0 (no)	2001-01-05
CN1152716C (zh)	2004-06-09
CZ20004777A3 (en)	2001-05-16
AU762423B2 (en)	2003-06-26
CA2336624A1 (en)	2000-01-13
SI1094839T1 (en)	2003-12-31
IL140721A0 (en)	2002-02-10
PL193464B1 (pl)	2007-02-28
AP2001002057A0 (en)	2001-03-31
NO20010082L (no)	2001-01-05
BG105108A (en)	2001-11-30
CN1311692A (zh)	2001-09-05
ATE238811T1 (de)	2003-05-15
ID26987A (id)	2001-02-22
ES2199579T3 (es)	2004-02-16
HRP20000903A2 (en)	2001-12-31
PL347979A1 (en)	2002-05-06
HU229076B1 (en)	2013-07-29
TR200003879T2 (tr)	2007-01-22
DK1094839T3 (da)	2003-08-18
HK1034451A1 (en)	2001-10-26
DE69907461D1 (de)	2003-06-05
JP4530537B2 (ja)	2010-08-25
HUP0103689A3 (en)	2003-01-28
KR100591603B1 (ko)	2006-06-20
CA2336624C (en)	2008-10-21
DE69907461T2 (de)	2004-02-19
AU4780599A (en)	2000-01-24
KR20010052770A (ko)	2001-06-25
EP1094839A1 (en)	2001-05-02
CZ300968B6 (cs)	2009-09-30
PT1094839E (pt)	2003-09-30
EA003877B1 (ru)	2003-10-30
SK284723B6 (sk)	2005-10-06
BG64941B1 (bg)	2006-10-31
EA200100111A1 (ru)	2001-06-25
EP1094839B1 (en)	2003-05-02
AP1599A (en)	2006-04-27
HUP0103689A2 (hu)	2002-02-28
JP2002519389A (ja)	2002-07-02
IL140721A (en)	2008-11-26
EE200000794A (et)	2002-06-17
US6545020B1 (en)	2003-04-08

Publication	Publication Date	Title
NO328178B1 (no)	2009-12-28	Anvendelse av farnesyl proteintransferaseinhibitorer for fremstilling av en farmasoytisk sammensetning med in vivo radiosensibiliserende egenskaper
CA2397558A1 (en)	2001-08-30	Dosing regimen
JP5491681B2 (ja)	2014-05-14	乳ガンの治療のためのファルネシルタンパク質トランスフェラーゼ阻害剤
US20030022918A1 (en)	2003-01-30	Farnesyl protein transferase inhibitor combinations with an her2 antibody
US20030027808A1 (en)	2003-02-06	Farnesyl protein transferase inhibitor combinations with platinum compounds
JP2003525238A (ja)	2003-08-26	抗腫瘍性ポドフィロトキシン誘導体とのファルネシルタンパク質トランスフェラーゼ阻害剤組み合わせ剤
JP2003525244A (ja)	2003-08-26	抗腫瘍性アルキル化剤とのファルネシルタンパク質トランスフェラーゼ阻害剤組み合わせ剤
US20030186925A1 (en)	2003-10-02	Farnesyl protein transferase inhibitor combinations with anti-tumor nucleoside derivatives
US20030181473A1 (en)	2003-09-25	Farnesyl protein transferase inhibitor combinations with taxane compounds
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