NO311492B1 - Fremgangsmåte for fremstilling av doseringsenheter omfattende ett steroid progestogen, ved våtgranulering, samt tabletter derav - Google Patents

Fremgangsmåte for fremstilling av doseringsenheter omfattende ett steroid progestogen, ved våtgranulering, samt tabletter derav Download PDF

Info

Publication number: NO311492B1
Authority: NO; Norway
Prior art keywords: tablets; desogestrel; progestogen; granulation; water
Prior art date: 1994-09-22

Application number

NO19971361A

Other languages

English (en)

Norwegian (no)

Other versions

NO971361D0 (no

NO971361L (no

Inventor

Pieter De Haan

Jocominus Antonius Ma Zwinkels

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-22

Filing date

1997-03-21

Publication date

2001-12-03

1997-03-21 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1997-03-21 Publication of NO971361D0 publication Critical patent/NO971361D0/no

1997-05-21 Publication of NO971361L publication Critical patent/NO971361L/no

2001-12-03 Publication of NO311492B1 publication Critical patent/NO311492B1/no

Links

238000000034 method Methods 0.000 title claims abstract description 26
230000008569 process Effects 0.000 title claims abstract description 6
238000002360 preparation method Methods 0.000 title claims abstract description 5
239000000583 progesterone congener Substances 0.000 title claims description 15
150000003431 steroids Chemical class 0.000 title claims description 6
-1 by wet granulation Substances 0.000 title abstract 2
238000005550 wet granulation Methods 0.000 title description 12
229960004976 desogestrel Drugs 0.000 claims abstract description 18
RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 claims abstract description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 11
239000008187 granular material Substances 0.000 claims description 24
BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 10
BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 10
229960002568 ethinylestradiol Drugs 0.000 claims description 10
239000000262 estrogen Substances 0.000 claims description 7
229940011871 estrogen Drugs 0.000 claims description 6
239000003960 organic solvent Substances 0.000 claims description 5
YJSTYQGZKJHXLN-OLGWUGKESA-N (8r,9s,10r,13s,14s,17r)-17-ethynyl-17-hydroxy-13-methyl-11-methylidene-2,6,7,8,9,10,12,14-octahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](C)([C@](C=C4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 YJSTYQGZKJHXLN-OLGWUGKESA-N 0.000 abstract description 9
230000003637 steroidlike Effects 0.000 abstract description 2
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003826 tablet Substances 0.000 description 47
238000005469 granulation Methods 0.000 description 19
230000003179 granulation Effects 0.000 description 19
239000000203 mixture Substances 0.000 description 19
239000011230 binding agent Substances 0.000 description 17
238000002156 mixing Methods 0.000 description 10
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
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238000007873 sieving Methods 0.000 description 6
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 5
239000008101 lactose Substances 0.000 description 5
229920002261 Corn starch Polymers 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
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VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
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239000006187 pill Substances 0.000 description 4
229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 4
230000035945 sensitivity Effects 0.000 description 4
238000003860 storage Methods 0.000 description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
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WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
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CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
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SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 2
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IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
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GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
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239000004135 Bone phosphate Substances 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920002907 Guar gum Polymers 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
239000004368 Modified starch Substances 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
238000013019 agitation Methods 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
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150000004781 alginic acids Chemical class 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
239000004067 bulking agent Substances 0.000 description 1
235000010410 calcium alginate Nutrition 0.000 description 1
239000000648 calcium alginate Substances 0.000 description 1
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235000010216 calcium carbonate Nutrition 0.000 description 1
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239000001506 calcium phosphate Substances 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical class [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 description 1
DIOLOCSXUMYFJN-UHFFFAOYSA-N calcium;azane Chemical compound N.[Ca+2] DIOLOCSXUMYFJN-UHFFFAOYSA-N 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
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235000010980 cellulose Nutrition 0.000 description 1
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239000001913 cellulose Substances 0.000 description 1
239000004927 clay Substances 0.000 description 1
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229960002665 desogestrel and ethinylestradiol Drugs 0.000 description 1
238000007907 direct compression Methods 0.000 description 1
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239000000428 dust Substances 0.000 description 1
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229930182833 estradiol Natural products 0.000 description 1
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MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 description 1
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239000007888 film coating Substances 0.000 description 1
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238000007429 general method Methods 0.000 description 1
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235000010417 guar gum Nutrition 0.000 description 1
239000000665 guar gum Substances 0.000 description 1
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239000008172 hydrogenated vegetable oil Substances 0.000 description 1
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229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
229940071676 hydroxypropylcellulose Drugs 0.000 description 1
230000006872 improvement Effects 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
230000001050 lubricating effect Effects 0.000 description 1
229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 description 1
229960001390 mestranol Drugs 0.000 description 1
239000002207 metabolite Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
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239000004570 mortar (masonry) Substances 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
239000002245 particle Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000012254 powdered material Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
238000005204 segregation Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000012748 slip agent Substances 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
229920003109 sodium starch glycolate Polymers 0.000 description 1
239000008109 sodium starch glycolate Substances 0.000 description 1
229940079832 sodium starch glycolate Drugs 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
241000894007 species Species 0.000 description 1
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239000010935 stainless steel Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
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235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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238000005303 weighing Methods 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Medical Preparation Storing Or Oral Administration Devices (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19971361A 1994-09-22 1997-03-21 Fremgangsmåte for fremstilling av doseringsenheter omfattende ett steroid progestogen, ved våtgranulering, samt tabletter derav NO311492B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94202728		1994-09-22
PCT/EP1995/003692 WO1996009056A1 (en)	1994-09-22	1995-09-19	Process of making dosage units by wet granulation

Publications (3)

Publication Number	Publication Date
NO971361D0 NO971361D0 (no)	1997-03-21
NO971361L NO971361L (no)	1997-05-21
NO311492B1 true NO311492B1 (no)	2001-12-03

Family

ID=8217217

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19971361A NO311492B1 (no)	1994-09-22	1997-03-21	Fremgangsmåte for fremstilling av doseringsenheter omfattende ett steroid progestogen, ved våtgranulering, samt tabletter derav

Country Status (22)

Country	Link
US (1)	US5916593A (pt)
EP (1)	EP0782449B1 (pt)
JP (1)	JP4334616B2 (pt)
KR (1)	KR100384264B1 (pt)
CN (1)	CN1101681C (pt)
AT (1)	ATE236639T1 (pt)
AU (1)	AU700645B2 (pt)
BR (1)	BR9509019B1 (pt)
CA (1)	CA2200754C (pt)
CZ (1)	CZ289081B6 (pt)
DE (1)	DE69530308T2 (pt)
DK (1)	DK0782449T3 (pt)
ES (1)	ES2196079T3 (pt)
FI (1)	FI118791B (pt)
HU (1)	HU226619B1 (pt)
MX (1)	MX9702162A (pt)
NO (1)	NO311492B1 (pt)
NZ (1)	NZ293606A (pt)
PL (1)	PL181406B1 (pt)
PT (1)	PT782449E (pt)
RU (1)	RU2166936C2 (pt)
WO (1)	WO1996009056A1 (pt)

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US20030027848A1 (en) *	2001-06-15	2003-02-06	Anne Billotte	Stabilized formulations
ATE243028T1 (de) *	2001-07-11	2003-07-15	Applied Pharma Res	Fettlösliche substanzen enthaltende granulate und verfahren zu ihrer herstellung
DE10159120B4 (de) *	2001-12-01	2006-08-17	Lts Lohmann Therapie-Systeme Ag	Steroidhormonhaltige transdermale therapeutische Systeme enthaltend Propylenglycolmonocaprylat und seine Verwendung
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ES2530791T3 (es)	2002-12-20	2015-03-05	Hoffmann La Roche	Formulación de ibandronato de altas dosis
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ES2588584T3 (es) *	2005-01-21	2016-11-03	Warner Chilcott Company, Llc	Un complejo metálico de tetraciclina en una forma de dosificación sólida
WO2006089674A2 (en) *	2005-02-25	2006-08-31	F.Hoffmann-La Roche Ag	Tablets with improved drug substance dispersibility
CN101489563A (zh) *	2006-07-06	2009-07-22	拜耳先灵医药股份有限公司	用于避孕和预防先天性畸形风险的药物制剂
US8617597B2 (en) *	2006-07-06	2013-12-31	Bayer Intellectual Property Gmbh	Pharmaceutical composition containing a tetrahydrofolic acid
WO2009132208A1 (en) *	2008-04-24	2009-10-29	Evestra, Inc.	Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen
CA2732105A1 (en) *	2008-08-08	2010-02-11	Mcneil-Ppc, Inc.	Use of sucralose as a granulating agent
EA201170545A1 (ru)	2008-10-09	2012-01-30	Абды Ибрахым Иладж Санайи Ве Тыджарет Аноным Сыркеты	Применение органических растворителей в способе влажного гранулирования моксифлоксацина
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1995
- 1995-09-19 AT AT95933401T patent/ATE236639T1/de not_active IP Right Cessation
- 1995-09-19 NZ NZ293606A patent/NZ293606A/en not_active IP Right Cessation
- 1995-09-19 DE DE69530308T patent/DE69530308T2/de not_active Expired - Lifetime
- 1995-09-19 WO PCT/EP1995/003692 patent/WO1996009056A1/en not_active Ceased
- 1995-09-19 DK DK95933401T patent/DK0782449T3/da active
- 1995-09-19 PT PT95933401T patent/PT782449E/pt unknown
- 1995-09-19 AU AU36082/95A patent/AU700645B2/en not_active Ceased
- 1995-09-19 US US08/793,976 patent/US5916593A/en not_active Expired - Fee Related
- 1995-09-19 CZ CZ1997899A patent/CZ289081B6/cs not_active IP Right Cessation
- 1995-09-19 PL PL95319373A patent/PL181406B1/pl not_active IP Right Cessation
- 1995-09-19 MX MX9702162A patent/MX9702162A/es not_active IP Right Cessation
- 1995-09-19 RU RU97106339/14A patent/RU2166936C2/ru not_active IP Right Cessation
- 1995-09-19 CN CN95195823A patent/CN1101681C/zh not_active Expired - Fee Related
- 1995-09-19 HU HU9800154A patent/HU226619B1/hu not_active IP Right Cessation
- 1995-09-19 JP JP51058896A patent/JP4334616B2/ja not_active Expired - Fee Related
- 1995-09-19 CA CA002200754A patent/CA2200754C/en not_active Expired - Fee Related
- 1995-09-19 EP EP95933401A patent/EP0782449B1/en not_active Expired - Lifetime
- 1995-09-19 BR BRPI9509019-3A patent/BR9509019B1/pt not_active IP Right Cessation
- 1995-09-19 KR KR1019970701723A patent/KR100384264B1/ko not_active Expired - Fee Related
- 1995-09-19 ES ES95933401T patent/ES2196079T3/es not_active Expired - Lifetime
1997
- 1997-03-20 FI FI971172A patent/FI118791B/fi active
- 1997-03-21 NO NO19971361A patent/NO311492B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69530308T2 (de)	2003-10-16
BR9509019A (pt)	1997-12-30
JP4334616B2 (ja)	2009-09-30
EP0782449A1 (en)	1997-07-09
US5916593A (en)	1999-06-29
FI118791B (fi)	2008-03-31
JPH10505846A (ja)	1998-06-09
KR100384264B1 (ko)	2003-08-30
AU700645B2 (en)	1999-01-14
KR970706001A (ko)	1997-11-03
DK0782449T3 (da)	2003-08-04
ATE236639T1 (de)	2003-04-15
AU3608295A (en)	1996-04-09
HUT77611A (hu)	1998-06-29
NZ293606A (en)	1998-06-26
HU226619B1 (en)	2009-04-28
ES2196079T3 (es)	2003-12-16
PL319373A1 (en)	1997-08-04
CN1101681C (zh)	2003-02-19
CZ89997A3 (en)	1997-09-17
PT782449E (pt)	2003-07-31
BR9509019B1 (pt)	2009-01-13
MX9702162A (es)	1997-06-28
NO971361D0 (no)	1997-03-21
EP0782449B1 (en)	2003-04-09
CZ289081B6 (cs)	2001-10-17
HK1002172A1 (en)	1998-08-07
CA2200754C (en)	2008-04-15
RU2166936C2 (ru)	2001-05-20
CA2200754A1 (en)	1996-03-28
CN1161650A (zh)	1997-10-08
DE69530308D1 (de)	2003-05-15
PL181406B1 (pl)	2001-07-31
FI971172A0 (fi)	1997-03-20
WO1996009056A1 (en)	1996-03-28
NO971361L (no)	1997-05-21
FI971172L (fi)	1997-03-20

Publication	Publication Date	Title
NO311492B1 (no)	2001-12-03	Fremgangsmåte for fremstilling av doseringsenheter omfattende ett steroid progestogen, ved våtgranulering, samt tabletter derav
NO305055B1 (no)	1999-03-29	Farmas°ytisk t°rr blanding, farmas°ytisk doseringsenhet, fremgangsmÕte ved fremstilling derav og fremgangsmÕte ved fremstilling av tabletter
EP0657161B1 (en)	1998-12-02	Pharmaceutical granulate containing steroids
EP0975348B1 (en)	2004-11-10	Stabilized tibolone compositions
US6054145A (en)	2000-04-25	Making dosage units using low shear granulation
EP1594471B1 (en)	2009-03-25	Process for manufacturing a dexamethasone-containing formulation for oral administration
HK1023508B (en)	2005-03-24	Stabilized tibolone compositions
HK1002172B (en)	2003-08-22	Process of making dosage units by wet granulation
CZ374299A3 (cs)	2000-04-12	Farmaceutická léková forma
HK1001998A1 (en)	1998-07-24	Pharmaceutical granulate containing steroids
HK1001998B (en)	2000-03-17	Pharmaceutical granulate containing steroids

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