NO318239B1 - Farmasoytisk preparat med anestetisk virkning, fremgangsmate for fremstilling av samme og anvendelse for fremstilling av medikament. - Google Patents
Farmasoytisk preparat med anestetisk virkning, fremgangsmate for fremstilling av samme og anvendelse for fremstilling av medikament. Download PDFInfo
- Publication number
- NO318239B1 NO318239B1 NO19975831A NO975831A NO318239B1 NO 318239 B1 NO318239 B1 NO 318239B1 NO 19975831 A NO19975831 A NO 19975831A NO 975831 A NO975831 A NO 975831A NO 318239 B1 NO318239 B1 NO 318239B1
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutical preparation
- local anesthetic
- preparation according
- surfactant
- composition
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 32
- 238000000034 method Methods 0.000 title claims description 16
- 239000003814 drug Substances 0.000 title claims description 7
- 229940079593 drug Drugs 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title abstract description 33
- 230000003444 anaesthetic effect Effects 0.000 title description 7
- 239000003589 local anesthetic agent Substances 0.000 claims abstract description 43
- 239000004094 surface-active agent Substances 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 230000036407 pain Effects 0.000 claims abstract description 5
- 239000006068 taste-masking agent Substances 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 31
- 229920001983 poloxamer Polymers 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 7
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical group C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 6
- 230000003239 periodontal effect Effects 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000004530 micro-emulsion Substances 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 229960000502 poloxamer Drugs 0.000 claims description 3
- 230000036760 body temperature Effects 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000001879 gelation Methods 0.000 claims description 2
- 238000000265 homogenisation Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000002736 nonionic surfactant Substances 0.000 claims description 2
- 229920001992 poloxamer 407 Polymers 0.000 claims description 2
- 229940044476 poloxamer 407 Drugs 0.000 claims description 2
- WZSPWMATVLBWRS-UHFFFAOYSA-N 2-(diethylamino)-n-(2,6-dimethylphenyl)acetamide;n-(2-methylphenyl)-2-(propylamino)propanamide Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C.CCN(CC)CC(=O)NC1=C(C)C=CC=C1C WZSPWMATVLBWRS-UHFFFAOYSA-N 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 229960005015 local anesthetics Drugs 0.000 abstract description 5
- 210000000214 mouth Anatomy 0.000 abstract description 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
- 208000005888 Periodontal Pocket Diseases 0.000 description 13
- 239000003921 oil Substances 0.000 description 9
- 206010002091 Anaesthesia Diseases 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 230000037005 anaesthesia Effects 0.000 description 4
- 238000012377 drug delivery Methods 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 230000008595 infiltration Effects 0.000 description 3
- 238000001764 infiltration Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 238000001949 anaesthesia Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000001804 debridement Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000002690 local anesthesia Methods 0.000 description 2
- 239000011859 microparticle Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 102100025933 Cancer-associated gene 1 protein Human genes 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 101000933825 Homo sapiens Cancer-associated gene 1 protein Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229920001400 block copolymer Polymers 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 229920001993 poloxamer 188 Polymers 0.000 description 1
- 229940044519 poloxamer 188 Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- MVFGUOIZUNYYSO-UHFFFAOYSA-N prilocaine Chemical compound CCCNC(C)C(=O)NC1=CC=CC=C1C MVFGUOIZUNYYSO-UHFFFAOYSA-N 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000002691 topical anesthesia Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9601421A SE9601421D0 (sv) | 1996-04-12 | 1996-04-12 | New composition |
| PCT/SE1997/000566 WO1997038675A1 (en) | 1996-04-12 | 1997-04-01 | New pharmaceutical composition with anaesthetic effect |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO975831L NO975831L (no) | 1997-12-11 |
| NO975831D0 NO975831D0 (no) | 1997-12-11 |
| NO318239B1 true NO318239B1 (no) | 2005-02-21 |
Family
ID=20402194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19975831A NO318239B1 (no) | 1996-04-12 | 1997-12-11 | Farmasoytisk preparat med anestetisk virkning, fremgangsmate for fremstilling av samme og anvendelse for fremstilling av medikament. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6031007A (sk) |
| EP (1) | EP0833612B1 (sk) |
| JP (2) | JPH11501678A (sk) |
| KR (1) | KR100508601B1 (sk) |
| CN (1) | CN1149072C (sk) |
| AR (1) | AR006484A1 (sk) |
| AT (1) | ATE248584T1 (sk) |
| AU (1) | AU716540B2 (sk) |
| BR (1) | BR9702147A (sk) |
| CA (1) | CA2222676C (sk) |
| CZ (1) | CZ371197A3 (sk) |
| DE (1) | DE69724545T2 (sk) |
| DK (1) | DK0833612T3 (sk) |
| EE (1) | EE9700363A (sk) |
| ES (1) | ES2203799T3 (sk) |
| HU (1) | HUP9903544A3 (sk) |
| ID (1) | ID16420A (sk) |
| IL (1) | IL122447A (sk) |
| IS (1) | IS4618A (sk) |
| NO (1) | NO318239B1 (sk) |
| NZ (1) | NZ329246A (sk) |
| PL (1) | PL324170A1 (sk) |
| RU (1) | RU2185153C2 (sk) |
| SE (1) | SE9601421D0 (sk) |
| SK (1) | SK169897A3 (sk) |
| TR (1) | TR199701584T1 (sk) |
| TW (1) | TW473386B (sk) |
| WO (1) | WO1997038675A1 (sk) |
| ZA (1) | ZA973022B (sk) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2764800B1 (fr) * | 1997-06-23 | 1999-09-10 | Sanofi Sa | Composition pharmaceutique solide contenant des derives de benzofuranne |
| US7799337B2 (en) | 1997-07-21 | 2010-09-21 | Levin Bruce H | Method for directed intranasal administration of a composition |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| IL141095A0 (en) | 1998-08-19 | 2002-02-10 | Rtp Pharma Inc | Injectable aqueous dispersions of propofol |
| US6528086B2 (en) * | 1999-09-28 | 2003-03-04 | Zars, Inc. | Methods and apparatus for drug delivery involving phase changing formulations |
| US20020013331A1 (en) * | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
| KR100416646B1 (ko) * | 2000-08-14 | 2004-02-05 | 구주제약주식회사 | 리도카인을 함유한 조루치료용 마이크로에멀젼 하이드로겔 제형의 약학 조성물 |
| GB0120701D0 (en) | 2001-08-24 | 2001-10-17 | Maelor Pharmaceuticals Ltd | Pharmaceutical formulations |
| US20040087520A1 (en) * | 2002-10-25 | 2004-05-06 | Chowdhury Dipak K. | Compositions and methods for delivery of therapeutic agents |
| TW200410717A (en) * | 2002-12-31 | 2004-07-01 | Ind Tech Res Inst | Delivery system for control release of temperature sensitive bioactive material |
| AU2003900887A0 (en) * | 2003-02-27 | 2003-03-13 | Novasel Australia Pty Ltd | Poloxamer emulsion preparations |
| US8802116B2 (en) | 2003-02-27 | 2014-08-12 | Novasel Australia Pty. Ltd. | Poloxamer emulsion preparations |
| BR0301968A (pt) * | 2003-05-22 | 2005-06-28 | Cristalia Prod Quimicos Farm | Misturas eutéticas ternárias e quaternárias constituìdas por substâncias anestésicas locais, seu emprego no preparo de composições farmacêuticas e seu uso em anestesia e analgesia tópica |
| JP4669960B2 (ja) * | 2003-06-03 | 2011-04-13 | 株式会社 メドレックス | 局所麻酔薬を含有する口中用または咽頭部用製剤 |
| US20050123596A1 (en) * | 2003-09-23 | 2005-06-09 | Kohane Daniel S. | pH-triggered microparticles |
| US7943179B2 (en) * | 2003-09-23 | 2011-05-17 | Massachusetts Institute Of Technology | pH triggerable polymeric particles |
| US20070232695A1 (en) * | 2004-01-28 | 2007-10-04 | Collegium Pharmaceutical, Inc. | Gelled Periodontal Anesthetic Preparation |
| US8741332B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for dermally treating neuropathic pain |
| US8741333B2 (en) | 2004-06-07 | 2014-06-03 | Nuvo Research Inc. | Compositions and methods for treating dermatitis or psoriasis |
| US8907153B2 (en) | 2004-06-07 | 2014-12-09 | Nuvo Research Inc. | Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same |
| RU2274446C2 (ru) * | 2004-07-02 | 2006-04-20 | Наталья Александровна Уракова | Средство для локальной инъекционной химиоанестезии |
| WO2006036936A2 (en) * | 2004-09-27 | 2006-04-06 | Bridge Pharma, Inc. | The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents |
| WO2006037047A2 (en) * | 2004-09-27 | 2006-04-06 | Bridge Pharma, Inc. | The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents |
| CA2655809C (en) * | 2006-07-21 | 2013-10-01 | Bridge Pharma, Inc. | Dermal anesthetic compounds |
| US20090123527A1 (en) * | 2006-07-24 | 2009-05-14 | Akorn, Inc. | Method of inducing topical anesthesia and transdermal patch |
| US20080021068A1 (en) | 2006-07-24 | 2008-01-24 | Akorn, Inc. | Aqueous gel formulation and method for inducing topical anesthesia |
| US8473062B2 (en) | 2008-05-01 | 2013-06-25 | Autonomic Technologies, Inc. | Method and device for the treatment of headache |
| US8412336B2 (en) | 2008-12-29 | 2013-04-02 | Autonomic Technologies, Inc. | Integrated delivery and visualization tool for a neuromodulation system |
| US9012477B2 (en) | 2009-01-06 | 2015-04-21 | Nuvo Research Inc. | Method of treating neuropathic pain |
| US8494641B2 (en) | 2009-04-22 | 2013-07-23 | Autonomic Technologies, Inc. | Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism |
| US9320908B2 (en) | 2009-01-15 | 2016-04-26 | Autonomic Technologies, Inc. | Approval per use implanted neurostimulator |
| SG175327A1 (en) * | 2009-04-22 | 2011-11-28 | Agency Science Tech & Res | Emulsions for transdermal delivery |
| WO2011074015A2 (en) | 2009-12-17 | 2011-06-23 | Themis Medicare Limited | Novel composition of pharmaceutical product to treat sexual dysfunction |
| WO2011088333A2 (en) | 2010-01-14 | 2011-07-21 | Zars Pharma, Inc. | Solid-forming local anesthetic formulations for pain control |
| RU2435603C1 (ru) * | 2010-03-17 | 2011-12-10 | Федеральное государственное учреждение "Центральный научно-исследовательский институт стоматологии и челюстно-лицевой хирургии" Федерального агентства по высокотехнологичной медицинской помощи | Состав для местной анестезии и лечения воспалительных заболеваний слизистой оболочки полости рта |
| SG184072A1 (en) * | 2010-04-01 | 2012-10-30 | Pharmanest Ab | Bioadhesive compositions of local anaesthetics |
| EP2552408A2 (en) | 2010-04-01 | 2013-02-06 | Pharmanest AB | Water-free pharmaceutical compositions suitable for local anaesthetics |
| WO2011121074A1 (en) | 2010-04-01 | 2011-10-06 | Pharmanest Ab | Thermogelling anaesthetic compositions |
| KR20120118495A (ko) * | 2010-04-21 | 2012-10-26 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 국부 마취제 에멀전 조성물 및 이의 제조 및 사용 방법 |
| GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
| CA2914608A1 (en) * | 2013-03-14 | 2014-09-25 | Jsn I, Llc | Taste masking of anesthetics and analgesics |
| EP3344230B1 (en) | 2015-09-02 | 2022-04-06 | T.C. Istanbul Medipol Universitesi | Formulations of benzocaine loaded microemulsion based hydrogels for therapeutic purposes and their production method |
| WO2020182535A1 (en) | 2019-03-08 | 2020-09-17 | Bayer Oy | Uterine sound tube with anaesthetic applicator |
| CN113244167B (zh) * | 2021-05-20 | 2022-11-29 | 河北科技大学 | 一种盐酸利多卡因凝胶及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4188373A (en) * | 1976-02-26 | 1980-02-12 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
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1996
- 1996-04-12 SE SE9601421A patent/SE9601421D0/xx unknown
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1997
- 1997-03-31 TW TW086104109A patent/TW473386B/zh not_active IP Right Cessation
- 1997-04-01 SK SK1698-97A patent/SK169897A3/sk unknown
- 1997-04-01 ES ES97919826T patent/ES2203799T3/es not_active Expired - Lifetime
- 1997-04-01 NZ NZ329246A patent/NZ329246A/en not_active IP Right Cessation
- 1997-04-01 EE EE9700363A patent/EE9700363A/xx unknown
- 1997-04-01 WO PCT/SE1997/000566 patent/WO1997038675A1/en not_active Ceased
- 1997-04-01 RU RU98100471/14A patent/RU2185153C2/ru active
- 1997-04-01 CZ CZ973711A patent/CZ371197A3/cs unknown
- 1997-04-01 PL PL97324170A patent/PL324170A1/xx unknown
- 1997-04-01 IL IL12244797A patent/IL122447A/en not_active IP Right Cessation
- 1997-04-01 JP JP9537002A patent/JPH11501678A/ja not_active Withdrawn
- 1997-04-01 CN CNB971903425A patent/CN1149072C/zh not_active Expired - Lifetime
- 1997-04-01 HU HU9903544A patent/HUP9903544A3/hu unknown
- 1997-04-01 KR KR1019970709302A patent/KR100508601B1/ko not_active Expired - Lifetime
- 1997-04-01 EP EP97919826A patent/EP0833612B1/en not_active Expired - Lifetime
- 1997-04-01 US US08/875,888 patent/US6031007A/en not_active Expired - Lifetime
- 1997-04-01 BR BR9702147A patent/BR9702147A/pt not_active Application Discontinuation
- 1997-04-01 TR TR97/01584T patent/TR199701584T1/xx unknown
- 1997-04-01 AT AT97919826T patent/ATE248584T1/de not_active IP Right Cessation
- 1997-04-01 DE DE69724545T patent/DE69724545T2/de not_active Expired - Lifetime
- 1997-04-01 AU AU24168/97A patent/AU716540B2/en not_active Expired
- 1997-04-01 CA CA002222676A patent/CA2222676C/en not_active Expired - Lifetime
- 1997-04-01 DK DK97919826T patent/DK0833612T3/da active
- 1997-04-02 AR ARP970101317A patent/AR006484A1/es active IP Right Grant
- 1997-04-09 ZA ZA9703022A patent/ZA973022B/xx unknown
- 1997-04-14 ID IDP971235A patent/ID16420A/id unknown
- 1997-11-21 IS IS4618A patent/IS4618A/is unknown
- 1997-12-11 NO NO19975831A patent/NO318239B1/no not_active IP Right Cessation
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2003
- 2003-12-18 JP JP2003421386A patent/JP2004149544A/ja active Pending
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