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NO2367570T3 - - Google Patents

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Publication number
NO2367570T3
NO2367570T3 NO09830697A NO09830697A NO2367570T3 NO 2367570 T3 NO2367570 T3 NO 2367570T3 NO 09830697 A NO09830697 A NO 09830697A NO 09830697 A NO09830697 A NO 09830697A NO 2367570 T3 NO2367570 T3 NO 2367570T3
Authority
NO
Norway
Application number
NO09830697A
Other languages
Norwegian (no)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/366,567 external-priority patent/US8062864B2/en
Priority claimed from US12/391,717 external-priority patent/US8178101B2/en
Priority claimed from US12/399,156 external-priority patent/US20090238825A1/en
Priority claimed from US12/502,581 external-priority patent/US8323649B2/en
Application filed filed Critical
Publication of NO2367570T3 publication Critical patent/NO2367570T3/no

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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • CCHEMISTRY; METALLURGY
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    • CCHEMISTRY; METALLURGY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
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  • Immunology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
NO09830697A 2008-11-25 2009-11-24 NO2367570T3 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US11783908P 2008-11-25 2008-11-25
US11781108P 2008-11-25 2008-11-25
US11786108P 2008-11-25 2008-11-25
US12/366,567 US8062864B2 (en) 2007-05-21 2009-02-05 Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US39161509A 2009-02-24 2009-02-24
US12/391,717 US8178101B2 (en) 2007-05-21 2009-02-24 Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
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US12/502,581 US8323649B2 (en) 2008-11-25 2009-07-14 Antibodies to IL-6 and use thereof
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Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007114319A1 (ja) 2006-03-31 2007-10-11 Chugai Seiyaku Kabushiki Kaisha 抗体の血中動態を制御する方法
US8404235B2 (en) 2007-05-21 2013-03-26 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US7906117B2 (en) 2007-05-21 2011-03-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US9701747B2 (en) 2007-05-21 2017-07-11 Alderbio Holdings Llc Method of improving patient survivability and quality of life by anti-IL-6 antibody administration
CA2688146C (en) 2007-05-21 2018-03-06 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
US8252286B2 (en) 2007-05-21 2012-08-28 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
EP3127921A1 (en) 2007-09-26 2017-02-08 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substition in cdr
CN101874041B (zh) 2007-09-26 2013-06-19 中外制药株式会社 抗体恒定区修饰体
EP2708559B1 (en) 2008-04-11 2018-03-28 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
US8337847B2 (en) 2008-11-25 2012-12-25 Alderbio Holdings Llc Methods of treating anemia using anti-IL-6 antibodies
US9212223B2 (en) 2008-11-25 2015-12-15 Alderbio Holdings Llc Antagonists of IL-6 to prevent or treat thrombosis
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US8420089B2 (en) 2008-11-25 2013-04-16 Alderbio Holdings Llc Antagonists of IL-6 to raise albumin and/or lower CRP
JP5898496B2 (ja) * 2008-11-25 2016-04-06 アルダーバイオ ホールディングス エルエルシー Il−6に対する抗体およびその使用
US8992920B2 (en) 2008-11-25 2015-03-31 Alderbio Holdings Llc Anti-IL-6 antibodies for the treatment of arthritis
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
WO2011066371A2 (en) * 2009-11-24 2011-06-03 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
US7947653B1 (en) 2009-10-09 2011-05-24 Cold Spring Harbor Laboratory Methods for treating epidermal growth factor receptor tyrosine kinase inhibitor-resistant cancers
US8323883B1 (en) 2009-10-09 2012-12-04 Cold Spring Harbor Laboratory Methods of assessing therapeutic benefits of patients having cancers resistant to epidermal growth factor receptor kinase inhibitors
US9775921B2 (en) 2009-11-24 2017-10-03 Alderbio Holdings Llc Subcutaneously administrable composition containing anti-IL-6 antibody
JP2012041271A (ja) * 2010-08-12 2012-03-01 Univ Of Tokyo 血栓形成を抑制する作用を有する組成物
EP3351559A3 (en) * 2010-11-08 2018-10-31 F. Hoffmann-La Roche AG Subcutaneously administered anti-il-6 receptor antibody
DK2643018T3 (da) 2010-11-23 2021-01-18 Vitaeris Inc Anti-il-6-antistoffer til behandling af oral mucositis
TWI654204B (zh) 2010-11-30 2019-03-21 中外製藥股份有限公司 具有鈣依存性的抗原結合能力之抗體
CN104066428A (zh) * 2011-10-12 2014-09-24 思佰益药业股份有限公司 抗癌剂的副作用的预防剂和/或治疗剂
JO3370B1 (ar) 2011-11-10 2019-03-13 Regeneron Pharma طريقة لتثبيط نمو الورم عن طريق تثبيط مستقبل انترلوكين 6
CN104507497B (zh) * 2012-05-03 2018-10-19 勃林格殷格翰国际有限公司 抗IL-23p19抗体
DK2872171T3 (da) 2012-07-13 2021-03-08 Univ Pennsylvania Toksicitet administration for anti-tumor aktivitet af car
EP2875360B1 (en) * 2012-07-20 2018-08-08 Agency For Science, Technology And Research In vitro assay for predicting renal proximal tubular cell toxicity
US10822420B2 (en) * 2012-09-13 2020-11-03 Chugai Seiyaku Kabushiki Kaisha Gene knock-in non-human animal
KR102321372B1 (ko) * 2012-10-22 2021-11-11 원니스 바이오테크 컴퍼니 리미티드 인터류킨-6에 대한 항체 및 그의 용도
AU2014218318B2 (en) 2013-02-18 2018-02-15 Vegenics Pty Limited Ligand binding molecules and uses thereof
KR101332836B1 (ko) * 2013-05-15 2013-11-27 재단법인 통합의료진흥원 자음강화탕을 포함하는 유방암 치료용 조성물
EP3009518B1 (en) 2013-06-11 2020-08-12 National Center of Neurology and Psychiatry Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (rrms) patient, and method for determining applicability of novel therapy
WO2015054293A1 (en) * 2013-10-07 2015-04-16 Alder Biopharmaceuticals, Inc. Anti-il-6 antibodies for the treatment of psoriatic arthritis
CN103739672B (zh) * 2013-12-31 2015-06-10 威特曼生物科技(南京)有限公司 一种聚乙二醇修饰的抑制vegfr2酪氨酸激酶多肽及其应用
EP2926815A1 (en) * 2014-04-03 2015-10-07 Institut Curie New derivatives of cephalosporin for treating cancer
JO3663B1 (ar) * 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
CN104147120A (zh) * 2014-09-04 2014-11-19 成都市飞龙水处理技术研究所 一种治疗多发性神经纤维瘤的内服中药液及其制备方法
CN107074976B (zh) * 2014-11-04 2020-10-09 北京韩美药品有限公司 同时阻断b7/cd28和il6/il6r/gp130信号通路的重组融合蛋白
ES2967627T3 (es) 2015-02-27 2024-05-03 Chugai Pharmaceutical Co Ltd Composición para tratar enfermedades relacionadas con IL-6
ES2888801T3 (es) 2015-05-19 2022-01-07 Nat Center Neurology & Psychiatry Método para determinar la aplicación de una terapia nueva en pacientes con esclerosis múltiple (EM)
WO2016195088A1 (ja) 2015-06-04 2016-12-08 国立研究開発法人 国立精神・神経医療研究センター Il-6阻害剤を有効成分とする精神疾患治療剤
CA3119498A1 (en) * 2015-07-31 2017-02-09 Medimmune Limited Methods for treating hepcidin-mediated disorders
CN105586426B (zh) * 2016-03-01 2019-02-26 浙江大学 与慢性乙型肝炎病毒感染相关的IL-6基因rs2069852位点标志物及其应用
KR102055390B1 (ko) * 2017-01-06 2019-12-12 경북대학교 산학협력단 혈전-표적성 펩타이드, 페리틴 단편 및 혈전 용해성 펩타이드를 포함하는 융합 펩타이드 및 이의 용도
TWI850514B (zh) 2017-02-01 2024-08-01 耶魯大學 心臟衰竭及心腎症候群之精準治療
EP3620531A4 (en) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS
CA3073576C (en) * 2017-08-31 2023-01-24 Hanyi Biotechnology (Beijing) Co., Ltd Use of cannabidiol in preparation of drugs for resisting against influenza
WO2019078344A1 (ja) 2017-10-20 2019-04-25 学校法人兵庫医科大学 抗il-6受容体抗体を含有する術後の癒着を抑制するための医薬組成物
WO2019103138A1 (ja) * 2017-11-24 2019-05-31 国立研究開発法人理化学研究所 IL‐1β及び/又はIL‐6の発現抑制剤とその利用
CN111867627A (zh) * 2018-01-04 2020-10-30 维塔里斯股份有限公司 抗IL-6抗体例如克拉扎珠单抗(Clazakizumab)用于使实体器官移植接受者脱敏和/或用于预防、稳定或减轻抗体介导的排斥(ABMR)的用途
MX2020006882A (es) 2018-01-05 2020-09-07 Novo Nordisk As Metodos para tratar inflamacion mediada por interleucina-6 sin inmunosupresion.
CA3087259A1 (en) * 2018-01-05 2019-07-11 Immunext, Inc. Anti-mct1 antibodies and uses thereof
US20210071183A1 (en) * 2018-02-26 2021-03-11 The Trustees Of Columbia University In The City Of New York Zinc associated treatment for and diagnosis of cachexia
US11633399B2 (en) 2018-12-25 2023-04-25 Sol-Gel Technologies Ltd. Treatment of skin disorders with compositions comprising an EGFR inhibitor
CN110297093B (zh) * 2019-03-18 2022-04-22 山西瑞豪生物科技有限公司 一种检测人免疫球蛋白g4的方法和试剂盒
WO2021062163A1 (en) 2019-09-27 2021-04-01 Disc Medicine, Inc. Methods for treating myelofibrosis and related conditions
PH12022551091A1 (en) 2019-11-05 2024-06-24 Abbvie Deutschland Dosing regimens for use in treating myelofibrosis and mpn-related disorders with navitoclax
CN111053909A (zh) * 2020-02-27 2020-04-24 南通大学 2019-nCoV3CL水解酶抑制剂与IL-6单抗在制备治疗新冠肺炎药物中的应用
EP4121455A1 (en) * 2020-03-18 2023-01-25 Vitaeris Inc. Use of anti-il-6 antibody, e.g., clazakizumab for treatment/prevention of ards associated with coronavirus (covid-19) infection
US20230151107A1 (en) * 2020-04-04 2023-05-18 Biocon Limited Anti-cd6 antibody compositions and methods for treating and reducing negative effects of a coronavirus including covid-19
CA3177830A1 (en) 2020-05-13 2021-11-18 Maria BECONI Anti-hemojuvelin (hjv) antibodies for treating myelofibrosis
CN112098549B (zh) * 2020-09-03 2022-11-15 长沙创新药物工业技术研究院有限公司 一种测定盐酸阿比多尔溶液中杂质含量的方法
CN112175080B (zh) * 2020-10-22 2021-05-25 优睿赛思(武汉)生物科技有限公司 抗人白介素-6高亲和力兔单克隆抗体及应用
KR20230113306A (ko) 2020-10-30 2023-07-28 고쿠리츠켄큐카이하츠호진 고쿠리츠쥰칸키뵤 겐큐센터 주산기 심근증 치료제
WO2022188013A1 (zh) * 2021-03-08 2022-09-15 苏州大学 化学发光介导的纳米颗粒、自组装聚集体及其制备方法和应用
JPWO2023008404A1 (ja) * 2021-07-26 2023-02-02
US20250205281A1 (en) * 2022-03-24 2025-06-26 Therabest Co., Ltd. Pharmaceutical composition for preventing or treating degenerative brain disease comprising natural killer cell

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5202422A (en) 1989-10-27 1993-04-13 The Scripps Research Institute Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5210075A (en) 1990-02-16 1993-05-11 Tanabe Seiyaku Co., Ltd. Interleukin 6 antagonist peptides
WO1992002551A1 (en) 1990-08-02 1992-02-20 B.R. Centre Limited Methods for the production of proteins with a desired function
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
AU6445894A (en) 1993-03-19 1994-10-11 Duke University Method of treatment of tumors with an antibody binding to tenascin
WO1994028159A1 (en) 1993-05-31 1994-12-08 Chugai Seiyaku Kabushiki Kaisha Reconstructed human antibody against human interleukin-6
WO1994027435A1 (en) 1993-06-01 1994-12-08 Life Technologies, Inc. Genetic immunization with cationic lipids
ES2251723T3 (es) 1994-08-12 2006-05-01 Immunomedics, Inc. Inmunoconjugados y anticuerpos humanizados especificos para linfoma de celulas b y celulas de leucemia.
JP3913273B2 (ja) 1995-09-28 2007-05-09 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド Il−6活性を阻害する合成ペプチド
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
US6653104B2 (en) 1996-10-17 2003-11-25 Immunomedics, Inc. Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
ES2333071T5 (es) * 1998-01-14 2015-08-17 Novartis Vaccines And Diagnostics S.R.L. Antígenos de Neisseria meningitidis
EP0972780A1 (en) 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides
US7345217B2 (en) * 1998-09-22 2008-03-18 Mendel Biotechnology, Inc. Polynucleotides and polypeptides in plants
IL139380A0 (en) * 2000-10-31 2001-11-25 Prochon Biotech Ltd Active variants of fibroblast growth factor
US20040198661A1 (en) * 2000-12-08 2004-10-07 Bowdish Katherine S. Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
US7169573B2 (en) * 2001-02-20 2007-01-30 Oklahoma Medical Research Foundation Method for monitoring coagulability and hypercoagulable states
JP2003066047A (ja) * 2001-06-14 2003-03-05 Matsushita Electric Ind Co Ltd 免疫反応測定方法及びそれに用いる免疫反応測定用試薬
US20030219839A1 (en) * 2001-09-20 2003-11-27 Katherine Bowdish Anti-PDGF antibodies and methods for producing engineered antibodies
KR20100120246A (ko) 2001-11-14 2010-11-12 센토코 오르토 바이오테크 인코포레이티드 항 il-6 항체, 조성물, 방법 및 용도
KR100468316B1 (ko) 2002-01-29 2005-01-27 주식회사 웰진 Dna의 세포 또는 조직 내 전달 효율을 높이는 펩타이드
US20040086979A1 (en) * 2002-08-15 2004-05-06 Dongxiao Zhang Humanized rabbit antibodies
KR20050058486A (ko) 2002-08-30 2005-06-16 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 인간형 항인간 인터루킨-6 항체 및 항체 단편
US20050090453A1 (en) 2003-01-15 2005-04-28 Solbec Pharmaceuticals Co., Ltd. Methods of modulating IL-6
JPWO2004101529A1 (ja) 2003-05-19 2006-07-13 小野薬品工業株式会社 含窒素複素環化合物およびその医薬用途
RU2392967C2 (ru) * 2003-10-17 2010-06-27 Тугаи Сейяку Кабусики Кайся Терапевтический агент для мезотелиомы
DK1678314T3 (da) 2003-10-22 2012-12-03 Keck Graduate Inst Fremgangsmåde til syntetisering af heteromultimere polypeptider i gær ved anvendelse af en haploid parringsstrategi
WO2006003517A1 (en) * 2004-06-29 2006-01-12 Warner-Lambert Company Llc Combination therapies utilizing benzamide inhibitors of the p2x7 receptor
GB0419424D0 (en) 2004-09-02 2004-10-06 Viragen Scotland Ltd Transgene optimisation
EP1809326A4 (en) * 2004-10-27 2009-11-04 Medimmune Inc MODULATION OF ANTIBODY SPECIFICITY BY MEASURING ADAPTATION OF ITS AFFINITY TO AN APPARENT ANTIGEN
US20080033027A1 (en) * 2005-03-21 2008-02-07 Vicus Therapeutics Spe 1, Llc Drug combination pharmaceutical compositions and methods for using them
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
PE20061324A1 (es) * 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
CN101356194B (zh) 2005-12-09 2013-06-12 Ucb医药有限公司 对人il-6具有特异性的抗体分子
EP1991270A4 (en) * 2005-12-22 2009-12-02 Anaborex Inc COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CACHEXIA
CA2635615A1 (en) 2005-12-30 2007-07-12 Merck Patent Gesellschaft Mit Beschraenkter Haftung Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130
WO2007120656A2 (en) * 2006-04-10 2007-10-25 Abbott Biotechnology Ltd. Uses and compositions for treatment of rheumatoid arthritis
NZ572807A (en) * 2006-05-19 2011-10-28 Alder Biopharmaceuticals Inc Culture method for obtaining a clonal population of antigen-specific b cells
CH701730B1 (de) * 2006-05-31 2011-03-15 Hanwha Chemical Corp VCAM-1 spezifischer monoklonaler Antikörper.
EP2064241B1 (en) * 2006-08-03 2015-10-07 Vaccinex, Inc. Anti-il-6 monoclonal antibodies and uses thereof
US20080081041A1 (en) 2006-09-29 2008-04-03 Jeffrey Nemeth Method of Using IL6 Antagonists with Mitoxantrone for Prostate Cancer
TW200831528A (en) * 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
TWI501976B (zh) * 2007-05-21 2015-10-01 Alder Biopharmaceuticals Inc 抗TNF-α之抗體及其用途
US8062864B2 (en) 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US8178101B2 (en) 2007-05-21 2012-05-15 Alderbio Holdings Inc. Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
CA2688146C (en) 2007-05-21 2018-03-06 Alder Biopharmaceuticals, Inc. Antibodies to il-6 and use thereof
JP5898496B2 (ja) * 2008-11-25 2016-04-06 アルダーバイオ ホールディングス エルエルシー Il−6に対する抗体およびその使用
US11783908B2 (en) 2019-10-11 2023-10-10 SK Hynix Inc. Stacked semiconductor device and semiconductor system including the same

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TWI617318B (zh) 2018-03-11
CN102292107A (zh) 2011-12-21
AU2009323002B2 (en) 2016-01-28
TW201609139A (zh) 2016-03-16
BRPI0921569A2 (pt) 2019-09-24
WO2010065077A3 (en) 2010-09-10
NZ592516A (en) 2013-02-22
JP6050430B2 (ja) 2016-12-21
JP5620918B2 (ja) 2014-11-05
TW201527321A (zh) 2015-07-16
AU2009323009A1 (en) 2010-06-10
EP3338799A1 (en) 2018-06-27
AU2009323008A1 (en) 2010-06-10
KR20110112307A (ko) 2011-10-12
AU2009323002A1 (en) 2010-06-10
EP3338799B1 (en) 2021-04-07
WO2010065079A3 (en) 2010-07-29
JP2015164951A (ja) 2015-09-17
TWI498120B (zh) 2015-09-01
HK1256622A1 (en) 2019-09-27
IL212728A0 (en) 2011-07-31
JP5815098B2 (ja) 2015-11-17
CN103861106B (zh) 2017-03-22
CN102438653A (zh) 2012-05-02
JP2012509874A (ja) 2012-04-26
JP2015028048A (ja) 2015-02-12
CN103861106A (zh) 2014-06-18
JP5898496B2 (ja) 2016-04-06
EP2367570A4 (en) 2013-07-31
TW201028164A (en) 2010-08-01
MX2011005396A (es) 2011-06-09

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