[go: up one dir, main page]

NO20100307L - GLP-1 analoger - Google Patents

GLP-1 analoger

Info

Publication number
NO20100307L
NO20100307L NO20100307A NO20100307A NO20100307L NO 20100307 L NO20100307 L NO 20100307L NO 20100307 A NO20100307 A NO 20100307A NO 20100307 A NO20100307 A NO 20100307A NO 20100307 L NO20100307 L NO 20100307L
Authority
NO
Norway
Prior art keywords
analogs
glp
analogues
peptide
glucagon
Prior art date
Application number
NO20100307A
Other languages
English (en)
Inventor
Zheng Xin Dong
David H Coy
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20100307L publication Critical patent/NO20100307L/no
Application filed by Univ Tulane filed Critical Univ Tulane

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)

Abstract

Det er beskrevet peptidanaloger av glukagon-lignende peptid-1, farmasøytisk akseptable salter derav, fremgangsmåte for anvendelse av slike analoger for behandling av pattedyr og farmasøytiske sammensetninger nyttige for dette og som derfor omfatter nevnte analoger.
NO20100307A 1998-12-07 2010-03-04 GLP-1 analoger NO20100307L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20683398A 1998-12-07 1998-12-07
US11118698P 1998-12-07 1998-12-07
PCT/US1999/028929 WO2000034332A1 (en) 1998-12-07 1999-12-07 Glp-1 analogues

Publications (1)

Publication Number Publication Date
NO20100307L true NO20100307L (no) 2001-08-06

Family

ID=26808707

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20012787A NO330293B1 (no) 1998-12-07 2001-06-06 GLP-1 analoger samt anvendelse derav og farmasoytisk sammensetning
NO20100307A NO20100307L (no) 1998-12-07 2010-03-04 GLP-1 analoger

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20012787A NO330293B1 (no) 1998-12-07 2001-06-06 GLP-1 analoger samt anvendelse derav og farmasoytisk sammensetning

Country Status (21)

Country Link
US (2) US7368427B1 (no)
EP (2) EP1992641A3 (no)
JP (3) JP2002538081A (no)
KR (1) KR100458748B1 (no)
CN (2) CN100334109C (no)
AT (1) ATE394423T1 (no)
AU (1) AU770609B2 (no)
BR (1) BR9916027A (no)
CA (1) CA2352573C (no)
CZ (2) CZ303399B6 (no)
DE (1) DE69938669D1 (no)
DK (1) DK1137666T5 (no)
ES (1) ES2302390T3 (no)
HU (1) HUP0104579A3 (no)
IL (2) IL143481A0 (no)
NO (2) NO330293B1 (no)
PL (3) PL393611A1 (no)
PT (1) PT1137666E (no)
RU (1) RU2208015C2 (no)
TW (2) TWI262925B (no)
WO (1) WO2000034332A1 (no)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2352573C (en) 1998-12-07 2012-04-10 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Glp-1 analogues
CZ295889B6 (cs) 1998-12-07 2005-11-16 Societe De Conseils De Recherches Et D'application Analogy GLP-1, mající arginin na pozicích 26 a 34, jejich použití a farmaceutické prostředky je obsahující
WO2002010195A2 (en) * 2000-08-02 2002-02-07 Theratechnologies Inc. Modified peptides with increased potency
US7186683B2 (en) 2000-09-18 2007-03-06 Sanos Bioscience A/S Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders
US7371721B2 (en) 2000-09-18 2008-05-13 Sanos Bioscience A/S Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
PT1326630E (pt) * 2000-09-18 2008-09-02 Sanos Bioscience As Utilização de péptidos glp-2
US6894024B2 (en) 2000-10-20 2005-05-17 Amylin Pharmaceuticals, Inc. Treatment of hibernating myocardium and diabetic cardiomyopathy with a GLP-1 peptide
DE60136958D1 (de) 2000-12-01 2009-01-22 Takeda Pharmaceutical Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz
EP1411968B1 (en) 2001-07-31 2008-09-17 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Glp-1 exendin-4 peptide analogs and uses thereof
AU2012202081B2 (en) * 2001-07-31 2014-09-25 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services GLP-1 Exendin-4 peptide analogs and uses thereof
CA2463908A1 (en) 2001-10-18 2003-04-24 Bristol-Myers Squibb Company Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
US7238671B2 (en) 2001-10-18 2007-07-03 Bristol-Myers Squibb Company Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions
AR040955A1 (es) * 2002-07-23 2005-04-27 Sod Conseils Rech Applic Analogos de ghrelina
US7811989B2 (en) 2003-01-17 2010-10-12 Ipsen Pharma S.A.S. Peptide YY analogs
EP2067483A1 (en) * 2003-02-19 2009-06-10 Ipsen Pharma Analogues of GLP-1
US7847063B2 (en) * 2003-03-28 2010-12-07 Sanwa Kagaku Kenkyusho Co., Ltd. GLP-1 derivative
US7008957B2 (en) 2003-07-25 2006-03-07 Sanofi-Aventis Deutschland Gmbh Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments
US7094800B2 (en) 2003-07-25 2006-08-22 Sanofi-Aventis Deutschland Gmbh Cyanopyrrolidides, process for their preparation and their use as medicaments
US7094794B2 (en) 2003-07-28 2006-08-22 Sanofi-Aventis Deutschland Gmbh Substituted thiazole-benzoisothiazole dioxide derivatives, process for their preparation and their use
DE10335092B3 (de) 2003-08-01 2005-02-03 Aventis Pharma Deutschland Gmbh Substituierte Benzoylureido-o-benzoylamide, Verfahren zu deren Herstellung und deren Verwendung
EP1711523B1 (en) * 2003-12-16 2012-10-10 Ipsen Pharma Analogues of glp-1
CA2550695A1 (en) * 2003-12-16 2005-06-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Glp-1 pharmaceutical compositions
AU2005203925A1 (en) * 2004-01-08 2005-07-21 Theratechnologies Inc. Glucagon-Like Peptide-1 analogs with long duration of action
US7534763B2 (en) 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
TW200611704A (en) 2004-07-02 2006-04-16 Bristol Myers Squibb Co Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
ATE553124T1 (de) * 2005-06-13 2012-04-15 Imp Innovations Ltd Oxyntomodulinanaloga und ihre wirkungen auf das fressverhalten
WO2007051987A1 (en) * 2005-11-01 2007-05-10 Activotec Spp Limited Insulinotropic compounds and uses thereof
EP2364735A3 (en) 2005-12-16 2012-04-11 Nektar Therapeutics Branched PEG conjugates of GLP-1
CA2648936C (en) 2006-04-20 2013-07-09 Amgen Inc. Glp-1 compounds
EP2021014A1 (en) 2006-05-26 2009-02-11 Brystol-Myers Squibb Company Sustained release glp-1 receptor modulators
CA2674354A1 (en) * 2007-01-05 2008-07-17 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
WO2009035540A2 (en) * 2007-09-07 2009-03-19 Ipsen Pharma S.A.S. Analogues of exendin-4 and exendin-3
EP2307037A4 (en) * 2008-06-17 2011-08-03 Univ Indiana Res & Tech Corp GLUCAGON ANALOGUE WITH IMPROVED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL PH BUFFERS
RU2011131714A (ru) * 2008-12-29 2013-02-10 Панацеа Биотек Лтд. Аналоги glp-1 и их использования
MX2012014576A (es) * 2010-06-24 2013-02-21 Univ Indiana Res & Tech Corp Profarmacos de peptido de la superfamilia de glucagon basado en amida.
WO2012054822A1 (en) 2010-10-22 2012-04-26 Nektar Therapeutics Pharmacologically active polymer-glp-1 conjugates
WO2012054861A1 (en) 2010-10-22 2012-04-26 Nektar Therapeutics Glp-1 polymer conjugates having a releasable linkage
PT2713722T (pt) 2011-05-31 2017-06-27 Receptos Llc Novos estabilizadores e moduladores do receptor glp-1
AU2012352349B2 (en) 2011-12-12 2017-08-17 Receptos Llc Carboxylic acid derivatives comprising four cycles acting as GLP-1 receptor modulators for therapy of diseases such as diabetes
CN102584982B (zh) * 2012-02-10 2014-02-05 深圳翰宇药业股份有限公司 一种纯化固相合成利拉鲁肽粗肽的方法
US20150157619A1 (en) 2012-07-10 2015-06-11 Takeda Pharmaceutical Company Limited Pharmaceutical preparation for injection
UA118558C2 (uk) * 2013-05-28 2019-02-11 Такеда Фармасьютікал Компані Лімітед Пептидна сполука
CN103285379A (zh) * 2013-06-09 2013-09-11 南方医科大学 Glp-1用于制备预防与治疗2型糖尿病大血管并发症的药物的用途
AU2014278183B2 (en) 2013-06-11 2018-10-04 Receptos Llc Novel GLP-1 receptor modulators
CN107074820B (zh) 2014-07-25 2021-05-18 赛尔基因第二国际有限公司 Glp-1受体调节剂
JP2018012644A (ja) * 2014-11-26 2018-01-25 武田薬品工業株式会社 ペプチド化合物
EP3230276B1 (en) 2014-12-10 2020-09-02 Celgene International II Sarl Glp-1 receptor modulators
KR20220070057A (ko) 2015-03-09 2022-05-27 인테크린 테라퓨틱스, 아이엔씨. 비알코올성 지방간 질환 및/또는 지방이영양증의 치료 방법
UA127495C2 (uk) 2015-12-23 2023-09-13 Амджен Інк. Виділений антигензв'язуючий білок, який специфічно зв'язується з поліпептидом рецептора шлункового інгібіторного пептиду (gipr) людини, та фармацевтична композиція, яка його містить
EA201891469A1 (ru) 2015-12-23 2018-12-28 Дзе Джонс Хопкинс Юниверсити Агонист длительного действия glp-1r как терапия для лечения неврологических и нейродегенеративных патологических состояний
US10501516B2 (en) 2016-05-24 2019-12-10 Takeda Pharmaceutical Company Limited Peptide compound
EP3463415A4 (en) * 2016-06-02 2020-03-25 Indiana University Research & Technology Corporation WATER-SOLUBLE AND CHEMICALLY STABLE GLUCAGON PEPTIDES
JOP20190177A1 (ar) 2017-01-17 2019-07-16 Amgen Inc طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr)
EP3606527A1 (en) 2017-04-03 2020-02-12 Coherus Biosciences, Inc. Ppar-gamma agonist for treatment of progressive supranuclear palsy
MA49460A (fr) 2017-06-20 2020-04-29 Amgen Inc Méthode de traitement ou de réduction de troubles métaboliques à l'aide de protéines de liaison au récepteur du peptide inhibiteur gastrique (gipr) en association avec des agonistes du glp-1
AU2018288852B2 (en) 2017-06-21 2025-02-27 Amgen Inc. Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (GIPR)/GLP-1 receptor agonist fusion proteins
CN109942696A (zh) * 2017-12-21 2019-06-28 中国药科大学 长效化胰高血糖素样肽-1(glp-1)类似物及其应用
CN116970062B (zh) * 2022-04-29 2024-04-09 南京知和医药科技有限公司 一种超长效glp-1多肽衍生物及其制备方法和用途
KR20250027558A (ko) 2022-06-23 2025-02-26 광저우 이노젠 파마슈티컬 그룹 컴퍼니 리미티드 개선된 glp-1 수용체 작용제 및 그 용도를 포함하는 융합 단백질
CN121152639A (zh) 2023-03-30 2025-12-16 广州银诺医药集团股份有限公司 一种包含glp‐1融合蛋白的药物制剂及其应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1539498A (en) 1925-05-26 And fifteen
US5545618A (en) * 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
ES2113879T3 (es) * 1990-01-24 1998-05-16 Douglas I Buckley Analogos de glp-1 utiles para el tratamiento de diabetes.
DE69101486T2 (de) * 1990-01-24 1994-08-04 Upjohn Co Verfahren zur reinigung rekombinanter polypeptide.
DK36392D0 (da) * 1992-03-19 1992-03-19 Novo Nordisk As Anvendelse af kemisk forbindelse
KR0154880B1 (ko) * 1992-06-15 1998-10-15 피터 알.셰어러 글루카곤-유사 펩티드 및 인슐리노트로핀 유도체
US5672659A (en) 1993-01-06 1997-09-30 Kinerton Limited Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
US5705483A (en) * 1993-12-09 1998-01-06 Eli Lilly And Company Glucagon-like insulinotropic peptides, compositions and methods
US5595760A (en) 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
US5512549A (en) * 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5665702A (en) 1995-06-06 1997-09-09 Biomeasure Incorporated Ionic molecular conjugates of N-acylated derivatives of poly(2-amino-2-deoxy-D-glucose) and polypeptides
AU2263197A (en) * 1996-02-06 1997-08-28 Eli Lilly And Company Diabetes therapy
EP1826216A1 (en) * 1996-08-30 2007-08-29 Novo Nordisk A/S Glp-1 derivatives
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
US5916883A (en) 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives
UA65549C2 (uk) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
WO1998043658A1 (en) * 1997-03-31 1998-10-08 Eli Lilly And Company Glucagon-like peptide-1 analogs
AU2610599A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S N-terminally truncated glp-1 derivatives
FR2777283B1 (fr) 1998-04-10 2000-11-24 Adir Nouveaux composes peptidiques analogues du glucagon-peptide- 1 (7-37), leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6720407B1 (en) 1998-08-28 2004-04-13 Eli Lilly And Company Method for administering insulinotropic peptides
CA2352573C (en) 1998-12-07 2012-04-10 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Glp-1 analogues
CZ295889B6 (cs) 1998-12-07 2005-11-16 Societe De Conseils De Recherches Et D'application Analogy GLP-1, mající arginin na pozicích 26 a 34, jejich použití a farmaceutické prostředky je obsahující
AU1269501A (en) 1999-11-12 2001-05-30 Novo Nordisk A/S Use of glp-1 agonists for the inhibition of beta cell degeneration
CN114612953B (zh) 2020-12-09 2025-09-26 佳能株式会社 对象识别模型的训练方法及装置

Also Published As

Publication number Publication date
EP1137666B1 (en) 2008-05-07
JP2010001301A (ja) 2010-01-07
IL143481A0 (en) 2002-04-21
US20090149378A1 (en) 2009-06-11
NO330293B1 (no) 2011-03-21
ES2302390T3 (es) 2008-07-01
CN1342166A (zh) 2002-03-27
TWI339208B (en) 2011-03-21
DK1137666T5 (da) 2009-10-05
BR9916027A (pt) 2001-08-28
AU1751200A (en) 2000-06-26
EP1137666A1 (en) 2001-10-04
DE69938669D1 (de) 2008-06-19
PT1137666E (pt) 2008-06-02
ATE394423T1 (de) 2008-05-15
JP2002538081A (ja) 2002-11-12
KR20010102953A (ko) 2001-11-17
TWI262925B (en) 2006-10-01
EP1992641A2 (en) 2008-11-19
CN101108878B (zh) 2012-08-29
TW200628489A (en) 2006-08-16
AU770609B2 (en) 2004-02-26
JP2006077022A (ja) 2006-03-23
HUP0104579A3 (en) 2002-05-28
IL143481A (en) 2010-02-17
HUP0104579A2 (hu) 2002-04-29
EP1992641A3 (en) 2009-07-29
KR100458748B1 (ko) 2004-12-03
NO20012787D0 (no) 2001-06-06
PL393611A1 (pl) 2011-05-09
DK1137666T3 (da) 2008-09-08
US7368427B1 (en) 2008-05-06
WO2000034332A1 (en) 2000-06-15
NO20012787L (no) 2001-08-06
CA2352573A1 (en) 2000-06-15
PL208751B1 (pl) 2011-06-30
PL205713B1 (pl) 2010-05-31
CZ303399B6 (cs) 2012-08-29
CA2352573C (en) 2012-04-10
CN101108878A (zh) 2008-01-23
CZ303120B6 (cs) 2012-04-11
CZ20011895A3 (cs) 2001-12-12
RU2208015C2 (ru) 2003-07-10
EP1137666B9 (en) 2009-04-01
CN100334109C (zh) 2007-08-29

Similar Documents

Publication Publication Date Title
NO20100307L (no) GLP-1 analoger
SG125915A1 (en) Analogues of glp-1
MXPA02012203A (es) Analogos de peptido 1 tipo glucagon.
MX9704439A (es) Derivados heterociclicos aromaticos como inhibidores de enzima.
BR0212080A (pt) composto de glp-1, método de estimulação de receptor de glp-1 em um indivìduo necessitando de tal estimulação, e, uso de um composto de glp-1
EA200100289A1 (ru) Способ введения инсулинотропных пептидов
DE69837809D1 (de) Apolipoprotein a-i agonisten sowie deren verwendung zur behandlung dislipidemischer erkrankungen
DK0946191T3 (da) Anvendelse af GLP-1-analoge og -derivater indgivet perifert til regulering af fedme
WO2005058252A3 (en) Glp-1 pharmaceutical compositions
BG104089A (en) Dolastatine 15 derivatives
MX9704684A (es) Derivados de glicina n-sustituidos, como inhibidores del factor xa.
EP0981352A4 (en) APLIDINE AS AN AGENT PROMOTING THE L-TYPE CALCIUM CHANNEL
NO20080552L (no) GLP-1 farmasoytiske sammensetninger
NO20000093D0 (no) (+)-Norcisaprid nyttig for 5-HT3 og 5-HT4-medierte forstyrrelser
EP2210900A3 (en) Analogues of GLP-1
DK0630365T3 (da) Fremgangsmåde til fremstilling af beta-phenylisoserin og analoge deraf
MY128529A (en) Use of cilobradine or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
EP1359159A3 (en) Analogues of GLP-1
DK1090028T3 (da) Umættede 14,15-cyclopropano-androstaner, fremgangsmåde til deres fremstilling og farmaceutiske præparater indeholdende disse forbindelser
UA88862C2 (en) Glucagon-like peptide-1 analogs
ECSP972074A (es) Composiciones farmaceuticas para el tratamiento de rinitis

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application