[go: up one dir, main page]

NO20093543L - Fremgangsmate for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer - Google Patents

Fremgangsmate for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer

Info

Publication number
NO20093543L
NO20093543L NO20093543A NO20093543A NO20093543L NO 20093543 L NO20093543 L NO 20093543L NO 20093543 A NO20093543 A NO 20093543A NO 20093543 A NO20093543 A NO 20093543A NO 20093543 L NO20093543 L NO 20093543L
Authority
NO
Norway
Prior art keywords
polymorphs
receptor agonist
adenosine receptor
preparation
isolating
Prior art date
Application number
NO20093543A
Other languages
English (en)
Other versions
NO341758B1 (no
Inventor
Elfatih Elzein
Jeff Zablocki
Original Assignee
Cv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38543556&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20093543(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Publication of NO20093543L publication Critical patent/NO20093543L/no
Publication of NO341758B1 publication Critical patent/NO341758B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det beskrives en syntese som er egnet for fremstilling i stor skala av en A2A- adenosinreseptroagonist. oppfinnelsen angår også polymorfer av forbindelsen og fremgangsmåter for å isolere en spesifikk polymorf.
NO20093543A 2007-05-17 2009-12-16 Fremgangsmåte for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer NO341758B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/069190 WO2008143667A1 (en) 2007-05-17 2007-05-17 Process for preparing an a2a-adenosine receptor agonist and its polymorphs

Publications (2)

Publication Number Publication Date
NO20093543L true NO20093543L (no) 2009-12-16
NO341758B1 NO341758B1 (no) 2018-01-15

Family

ID=38543556

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20093543A NO341758B1 (no) 2007-05-17 2009-12-16 Fremgangsmåte for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer

Country Status (14)

Country Link
EP (1) EP2158208B1 (no)
JP (1) JP5349461B2 (no)
KR (2) KR20140041965A (no)
CN (1) CN101668768B (no)
AU (1) AU2007353780B2 (no)
CA (1) CA2685589C (no)
ES (1) ES2537959T3 (no)
IL (1) IL201856A (no)
MX (1) MX2009012369A (no)
NO (1) NO341758B1 (no)
NZ (1) NZ580940A (no)
PT (1) PT2158208E (no)
WO (1) WO2008143667A1 (no)
ZA (1) ZA200907565B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
WO2001062979A2 (en) 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Dentification of partial agonists of the a2a adenosine receptor
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
KR20080090491A (ko) 2006-02-03 2008-10-08 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ-아데노신 수용체 효능제 및 이의 다형체의 제조 방법
CZ308577B6 (cs) * 2011-08-18 2020-12-16 Farmak, A. S. Způsob přípravy 2-(4-methoxykarbonylpyrazol-1-yl)adenosinu a 2-(4-ethoxykarbonylpyrazol-1-yl)adenosinu
CZ304053B6 (cs) 2011-08-22 2013-09-04 Farmak, A. S. Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
MX367879B (es) 2012-08-01 2019-09-10 Lewis And Clark Pharmaceuticals Inc N-alquil 2-(disustituido)alquiladenosin-5-uronamidas como agonistas a2a.
CZ305213B6 (cs) * 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
EP3003320A4 (en) 2013-05-30 2016-10-19 Biophore India Pharmaceuticals Pvt Ltd NOVEL POLYMORPH OF REGADENOSON
CN104744540A (zh) * 2013-12-26 2015-07-01 上海紫源制药有限公司 一种制备瑞加德松的方法
CN105085593A (zh) * 2014-04-21 2015-11-25 上海紫源制药有限公司 瑞加德松的晶型及其制备方法
CN105198950B (zh) * 2014-06-17 2018-10-02 上海紫源制药有限公司 一种瑞加德松晶型e的制备方法
CN105315284A (zh) * 2014-07-23 2016-02-10 上海医药工业研究院 阿拉格列汀中间体的制备方法
WO2016126734A1 (en) 2015-02-06 2016-08-11 Apicore Us Llc Process of making regadenoson and novel polymorph thereof
CN106397442B (zh) * 2015-07-28 2020-03-27 国药集团国瑞药业有限公司 一种瑞加德松的纯化方法
US20180208622A1 (en) * 2015-09-11 2018-07-26 Sun Pharmaceutical Industries Limited Stable crystalline form of regadenoson
US10392417B2 (en) * 2016-11-04 2019-08-27 Apicore Us Llc Polymorph of regadenoson and process for preparation thereof
CN117430647A (zh) * 2023-11-02 2024-01-23 康普药业股份有限公司 一种瑞加诺生的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
AU2003263846B2 (en) * 2002-08-15 2009-12-17 Gilead Palo Alto, Inc. Partial and full agonists of A1 adenosine receptors
WO2006125190A1 (en) * 2005-05-19 2006-11-23 Cv Therapeutics, Inc. A1 adenosine receptor agonists
KR20080090491A (ko) * 2006-02-03 2008-10-08 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ-아데노신 수용체 효능제 및 이의 다형체의 제조 방법

Also Published As

Publication number Publication date
KR20100021462A (ko) 2010-02-24
EP2158208A1 (en) 2010-03-03
JP2010527351A (ja) 2010-08-12
NZ580940A (en) 2012-02-24
KR101464794B1 (ko) 2014-11-27
HK1140771A1 (en) 2010-10-22
AU2007353780B2 (en) 2013-11-14
CN101668768A (zh) 2010-03-10
EP2158208B1 (en) 2015-04-08
IL201856A (en) 2013-07-31
CN101668768B (zh) 2012-08-29
KR20140041965A (ko) 2014-04-04
CA2685589A1 (en) 2008-11-27
IL201856A0 (en) 2010-06-16
ZA200907565B (en) 2011-10-26
ES2537959T8 (es) 2016-08-19
ES2537959T3 (es) 2015-06-16
MX2009012369A (es) 2009-12-01
WO2008143667A1 (en) 2008-11-27
CA2685589C (en) 2014-09-16
PT2158208E (pt) 2015-06-11
AU2007353780A1 (en) 2008-11-27
NO341758B1 (no) 2018-01-15
JP5349461B2 (ja) 2013-11-20

Similar Documents

Publication Publication Date Title
NO20093543L (no) Fremgangsmate for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer
NO20083395L (no) Fremgangsmåte for fremstilling av en A2A-adenosinreseptoragonist og dens polymorfer
MY152281A (en) 4-pyrimidinesulfamide derivative
NO20082121L (no) Imidazopyridinderivater som A2B-adenosinreseptorantagonister
Neto et al. Studies on the Eschenmoser coupling reaction and insights on its mechanism. Application in the synthesis of Norallosedamine and other alkaloids
UA107175C2 (uk) Спосіб і сполука, призначені для одержання інгібіторів контранспортера натрій-глюкози 2 типу, варіанти
EA201170618A1 (ru) Способ получения защищенных производных l-аланина
ZA200709926B (en) Process for the conversion of synthesis gas to oxygenates
MX2010003599A (es) Intermediarios y metodos para la sintesis de analogos de halicondrina b.
ZA200905981B (en) Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors
NO20065321L (no) Fremgangsmate for fremstilling av clopidogrelhydrogensulfat polymorf for I
IN2014CN03557A (no)
NO20083988L (no) Anvendelse av polyoler for å oppnå stabile polymorfe former av rifaximin
WO2012031045A3 (en) Phosphonate ester derivatives and methods of synthesis thereof
NO20080468L (no) Diazepinokinoliner, synteser av disse samt intermediater
EA201000147A1 (ru) Способ выделения и очистки монтелукаста
NO20081621L (no) Tetrahydrokinoliner, syntese og intermediater
BRPI0608819A8 (pt) Formas cristalinas de um derivado de imidazol
WO2012172566A3 (en) Novel sglt inhibitors
NO20092528L (no) Krystallinske kaliumsalter av lipoksin A4-analoger
NO20065046L (no) Krystallinsk polymorf av bazedoksifenacetat
Lone et al. Hemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin
EA201200820A1 (ru) Способ синтеза промежуточных продуктов, применимых для получения замещенных индазолов и азаиндазолов
GB0723932D0 (en) Method for purification of chlorinated sucrose derivatives from reaction mixture by chromatography
WO2008054690A3 (en) Polymorphs of a hydroisoindoline tachykinin receptor antagonist

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: CV THERAPEUTICS INC, US