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MX2009012369A - Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos. - Google Patents

Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos.

Info

Publication number
MX2009012369A
MX2009012369A MX2009012369A MX2009012369A MX2009012369A MX 2009012369 A MX2009012369 A MX 2009012369A MX 2009012369 A MX2009012369 A MX 2009012369A MX 2009012369 A MX2009012369 A MX 2009012369A MX 2009012369 A MX2009012369 A MX 2009012369A
Authority
MX
Mexico
Prior art keywords
polymorphs
receptor agonist
adenosine receptor
preparing
isolating
Prior art date
Application number
MX2009012369A
Other languages
English (en)
Inventor
Jeff Zablocki
Elfatih Elzein
Original Assignee
Cv Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38543556&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009012369(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cv Therapeutics Inc filed Critical Cv Therapeutics Inc
Publication of MX2009012369A publication Critical patent/MX2009012369A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se describe una síntesis adecuada para la fabricación a gran escala de un agonista del receptor de adenosina-A2A, y también se refiere a sus polimorfos del compuesto, y a métodos para aislar un polimorfo específico.
MX2009012369A 2007-05-17 2007-05-17 Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos. MX2009012369A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/069190 WO2008143667A1 (en) 2007-05-17 2007-05-17 Process for preparing an a2a-adenosine receptor agonist and its polymorphs

Publications (1)

Publication Number Publication Date
MX2009012369A true MX2009012369A (es) 2009-12-01

Family

ID=38543556

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012369A MX2009012369A (es) 2007-05-17 2007-05-17 Proceso para preparar un agonista del receptor de adenosina-a2a y sus polimorfos.

Country Status (14)

Country Link
EP (1) EP2158208B1 (es)
JP (1) JP5349461B2 (es)
KR (2) KR20140041965A (es)
CN (1) CN101668768B (es)
AU (1) AU2007353780B2 (es)
CA (1) CA2685589C (es)
ES (1) ES2537959T3 (es)
IL (1) IL201856A (es)
MX (1) MX2009012369A (es)
NO (1) NO341758B1 (es)
NZ (1) NZ580940A (es)
PT (1) PT2158208E (es)
WO (1) WO2008143667A1 (es)
ZA (1) ZA200907565B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
WO2001062979A2 (en) 2000-02-23 2001-08-30 Cv Therapeutics, Inc. Dentification of partial agonists of the a2a adenosine receptor
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
KR20080090491A (ko) 2006-02-03 2008-10-08 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ-아데노신 수용체 효능제 및 이의 다형체의 제조 방법
CZ308577B6 (cs) * 2011-08-18 2020-12-16 Farmak, A. S. Způsob přípravy 2-(4-methoxykarbonylpyrazol-1-yl)adenosinu a 2-(4-ethoxykarbonylpyrazol-1-yl)adenosinu
CZ304053B6 (cs) 2011-08-22 2013-09-04 Farmak, A. S. Zpusob prípravy 2-[4-[(methylamino)karbonyl]-1-H-pyrazol-1-yl]adenosinu monohydrátu
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
MX367879B (es) 2012-08-01 2019-09-10 Lewis And Clark Pharmaceuticals Inc N-alquil 2-(disustituido)alquiladenosin-5-uronamidas como agonistas a2a.
CZ305213B6 (cs) * 2013-04-29 2015-06-10 Farmak, A. S. Polymorf E 2-[4-[(methylamino)karbonyl]-1H-pyrazol-1-yl]adenosinu a způsob jeho přípravy
EP3003320A4 (en) 2013-05-30 2016-10-19 Biophore India Pharmaceuticals Pvt Ltd NOVEL POLYMORPH OF REGADENOSON
CN104744540A (zh) * 2013-12-26 2015-07-01 上海紫源制药有限公司 一种制备瑞加德松的方法
CN105085593A (zh) * 2014-04-21 2015-11-25 上海紫源制药有限公司 瑞加德松的晶型及其制备方法
CN105198950B (zh) * 2014-06-17 2018-10-02 上海紫源制药有限公司 一种瑞加德松晶型e的制备方法
CN105315284A (zh) * 2014-07-23 2016-02-10 上海医药工业研究院 阿拉格列汀中间体的制备方法
WO2016126734A1 (en) 2015-02-06 2016-08-11 Apicore Us Llc Process of making regadenoson and novel polymorph thereof
CN106397442B (zh) * 2015-07-28 2020-03-27 国药集团国瑞药业有限公司 一种瑞加德松的纯化方法
US20180208622A1 (en) * 2015-09-11 2018-07-26 Sun Pharmaceutical Industries Limited Stable crystalline form of regadenoson
US10392417B2 (en) * 2016-11-04 2019-08-27 Apicore Us Llc Polymorph of regadenoson and process for preparation thereof
CN117430647A (zh) * 2023-11-02 2024-01-23 康普药业股份有限公司 一种瑞加诺生的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403567B1 (en) * 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
AU2003263846B2 (en) * 2002-08-15 2009-12-17 Gilead Palo Alto, Inc. Partial and full agonists of A1 adenosine receptors
WO2006125190A1 (en) * 2005-05-19 2006-11-23 Cv Therapeutics, Inc. A1 adenosine receptor agonists
KR20080090491A (ko) * 2006-02-03 2008-10-08 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ-아데노신 수용체 효능제 및 이의 다형체의 제조 방법

Also Published As

Publication number Publication date
KR20100021462A (ko) 2010-02-24
EP2158208A1 (en) 2010-03-03
JP2010527351A (ja) 2010-08-12
NZ580940A (en) 2012-02-24
KR101464794B1 (ko) 2014-11-27
HK1140771A1 (en) 2010-10-22
AU2007353780B2 (en) 2013-11-14
CN101668768A (zh) 2010-03-10
EP2158208B1 (en) 2015-04-08
IL201856A (en) 2013-07-31
CN101668768B (zh) 2012-08-29
KR20140041965A (ko) 2014-04-04
CA2685589A1 (en) 2008-11-27
IL201856A0 (en) 2010-06-16
ZA200907565B (en) 2011-10-26
ES2537959T8 (es) 2016-08-19
ES2537959T3 (es) 2015-06-16
NO20093543L (no) 2009-12-16
WO2008143667A1 (en) 2008-11-27
CA2685589C (en) 2014-09-16
PT2158208E (pt) 2015-06-11
AU2007353780A1 (en) 2008-11-27
NO341758B1 (no) 2018-01-15
JP5349461B2 (ja) 2013-11-20

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Legal Events

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GB Transfer or rights

Owner name: GILEAD SCIENCES, INC.

HC Change of company name or juridical status

Owner name: GILEAD SCIENCES, INC.

FG Grant or registration