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NO20092356L - Indoler - Google Patents

Indoler

Info

Publication number
NO20092356L
NO20092356L NO20092356A NO20092356A NO20092356L NO 20092356 L NO20092356 L NO 20092356L NO 20092356 A NO20092356 A NO 20092356A NO 20092356 A NO20092356 A NO 20092356A NO 20092356 L NO20092356 L NO 20092356L
Authority
NO
Norway
Prior art keywords
present
relates
compounds
indoles
benzopyrrolone
Prior art date
Application number
NO20092356A
Other languages
English (en)
Inventor
Patrick Schnider
Hasane Ratni
Christophe Grundschober
Mark Rogers-Evans
Rafaello Masciadri
Caterina Bissantz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20092356L publication Critical patent/NO20092356L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår nye indol-3-yl-karbonyl-piperidin-benzopyrrolon, -benzoksazolon og -benzotriazolderivater som V1a reseptorantagonister, fremstilling av dem, farmasøytiske preparater inneholdende dem og anvendelse av dem som medikamenter. De aktive forbindelser ifølge foreliggende oppfinnelse er anvendelige ved forebygging og/eller behandling av angst og depressive lidelser og andre sykdommer. Spesielt angår foreliggende oppfinnelse forbindelser med den generelle formel (I) hvor X, Y og R1 til R10 er som beskrevet i beskrivelsen.
NO20092356A 2006-12-28 2009-06-19 Indoler NO20092356L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06127307 2006-12-28
PCT/EP2007/064176 WO2008080842A1 (en) 2006-12-28 2007-12-19 Indoles

Publications (1)

Publication Number Publication Date
NO20092356L true NO20092356L (no) 2009-06-30

Family

ID=39198190

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092356A NO20092356L (no) 2006-12-28 2009-06-19 Indoler

Country Status (18)

Country Link
US (3) US8143281B2 (no)
EP (1) EP2125785B1 (no)
JP (1) JP2010514726A (no)
KR (1) KR101134255B1 (no)
CN (1) CN101583609A (no)
AR (1) AR064546A1 (no)
AT (1) ATE533760T1 (no)
AU (1) AU2007341377B2 (no)
BR (1) BRPI0720968A2 (no)
CA (1) CA2674133A1 (no)
CL (1) CL2007003831A1 (no)
ES (1) ES2375520T3 (no)
MX (1) MX2009006920A (no)
NO (1) NO20092356L (no)
PE (1) PE20081401A1 (no)
RU (1) RU2009124111A (no)
TW (1) TWI345468B (no)
WO (1) WO2008080842A1 (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093578A1 (en) * 2009-02-10 2010-08-19 Glaxo Group Limited Indolinyl-, benzofuranyl-, and benzothienyl- amides as modulators of chemokine receptors
MA43159B1 (fr) 2015-11-06 2020-08-31 Hoffmann La Roche Dérivés d'indoline-2-one

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5686624A (en) 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
ATE216580T1 (de) * 1993-07-16 2002-05-15 Merck & Co Inc Benzoxazinon- und benzopyrimidinon- piperidinyl- verbindungen als tokolytische oxytocin-rezeptor- antagonisten
JPH0920779A (ja) * 1995-05-01 1997-01-21 Japan Tobacco Inc 縮合ヘテロ５員環アゼピン化合物類及びその医薬用途
CA2605899C (en) * 2005-04-26 2011-02-08 Pfizer Limited Triazole derivatives as vasopressin antagonists
EP1912976B1 (en) * 2005-07-21 2008-11-12 F. Hoffmann-Roche AG Indol-3-yl-carbonyl-piperidin-benzoimidazole derivatives as v1a receptor antagonists
CN102295636A (zh) 2005-07-29 2011-12-28 弗·哈夫曼-拉罗切有限公司 吲哚-3-基-羰基-哌啶和哌嗪衍生物
JP2010511660A (ja) 2006-12-08 2010-04-15 エフ．ホフマン−ラ ロシュ アーゲー 受容体アンタゴニストを介して作用するインドール

Also Published As

Publication number Publication date
US8143281B2 (en) 2012-03-27
CA2674133A1 (en) 2008-07-10
KR101134255B1 (ko) 2012-04-12
WO2008080842A1 (en) 2008-07-10
US20080167344A1 (en) 2008-07-10
US20080161316A1 (en) 2008-07-03
BRPI0720968A2 (pt) 2014-03-11
AU2007341377A1 (en) 2008-07-10
MX2009006920A (es) 2009-07-06
US20080161315A1 (en) 2008-07-03
TWI345468B (en) 2011-07-21
RU2009124111A (ru) 2011-02-10
JP2010514726A (ja) 2010-05-06
ATE533760T1 (de) 2011-12-15
PE20081401A1 (es) 2008-10-24
KR20090094395A (ko) 2009-09-04
TW200835491A (en) 2008-09-01
ES2375520T3 (es) 2012-03-01
AR064546A1 (es) 2009-04-08
CN101583609A (zh) 2009-11-18
AU2007341377B2 (en) 2012-03-22
EP2125785B1 (en) 2011-11-16
CL2007003831A1 (es) 2008-07-11
EP2125785A1 (en) 2009-12-02

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