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NO20091598L - P-toluensulfonsyresalt av 5-amino-3-(2'-O-acetyl-3'-deoksy-beta-D-ribofuranosyl)-3H-tiazol(4,5-d)pyrimidin-2-on og fremgangsmater for fremstilling derav - Google Patents

P-toluensulfonsyresalt av 5-amino-3-(2'-O-acetyl-3'-deoksy-beta-D-ribofuranosyl)-3H-tiazol(4,5-d)pyrimidin-2-on og fremgangsmater for fremstilling derav

Info

Publication number
NO20091598L
NO20091598L NO20091598A NO20091598A NO20091598L NO 20091598 L NO20091598 L NO 20091598L NO 20091598 A NO20091598 A NO 20091598A NO 20091598 A NO20091598 A NO 20091598A NO 20091598 L NO20091598 L NO 20091598L
Authority
NO
Norway
Prior art keywords
ribofuranosyl
deoxy
acetyl
amino
preparation
Prior art date
Application number
NO20091598A
Other languages
English (en)
Inventor
David J Kucera
Tingmin Wang
Gregory J Haley
Erik J Rueden
Fritz Blatter
Martin Viertelhaus
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Publication of NO20091598L publication Critical patent/NO20091598L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives p-toluensulfonsyresalt av 5-amino-3-(2'-O-acetyl-3'-deoksy-beta-D-ribofuranosyl)-3H-tiazolo[4,5-d]pyrimidin-2-on og dets anvendelse til behandling av slike tilstander som virusinfeksjoner, tumorer og cancer. Videre beskrives en fremgangsmåte for fremstilling av p-toluensulfonsyresalt av 5-amino-3-(2'-O-acetyl-3'-deoksy-?-D-ribofuranosyl)-3H-tiazolo[4,5-d]pyrimidin-2-on og fremgangsmåter for fremstilling av furanoseforbindelser som er anvendelige mellomprodukter ved fremstillingen av farmasøytiske forbindelser som p-toluensulfonsyresalt av 5-amino-3-(2'-O-acetyl-3'-deoksy-?-D-ribofuranosyl)-3H-tiazolo[4,5-d]pyrimidin-2-on og lignende.
NO20091598A 2006-10-17 2009-04-22 P-toluensulfonsyresalt av 5-amino-3-(2'-O-acetyl-3'-deoksy-beta-D-ribofuranosyl)-3H-tiazol(4,5-d)pyrimidin-2-on og fremgangsmater for fremstilling derav NO20091598L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US85200206P 2006-10-17 2006-10-17
US89940507P 2007-02-05 2007-02-05
US95359707P 2007-08-02 2007-08-02
PCT/US2007/081526 WO2008140549A1 (en) 2006-10-17 2007-10-16 P-TOLUENE SULFONIC ACID SALT OF 5-AMINO-3-(2'-O-ACETYL-3'-DEOXY-β-D-RIBOFURANOSYL)-3H-THIAZOLE [4, 5-D] PYRIMIDINE-2-ONE AND METHODS FOR PREPARATION

Publications (1)

Publication Number Publication Date
NO20091598L true NO20091598L (no) 2009-07-10

Family

ID=39472747

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091598A NO20091598L (no) 2006-10-17 2009-04-22 P-toluensulfonsyresalt av 5-amino-3-(2'-O-acetyl-3'-deoksy-beta-D-ribofuranosyl)-3H-tiazol(4,5-d)pyrimidin-2-on og fremgangsmater for fremstilling derav

Country Status (24)

Country Link
US (2) US7928085B2 (no)
EP (1) EP2076132B1 (no)
JP (2) JP5279715B2 (no)
KR (2) KR101486444B1 (no)
AR (1) AR063484A1 (no)
AU (1) AU2007353381B2 (no)
BR (1) BRPI0717741A2 (no)
CA (2) CA2898225A1 (no)
CY (1) CY1113368T1 (no)
DK (1) DK2076132T3 (no)
DO (1) DOP2007000131A (no)
EA (1) EA017005B1 (no)
ES (1) ES2390930T3 (no)
IL (2) IL198180A (no)
MX (1) MX2009004028A (no)
MY (1) MY150408A (no)
NO (1) NO20091598L (no)
NZ (1) NZ576408A (no)
PE (1) PE20081105A1 (no)
PL (1) PL2076132T3 (no)
PT (1) PT2076132E (no)
TW (1) TWI415854B (no)
UY (1) UY30650A1 (no)
WO (1) WO2008140549A1 (no)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2034834B1 (en) 2006-06-22 2011-01-26 Anadys Pharmaceuticals, Inc. Prodrugs of 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
US20110166092A1 (en) * 2007-08-20 2011-07-07 Anadys Pharmaceuticals, Inc. Dosing methods for treating disease
PE20170679A1 (es) 2014-12-08 2017-05-22 Hoffmann La Roche Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales
US9676793B2 (en) 2014-12-23 2017-06-13 Hoffmann-Laroche Inc. Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
CR20170424A (es) 2015-03-16 2018-01-26 Hoffmann La Roche Tratamiento combinado con un agonista de tlr7 y un inhibidor del ensamblaje de la cápsula del vhb
JP6779232B2 (ja) 2015-05-08 2020-11-04 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ウイルス感染の治療又は予防のための新規オキサチオランカルボン酸と誘導体
EP3294746B1 (en) 2015-05-12 2021-10-06 F. Hoffmann-La Roche AG Substituted aminothiazolopyrimidinedione derivatives for the treatment and prophylaxis of virus infection
WO2017001307A1 (en) 2015-06-30 2017-01-05 F. Hoffmann-La Roche Ag Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
US11142534B2 (en) * 2017-01-06 2021-10-12 Hoffmann-La Roche Inc. Process for the preparation of 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds
CN110007010A (zh) * 2018-01-05 2019-07-12 大鹏药品工业株式会社 源自曲氟尿苷的类似物质的检测方法

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US5532374A (en) * 1995-06-06 1996-07-02 Hitachi Chemical Company, Ltd. Method of preparation of bis-quinolines
JP4067226B2 (ja) * 1999-04-01 2008-03-26 三井化学株式会社 １―ハロゲノ−２−デオキシリボフラノース誘導体の製造方法
JP2000327693A (ja) * 1999-05-21 2000-11-28 Mitsui Chemicals Inc ２’−デオキシ−β−シチジン誘導体の製造方法
US6649761B2 (en) * 2001-05-30 2003-11-18 Merck & Co., Inc. Process for preparing piperazinepentaneamide HIV protease inhibitors
MXPA04004966A (es) * 2001-11-27 2006-03-21 Anadys Pharmaceuticals Inc Nucleosidos de 3-beta-d-ribofuranoziltiazol(4,5-d(pirimidina y uso de los mismos.
AU2003289995A1 (en) * 2002-12-09 2004-06-30 Texcontor Etablissement Anhydrous crystalline form of valacyclovir hydrochloride
EA200600540A1 (ru) * 2003-09-05 2006-08-25 Анадис Фармасьютикалз, Инк. Введение лигандов tlr7 и их пролекарств для лечения инфекции вируса гепатита с
EP1758916B1 (en) * 2004-06-07 2012-11-21 Anadys Pharmaceuticals, Inc. 3-BETA-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
BRPI0518861B8 (pt) * 2004-12-17 2021-05-25 Anadys Pharmaceuticals Inc compostos, sais ou hidratos farmaceuticamente aceitos, composição farmacêutica e uso de quantidade terapeutica ou profilaticamente eficaz de composto ou de composição farmacêutica
US7501526B2 (en) * 2005-01-20 2009-03-10 Taigen Biotechnology Synthesis of polyamine compounds
EP2034834B1 (en) * 2006-06-22 2011-01-26 Anadys Pharmaceuticals, Inc. Prodrugs of 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
KR101266843B1 (ko) * 2006-12-08 2013-05-24 가부시키가이샤 에이피아이 코포레이션 퓨라노스 유도체의 제조방법

Also Published As

Publication number Publication date
JP5279715B2 (ja) 2013-09-04
IL198180A0 (en) 2009-12-24
US7928085B2 (en) 2011-04-19
CY1113368T1 (el) 2016-06-22
ES2390930T3 (es) 2012-11-19
JP5703334B2 (ja) 2015-04-15
IL223126A (en) 2016-08-31
US20110172447A1 (en) 2011-07-14
NZ576408A (en) 2012-04-27
JP2013166782A (ja) 2013-08-29
KR101486444B1 (ko) 2015-01-26
PT2076132E (pt) 2012-10-03
TWI415854B (zh) 2013-11-21
JP2010506947A (ja) 2010-03-04
MX2009004028A (es) 2009-05-11
KR101515077B1 (ko) 2015-04-24
AU2007353381A1 (en) 2008-11-20
EA017005B1 (ru) 2012-09-28
KR20090074237A (ko) 2009-07-06
EP2076132A4 (en) 2011-05-04
CA2666537C (en) 2015-12-08
AU2007353381B2 (en) 2013-07-04
KR20140119203A (ko) 2014-10-08
DK2076132T3 (da) 2012-09-10
CA2898225A1 (en) 2008-11-20
IL198180A (en) 2015-06-30
WO2008140549A1 (en) 2008-11-20
PL2076132T3 (pl) 2013-01-31
CA2666537A1 (en) 2008-11-20
PE20081105A1 (es) 2008-08-15
HK1132429A1 (en) 2010-02-26
AR063484A1 (es) 2009-01-28
US20090197826A1 (en) 2009-08-06
TW200833699A (en) 2008-08-16
BRPI0717741A2 (pt) 2014-04-08
MY150408A (en) 2014-01-15
DOP2007000131A (es) 2008-09-15
EP2076132B1 (en) 2012-07-11
EP2076132A1 (en) 2009-07-08
EA200970387A1 (ru) 2009-10-30
UY30650A1 (es) 2008-05-31
US8193342B2 (en) 2012-06-05
IL223126A0 (en) 2012-12-31

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