PE20170679A1 - Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales - Google Patents
Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones viralesInfo
- Publication number
- PE20170679A1 PE20170679A1 PE2017000551A PE2017000551A PE20170679A1 PE 20170679 A1 PE20170679 A1 PE 20170679A1 PE 2017000551 A PE2017000551 A PE 2017000551A PE 2017000551 A PE2017000551 A PE 2017000551A PE 20170679 A1 PE20170679 A1 PE 20170679A1
- Authority
- PE
- Peru
- Prior art keywords
- thiazolo
- amino
- hydroxy
- pyrimidin
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 2
- 208000036142 Viral infection Diseases 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 102000002689 Toll-like receptor Human genes 0.000 abstract 2
- 108020000411 Toll-like receptor Proteins 0.000 abstract 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- SFUOKIWAHYUWBI-JHMXTYEHSA-N 5-amino-3-[(2R,3R,5S)-3-hydroxy-5-(1-hydroxypropyl)oxolan-2-yl]-6H-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione Chemical compound NC=1NC(C2=C(N=1)N(C(S2)=O)[C@@H]1O[C@@H](C[C@H]1O)C(CC)O)=O SFUOKIWAHYUWBI-JHMXTYEHSA-N 0.000 abstract 1
- FALKDYRPMOIMKW-UHFFFAOYSA-N 5-amino-3-[3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4h-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione Chemical compound C1=2NC(N)=NC(=O)C=2SC(=O)N1C1OC(CO)CC1O FALKDYRPMOIMKW-UHFFFAOYSA-N 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- VLUVPBONHLFKSJ-UHFFFAOYSA-N [2-(5-amino-2,7-dioxo-6H-[1,3]thiazolo[4,5-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolan-3-yl] acetate Chemical compound C(C)(=O)OC1C(OC(C1)CO)N1C(SC2=C1N=C(N=C2O)N)=O VLUVPBONHLFKSJ-UHFFFAOYSA-N 0.000 abstract 1
- -1 [4-acetoxy-5- (5-amino-7-hydroxy-2-oxo-thiazolo [4,5-d] pyrimidin-3-yl) tetrahydrofuran-2-yl] methyl Chemical group 0.000 abstract 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se refiere a un derivado de 5-amino-6H-tiazolo[4,5-D]pirimidin-2,7-diona-3-sustituida de formula (I) en la que R1 es hidroxi, alquilo C1-C6, entre otros; R2 es H, alquilo C1-C6, entre otros; R3 es H o alquil C1-C6 carbonilo con la exclusion de: 5-amino-7-hidroxi-3-[3-hidroxi-5-(hodroximetil)tetrahidrofuran-2-il]tiazolo[4,5-d]pirimidin-2-ona; acetato de [2-(5-amino-7-hidroxi-2-oxo-tiazolo[4,5-d]pirimidin-3-il)-5-(hidroximetil)tetrahidrofuran-3-ilo]; acetato de [4-acetoxi-5-(5-amino-7-hidroxi-2-oxo-tiazolo[4,5-d]pirimidin-3-il)tetrahidrofuran-2-il]metilo. Es un compuesto seleccionado: 5-amino-3-[(2R,3R,5S)-3-hidroxi-5-(1-hidroxipropil)tetrahidrofuran-2-il]-6H-tiazolo[4,5-d]pirimidin-2,7-diona; entre otros. Tambien se refiere a una composicion. Dicho compuesto tiene actividad agonista del receptor de tipo Toll (TLR), siendo util en el tratamiento de enfermedades infecciosas como VHB o VHC
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2014093224 | 2014-12-08 | ||
| CN2015086987 | 2015-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20170679A1 true PE20170679A1 (es) | 2017-05-22 |
Family
ID=54771116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2017000551A PE20170679A1 (es) | 2014-12-08 | 2015-12-03 | Nuevos compuestos de 5-amino-6h-tiazolo[4,5-d]pirimidin-2,7-diona 3-sustituidos para el tratamiento y profilaxis de infecciones virales |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9441008B2 (es) |
| EP (1) | EP3230298B1 (es) |
| JP (1) | JP6817217B2 (es) |
| KR (2) | KR20230113824A (es) |
| CN (2) | CN106164079B (es) |
| AU (1) | AU2015359692B2 (es) |
| BR (1) | BR112017011941B1 (es) |
| CA (1) | CA2963717C (es) |
| CL (1) | CL2017001426A1 (es) |
| CR (1) | CR20170237A (es) |
| DK (1) | DK3230298T3 (es) |
| EA (1) | EA038744B1 (es) |
| ES (1) | ES2864223T3 (es) |
| HR (1) | HRP20210454T1 (es) |
| HU (1) | HUE053704T2 (es) |
| IL (1) | IL251285B (es) |
| LT (1) | LT3230298T (es) |
| MA (1) | MA41134B1 (es) |
| MX (1) | MX379474B (es) |
| MY (1) | MY194002A (es) |
| PE (1) | PE20170679A1 (es) |
| PH (1) | PH12017501061B1 (es) |
| PL (1) | PL3230298T3 (es) |
| PT (1) | PT3230298T (es) |
| RS (1) | RS61612B1 (es) |
| SG (1) | SG11201704512PA (es) |
| SI (1) | SI3230298T1 (es) |
| TW (1) | TWI733656B (es) |
| UA (1) | UA124184C2 (es) |
| WO (1) | WO2016091698A1 (es) |
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| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
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| WO2009026292A1 (en) * | 2007-08-20 | 2009-02-26 | Anadys Pharmaceuticals, Inc. | Dosing methods for treating disease |
| SI3230298T1 (sl) | 2014-12-08 | 2021-04-30 | F. Hoffmann-La Roche Ag | Spojine 3-substituiranega 5-amino-6H-tiazolo(4,5-d)pirimidin-2,7-diona za zdravljenje ali preprečevanje okužbe z virusom |
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| JP6839104B2 (ja) | 2015-06-30 | 2021-03-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ウイルス感染の治療及び予防のための新規な置換アミノチアゾロピリミジンジオン |
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