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NO20090667L - Tartratsalt av (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1-yl]-6,7-dihydro-5H-syklopenta[b] pyridin - Google Patents

Tartratsalt av (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1-yl]-6,7-dihydro-5H-syklopenta[b] pyridin

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Publication number
NO20090667L
NO20090667L NO20090667A NO20090667A NO20090667L NO 20090667 L NO20090667 L NO 20090667L NO 20090667 A NO20090667 A NO 20090667A NO 20090667 A NO20090667 A NO 20090667A NO 20090667 L NO20090667 L NO 20090667L
Authority
NO
Norway
Prior art keywords
tartrate salt
cyclopenta
dihydro
oxy
fluoro
Prior art date
Application number
NO20090667A
Other languages
English (en)
Inventor
Kevin Kun-Chin Liu
Yuan Zeng
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20090667L publication Critical patent/NO20090667L/no

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61P13/10—Drugs for disorders of the urinary system of the bladder
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  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer et tartratsalt med formel (I), formel I er også kjent som (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1 -yl]-6,7-dihydro-5H-syklopenta[b]pyridin. Tartratsaltet er foretrukket krystallinsk.Tartratsaltet med formel I ifølge oppfinnelsen er anvendbart ved behandling av sykdommer koblet til aktivering av 5-HT2c reseptoren i dyr inkludert mennesker, feks. ved behandling av schizofreni, kognitiv deficit inkludert kognitiv deficit assosiert med schizofreni, angst, depresjon, tvangslidelse, epilepsi, fedme, seksuell dysfunksjon og urininkontinens, blant andre.
NO20090667A 2006-07-14 2009-02-11 Tartratsalt av (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1-yl]-6,7-dihydro-5H-syklopenta[b] pyridin NO20090667L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83089006P 2006-07-14 2006-07-14
PCT/IB2007/002025 WO2008010073A1 (en) 2006-07-14 2007-07-09 Tartrate salt of (7s)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2r)-2-methylpiperazin-1-yl]-6,7-dihydro-5h-cyclopenta[b]pyridine

Publications (1)

Publication Number Publication Date
NO20090667L true NO20090667L (no) 2009-02-11

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NO20090667A NO20090667L (no) 2006-07-14 2009-02-11 Tartratsalt av (7S)-7-[(5-fluor-2-metyl-benzyl)oksy]-2-[(2R)-2-metylpiperazin-1-yl]-6,7-dihydro-5H-syklopenta[b] pyridin

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US (1) US20100004259A1 (no)
EP (1) EP2044029B1 (no)
JP (1) JP4312243B2 (no)
KR (1) KR20090029299A (no)
CN (1) CN101506172A (no)
AR (1) AR062068A1 (no)
AT (1) ATE496894T1 (no)
AU (1) AU2007274710A1 (no)
CA (1) CA2657640A1 (no)
DE (1) DE602007012254D1 (no)
IL (1) IL196417A0 (no)
MX (1) MX2009000508A (no)
NO (1) NO20090667L (no)
TW (1) TW200821293A (no)
WO (1) WO2008010073A1 (no)
ZA (1) ZA200901051B (no)

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DE602007012254D1 (de) 2011-03-10
JP4312243B2 (ja) 2009-08-12
EP2044029B1 (en) 2011-01-26
ZA200901051B (en) 2010-01-27
EP2044029A1 (en) 2009-04-08
AU2007274710A1 (en) 2008-01-24
WO2008010073A1 (en) 2008-01-24
ATE496894T1 (de) 2011-02-15
IL196417A0 (en) 2009-09-22
JP2008044931A (ja) 2008-02-28
WO2008010073A8 (en) 2009-03-05
US20100004259A1 (en) 2010-01-07
AR062068A1 (es) 2008-10-15
TW200821293A (en) 2008-05-16
MX2009000508A (es) 2009-01-27
CA2657640A1 (en) 2008-01-24
KR20090029299A (ko) 2009-03-20
CN101506172A (zh) 2009-08-12

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