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MA31442B1 - 3-(imidazolyl)-pyrazolo [3,4-b]pyridines - Google Patents

3-(imidazolyl)-pyrazolo [3,4-b]pyridines

Info

Publication number
MA31442B1
MA31442B1 MA32416A MA32416A MA31442B1 MA 31442 B1 MA31442 B1 MA 31442B1 MA 32416 A MA32416 A MA 32416A MA 32416 A MA32416 A MA 32416A MA 31442 B1 MA31442 B1 MA 31442B1
Authority
MA
Morocco
Prior art keywords
pyrazolo
imidazolyl
ccr1
compounds
pyridines
Prior art date
Application number
MA32416A
Other languages
English (en)
Inventor
Lianfa Li
Andrew M K Pennell
Penglie Zhang
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of MA31442B1 publication Critical patent/MA31442B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS QUI AGISSENT COMME DE PUISSANTS ANTAGONISTES DU RÉCEPTEUR CCR1 ET QUI PRÉSENTENT UNE ACTIVITÉ ANTI-INFLAMMATOIRE IN VIVO. LES COMPOSÉS SONT DES DÉRIVÉS DE 3-IMIDAZOLYL-PYRAZOLO[3,4-B]PYRIDINE ET SONT UTILES DANS DES COMPOSITIONS PHARMACEUTIQUES, DES PROCÉDÉS DE TRAITEMENT DE MALADIES MÉDIÉES PAR LE CCR1, ET COMME CONTRÔLES DANS DES TESTS POUR L'IDENTIFICATION D'ANTAGONISTES COMPÉTITIFS DU CCR1.
MA32416A 2007-05-22 2009-12-14 3-(imidazolyl)-pyrazolo [3,4-b]pyridines MA31442B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93294807P 2007-05-22 2007-05-22

Publications (1)

Publication Number Publication Date
MA31442B1 true MA31442B1 (fr) 2010-06-01

Family

ID=40075474

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32416A MA31442B1 (fr) 2007-05-22 2009-12-14 3-(imidazolyl)-pyrazolo [3,4-b]pyridines

Country Status (26)

Country Link
US (4) US7629344B2 (fr)
EP (1) EP2155712B1 (fr)
JP (1) JP5457338B2 (fr)
KR (1) KR101534661B1 (fr)
CN (1) CN101743238B (fr)
AR (2) AR066701A1 (fr)
AU (1) AU2008256862B2 (fr)
BR (1) BRPI0811849A8 (fr)
CA (1) CA2687625C (fr)
CL (1) CL2008001493A1 (fr)
CO (1) CO6241152A2 (fr)
DK (1) DK2155712T3 (fr)
EA (1) EA015529B1 (fr)
ES (1) ES2600477T3 (fr)
HU (1) HUE032273T2 (fr)
IL (1) IL202248A (fr)
JO (1) JO3319B1 (fr)
MA (1) MA31442B1 (fr)
MX (1) MX2009012567A (fr)
NZ (1) NZ581405A (fr)
PE (1) PE20090293A1 (fr)
PL (1) PL2155712T3 (fr)
PT (1) PT2155712T (fr)
TW (1) TWI418353B (fr)
UA (1) UA99619C2 (fr)
WO (1) WO2008147815A1 (fr)

Families Citing this family (14)

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US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
EP2081921B1 (fr) 2006-07-10 2010-09-08 PAION UK Limited Sels de benzodiazépine et leurs formes polymorphes à action brève
DK2155712T3 (en) * 2007-05-22 2016-12-19 Chemocentryx Inc 3- (imidazolyl) pyrazolo [3,4-b] pyridines
ES2536884T3 (es) 2008-09-11 2015-05-29 Chemocentryx, Inc. 4-Amino-3-(imidazolil)pirazol[3,4-d]pirimidinas
EP2305647A1 (fr) 2009-09-18 2011-04-06 PAION UK Limited Procédé de préparation d'ester de méthyle d'acide 3-[(4S)-8-bromo-1-méthyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazépine-4-yl] propionique ou son sulfonate de benzène, et composants utiles dans ce procédé
EP2450039A1 (fr) 2010-11-08 2012-05-09 PAION UK Ltd. Régime de dosage permettant la sédation avec CNS 7056 (Remimazolam)
IN2015DN01736A (fr) * 2012-08-27 2015-05-29 Chemocentryx Inc
MX2015007051A (es) * 2012-12-07 2016-01-12 Chemocentryx Inc Diazol lactamas.
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
US20170195506A1 (en) * 2015-12-30 2017-07-06 Kabushiki Kaisha Toshiba Image forming apparatus forming location free print system and print job retrieval method by the same
TWI808938B (zh) * 2016-04-07 2023-07-21 美商卡默森屈有限公司 藉由投予ccr1拮抗劑與pd-1抑制劑或pd-l1抑制劑之組合減少腫瘤負荷
KR102890201B1 (ko) 2019-07-10 2025-11-24 케모센트릭스, 인크. Pd-l1 억제제로서의 인단
CA3152714A1 (fr) 2019-10-16 2021-04-22 Pingchen Fan Heteroaryl-biphenylamines pour le traitement de maladies pd-l1
PH12022550876A1 (en) 2019-10-16 2023-03-27 Chemocentryx Inc Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases

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DK2155712T3 (en) * 2007-05-22 2016-12-19 Chemocentryx Inc 3- (imidazolyl) pyrazolo [3,4-b] pyridines

Also Published As

Publication number Publication date
AU2008256862A8 (en) 2009-12-24
JP5457338B2 (ja) 2014-04-02
PE20090293A1 (es) 2009-04-04
HUE032273T2 (en) 2017-09-28
US8481545B2 (en) 2013-07-09
IL202248A0 (en) 2010-06-16
US20120010214A1 (en) 2012-01-12
AU2008256862A1 (en) 2008-12-04
DK2155712T3 (en) 2016-12-19
JP2010528038A (ja) 2010-08-19
AR110128A2 (es) 2019-02-27
CA2687625A1 (fr) 2008-12-04
MX2009012567A (es) 2010-02-17
CN101743238A (zh) 2010-06-16
EP2155712A1 (fr) 2010-02-24
NZ581405A (en) 2011-06-30
PT2155712T (pt) 2016-12-13
ES2600477T3 (es) 2017-02-09
CL2008001493A1 (es) 2008-08-29
CO6241152A2 (es) 2011-01-20
AU2008256862B2 (en) 2013-01-31
CA2687625C (fr) 2015-12-22
TWI418353B (zh) 2013-12-11
US20100173911A1 (en) 2010-07-08
IL202248A (en) 2015-04-30
BRPI0811849A8 (pt) 2019-01-15
EP2155712B1 (fr) 2016-09-07
TW200906402A (en) 2009-02-16
CN101743238B (zh) 2014-04-30
US7960388B2 (en) 2011-06-14
KR20100022998A (ko) 2010-03-03
KR101534661B1 (ko) 2015-07-09
AR066701A1 (es) 2009-09-09
HK1141524A1 (zh) 2010-11-12
EP2155712A4 (fr) 2011-05-11
US20130184289A1 (en) 2013-07-18
US20080300257A1 (en) 2008-12-04
EA015529B1 (ru) 2011-08-30
PL2155712T3 (pl) 2017-02-28
UA99619C2 (en) 2012-09-10
EA200901572A1 (ru) 2010-04-30
JO3319B1 (ar) 2019-03-13
US7629344B2 (en) 2009-12-08
BRPI0811849A2 (pt) 2014-11-18
WO2008147815A1 (fr) 2008-12-04

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