NO20084863L - "Insulinotropic" peptidsyntese - Google Patents
"Insulinotropic" peptidsynteseInfo
- Publication number
- NO20084863L NO20084863L NO20084863A NO20084863A NO20084863L NO 20084863 L NO20084863 L NO 20084863L NO 20084863 A NO20084863 A NO 20084863A NO 20084863 A NO20084863 A NO 20084863A NO 20084863 L NO20084863 L NO 20084863L
- Authority
- NO
- Norway
- Prior art keywords
- fragments
- phase
- solid
- solution
- insulinotropic
- Prior art date
Links
- 230000002473 insulinotropic effect Effects 0.000 title abstract 3
- 238000010647 peptide synthesis reaction Methods 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 7
- 239000012071 phase Substances 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- NGJOFQZEYQGZMB-KTKZVXAJSA-N (4S)-5-[[2-[[(2S,3R)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[2-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-2-oxoethyl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-4-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]-5-oxopentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NGJOFQZEYQGZMB-KTKZVXAJSA-N 0.000 abstract 1
- 101800004295 Glucagon-like peptide 1(7-36) Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 239000006104 solid solution Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Foreliggende oppfinnelse angår fremstilling av insulinotropiske peptider som blir syntetisert ved anvendelse av en fast- og løsnings-fase ("hybrid")-metode. Generelt omfatter metoden syntetisering av tre forskjellige peptid intermediat-fragmenter ved anvendelse av fastfase kjemi. Løsnings-fase kjemi blir deretter anvendt for å tilføye ytterligere aminosyre-materiale til ett av fragmentene. Fragmentene blir deretter koblet sammen i den faste løsning fasen. Anvendelse av en pseudoprolin i ett av fragmentene letter fastfasesyntese av dette fragmentet og letter også påfølgende løsnings-fase kobling av dette fragmentet til andre fragmenter. Foreliggende oppfinnelse er svært anvendelig for dannelse av insulinotropiske peptider slik som GLP-1(7-36) og dets naturlige og ikke-naturlige motstykker.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81591906P | 2006-06-23 | 2006-06-23 | |
| PCT/EP2007/056052 WO2007147816A1 (en) | 2006-06-23 | 2007-06-19 | Insulinotropic peptide synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20084863L true NO20084863L (no) | 2009-01-22 |
Family
ID=38596729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20084863A NO20084863L (no) | 2006-06-23 | 2008-11-19 | "Insulinotropic" peptidsyntese |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US20080004429A1 (no) |
| EP (1) | EP2035451B1 (no) |
| JP (1) | JP4537495B2 (no) |
| KR (1) | KR101087859B1 (no) |
| CN (1) | CN101563364B (no) |
| AR (1) | AR061604A1 (no) |
| AT (1) | ATE466881T1 (no) |
| AU (1) | AU2007263043B2 (no) |
| BR (1) | BRPI0713575A2 (no) |
| CA (1) | CA2654610C (no) |
| CL (1) | CL2007001835A1 (no) |
| CR (1) | CR10463A (no) |
| CY (1) | CY1110186T1 (no) |
| DE (1) | DE602007006310D1 (no) |
| DK (1) | DK2035451T3 (no) |
| EC (1) | ECSP088999A (no) |
| ES (1) | ES2341588T3 (no) |
| HR (1) | HRP20100302T1 (no) |
| IL (1) | IL195421A0 (no) |
| MA (1) | MA30530B1 (no) |
| MX (1) | MX2008015935A (no) |
| MY (1) | MY144608A (no) |
| NO (1) | NO20084863L (no) |
| NZ (1) | NZ573093A (no) |
| PL (1) | PL2035451T3 (no) |
| PT (1) | PT2035451E (no) |
| RS (1) | RS51281B (no) |
| RU (1) | RU2448978C2 (no) |
| SI (1) | SI2035451T1 (no) |
| TW (1) | TWI331155B (no) |
| UA (1) | UA96602C2 (no) |
| WO (1) | WO2007147816A1 (no) |
| ZA (1) | ZA200810072B (no) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101835794A (zh) * | 2007-10-27 | 2010-09-15 | 霍夫曼-拉罗奇有限公司 | 使用固相和溶液相组合技术的促胰岛素肽合成法 |
| JP2011506376A (ja) * | 2007-12-11 | 2011-03-03 | エフ．ホフマン−ラ ロシュ アーゲー | 固相及び溶液相の組み合わせ技術を使用したインシュリン分泌性ペプチド合成 |
| US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| US20100183876A1 (en) * | 2008-12-23 | 2010-07-22 | Hell Andre | Process for the Preparation of a Peptide Powder Form |
| EP2424888A2 (en) * | 2009-05-01 | 2012-03-07 | F. Hoffmann-La Roche AG | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| US20110313131A1 (en) * | 2010-06-21 | 2011-12-22 | Christelle Carl | Reversed phase hplc purification of a glp-1 analogue |
| US20120157382A1 (en) | 2010-12-21 | 2012-06-21 | Siegfried Krimmer | Pharmaceutical glp-1 compositions having an improved release profile |
| EP2788110B1 (en) * | 2011-12-08 | 2018-10-17 | Pentair Water Pool and Spa, Inc. | Aquaculture system and method of operating a pump in such a system |
| KR101922164B1 (ko) * | 2011-12-29 | 2019-02-13 | 노보 노르디스크 에이/에스 | 비-단백질원 아미노산을 포함하는 디펩티드 |
| WO2014077801A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification process for preparing highly pure taspoglutide |
| WO2014077802A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification method of a glp-1 analogue |
| GR20140100479A (el) * | 2014-09-23 | 2016-05-05 | Novetide, Ltd., | Συνθεση λιραγλουτιδης |
| WO2019170895A1 (en) | 2018-03-09 | 2019-09-12 | Enzypep B.V. | Chemo-enzymatic synthesis of semaglutide, liraglutide and glp-1 |
| US10883132B2 (en) | 2018-03-09 | 2021-01-05 | Enzypep B.V. | Chemo-enzymatic synthesis of Semaglutide, Liraglutide and GLP-1 |
| EP3864032B1 (en) * | 2018-10-09 | 2022-11-30 | Fresenius Kabi iPSUM S.r.l. | Process for the manufacture of glp-1 analogues |
| US12269844B2 (en) | 2019-03-25 | 2025-04-08 | Scinopharm Taiwan, Ltd. | Process for purifying semaglutide and liraglutide |
| TWI738260B (zh) | 2019-03-25 | 2021-09-01 | 台灣神隆股份有限公司 | 純化利拉魯肽之方法 |
| EP3986919A1 (en) * | 2019-06-18 | 2022-04-27 | Fresenius Kabi iPSUM S.r.l. | Process for the manufacture of glucagon |
| EP3753946A1 (en) | 2019-06-18 | 2020-12-23 | Fresenius Kabi iPSUM S.r.l. | Improved process for the preparation of high purity glucagon |
| US20230406900A1 (en) * | 2022-06-01 | 2023-12-21 | Scinopharm Taiwan, Ltd. | Process for preparing glucagon-like peptide-1 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281335B1 (en) * | 1993-10-08 | 2001-08-28 | Coulter Corporation | Hybridoma and anti-KC-4 humanized monoclonal antibody |
| US5705483A (en) * | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| AU5441096A (en) * | 1995-04-14 | 1996-10-30 | The Administrators Of The Tulane Eductional Fund | Analogs of growth hormone-releasing factor |
| UA65549C2 (uk) * | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| US6281331B1 (en) * | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| CZ295889B6 (cs) * | 1998-12-07 | 2005-11-16 | Societe De Conseils De Recherches Et D'application | Analogy GLP-1, mající arginin na pozicích 26 a 34, jejich použití a farmaceutické prostředky je obsahující |
| US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US7238671B2 (en) * | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
| WO2005063792A2 (en) * | 2003-12-31 | 2005-07-14 | F. Hoffmann-La Roche Ag | Methods for recovering cleaved peptide from a support |
-
2007
- 2007-06-19 EP EP07765481A patent/EP2035451B1/en active Active
- 2007-06-19 KR KR1020087031096A patent/KR101087859B1/ko not_active Expired - Fee Related
- 2007-06-19 NZ NZ573093A patent/NZ573093A/en not_active IP Right Cessation
- 2007-06-19 MX MX2008015935A patent/MX2008015935A/es active IP Right Grant
- 2007-06-19 SI SI200730229T patent/SI2035451T1/sl unknown
- 2007-06-19 MY MYPI20085211A patent/MY144608A/en unknown
- 2007-06-19 PL PL07765481T patent/PL2035451T3/pl unknown
- 2007-06-19 BR BRPI0713575-0A patent/BRPI0713575A2/pt not_active IP Right Cessation
- 2007-06-19 CA CA2654610A patent/CA2654610C/en not_active Expired - Fee Related
- 2007-06-19 PT PT07765481T patent/PT2035451E/pt unknown
- 2007-06-19 WO PCT/EP2007/056052 patent/WO2007147816A1/en not_active Ceased
- 2007-06-19 JP JP2009515856A patent/JP4537495B2/ja not_active Expired - Fee Related
- 2007-06-19 AT AT07765481T patent/ATE466881T1/de active
- 2007-06-19 ES ES07765481T patent/ES2341588T3/es active Active
- 2007-06-19 RU RU2009101969/04A patent/RU2448978C2/ru not_active IP Right Cessation
- 2007-06-19 DK DK07765481.2T patent/DK2035451T3/da active
- 2007-06-19 HR HR20100302T patent/HRP20100302T1/hr unknown
- 2007-06-19 DE DE602007006310T patent/DE602007006310D1/de active Active
- 2007-06-19 RS RSP-2010/0267A patent/RS51281B/sr unknown
- 2007-06-19 UA UAA200900414A patent/UA96602C2/ru unknown
- 2007-06-19 AU AU2007263043A patent/AU2007263043B2/en not_active Ceased
- 2007-06-19 CN CN200780023265.1A patent/CN101563364B/zh not_active Expired - Fee Related
- 2007-06-21 US US11/821,017 patent/US20080004429A1/en not_active Abandoned
- 2007-06-21 AR ARP070102735A patent/AR061604A1/es not_active Application Discontinuation
- 2007-06-22 TW TW096122579A patent/TWI331155B/zh not_active IP Right Cessation
- 2007-06-22 CL CL200701835A patent/CL2007001835A1/es unknown
-
2008
- 2008-11-19 NO NO20084863A patent/NO20084863L/no not_active Application Discontinuation
- 2008-11-20 IL IL195421A patent/IL195421A0/en unknown
- 2008-11-26 ZA ZA200810072A patent/ZA200810072B/xx unknown
- 2008-11-26 CR CR10463A patent/CR10463A/es not_active Application Discontinuation
- 2008-12-22 EC EC2008008999A patent/ECSP088999A/es unknown
- 2008-12-25 MA MA31510A patent/MA30530B1/fr unknown
-
2010
- 2010-06-11 CY CY20101100519T patent/CY1110186T1/el unknown
-
2011
- 2011-05-11 US US13/105,435 patent/US20110213082A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |