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NO20083267L - Azaindole inhibitorer av aurora kinaser - Google Patents

Azaindole inhibitorer av aurora kinaser

Info

Publication number
NO20083267L
NO20083267L NO20083267A NO20083267A NO20083267L NO 20083267 L NO20083267 L NO 20083267L NO 20083267 A NO20083267 A NO 20083267A NO 20083267 A NO20083267 A NO 20083267A NO 20083267 L NO20083267 L NO 20083267L
Authority
NO
Norway
Prior art keywords
aurora kinases
azaindole
inhibitors
azaindole inhibitors
cancers
Prior art date
Application number
NO20083267A
Other languages
English (en)
Inventor
Nicholas D Adams
Dashyant Dhanak
Cynthia A Parrish
Jerry Leroy Adams
Jeffrey Michael Axten
Amita M Chaudhari
Toshihiro Hamajima
Kenneth Allen Newlander
Martha A Sarpong
Domingos J Silva
Jun Tang
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20083267L publication Critical patent/NO20083267L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår en forbindelse representert ved formel (l): og farmasøytisk akseptable salter. Forbindelsene ifølge oppfinnelsen inhiberer Aurorakinase, som gjør dem særlig egnet for behandling av et antall sykdommer, som inkluderer fasttumorkreftformer og hematologiske kreftformer.
NO20083267A 2005-12-23 2008-07-23 Azaindole inhibitorer av aurora kinaser NO20083267L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75338305P 2005-12-23 2005-12-23
PCT/US2006/062289 WO2007076348A2 (en) 2005-12-23 2006-12-19 Azaindole inhibitors of aurora kinases

Publications (1)

Publication Number Publication Date
NO20083267L true NO20083267L (no) 2008-09-04

Family

ID=38218797

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083267A NO20083267L (no) 2005-12-23 2008-07-23 Azaindole inhibitorer av aurora kinaser

Country Status (22)

Country Link
US (4) US7282588B2 (no)
EP (1) EP1962830B1 (no)
JP (1) JP5140600B2 (no)
KR (1) KR20080083680A (no)
CN (1) CN101389324A (no)
AR (1) AR058614A1 (no)
AU (1) AU2006330587B2 (no)
BR (1) BRPI0620341A2 (no)
CA (1) CA2634787C (no)
CR (1) CR10125A (no)
DK (1) DK1962830T3 (no)
EA (1) EA200870117A1 (no)
ES (1) ES2408318T3 (no)
IL (1) IL192351A0 (no)
MA (1) MA30069B1 (no)
MX (1) MX2008008320A (no)
NO (1) NO20083267L (no)
PL (1) PL1962830T3 (no)
PT (1) PT1962830E (no)
SI (1) SI1962830T1 (no)
TW (1) TW200800990A (no)
WO (1) WO2007076348A2 (no)

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Publication number Publication date
US7282588B2 (en) 2007-10-16
CA2634787A1 (en) 2007-07-05
CN101389324A (zh) 2009-03-18
AR058614A1 (es) 2008-02-13
DK1962830T3 (da) 2013-06-24
JP5140600B2 (ja) 2013-02-06
SI1962830T1 (sl) 2013-07-31
CA2634787C (en) 2014-10-21
US20080081808A1 (en) 2008-04-03
EP1962830A4 (en) 2010-01-06
ES2408318T3 (es) 2013-06-20
BRPI0620341A2 (pt) 2011-11-08
AU2006330587A1 (en) 2007-07-05
US20080004308A1 (en) 2008-01-03
EP1962830A2 (en) 2008-09-03
EA200870117A1 (ru) 2008-12-30
MX2008008320A (es) 2008-09-03
TW200800990A (en) 2008-01-01
US7495102B2 (en) 2009-02-24
US20070149561A1 (en) 2007-06-28
JP2009521492A (ja) 2009-06-04
CR10125A (es) 2008-09-23
WO2007076348A2 (en) 2007-07-05
US7605266B2 (en) 2009-10-20
MA30069B1 (fr) 2008-12-01
IL192351A0 (en) 2008-12-29
PT1962830E (pt) 2013-05-29
US20080306120A1 (en) 2008-12-11
EP1962830B1 (en) 2013-03-27
PL1962830T3 (pl) 2013-08-30
KR20080083680A (ko) 2008-09-18
US7419988B2 (en) 2008-09-02
AU2006330587B2 (en) 2012-12-13
WO2007076348A3 (en) 2007-11-01

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