[go: up one dir, main page]

NO20083542L - Nye kumarinderivater med antitumoraktivitet - Google Patents

Nye kumarinderivater med antitumoraktivitet

Info

Publication number
NO20083542L
NO20083542L NO20083542A NO20083542A NO20083542L NO 20083542 L NO20083542 L NO 20083542L NO 20083542 A NO20083542 A NO 20083542A NO 20083542 A NO20083542 A NO 20083542A NO 20083542 L NO20083542 L NO 20083542L
Authority
NO
Norway
Prior art keywords
tumor activity
coumarin derivatives
salt
compound
new coumarin
Prior art date
Application number
NO20083542A
Other languages
English (en)
Other versions
NO341421B1 (no
Inventor
Fumio Watanabe
Sawako Ozawa
Hitoshi Iikura
Ikumi Hyoudoh
Toshihiro Aoki
Noriyuki Furuichi
Masayuki Matsushita
Masahiro Sakaitani
Pil-Su Ho
Yasushi Tomii
Kenji Takanashi
Naoki Harada
Original Assignee
Sakai Toshiyuki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38345317&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20083542(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sakai Toshiyuki filed Critical Sakai Toshiyuki
Publication of NO20083542L publication Critical patent/NO20083542L/no
Publication of NO341421B1 publication Critical patent/NO341421B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Det beskrives forbindelser representert med generell formel (1) nedenfor eller farmasøytisk akseptable salt derav: hvor: X er valgt blant heteroaryl etc, Y1 og Y2 er valgt blant -N= etc, Y3 og Y4 er valgt blant -CH= etc, A er valgt blant sulfamid etc, R1 er valgt blant hydrogen etc, og R2 er valgt blant C-|.6-alkyl etc. Forbindelsen eller saltet har tilstrekkelig høy antitumoraktivitet, og er nyttig behandling av celleproliferative forstyrrelser, fortrinnsvis kref.. Foreliggende oppfinnelse tilveiebringer også en farmasøytisk sammensetning inneholdende forbindelsen eller saltet som en aktiv ingrediens.
NO20083542A 2006-02-09 2008-08-14 Nye kumarinderivater med antitumoraktivitet NO341421B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006032903 2006-02-09
PCT/JP2007/052800 WO2007091736A1 (ja) 2006-02-09 2007-02-09 抗腫瘍活性を有する新規クマリン誘導体

Publications (2)

Publication Number Publication Date
NO20083542L true NO20083542L (no) 2008-11-06
NO341421B1 NO341421B1 (no) 2017-11-13

Family

ID=38345317

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083542A NO341421B1 (no) 2006-02-09 2008-08-14 Nye kumarinderivater med antitumoraktivitet

Country Status (24)

Country Link
US (2) US7897792B2 (no)
EP (1) EP1982982B1 (no)
JP (1) JP4334593B2 (no)
KR (1) KR101378634B1 (no)
CN (1) CN101384577B (no)
AR (1) AR059339A1 (no)
AU (1) AU2007212972B2 (no)
BR (1) BRPI0708038B8 (no)
CA (1) CA2640652C (no)
CL (2) CL2007000311A1 (no)
CR (2) CR10269A (no)
DK (1) DK1982982T3 (no)
EC (1) ECSP088724A (no)
ES (1) ES2395840T3 (no)
IL (1) IL193190A (no)
MA (1) MA30456B1 (no)
MY (1) MY144588A (no)
NO (1) NO341421B1 (no)
NZ (1) NZ570627A (no)
RU (1) RU2428420C2 (no)
TW (1) TWI376374B (no)
UA (1) UA97351C2 (no)
WO (1) WO2007091736A1 (no)
ZA (1) ZA200805759B (no)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10835307B2 (en) 2001-06-12 2020-11-17 Ethicon Llc Modular battery powered handheld surgical instrument containing elongated multi-layered shaft
US8182501B2 (en) 2004-02-27 2012-05-22 Ethicon Endo-Surgery, Inc. Ultrasonic surgical shears and method for sealing a blood vessel using same
US7846155B2 (en) 2004-10-08 2010-12-07 Ethicon Endo-Surgery, Inc. Handle assembly having hand activation for use with an ultrasonic surgical instrument
US20070191713A1 (en) 2005-10-14 2007-08-16 Eichmann Stephen E Ultrasonic device for cutting and coagulating
US7621930B2 (en) 2006-01-20 2009-11-24 Ethicon Endo-Surgery, Inc. Ultrasound medical instrument having a medical ultrasonic blade
US8911460B2 (en) 2007-03-22 2014-12-16 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
US8057498B2 (en) 2007-11-30 2011-11-15 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instrument blades
US8142461B2 (en) 2007-03-22 2012-03-27 Ethicon Endo-Surgery, Inc. Surgical instruments
CA2683805C (en) 2007-04-13 2014-09-23 The Regents Of The University Of Michigan Systems and methods for tissue imaging
EP2172198B1 (en) * 2007-07-20 2014-04-16 Chugai Seiyaku Kabushiki Kaisha p27 PROTEIN INDUCER
US8523889B2 (en) 2007-07-27 2013-09-03 Ethicon Endo-Surgery, Inc. Ultrasonic end effectors with increased active length
US8808319B2 (en) 2007-07-27 2014-08-19 Ethicon Endo-Surgery, Inc. Surgical instruments
US8512365B2 (en) 2007-07-31 2013-08-20 Ethicon Endo-Surgery, Inc. Surgical instruments
US8430898B2 (en) 2007-07-31 2013-04-30 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
US9044261B2 (en) 2007-07-31 2015-06-02 Ethicon Endo-Surgery, Inc. Temperature controlled ultrasonic surgical instruments
US8623027B2 (en) 2007-10-05 2014-01-07 Ethicon Endo-Surgery, Inc. Ergonomic surgical instruments
US10010339B2 (en) 2007-11-30 2018-07-03 Ethicon Llc Ultrasonic surgical blades
CA2716940C (en) * 2008-02-29 2016-01-19 The Regents Of The University Of Michigan Systems and methods for imaging changes in tissue
US9089360B2 (en) 2008-08-06 2015-07-28 Ethicon Endo-Surgery, Inc. Devices and techniques for cutting and coagulating tissue
US9700339B2 (en) 2009-05-20 2017-07-11 Ethicon Endo-Surgery, Inc. Coupling arrangements and methods for attaching tools to ultrasonic surgical instruments
US8663220B2 (en) 2009-07-15 2014-03-04 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments
US8986302B2 (en) 2009-10-09 2015-03-24 Ethicon Endo-Surgery, Inc. Surgical generator for ultrasonic and electrosurgical devices
US10441345B2 (en) 2009-10-09 2019-10-15 Ethicon Llc Surgical generator for ultrasonic and electrosurgical devices
US11090104B2 (en) 2009-10-09 2021-08-17 Cilag Gmbh International Surgical generator for ultrasonic and electrosurgical devices
US8951272B2 (en) 2010-02-11 2015-02-10 Ethicon Endo-Surgery, Inc. Seal arrangements for ultrasonically powered surgical instruments
US8469981B2 (en) 2010-02-11 2013-06-25 Ethicon Endo-Surgery, Inc. Rotatable cutting implement arrangements for ultrasonic surgical instruments
US8486096B2 (en) 2010-02-11 2013-07-16 Ethicon Endo-Surgery, Inc. Dual purpose surgical instrument for cutting and coagulating tissue
US8841458B2 (en) 2010-03-12 2014-09-23 Nippon Soda Co., Ltd. Compound containing pyridine ring and method for producing halogenated picoline derivative and tetrazolyloxime derivative
US8795327B2 (en) 2010-07-22 2014-08-05 Ethicon Endo-Surgery, Inc. Electrosurgical instrument with separate closure and cutting members
US9192431B2 (en) 2010-07-23 2015-11-24 Ethicon Endo-Surgery, Inc. Electrosurgical cutting and sealing instrument
CN102532084B (zh) * 2010-12-29 2015-08-19 华北制药集团新药研究开发有限责任公司 一类香豆素类化合物、其制备方法及用途
EP2720695A4 (en) * 2011-06-15 2014-11-12 Nono Inc ACTIVE AGENTS AND METHODS FOR TREATING ISCHEMIC AND OTHER DISEASES
WO2012171488A1 (en) * 2011-06-17 2012-12-20 Beijing Hanmi Pharmaceutical Co., Ltd. Coumarin derivative, pharmaceutical composition and use thereof
WO2013003826A1 (en) 2011-06-29 2013-01-03 The Regents Of The University Of Michigan Analysis of temporal changes in registered tomographic images
US9259265B2 (en) 2011-07-22 2016-02-16 Ethicon Endo-Surgery, Llc Surgical instruments for tensioning tissue
JP6061856B2 (ja) 2011-09-05 2017-01-18 中外製薬株式会社 クマリン誘導体の製造方法
US9053534B2 (en) 2011-11-23 2015-06-09 The Regents Of The University Of Michigan Voxel-based approach for disease detection and evolution
CN103130760B (zh) * 2011-11-29 2015-06-17 中国科学院大连化学物理研究所 一种新型靶向性抗肿瘤药物及其制备方法与应用
US20130166458A1 (en) * 2011-12-22 2013-06-27 Embraer S.A. System and method for remote and automatic assessment of structural damage and repair
EA029984B1 (ru) * 2011-12-30 2018-06-29 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Соединения для лечения спинальной мышечной атрофии
WO2013112788A1 (en) 2012-01-26 2013-08-01 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
SG11201404713PA (en) 2012-02-10 2014-09-26 Ptc Therapeutics Inc Compounds for treating spinal muscular atrophy
WO2013119545A1 (en) 2012-02-10 2013-08-15 Ethicon-Endo Surgery, Inc. Robotically controlled surgical instrument
MX352962B (es) 2012-03-01 2017-12-15 Ptc Therapeutics Inc Compuestos para tratar atrofia muscular espinal.
KR102109992B1 (ko) 2012-03-23 2020-05-13 피티씨 테라퓨틱스, 인크. 척수성 근위축증을 치료하기 위한 화합물
US9439668B2 (en) 2012-04-09 2016-09-13 Ethicon Endo-Surgery, Llc Switch arrangements for ultrasonic surgical instruments
WO2013166416A1 (en) 2012-05-04 2013-11-07 The Regents Of The University Of Michigan Mean diffusivity measurement corrections for gradient non-linearity
CN103420990B (zh) * 2012-05-23 2016-04-20 复旦大学 7-氧、硫或氮杂取代香豆素及其衍生物和用途
US20140005705A1 (en) 2012-06-29 2014-01-02 Ethicon Endo-Surgery, Inc. Surgical instruments with articulating shafts
US9198714B2 (en) 2012-06-29 2015-12-01 Ethicon Endo-Surgery, Inc. Haptic feedback devices for surgical robot
US20140005702A1 (en) 2012-06-29 2014-01-02 Ethicon Endo-Surgery, Inc. Ultrasonic surgical instruments with distally positioned transducers
US9820768B2 (en) 2012-06-29 2017-11-21 Ethicon Llc Ultrasonic surgical instruments with control mechanisms
US9326788B2 (en) 2012-06-29 2016-05-03 Ethicon Endo-Surgery, Llc Lockout mechanism for use with robotic electrosurgical device
US9393037B2 (en) 2012-06-29 2016-07-19 Ethicon Endo-Surgery, Llc Surgical instruments with articulating shafts
US9351754B2 (en) 2012-06-29 2016-05-31 Ethicon Endo-Surgery, Llc Ultrasonic surgical instruments with distally positioned jaw assemblies
US9408622B2 (en) 2012-06-29 2016-08-09 Ethicon Endo-Surgery, Llc Surgical instruments with articulating shafts
US9226767B2 (en) 2012-06-29 2016-01-05 Ethicon Endo-Surgery, Inc. Closed feedback control for electrosurgical device
CN102731458B (zh) * 2012-07-12 2014-03-26 中国科学院南海海洋研究所 双异戊烯基香豆素及其制备方法和应用
US9492224B2 (en) 2012-09-28 2016-11-15 EthiconEndo-Surgery, LLC Multi-function bi-polar forceps
US9095367B2 (en) 2012-10-22 2015-08-04 Ethicon Endo-Surgery, Inc. Flexible harmonic waveguides/blades for surgical instruments
US20140135804A1 (en) 2012-11-15 2014-05-15 Ethicon Endo-Surgery, Inc. Ultrasonic and electrosurgical devices
EP2752191A1 (en) 2013-01-07 2014-07-09 Sanofi Compositions and methods using hdm2 antagonist and mek inhibitor
ES2703208T3 (es) 2013-02-27 2019-03-07 Daiichi Sankyo Co Ltd Método de predicción de la sensibilidad a un compuesto que inhibe la vía de transducción de señales de MAPK
CA2901613C (en) 2013-03-13 2020-10-20 The Regents Of The University Of Michigan Dual mek/pi3k inhibitors and therapeutic methods using the same
US10226273B2 (en) 2013-03-14 2019-03-12 Ethicon Llc Mechanical fasteners for use with surgical energy devices
US9862697B2 (en) * 2013-08-01 2018-01-09 The Curators Of The University Of Missouri pH-sensitive fluorescent sensors for biological amines
US9814514B2 (en) 2013-09-13 2017-11-14 Ethicon Llc Electrosurgical (RF) medical instruments for cutting and coagulating tissue
US9265926B2 (en) 2013-11-08 2016-02-23 Ethicon Endo-Surgery, Llc Electrosurgical devices
GB2521229A (en) 2013-12-16 2015-06-17 Ethicon Endo Surgery Inc Medical device
GB2521228A (en) 2013-12-16 2015-06-17 Ethicon Endo Surgery Inc Medical device
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
US9795436B2 (en) 2014-01-07 2017-10-24 Ethicon Llc Harvesting energy from a surgical generator
US9554854B2 (en) 2014-03-18 2017-01-31 Ethicon Endo-Surgery, Llc Detecting short circuits in electrosurgical medical devices
US10092310B2 (en) 2014-03-27 2018-10-09 Ethicon Llc Electrosurgical devices
US10463421B2 (en) 2014-03-27 2019-11-05 Ethicon Llc Two stage trigger, clamp and cut bipolar vessel sealer
US9737355B2 (en) 2014-03-31 2017-08-22 Ethicon Llc Controlling impedance rise in electrosurgical medical devices
US9913680B2 (en) 2014-04-15 2018-03-13 Ethicon Llc Software algorithms for electrosurgical instruments
CN104119690B (zh) * 2014-06-27 2016-06-29 安徽大学 一种七位取代的香豆素衍生物双光子荧光染料及其制备方法
CN104059378B (zh) * 2014-06-27 2016-04-20 安徽大学 一种六位取代的香豆素衍生物双光子荧光染料及其制备方法
US10285724B2 (en) 2014-07-31 2019-05-14 Ethicon Llc Actuation mechanisms and load adjustment assemblies for surgical instruments
US10639092B2 (en) 2014-12-08 2020-05-05 Ethicon Llc Electrode configurations for surgical instruments
US10245095B2 (en) 2015-02-06 2019-04-02 Ethicon Llc Electrosurgical instrument with rotation and articulation mechanisms
US10321950B2 (en) 2015-03-17 2019-06-18 Ethicon Llc Managing tissue treatment
US10342602B2 (en) 2015-03-17 2019-07-09 Ethicon Llc Managing tissue treatment
US10595929B2 (en) 2015-03-24 2020-03-24 Ethicon Llc Surgical instruments with firing system overload protection mechanisms
WO2016196386A1 (en) 2015-05-30 2016-12-08 Ptc Therapeutics, Inc. Methods for modulating rna splicing
US11020140B2 (en) 2015-06-17 2021-06-01 Cilag Gmbh International Ultrasonic surgical blade for use with ultrasonic surgical instruments
US10357303B2 (en) 2015-06-30 2019-07-23 Ethicon Llc Translatable outer tube for sealing using shielded lap chole dissector
US11129669B2 (en) 2015-06-30 2021-09-28 Cilag Gmbh International Surgical system with user adaptable techniques based on tissue type
US10898256B2 (en) 2015-06-30 2021-01-26 Ethicon Llc Surgical system with user adaptable techniques based on tissue impedance
US11141213B2 (en) 2015-06-30 2021-10-12 Cilag Gmbh International Surgical instrument with user adaptable techniques
US10034704B2 (en) 2015-06-30 2018-07-31 Ethicon Llc Surgical instrument with user adaptable algorithms
US11051873B2 (en) 2015-06-30 2021-07-06 Cilag Gmbh International Surgical system with user adaptable techniques employing multiple energy modalities based on tissue parameters
US10154852B2 (en) 2015-07-01 2018-12-18 Ethicon Llc Ultrasonic surgical blade with improved cutting and coagulation features
US20170086909A1 (en) 2015-09-30 2017-03-30 Ethicon Endo-Surgery, Llc Frequency agile generator for a surgical instrument
US10595930B2 (en) 2015-10-16 2020-03-24 Ethicon Llc Electrode wiping surgical device
HUE055031T2 (hu) 2015-12-10 2021-10-28 Ptc Therapeutics Inc Módszerek Huntington-kór kezelésére
US10179022B2 (en) 2015-12-30 2019-01-15 Ethicon Llc Jaw position impedance limiter for electrosurgical instrument
US10575892B2 (en) 2015-12-31 2020-03-03 Ethicon Llc Adapter for electrical surgical instruments
US10716615B2 (en) 2016-01-15 2020-07-21 Ethicon Llc Modular battery powered handheld surgical instrument with curved end effectors having asymmetric engagement between jaw and blade
US10251664B2 (en) 2016-01-15 2019-04-09 Ethicon Llc Modular battery powered handheld surgical instrument with multi-function motor via shifting gear assembly
US11129670B2 (en) 2016-01-15 2021-09-28 Cilag Gmbh International Modular battery powered handheld surgical instrument with selective application of energy based on button displacement, intensity, or local tissue characterization
US11229471B2 (en) 2016-01-15 2022-01-25 Cilag Gmbh International Modular battery powered handheld surgical instrument with selective application of energy based on tissue characterization
US12193698B2 (en) 2016-01-15 2025-01-14 Cilag Gmbh International Method for self-diagnosing operation of a control switch in a surgical instrument system
US10555769B2 (en) 2016-02-22 2020-02-11 Ethicon Llc Flexible circuits for electrosurgical instrument
CN107200716B (zh) * 2016-03-17 2020-04-17 北京大学 苯并噁嗪类化合物及其制备方法与应用
US10646269B2 (en) 2016-04-29 2020-05-12 Ethicon Llc Non-linear jaw gap for electrosurgical instruments
US10702329B2 (en) 2016-04-29 2020-07-07 Ethicon Llc Jaw structure with distal post for electrosurgical instruments
US10485607B2 (en) 2016-04-29 2019-11-26 Ethicon Llc Jaw structure with distal closure for electrosurgical instruments
US10456193B2 (en) 2016-05-03 2019-10-29 Ethicon Llc Medical device with a bilateral jaw configuration for nerve stimulation
US10650512B2 (en) 2016-06-14 2020-05-12 The Regents Of The University Of Michigan Systems and methods for topographical characterization of medical image data
EP3481822B1 (en) 2016-07-06 2022-06-22 The Regents of The University of Michigan Multifunctional inhibitors of mek/pi3k and mtor/mek/pi3k biological pathways and therapeutic methods using the same
US10245064B2 (en) 2016-07-12 2019-04-02 Ethicon Llc Ultrasonic surgical instrument with piezoelectric central lumen transducer
US10893883B2 (en) 2016-07-13 2021-01-19 Ethicon Llc Ultrasonic assembly for use with ultrasonic surgical instruments
US10842522B2 (en) 2016-07-15 2020-11-24 Ethicon Llc Ultrasonic surgical instruments having offset blades
US10376305B2 (en) 2016-08-05 2019-08-13 Ethicon Llc Methods and systems for advanced harmonic energy
US10285723B2 (en) 2016-08-09 2019-05-14 Ethicon Llc Ultrasonic surgical blade with improved heel portion
USD847990S1 (en) 2016-08-16 2019-05-07 Ethicon Llc Surgical instrument
US10736649B2 (en) 2016-08-25 2020-08-11 Ethicon Llc Electrical and thermal connections for ultrasonic transducer
US10952759B2 (en) 2016-08-25 2021-03-23 Ethicon Llc Tissue loading of a surgical instrument
US10603064B2 (en) 2016-11-28 2020-03-31 Ethicon Llc Ultrasonic transducer
AU2017363369A1 (en) 2016-11-28 2019-05-30 Ptc Therapeutics, Inc Methods for modulating RNA splicing
US11266430B2 (en) 2016-11-29 2022-03-08 Cilag Gmbh International End effector control and calibration
JP7376471B2 (ja) 2017-06-05 2023-11-08 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するための化合物
WO2018232039A1 (en) 2017-06-14 2018-12-20 Ptc Therapeutics, Inc. Methods for modifying rna splicing
AU2018289864B2 (en) 2017-06-23 2022-03-31 Cstone Pharmaceuticals Coumarin-like cyclic compound as MEK inhibitor and use thereof
WO2019005993A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
US10820920B2 (en) 2017-07-05 2020-11-03 Ethicon Llc Reusable ultrasonic medical devices and methods of their use
WO2019032640A1 (en) 2017-08-11 2019-02-14 The Regents Of The University Of Michigan MEK / P13K, JAK / MEK, JAK / P13K / MTOR AND MEK / P13K / MTOR BIKE INHIBITORS AND METHODS FOR ENHANCING LYMPHATIC ABSORPTION, BIOAVAILABILITY AND SOLUBILITY OF THERAPEUTIC COMPOUNDS
JP7707329B2 (ja) * 2017-11-16 2025-07-16 ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル クマリン誘導体を含有する、細胞増殖性疾患の治療又は予防用医薬
WO2019096397A1 (en) 2017-11-16 2019-05-23 The Institute Of Cancer Research: Royal Cancer Hospital Coumarin derivative for therapy or prophylaxis of a cell proliferative disorder
JP7140645B2 (ja) * 2017-11-16 2022-09-21 ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル クマリン誘導体を含有する、細胞増殖性疾患の治療又は予防用医薬
CN112135815A (zh) 2018-03-27 2020-12-25 Ptc医疗公司 用于治疗亨廷顿氏病的化合物
US11685746B2 (en) 2018-06-27 2023-06-27 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
ES2983003T3 (es) 2018-06-27 2024-10-21 Ptc Therapeutics Inc Compuestos heterocíclicos y heteroarílicos para el tratamiento de la enfermedad de Huntington
MX2020014315A (es) 2018-06-27 2021-05-27 Ptc Therapeutics Inc Compuestos de heteroarilo para tratar la enfermedad de huntington.
PT3594199T (pt) * 2018-07-09 2020-09-04 Amgen Inc 2-fluoro-3-nitrotolueno cristalino e processo para a sua preparação
US10730885B1 (en) 2019-04-30 2020-08-04 King Saud University Coumarin derivatives
JP2022547358A (ja) 2019-09-13 2022-11-14 ジ インスティテュート オブ キャンサー リサーチ：ロイヤル キャンサー ホスピタル 治療組成物、組み合わせ、及び使用方法
US12336747B2 (en) 2019-12-30 2025-06-24 Cilag Gmbh International Method of operating a combination ultrasonic / bipolar RF surgical device with a combination energy modality end-effector
US11779329B2 (en) 2019-12-30 2023-10-10 Cilag Gmbh International Surgical instrument comprising a flex circuit including a sensor system
US11589916B2 (en) 2019-12-30 2023-02-28 Cilag Gmbh International Electrosurgical instruments with electrodes having variable energy densities
US12076006B2 (en) 2019-12-30 2024-09-03 Cilag Gmbh International Surgical instrument comprising an orientation detection system
US12064109B2 (en) 2019-12-30 2024-08-20 Cilag Gmbh International Surgical instrument comprising a feedback control circuit
US11779387B2 (en) 2019-12-30 2023-10-10 Cilag Gmbh International Clamp arm jaw to minimize tissue sticking and improve tissue control
US11660089B2 (en) 2019-12-30 2023-05-30 Cilag Gmbh International Surgical instrument comprising a sensing system
US11744636B2 (en) 2019-12-30 2023-09-05 Cilag Gmbh International Electrosurgical systems with integrated and external power sources
US12262937B2 (en) 2019-12-30 2025-04-01 Cilag Gmbh International User interface for surgical instrument with combination energy modality end-effector
US11950797B2 (en) 2019-12-30 2024-04-09 Cilag Gmbh International Deflectable electrode with higher distal bias relative to proximal bias
US11986201B2 (en) 2019-12-30 2024-05-21 Cilag Gmbh International Method for operating a surgical instrument
US11452525B2 (en) 2019-12-30 2022-09-27 Cilag Gmbh International Surgical instrument comprising an adjustment system
US11944366B2 (en) 2019-12-30 2024-04-02 Cilag Gmbh International Asymmetric segmented ultrasonic support pad for cooperative engagement with a movable RF electrode
US11937866B2 (en) 2019-12-30 2024-03-26 Cilag Gmbh International Method for an electrosurgical procedure
US12343063B2 (en) 2019-12-30 2025-07-01 Cilag Gmbh International Multi-layer clamp arm pad for enhanced versatility and performance of a surgical device
US12053224B2 (en) 2019-12-30 2024-08-06 Cilag Gmbh International Variation in electrode parameters and deflectable electrode to modify energy density and tissue interaction
US11937863B2 (en) 2019-12-30 2024-03-26 Cilag Gmbh International Deflectable electrode with variable compression bias along the length of the deflectable electrode
US11684412B2 (en) 2019-12-30 2023-06-27 Cilag Gmbh International Surgical instrument with rotatable and articulatable surgical end effector
US11812957B2 (en) 2019-12-30 2023-11-14 Cilag Gmbh International Surgical instrument comprising a signal interference resolution system
US11786291B2 (en) 2019-12-30 2023-10-17 Cilag Gmbh International Deflectable support of RF energy electrode with respect to opposing ultrasonic blade
US11986234B2 (en) 2019-12-30 2024-05-21 Cilag Gmbh International Surgical system communication pathways
US11911063B2 (en) 2019-12-30 2024-02-27 Cilag Gmbh International Techniques for detecting ultrasonic blade to electrode contact and reducing power to ultrasonic blade
US12082808B2 (en) 2019-12-30 2024-09-10 Cilag Gmbh International Surgical instrument comprising a control system responsive to software configurations
US11696776B2 (en) 2019-12-30 2023-07-11 Cilag Gmbh International Articulatable surgical instrument
US12114912B2 (en) 2019-12-30 2024-10-15 Cilag Gmbh International Non-biased deflectable electrode to minimize contact between ultrasonic blade and electrode
US12023086B2 (en) 2019-12-30 2024-07-02 Cilag Gmbh International Electrosurgical instrument for delivering blended energy modalities to tissue
AU2021206684B2 (en) 2020-01-10 2024-01-18 Immuneering Corporation MEK inhibitors and therapeutic uses thereof
AR121078A1 (es) 2020-01-22 2022-04-13 Chugai Pharmaceutical Co Ltd Derivados de arilamida con actividad antitumoral
WO2022018875A1 (ja) 2020-07-22 2022-01-27 中外製薬株式会社 アリールアミド誘導体を含む細胞増殖性疾患の治療又は予防用医薬組成物
AU2021311665A1 (en) 2020-07-22 2023-03-16 Chugai Seiyaku Kabushiki Kaisha Composition containing arylamide derivative
TW202321198A (zh) 2021-07-21 2023-06-01 日商中外製藥股份有限公司 芳基醯胺衍生物的製造方法
WO2023108110A2 (en) * 2021-12-10 2023-06-15 Verastem, Inc. Combination therapy for treating abnormal cell growth
MX2024008462A (es) * 2022-01-06 2024-09-06 Immuneering Corp Inhibidores de inmunooncología mek y usos terapéuticos de estos.
EP4471026A1 (en) * 2022-01-26 2024-12-04 Medshine Discovery Inc. Coumarin compounds and uses thereof
WO2023173057A1 (en) * 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023211812A1 (en) * 2022-04-25 2023-11-02 Nested Therapeutics, Inc. Heterocyclic derivatives as mitogen-activated protein kinase (mek) inhibitors
KR20250040894A (ko) 2022-05-25 2025-03-25 이케나 온콜로지, 인코포레이티드 Mek 억제제 및 이의 용도
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor
WO2024220708A1 (en) * 2023-04-19 2024-10-24 Gandeeva Therapeutics, Inc. Raf-mek protein complex modulators and methods of use thereof
AU2024262795A1 (en) * 2023-04-24 2025-11-13 Nested Therapeutics, Inc. Heterocyclic derivative as mitogen-activated protein kinase (mek) inhibitor
WO2025010287A2 (en) * 2023-07-03 2025-01-09 Immuneering Corporation Mek immune oncology inhibitors and therapeutic uses thereof
CN116509868B (zh) * 2023-07-04 2023-10-20 四川大学华西医院 Vs6766联合bay293的应用及药物组合物
CN117362259B (zh) * 2023-09-21 2025-08-08 南京林业大学 6-偶氮苯基香豆素-3-甲酰胺化合物及其制备方法和应用
WO2025090905A1 (en) * 2023-10-26 2025-05-01 Nested Therapeutics, Inc. Crystalline forms of 3-[[3-fluoro-2-(methylsulfamoylamino)-4-pyridyl]methyl]-7-[(3-fluoro-2-pyridyl)oxy]-4-methyl-chromen-2-one

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT63843A (en) 1992-02-13 1993-10-28 Biosignal Kutato Fejlesztoe Kf Process for producing new kumarin derivatives and their analogs inhibiting mammal cell proliferation and tumour growth, as well as pharmaceutical comkpositions comprising such compounds
WO1994005649A1 (en) 1992-09-01 1994-03-17 Pfizer Inc. 4-hydroxy coumarin derivatives with antibacterial activity
DE4233963A1 (de) * 1992-10-08 1994-04-14 Schwabe Willmar Gmbh & Co Neue Benzopyranone, Verfahren zu ihrer Herstellung und Verwendung
IL108459A0 (en) 1993-02-05 1994-04-12 Opjohn Company 4-Hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl [B] pyran-2-ones useful for treating infections due to hiv and other retroviruses
FR2763944B1 (fr) * 1997-06-03 2000-12-15 Centre Nat Rech Scient Nouveaux derives de coumarines, leurs procedes de preparation et leur application comme medicaments en tant qu'inhibiteurs de proteases
GB9722600D0 (en) 1997-10-24 1997-12-24 Bio Monde Holdings Internation Pharmaceutical compositon
US6331562B1 (en) 1998-12-30 2001-12-18 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
HK1041258B (en) * 1998-12-30 2003-12-12 Signal Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
AU2001278980A1 (en) * 2000-07-21 2002-02-05 Chugai Seiyaku Kabushiki Kaisha Coumarin derivatives useful as tnfalpha inhibitors
CA2445160A1 (en) 2001-04-24 2002-10-31 Aryx Therapeutics Coumarin derivatives to be used as anticoagulants
JP4604147B2 (ja) * 2001-09-12 2010-12-22 株式会社医薬分子設計研究所 クマリン誘導体
US7148252B2 (en) 2001-10-03 2006-12-12 Signal Pharmaceuticals, Llc Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis
NZ533893A (en) * 2002-01-11 2006-06-30 Takeda Pharmaceutical Coumarin derivatives, process for their production and use thereof
FR2849653B1 (fr) 2003-01-08 2006-08-25 B F B Etudes Et Rech S Experim Derives de la coumarine ayant une affinite pour les recepteurs aux estrogenes, procede pour leur preparation et compositions pharmaceutiques en contenant
JP2005162727A (ja) 2003-03-18 2005-06-23 Sankyo Co Ltd スルファミド誘導体及びその医薬組成物
US20050054586A1 (en) 2003-06-30 2005-03-10 Bartels Stephen P. Treatment of ophthalmic disorders
CA2595472A1 (en) 2005-01-21 2006-07-27 Janssen Pharmaceutica N.V. Novel coumarin derivatives as ion channel openers
ES2481402T3 (es) 2005-07-21 2014-07-30 Ardea Biosciences, Inc. Inhibidores de N-(arilamino)sulfonamida de MEK
US20070183995A1 (en) * 2006-02-09 2007-08-09 Conopco, Inc., D/B/A Unilever Compounds useful as agonists of A2A adenosine receptors, cosmetic compositions with A2A agonists and a method for using the same
DE102006005861A1 (de) * 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituierte Chinolone III
WO2007121269A2 (en) 2006-04-11 2007-10-25 Ardea Biosciences, Inc. N-aryl-n'alkyl sulfamides as mek inhibitors

Also Published As

Publication number Publication date
CL2012002844A1 (es) 2012-12-07
AR059339A1 (es) 2008-03-26
CR20150075A (es) 2015-05-06
JPWO2007091736A1 (ja) 2009-07-02
CN101384577A (zh) 2009-03-11
CR10269A (es) 2009-08-04
ES2395840T3 (es) 2013-02-15
US7897792B2 (en) 2011-03-01
ECSP088724A (es) 2008-11-27
HK1129100A1 (en) 2009-11-20
MA30456B1 (fr) 2009-06-01
KR20080103989A (ko) 2008-11-28
CL2007000311A1 (es) 2008-01-25
CN101384577B (zh) 2011-10-19
TWI376374B (en) 2012-11-11
RU2008136187A (ru) 2010-03-20
MY144588A (en) 2011-10-14
US20100004233A1 (en) 2010-01-07
EP1982982B1 (en) 2012-09-26
DK1982982T3 (da) 2012-10-08
CA2640652C (en) 2013-09-24
AU2007212972A1 (en) 2007-08-16
IL193190A (en) 2014-05-28
BRPI0708038B1 (pt) 2020-05-19
BRPI0708038B8 (pt) 2021-05-25
ZA200805759B (en) 2009-11-25
UA97351C2 (ru) 2012-02-10
TW200800936A (en) 2008-01-01
KR101378634B1 (ko) 2014-03-26
CA2640652A1 (en) 2007-08-16
AU2007212972B2 (en) 2012-03-01
EP1982982A1 (en) 2008-10-22
BRPI0708038A2 (pt) 2011-04-26
US20110092700A1 (en) 2011-04-21
EP1982982A4 (en) 2009-07-22
NZ570627A (en) 2010-05-28
NO341421B1 (no) 2017-11-13
WO2007091736A1 (ja) 2007-08-16
US8278465B2 (en) 2012-10-02
JP4334593B2 (ja) 2009-09-30
IL193190A0 (en) 2009-02-11
RU2428420C2 (ru) 2011-09-10

Similar Documents

Publication Publication Date Title
NO20083542L (no) Nye kumarinderivater med antitumoraktivitet
NO20051165L (no) Benzotiazolderivater som har -adrenoerseptorantagonist aktivitet
NO20071504L (no) Pyrimidinderivanter.
NO20071137L (no) Nye piperidinderivater for behandling av depresjon
NO20055219L (no) Nye forbindelser
NO20076196L (no) Nye 2-azetidinonderivater som kolesterolabsorpsjonsinhibitorer for behandling av hyperlipidemiske tilstander
NO20085176L (no) Fenyl substituerte heteroaryl-derivater og andvendelse som anti-tumor agenter
NO20080981L (no) Nitrocatechol-derivater som COMT-inhibitorer
NO20083434L (no) Benzamid- og heteroarenderivater
NO20082643L (no) Isokinolinaminopyrazolderivater, deres fremstilling og anvendelse som farmasoytiske midler for behandling av kreft
NO20071125L (no) Substituerte indolyl-alkyl-aminoderivater som nye inhibitorer av histondeacetylase
NO20076197L (no) Nye 2-azetidinonderivater anvendbare i behandling av hyperlipidemiske tilstander
NO20074703L (no) Antibakterielle piperidinderivater
NO20081729L (no) Nye diazaspiroalkaner og deres anvendelse for behandling av CCR8-medierte sykdommer
NO20081315L (no) Benzokinazolinderivater og deres anvendelse ved behandling av benlidelser
NO20076006L (no) Acetylenderivater
NO20081217L (no) Nye benzotiazolonderivater
NO20084363L (no) 2-Substituerte 4-benzylftalazinonderivater som histamin H1- og H3-antagonister
NO20076138L (no) Nye 2-azetidinonderivater som kolesterolabsorpsjonsinhibitorer for behandling av hyperlipidemiske tilstander
NO20072939L (no) Makroloner - aminosubstituerte kinoloner
NO20076682L (no) Nye pyridinanaloger
NO20073572L (no) Nye forbindelser
NO20085213L (no) Nye pyridinanaloger
NO20081169L (no) Nye camptothecinanalogforbindelser, en fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem
NO20064160L (no) Nye azaibicykliske forbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem