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NO20083493L - Fremgangsmate for fremstilling av 3-[5-[4-(cyklopentyloksy)-2-hydroksybenzoyl]-2-[3-okso-2-substituert-2,3-dihydro-1,2-benzisoksazol-6-yl)metoksy]-fenyl]-propionatester og mellomprodukt for metoden - Google Patents

Fremgangsmate for fremstilling av 3-[5-[4-(cyklopentyloksy)-2-hydroksybenzoyl]-2-[3-okso-2-substituert-2,3-dihydro-1,2-benzisoksazol-6-yl)metoksy]-fenyl]-propionatester og mellomprodukt for metoden

Info

Publication number
NO20083493L
NO20083493L NO20083493A NO20083493A NO20083493L NO 20083493 L NO20083493 L NO 20083493L NO 20083493 A NO20083493 A NO 20083493A NO 20083493 A NO20083493 A NO 20083493A NO 20083493 L NO20083493 L NO 20083493L
Authority
NO
Norway
Prior art keywords
preparation
benzisoxazol
hydroxybenzoyl
cyclopentyloxy
dihydro
Prior art date
Application number
NO20083493A
Other languages
English (en)
Inventor
Yoshiaki Suzuki
Kenji Yonezawa
Tamotsu Takamatsu
Naokatu Aoki
Tomohiro Hashimoto
Masahiro Takebayashi
Yuji Oonishi
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of NO20083493L publication Critical patent/NO20083493L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrane Compounds (AREA)

Abstract

En fremstillingsmetode hvor et 6-(halogenmetyl)-1,2-benzisoksazol-3(2H)-on derivat representert ved generell formel hvor R5 er en metylgruppe som er substituert med én eller flere eventuelt substituert fenylgrupper eller en eventuelt substituert oksygen-inneholdende heterosyklisk gruppe; X representerer et halogenatom, brukes som et mellomprodukt, og fremstillingsmetoden kan anvendes for en trygg og enkel fremstilling med høyt utbytte av 3-{5-[4-(syklopentyloksy)-2-hydroksybenzoyl]-2-[(3-hydroksy-1,2-benzisoksazol-6-yl)metoksy]fenyl}propionsyre, som er anvendelig som et anti-revmatisk middel.
NO20083493A 2006-02-21 2008-08-12 Fremgangsmate for fremstilling av 3-[5-[4-(cyklopentyloksy)-2-hydroksybenzoyl]-2-[3-okso-2-substituert-2,3-dihydro-1,2-benzisoksazol-6-yl)metoksy]-fenyl]-propionatester og mellomprodukt for metoden NO20083493L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006043777 2006-02-21
JP2006121601 2006-04-26
JP2006121582 2006-04-26
PCT/JP2007/052953 WO2007097279A1 (ja) 2006-02-21 2007-02-19 ３－｛５－［４－（シクロペンチルオキシ）－２－ヒドロキシベンゾイル］－２－［（３－オキソ－２－置換－２，３－ジヒドロ－１，２－ベンズイソオキサゾール－６－イル）メトキシ］フェニル｝プロピオン酸エステルの製造法およびその中間体

Publications (1)

Publication Number Publication Date
NO20083493L true NO20083493L (no) 2008-08-14

Family

ID=38437319

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083493A NO20083493L (no) 2006-02-21 2008-08-12 Fremgangsmate for fremstilling av 3-[5-[4-(cyklopentyloksy)-2-hydroksybenzoyl]-2-[3-okso-2-substituert-2,3-dihydro-1,2-benzisoksazol-6-yl)metoksy]-fenyl]-propionatester og mellomprodukt for metoden

Country Status (20)

Country Link
US (2) US8017789B2 (no)
EP (2) EP1988085B8 (no)
JP (1) JP5236456B2 (no)
KR (1) KR101374592B1 (no)
CN (1) CN102285931B (no)
AU (1) AU2007218772B2 (no)
BR (1) BRPI0707989A2 (no)
CA (2) CA2643052C (no)
CY (2) CY1115763T1 (no)
DK (2) DK2562170T3 (no)
ES (2) ES2524474T3 (no)
IL (2) IL193508A (no)
MX (1) MX2008010787A (no)
NO (1) NO20083493L (no)
NZ (2) NZ570634A (no)
PL (2) PL2562170T3 (no)
PT (2) PT2562170E (no)
SG (1) SG179300A1 (no)
SI (2) SI2562170T1 (no)
WO (1) WO2007097279A1 (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2719290A1 (en) * 2008-03-27 2009-10-01 Toyama Chemical Co., Ltd. Use of benzophenone derivative or salt thereof and tnf.alpha. inhibitor in combination and pharmaceutical composition containing the derivative or salt thereof and the inhibitor
MX2010011666A (es) 2008-04-22 2010-12-06 Toyama Chemical Co Ltd Metodo para usar una combinacion de derivado de benzofenona o sal del mismo y un agente inmunosupresor, y una composicion farmaceutica que consta de estos compuestos.
CN103183606B (zh) * 2011-12-28 2016-09-14 天津市国际生物医药联合研究院有限公司 一种4,4'-二取代二苯甲酮类化合物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2019335C (en) * 1989-06-27 2000-08-01 Mitoshi Konno Phenylalkan (en)oic acids
LU87821A1 (fr) 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
SE9501919L (sv) 1995-05-19 1996-07-01 Dimbis Ab Detektering och prediktion av trafikstörningar
US7314888B1 (en) * 1998-11-05 2008-01-01 Toyama Chemical Co., Ltd. Compounds and medicinal use thereof
CN1602291B (zh) * 2001-11-16 2010-05-12 富山化学工业株式会社 新二苯甲酮衍生物或其盐
CN1506359A (zh) 2002-12-05 2004-06-23 �й�ҽѧ��ѧԺҩ���о��� 新的香豆素酰胺衍生物及其制法和其药物组合物与用途
CN1764635A (zh) * 2003-02-07 2006-04-26 小野药品工业株式会社 羧酸化合物
US20070179143A1 (en) 2003-06-25 2007-08-02 Je Il Pharmaceutical Co., Ltd. Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them
CN1922157B (zh) 2003-12-29 2011-01-12 塞普拉科公司 苯并[d]异噁唑-3-醇DAAO抑制剂
HRP20100544T1 (hr) * 2006-05-26 2010-11-30 Toyama Chemical Co. Novi kristal 3-[5-[4-(ciklopentiloksi)-2-hidroksibenzoil]-2-[(3-hidroksi-1,2-benzizoksazol-6-il)metoksi]fenil]propionske kiseline

Also Published As

Publication number Publication date
EP1988085A4 (en) 2012-05-30
CY1115787T1 (el) 2017-01-25
ES2523822T3 (es) 2014-12-01
IL219282A (en) 2013-10-31
SI2562170T1 (sl) 2015-03-31
CA2817676A1 (en) 2007-08-30
NZ593062A (en) 2012-04-27
CN102285931A (zh) 2011-12-21
US8153816B2 (en) 2012-04-10
EP1988085B1 (en) 2014-11-12
ES2524474T3 (es) 2014-12-09
BRPI0707989A2 (pt) 2011-05-17
CY1115763T1 (el) 2017-01-25
PT2562170E (pt) 2014-12-26
JPWO2007097279A1 (ja) 2009-07-16
CA2643052C (en) 2014-02-11
US8017789B2 (en) 2011-09-13
PL2562170T3 (pl) 2015-03-31
US20110263866A1 (en) 2011-10-27
DK2562170T3 (en) 2014-11-24
JP5236456B2 (ja) 2013-07-17
IL193508A (en) 2013-10-31
MX2008010787A (es) 2008-10-27
EP2562170A1 (en) 2013-02-27
SI1988085T1 (sl) 2015-03-31
US20090099369A1 (en) 2009-04-16
IL219282A0 (en) 2012-06-28
NZ570634A (en) 2011-08-26
AU2007218772A1 (en) 2007-08-30
CN102285931B (zh) 2014-01-01
KR101374592B1 (ko) 2014-03-17
SG179300A1 (en) 2012-04-27
EP2562170B1 (en) 2014-10-29
IL193508A0 (en) 2009-05-04
DK1988085T3 (en) 2014-12-01
CA2643052A1 (en) 2007-08-30
PL1988085T3 (pl) 2015-04-30
KR20080098666A (ko) 2008-11-11
PT1988085E (pt) 2015-02-05
WO2007097279A1 (ja) 2007-08-30
EP1988085A1 (en) 2008-11-05
EP1988085B8 (en) 2015-01-28
AU2007218772B2 (en) 2012-02-23

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