NO20070334L - 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer - Google Patents
4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorerInfo
- Publication number
- NO20070334L NO20070334L NO20070334A NO20070334A NO20070334L NO 20070334 L NO20070334 L NO 20070334L NO 20070334 A NO20070334 A NO 20070334A NO 20070334 A NO20070334 A NO 20070334A NO 20070334 L NO20070334 L NO 20070334L
- Authority
- NO
- Norway
- Prior art keywords
- protein kinase
- kinase inhibitors
- disubstituted pyrimidines
- pyrimidines
- disubstituted
- Prior art date
Links
- -1 4,6-disubstituted pyrimidines Chemical class 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 108091008611 Protein Kinase B Proteins 0.000 abstract 2
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04103011 | 2004-06-28 | ||
| EP05102355 | 2005-03-23 | ||
| PCT/EP2005/053019 WO2006000589A1 (fr) | 2004-06-28 | 2005-06-28 | Pyrimidines 4,6-disubstituees et leur utilisation comme inhibiteurs des proteines kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20070334L true NO20070334L (no) | 2007-03-28 |
Family
ID=34973043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20070334A NO20070334L (no) | 2004-06-28 | 2007-01-18 | 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7879853B2 (fr) |
| EP (1) | EP1763526B1 (fr) |
| JP (1) | JP5065017B2 (fr) |
| KR (1) | KR20070027723A (fr) |
| CN (1) | CN1972934A (fr) |
| AT (1) | ATE434614T1 (fr) |
| AU (1) | AU2005256659A1 (fr) |
| BR (1) | BRPI0512547A (fr) |
| CA (1) | CA2570552A1 (fr) |
| DE (1) | DE602005015110D1 (fr) |
| ES (1) | ES2328601T3 (fr) |
| IL (1) | IL179883A0 (fr) |
| MX (1) | MXPA06014747A (fr) |
| NO (1) | NO20070334L (fr) |
| WO (1) | WO2006000589A1 (fr) |
| ZA (1) | ZA200609637B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6907921B2 (en) | 1998-06-18 | 2005-06-21 | 3M Innovative Properties Company | Microchanneled active fluid heat exchanger |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| JP5268904B2 (ja) | 2006-07-06 | 2013-08-21 | アレイ バイオファーマ、インコーポレイテッド | Ａｋｔプロテインキナーゼ阻害剤としてのシクロペンタ［ｄ］ピリミジン |
| MX2009003793A (es) | 2006-10-09 | 2009-12-14 | Takeda Pharmaceutical | Inhibidores de cinasa. |
| US20090012434A1 (en) * | 2007-07-03 | 2009-01-08 | Anderson Robert S | Apparatus, method, and system to treat a volume of skin |
| CN101902911B (zh) * | 2007-10-19 | 2015-12-16 | 阿维拉制药公司 | 杂芳基化合物和其用途 |
| PL2694073T3 (pl) | 2011-04-01 | 2019-06-28 | Genentech, Inc. | Kombinacje inhibitorów AKT i MEK do leczenia nowotworu |
| RU2631240C2 (ru) | 2011-04-01 | 2017-09-20 | Дженентек, Инк. | Комбинации соединений-ингибиторов акт и абиратерона, и способы применения |
| AU2012321091B2 (en) * | 2011-10-28 | 2016-05-12 | Celgene Avilomics Research, Inc. | Methods of treating a Bruton's Tyrosine Kinase disease or disorder |
| TW201325593A (zh) * | 2011-10-28 | 2013-07-01 | Celgene Avilomics Res Inc | 治療布魯頓（ｂｒｕｔｏｎ’ｓ）酪胺酸激酶疾病或病症之方法 |
| PE20142457A1 (es) * | 2012-04-04 | 2015-02-07 | Amgen Inc | Compuestos heterociclicos y sus usos |
| KR20150119012A (ko) | 2013-02-08 | 2015-10-23 | 셀진 아빌로믹스 리서치, 인코포레이티드 | Erk 억제제 및 이의 용도 |
| AU2014293013A1 (en) | 2013-07-26 | 2016-03-17 | Race Oncology Ltd. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| CN103601675B (zh) * | 2013-10-08 | 2015-10-28 | 南京复兴生物科技有限公司 | 一种5-氨甲基烟酸的制备方法 |
| CN103483250B (zh) * | 2013-10-08 | 2015-07-22 | 南京复兴生物科技有限公司 | 一种5-氨甲基烟酸的制备方法 |
| DK3179858T3 (da) | 2014-08-13 | 2019-07-22 | Celgene Car Llc | Forme og sammensætninger af en ERK-inhibitor |
| CN113509471B (zh) * | 2021-07-19 | 2023-06-13 | 中国药科大学 | Akt2抑制剂在制备治疗阿霉素引发心肌损伤药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW321649B (fr) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| HUP0100287A3 (en) | 1997-11-11 | 2003-04-28 | Pfizer Prod Inc | Thienopyrimidine and thienopyridine derivatives useful as anticancer agents |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| JP2003519143A (ja) * | 1999-12-28 | 2003-06-17 | ファーマコピーア，インコーポレーティッド | ピリミジン及びトリアジン系キナーゼ阻害剤 |
| US20020065270A1 (en) * | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
| MXPA03001226A (es) | 2000-08-08 | 2004-09-10 | Johnson & Johnson | Derivados de 4-pirimidinamina, composiciones farmaceuticas y metodos relacionados. |
| AR035967A1 (es) | 2001-05-18 | 2004-07-28 | Altana Pharma Ag | Un compuesto de piridilmetilaminopirimidina, un medicamento que lo comprende y el uso del mismo |
| BR0213792A (pt) * | 2001-11-01 | 2004-12-07 | Janssen Pharmaceutica Nv | Heteroaril aminas como inibidores de glicogênio sintase cinase 3beta (inibidores de gsk3) |
| US7183288B2 (en) | 2001-11-01 | 2007-02-27 | Herwig Josephus Margareta Janssen, legal representative | Amide derivatives as glycogen synthase kinase 3-β inhibitors |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| WO2003057165A2 (fr) | 2002-01-04 | 2003-07-17 | The Rockefeller University | Compositions et procedes de prevention et de traitement de troubles lies au peptide beta-amyloide |
| ATE527250T1 (de) | 2002-11-21 | 2011-10-15 | Novartis Ag | 2,4,6-trisubstituierten pyrimidinen als phosphotidylinositol (pi) 3-kinase inhibitoren und deren verwendung zur behandlung von krebs |
| EP1678147B1 (fr) * | 2003-09-15 | 2012-08-08 | Lead Discovery Center GmbH | Derives d'aminopyrimidine a disubstitution 4,6 actifs sur le plan pharmaceutique en tant que modulateurs des proteine kinases |
| US20080242681A1 (en) | 2004-01-22 | 2008-10-02 | Altana Pharma Ag | N-4-(6-(Hetero)Aryl-Pyrimidin-4-Ylaminophenyl)-Benzenesulfonamides as Kinase Inhibitors |
| EP1901747A2 (fr) * | 2005-05-25 | 2008-03-26 | Ingenium Pharmaceuticals AG | Inhibiteurs du cdk bases sur des pyrimidines destines au traitement de la douleur |
-
2005
- 2005-06-28 KR KR1020077001451A patent/KR20070027723A/ko not_active Withdrawn
- 2005-06-28 AU AU2005256659A patent/AU2005256659A1/en not_active Abandoned
- 2005-06-28 MX MXPA06014747A patent/MXPA06014747A/es not_active Application Discontinuation
- 2005-06-28 CN CNA2005800205458A patent/CN1972934A/zh active Pending
- 2005-06-28 WO PCT/EP2005/053019 patent/WO2006000589A1/fr not_active Ceased
- 2005-06-28 ES ES05769611T patent/ES2328601T3/es not_active Expired - Lifetime
- 2005-06-28 JP JP2007517306A patent/JP5065017B2/ja not_active Expired - Fee Related
- 2005-06-28 US US11/630,352 patent/US7879853B2/en not_active Expired - Fee Related
- 2005-06-28 EP EP05769611A patent/EP1763526B1/fr not_active Expired - Lifetime
- 2005-06-28 CA CA002570552A patent/CA2570552A1/fr not_active Abandoned
- 2005-06-28 AT AT05769611T patent/ATE434614T1/de not_active IP Right Cessation
- 2005-06-28 DE DE602005015110T patent/DE602005015110D1/de not_active Expired - Lifetime
- 2005-06-28 BR BRPI0512547-2A patent/BRPI0512547A/pt not_active IP Right Cessation
-
2006
- 2006-11-20 ZA ZA200609637A patent/ZA200609637B/xx unknown
- 2006-12-06 IL IL179883A patent/IL179883A0/en unknown
-
2007
- 2007-01-18 NO NO20070334A patent/NO20070334L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06014747A (es) | 2007-02-16 |
| BRPI0512547A (pt) | 2008-03-25 |
| KR20070027723A (ko) | 2007-03-09 |
| WO2006000589A1 (fr) | 2006-01-05 |
| CA2570552A1 (fr) | 2006-01-05 |
| DE602005015110D1 (de) | 2009-08-06 |
| JP2008504251A (ja) | 2008-02-14 |
| US7879853B2 (en) | 2011-02-01 |
| US20070208034A1 (en) | 2007-09-06 |
| ZA200609637B (en) | 2008-08-27 |
| EP1763526B1 (fr) | 2009-06-24 |
| JP5065017B2 (ja) | 2012-10-31 |
| EP1763526A1 (fr) | 2007-03-21 |
| CN1972934A (zh) | 2007-05-30 |
| ATE434614T1 (de) | 2009-07-15 |
| WO2006000589A8 (fr) | 2006-11-16 |
| IL179883A0 (en) | 2007-05-15 |
| AU2005256659A1 (en) | 2006-01-05 |
| ES2328601T3 (es) | 2009-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CREP | Change of representative |
Representative=s name: PLOUGMANN & VINGTOFT, POSTBOKS 1003 SENTRUM, 0104 |
|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |