NO20070334L - 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer - Google Patents
4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorerInfo
- Publication number
- NO20070334L NO20070334L NO20070334A NO20070334A NO20070334L NO 20070334 L NO20070334 L NO 20070334L NO 20070334 A NO20070334 A NO 20070334A NO 20070334 A NO20070334 A NO 20070334A NO 20070334 L NO20070334 L NO 20070334L
- Authority
- NO
- Norway
- Prior art keywords
- protein kinase
- kinase inhibitors
- disubstituted pyrimidines
- pyrimidines
- disubstituted
- Prior art date
Links
- -1 4,6-disubstituted pyrimidines Chemical class 0.000 title 1
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
- 108091008611 Protein Kinase B Proteins 0.000 abstract 2
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 102000005765 Proto-Oncogene Proteins c-akt Human genes 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04103011 | 2004-06-28 | ||
| EP05102355 | 2005-03-23 | ||
| PCT/EP2005/053019 WO2006000589A1 (fr) | 2004-06-28 | 2005-06-28 | Pyrimidines 4,6-disubstituees et leur utilisation comme inhibiteurs des proteines kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20070334L true NO20070334L (no) | 2007-03-28 |
Family
ID=34973043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20070334A NO20070334L (no) | 2004-06-28 | 2007-01-18 | 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7879853B2 (fr) |
| EP (1) | EP1763526B1 (fr) |
| JP (1) | JP5065017B2 (fr) |
| KR (1) | KR20070027723A (fr) |
| CN (1) | CN1972934A (fr) |
| AT (1) | ATE434614T1 (fr) |
| AU (1) | AU2005256659A1 (fr) |
| BR (1) | BRPI0512547A (fr) |
| CA (1) | CA2570552A1 (fr) |
| DE (1) | DE602005015110D1 (fr) |
| ES (1) | ES2328601T3 (fr) |
| IL (1) | IL179883A0 (fr) |
| MX (1) | MXPA06014747A (fr) |
| NO (1) | NO20070334L (fr) |
| WO (1) | WO2006000589A1 (fr) |
| ZA (1) | ZA200609637B (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6907921B2 (en) | 1998-06-18 | 2005-06-21 | 3M Innovative Properties Company | Microchanneled active fluid heat exchanger |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| UA99597C2 (ru) | 2006-07-06 | 2012-09-10 | Еррей Біофарма Інк. | Пиримидилциклопентаны как ингибиторы акт протеинкиназ |
| SG175609A1 (en) | 2006-10-09 | 2011-11-28 | Takeda Pharmaceutical | Kinase inhibitors |
| US20090012434A1 (en) * | 2007-07-03 | 2009-01-08 | Anderson Robert S | Apparatus, method, and system to treat a volume of skin |
| CN101902911B (zh) * | 2007-10-19 | 2015-12-16 | 阿维拉制药公司 | 杂芳基化合物和其用途 |
| EP2694071B1 (fr) | 2011-04-01 | 2017-01-04 | Genentech, Inc. | Combinaisons de composés inhibiteurs d'akt et d'agents chimiothérapeutiques, et procédés d'utilisation |
| WO2012135779A1 (fr) | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinaisons de composés inhibiteurs d'akt et mek, et procédés d'utilisation |
| AU2012321091B2 (en) * | 2011-10-28 | 2016-05-12 | Celgene Avilomics Research, Inc. | Methods of treating a Bruton's Tyrosine Kinase disease or disorder |
| EP2770830A4 (fr) * | 2011-10-28 | 2015-05-27 | Celgene Avilomics Res Inc | Méthodes de traitement d'une maladie ou d'une affection associée à la tyrosine-kinase btk (bruton's tyrosine kinase) |
| PL2834231T3 (pl) * | 2012-04-04 | 2016-07-29 | Amgen Inc | Związki heterocykliczne i ich zastosowanie |
| KR20150119012A (ko) | 2013-02-08 | 2015-10-23 | 셀진 아빌로믹스 리서치, 인코포레이티드 | Erk 억제제 및 이의 용도 |
| KR20160099081A (ko) | 2013-07-26 | 2016-08-19 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조합 방법 |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| CN103601675B (zh) * | 2013-10-08 | 2015-10-28 | 南京复兴生物科技有限公司 | 一种5-氨甲基烟酸的制备方法 |
| CN103483250B (zh) * | 2013-10-08 | 2015-07-22 | 南京复兴生物科技有限公司 | 一种5-氨甲基烟酸的制备方法 |
| WO2016025561A1 (fr) | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Formes et compositions d'un inhibiteur d'erk |
| CN113509471B (zh) * | 2021-07-19 | 2023-06-13 | 中国药科大学 | Akt2抑制剂在制备治疗阿霉素引发心肌损伤药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW321649B (fr) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ID23978A (id) | 1997-11-11 | 2000-06-14 | Pfizer Prod Inc | Turunan-turunan tienopirimidin dan tienopiridin yang berguna sebagai zat-zat anti kangker |
| GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
| ES2335265T3 (es) * | 1999-12-28 | 2010-03-24 | Pharmacopeia, Inc. | Inhibidores de citoquina, especialmente de tnf-alfa. |
| US20020065270A1 (en) * | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
| IL154240A0 (en) | 2000-08-08 | 2003-07-31 | Ortho Mcneil Pharm Inc | 4-pyrimidinamine derivatives, pharmaceutical compositions and related methods |
| AR035967A1 (es) | 2001-05-18 | 2004-07-28 | Altana Pharma Ag | Un compuesto de piridilmetilaminopirimidina, un medicamento que lo comprende y el uso del mismo |
| WO2003037869A1 (fr) | 2001-11-01 | 2003-05-08 | Janssen Pharmaceutica N.V. | Derives amides utilises en tant qu'inhibiteurs de la glycogene synthase kinase 3-beta |
| KR20040048920A (ko) | 2001-11-01 | 2004-06-10 | 얀센 파마슈티카 엔.브이. | 글리코겐 신타아제 키나제 3-베타 저해제(ｇｓｋ저해제)로서의 헤테로아릴 아민 |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| WO2003057165A2 (fr) | 2002-01-04 | 2003-07-17 | The Rockefeller University | Compositions et procedes de prevention et de traitement de troubles lies au peptide beta-amyloide |
| AU2003295776B2 (en) | 2002-11-21 | 2011-05-12 | Novartis Vaccines And Diagnostics, Inc. | 2,4,6-trisubstituted pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer |
| EP1678147B1 (fr) * | 2003-09-15 | 2012-08-08 | Lead Discovery Center GmbH | Derives d'aminopyrimidine a disubstitution 4,6 actifs sur le plan pharmaceutique en tant que modulateurs des proteine kinases |
| EP1709007A1 (fr) | 2004-01-22 | 2006-10-11 | Altana Pharma AG | N-4-(6-(hetero)aryle-pyrimidine-4-ylaminophenyle)-bezenesulfonamides en tant qu'inhibiteurs de kinase |
| US20090221581A1 (en) * | 2005-05-25 | 2009-09-03 | Philipp Wabnitz | Methods of treating pain |
-
2005
- 2005-06-28 JP JP2007517306A patent/JP5065017B2/ja not_active Expired - Fee Related
- 2005-06-28 KR KR1020077001451A patent/KR20070027723A/ko not_active Withdrawn
- 2005-06-28 EP EP05769611A patent/EP1763526B1/fr not_active Expired - Lifetime
- 2005-06-28 AU AU2005256659A patent/AU2005256659A1/en not_active Abandoned
- 2005-06-28 ES ES05769611T patent/ES2328601T3/es not_active Expired - Lifetime
- 2005-06-28 WO PCT/EP2005/053019 patent/WO2006000589A1/fr not_active Ceased
- 2005-06-28 AT AT05769611T patent/ATE434614T1/de not_active IP Right Cessation
- 2005-06-28 CN CNA2005800205458A patent/CN1972934A/zh active Pending
- 2005-06-28 DE DE602005015110T patent/DE602005015110D1/de not_active Expired - Lifetime
- 2005-06-28 US US11/630,352 patent/US7879853B2/en not_active Expired - Fee Related
- 2005-06-28 BR BRPI0512547-2A patent/BRPI0512547A/pt not_active IP Right Cessation
- 2005-06-28 CA CA002570552A patent/CA2570552A1/fr not_active Abandoned
- 2005-06-28 MX MXPA06014747A patent/MXPA06014747A/es not_active Application Discontinuation
-
2006
- 2006-11-20 ZA ZA200609637A patent/ZA200609637B/xx unknown
- 2006-12-06 IL IL179883A patent/IL179883A0/en unknown
-
2007
- 2007-01-18 NO NO20070334A patent/NO20070334L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP5065017B2 (ja) | 2012-10-31 |
| BRPI0512547A (pt) | 2008-03-25 |
| US20070208034A1 (en) | 2007-09-06 |
| JP2008504251A (ja) | 2008-02-14 |
| AU2005256659A1 (en) | 2006-01-05 |
| CN1972934A (zh) | 2007-05-30 |
| WO2006000589A8 (fr) | 2006-11-16 |
| ZA200609637B (en) | 2008-08-27 |
| MXPA06014747A (es) | 2007-02-16 |
| EP1763526B1 (fr) | 2009-06-24 |
| ATE434614T1 (de) | 2009-07-15 |
| ES2328601T3 (es) | 2009-11-16 |
| EP1763526A1 (fr) | 2007-03-21 |
| WO2006000589A1 (fr) | 2006-01-05 |
| US7879853B2 (en) | 2011-02-01 |
| KR20070027723A (ko) | 2007-03-09 |
| CA2570552A1 (fr) | 2006-01-05 |
| IL179883A0 (en) | 2007-05-15 |
| DE602005015110D1 (de) | 2009-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20070334L (no) | 4,6-disubstituerte pyrimidiner og deres anvendelse som proteinkinaseinhibitorer | |
| NO20074431L (no) | Pyrrolopyrimidiner nyttige som proteinkinaseinhibitorer | |
| DK1567522T3 (da) | Pyrimidinforbindelser | |
| NO20082508L (no) | Aminopyrimidiner anvendelige som kinaseinhibitorer | |
| WO2005116025A3 (fr) | Composes | |
| NO20081893L (no) | 4-(3-aminopyrazol)pyrimidinderivater til anvendelse som tyrosin-kinaseinhibitorer i behandling av kreft | |
| ATE466580T1 (de) | Azolylaminoazine als proteinkinasehemmer | |
| ATE468336T1 (de) | Azolylaminoazine als proteinkinasehemmer | |
| ATE365733T1 (de) | Zusammensetzungen brauchbar als protein-kinase- inhibitoren | |
| NO20085373L (no) | P38 inhibitorer, deres fremstilling og anvendelse | |
| NO20072567L (no) | Triazoler nyttige som proteinkinase-inhibitorer | |
| WO2007079164A3 (fr) | Inhibiteurs de protéines kinases | |
| NO20065727L (no) | Pyrrolinhibitorer av erk-proteinkinase, syntese derav og deres mellomprodukter | |
| NO20076502L (no) | Pyrrolopyridiner nyttige som inhibitorer av proteinkinase | |
| ATE474835T1 (de) | Als inhibitoren von proteinkinasen geeignete aminopyrimidine | |
| NO20071915L (no) | Diaminotriazolforbindelser nyttige som proteinkinaseinhibitorer | |
| DK2089369T3 (da) | 2,4-pyrimidindiaminderivater som hæmmere af JAK-kinaser til behandling af autoimmune sygdomme | |
| DK1483265T3 (da) | Purinderivater som kinaseinhibitorer | |
| ATE508126T1 (de) | Als kinaseinhibitoren geeignete aminopyrimidine | |
| NO20082026L (no) | Deazapuriner som er nyttige som inhibitorer for Janus-kinaser | |
| WO2006083673A3 (fr) | Inhibiteurs des c-jun n-terminal kinases | |
| BRPI0509369A (pt) | azaindóis úteis como inibidores de jak e outras proteìna cinases | |
| ATE450530T1 (de) | Zusammensetzungen zur verwendung als protein- kinase-inhibitoren | |
| NO20075275L (no) | Nye forbindelser | |
| NO20034434D0 (no) | Indolinoner substituert i 6-stilling og deres anvendelse som kinase-inhibitorer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CREP | Change of representative |
Representative=s name: PLOUGMANN & VINGTOFT, POSTBOKS 1003 SENTRUM, 0104 |
|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |