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NO20063958L - HIV integrase inhibitorer - Google Patents

HIV integrase inhibitorer

Info

Publication number
NO20063958L
NO20063958L NO20063958A NO20063958A NO20063958L NO 20063958 L NO20063958 L NO 20063958L NO 20063958 A NO20063958 A NO 20063958A NO 20063958 A NO20063958 A NO 20063958A NO 20063958 L NO20063958 L NO 20063958L
Authority
NO
Norway
Prior art keywords
integrase inhibitors
hiv integrase
hiv
treatment
aids
Prior art date
Application number
NO20063958A
Other languages
English (en)
Inventor
Eric Eugene Boros
Ronald George Sherrill
Brian A Johns
Cecilia Koble
Takashi Kawasuji
Noriyuki Kurose
Hitoshi Mural
Jason Gordon Weatherhead
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20063958L publication Critical patent/NO20063958L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Foreliggende oppfinnelse omfatter forbindelser som er HIV integrase inhibitorer og som derfor er anvendelige ved hemning av HIV replikasjon, forebygging og/eller behandling av infeksjon ved HIV og ved behandling av AIDS og/eller ARC.
NO20063958A 2004-02-11 2006-09-05 HIV integrase inhibitorer NO20063958L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54367004P 2004-02-11 2004-02-11
PCT/US2005/004085 WO2005077050A2 (en) 2004-02-11 2005-02-10 Hiv integrase inhibitors

Publications (1)

Publication Number Publication Date
NO20063958L true NO20063958L (no) 2006-09-22

Family

ID=34860447

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063958A NO20063958L (no) 2004-02-11 2006-09-05 HIV integrase inhibitorer

Country Status (15)

Country Link
US (3) US8691991B2 (no)
EP (1) EP1720856B1 (no)
JP (1) JP4859676B2 (no)
KR (1) KR20070002006A (no)
CN (1) CN1976915A (no)
AU (1) AU2005211733A1 (no)
BR (1) BRPI0507628A (no)
CA (1) CA2555176A1 (no)
ES (1) ES2433477T3 (no)
IL (1) IL177189A0 (no)
MA (1) MA28358A1 (no)
MX (1) MXPA06009132A (no)
NO (1) NO20063958L (no)
RU (1) RU2006128848A (no)
WO (1) WO2005077050A2 (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2433477T3 (es) 2004-02-11 2013-12-11 Glaxosmithkline Llc Inhibidores de integrasa de VIH
MX302718B (es) 2005-04-28 2012-08-27 Smithkline Beecham Corp Derivado de carbamoilpiridona policiclico que tiene actividad inhibidora de la integrasa de hiv.
US20080194523A1 (en) * 2005-08-04 2008-08-14 Smithkline Beecham Corporation Hiv Integrase Inhibitors
US20080214527A1 (en) * 2005-08-04 2008-09-04 Takashi Kawasuji Hiv Integrase Inhibitors
EP1909578A4 (en) * 2005-08-04 2010-07-14 Glaxosmithkline Llc INHIBITORS OF HIV INTEGRASE
EP1910356A4 (en) * 2005-08-04 2009-10-21 Smithkline Beecham Corp HIV integrase
PE20071020A1 (es) * 2006-03-07 2007-12-11 Smithkline Beecham Corp Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa
KR101409261B1 (ko) * 2006-05-26 2014-06-18 다이쇼 세이야꾸 가부시끼가이샤 신규의 복소환 화합물 또는 그 염 및 그 중간체
EP1956016A1 (en) * 2006-12-15 2008-08-13 Bayer Schering Pharma Aktiengesellschaft Bicyclic acyltryptophanols
CA2672656C (en) 2006-12-18 2012-03-20 Amgen Inc. Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
US8048892B2 (en) 2006-12-18 2011-11-01 Amgen Inc. Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
JP2010524935A (ja) * 2007-04-18 2010-07-22 メルク・シャープ・エンド・ドーム・コーポレイション 新規１，８−ナフチリジン化合物
AU2008241483B2 (en) 2007-04-18 2011-03-24 Amgen Inc. Quinolones and azaquinolones that inhibit prolyl hydroxylase
WO2008130508A1 (en) 2007-04-18 2008-10-30 Amgen Inc. Indanone derivatives that inhibit prolyl hydroxylase
WO2008137060A1 (en) 2007-05-04 2008-11-13 Amgen Inc. Thienopyridine and thiazolopyridine derivatives that inhibit prolyl hydroxylase activity
CA2685219C (en) 2007-05-04 2012-06-19 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
WO2010011818A1 (en) * 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
WO2010011819A1 (en) * 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
US8283366B2 (en) * 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
LT3494972T (lt) 2010-01-27 2024-03-12 Viiv Healthcare Company Dolutegraviro ir lamivudino kompozicija živ infekcijai gydyti
US20110223131A1 (en) * 2010-02-24 2011-09-15 Gilead Sciences, Inc. Antiviral compounds
RU2605549C2 (ru) * 2010-04-02 2016-12-20 Синомикс, Инк. Производные 3-карбокси-4-аминохинолина, полезные как модификаторы сладкого вкуса
CN103153959A (zh) 2010-10-14 2013-06-12 伊姆纳尔公司 作为AhR活化剂的1，2-二氢-4-羟基-2-氧代-喹啉-3-甲酰苯胺类
US9359300B2 (en) 2010-12-06 2016-06-07 Confluence Life Sciences, Inc. Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
ES2873029T3 (es) 2010-12-06 2021-11-03 Aclaris Therapeutics Inc Compuestos de piridinona-piridinilo sustituidos
CN103608345A (zh) 2011-04-26 2014-02-26 盐野义制药株式会社 噁嗪衍生物和含有该噁嗪衍生物的bace1抑制剂
BR112014003285B1 (pt) 2011-08-12 2020-01-14 Firmenich Incorporated modificador de sabor doce
PT3067358T (pt) 2012-12-21 2019-11-18 Gilead Sciences Inc Compostos carbamoílpiridona policíclicos e sua utilização farmacêutica
HRP20210813T1 (hr) 2013-06-07 2021-06-25 Aclaris Therapeutics, Inc. Piridinonpiridinilni spojevi supstituirani s metil/fluorpiridinilmetoksi i piridinonpiridinilni spojevi supstituirani s fluorpirimidinilmetoksi
WO2016073251A1 (en) 2014-11-07 2016-05-12 Senomyx, Inc. Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
CN105348282B (zh) * 2015-12-02 2018-06-29 北京工业大学 一种hiv-1整合酶抑制剂化合物及其制备方法和应用
CN115666566A (zh) 2020-03-27 2023-01-31 阿克拉瑞斯治疗股份有限公司 用于免疫病况的治疗的mk2途径抑制剂的口服组合物
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK4322003A3 (en) 2000-10-12 2003-09-11 Merck & Co Inc Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
ATE364385T1 (de) 2000-10-12 2007-07-15 Merck & Co Inc Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
AU2002230392A1 (en) 2000-10-12 2002-05-15 Merck & Co., Inc. AZA-and polyaza-naphthalenyl ketones useful as HIV integrase inhibitors
DE60124577T2 (de) 2000-10-12 2007-09-27 Merck & Co., Inc. Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer
PL365027A1 (en) 2001-03-01 2004-12-27 Shionogi & Co, Ltd. Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity
JP4523281B2 (ja) 2002-01-17 2010-08-11 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシナフチリジノンカルボキサミド類
JP3908248B2 (ja) * 2002-08-13 2007-04-25 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有するヘテロ環化合物
EP1545538A2 (en) 2002-08-29 2005-06-29 Merck & Co., Inc. N-biarylmethyl aminocycloalkanecarboxamide derivatives
TW200505902A (en) * 2003-03-20 2005-02-16 Schering Corp Cannabinoid receptor ligands
WO2005023189A2 (en) 2003-09-03 2005-03-17 Pharmacia Corporation Method of cox-2 selective inhibitor and nitric oxide-donating agent
US7462721B2 (en) 2003-09-19 2008-12-09 Gilead Sciences, Inc. Aza-quinolinol phosphonate integrase inhibitor compounds
ES2433477T3 (es) 2004-02-11 2013-12-11 Glaxosmithkline Llc Inhibidores de integrasa de VIH

Also Published As

Publication number Publication date
ES2433477T3 (es) 2013-12-11
CA2555176A1 (en) 2005-08-25
BRPI0507628A (pt) 2007-07-03
JP2007523086A (ja) 2007-08-16
EP1720856A2 (en) 2006-11-15
MXPA06009132A (es) 2007-03-26
CN1976915A (zh) 2007-06-06
IL177189A0 (en) 2006-12-10
WO2005077050A2 (en) 2005-08-25
KR20070002006A (ko) 2007-01-04
MA28358A1 (fr) 2006-12-01
WO2005077050A3 (en) 2006-11-23
EP1720856A4 (en) 2009-11-11
US20150225399A1 (en) 2015-08-13
EP1720856B1 (en) 2013-08-14
RU2006128848A (ru) 2008-03-20
US20140256713A1 (en) 2014-09-11
US20070124152A1 (en) 2007-05-31
US8691991B2 (en) 2014-04-08
JP4859676B2 (ja) 2012-01-25
AU2005211733A1 (en) 2005-08-25

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