NO20060319L - 3,5-disubstituerte indazolforbindelser, farmasoytiske blandinger og fremgangsmater for a mediere eller inhibere celleproliferasjon - Google Patents
3,5-disubstituerte indazolforbindelser, farmasoytiske blandinger og fremgangsmater for a mediere eller inhibere celleproliferasjonInfo
- Publication number
- NO20060319L NO20060319L NO20060319A NO20060319A NO20060319L NO 20060319 L NO20060319 L NO 20060319L NO 20060319 A NO20060319 A NO 20060319A NO 20060319 A NO20060319 A NO 20060319A NO 20060319 L NO20060319 L NO 20060319L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- cell proliferation
- mediate
- methods
- inhibit cell
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- -1 3,5-Disubstituted Indazole Compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010012689 Diabetic retinopathy Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000003453 indazolyl group Chemical class N1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
- 201000003142 neovascular glaucoma Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49147403P | 2003-07-30 | 2003-07-30 | |
| US49207303P | 2003-07-31 | 2003-07-31 | |
| PCT/IB2004/002441 WO2005009997A1 (fr) | 2003-07-30 | 2004-07-19 | Composes d'indazole 3,5 disubstitutes, compositions pharmaceutiques, et procedes pour medier ou inhiber la proliferation cellulaire |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20060319L true NO20060319L (no) | 2006-02-24 |
Family
ID=34108010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20060319A NO20060319L (no) | 2003-07-30 | 2006-01-20 | 3,5-disubstituerte indazolforbindelser, farmasoytiske blandinger og fremgangsmater for a mediere eller inhibere celleproliferasjon |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7008953B2 (fr) |
| EP (1) | EP1658284A1 (fr) |
| JP (1) | JP3920914B2 (fr) |
| KR (1) | KR20060030914A (fr) |
| AR (1) | AR045143A1 (fr) |
| AU (1) | AU2004259531A1 (fr) |
| BR (1) | BRPI0413051A (fr) |
| CA (1) | CA2532908A1 (fr) |
| CO (1) | CO5650247A2 (fr) |
| EA (1) | EA200600123A1 (fr) |
| EC (1) | ECSP066335A (fr) |
| IL (1) | IL172924A0 (fr) |
| IS (1) | IS8214A (fr) |
| MA (1) | MA27937A1 (fr) |
| MX (1) | MXPA06001193A (fr) |
| NL (1) | NL1026761C2 (fr) |
| NO (1) | NO20060319L (fr) |
| OA (1) | OA13196A (fr) |
| PA (1) | PA8608201A1 (fr) |
| PE (1) | PE20050330A1 (fr) |
| TN (1) | TNSN06038A1 (fr) |
| TW (1) | TW200521124A (fr) |
| UY (1) | UY28442A1 (fr) |
| WO (1) | WO2005009997A1 (fr) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7008953B2 (en) * | 2003-07-30 | 2006-03-07 | Agouron Pharmaceuticals, Inc. | 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| WO2005094830A1 (fr) * | 2004-03-30 | 2005-10-13 | Pfizer Products Inc. | Combinaisons d'inhibiteurs de transduction de signaux |
| WO2006024945A1 (fr) * | 2004-09-03 | 2006-03-09 | Pfizer Inc. | Compositions pharmaceutiques contenant un inhibiteur des cdk |
| WO2006054143A1 (fr) * | 2004-11-17 | 2006-05-26 | Pfizer Inc. | Formes polymorphes de {5-[3-(4,6-difluoro-1h-benzimidazol-2-yl)-1h-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-ethyl-amine |
| US20060116519A1 (en) * | 2004-11-17 | 2006-06-01 | Agouron Pharmaceuticals, Inc. | Synthesis of 5-bromo-4-methyl-pyridin-3-ylmethyl)-ethyl-carbamic acid tert-butyl ester |
| US8028708B2 (en) | 2005-03-21 | 2011-10-04 | Koninklijke Philips Electronics N.V. | Appliance for personal care with automatic fluid dispenser |
| US8252945B2 (en) * | 2005-04-13 | 2012-08-28 | Ube Industries, Ltd. | Protective agent for retinal neuronal cell comprising indazole derivative as active ingredient |
| WO2006130673A1 (fr) | 2005-05-31 | 2006-12-07 | Janssen Pharmaceutica, N.V. | 3-benzoimidazolyl-pyrazolopyridines utilisees pour traiter des troubles dont la mediation est assuree par des kinases |
| KR20070077468A (ko) * | 2006-01-23 | 2007-07-26 | 크리스탈지노믹스(주) | 단백질 키나아제 활성을 저해하는 이미다조피리딘 유도체,이의 제조방법 및 이를 함유하는 약학 조성물 |
| RS20090036A (sr) * | 2006-07-05 | 2010-06-30 | Pfizer Products Inc. | Derivati pirazola kao inhibitori citohroma p450 |
| AU2007283113A1 (en) | 2006-08-08 | 2008-02-14 | Sanofi-Aventis | Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use |
| CN101790526A (zh) * | 2007-06-08 | 2010-07-28 | 雅培制药有限公司 | 用作激酶抑制剂的5-杂芳基取代的吲唑化合物 |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| BRPI0814939A2 (pt) * | 2007-08-10 | 2015-01-27 | Glaxosmithkline Llc | Entidade química, composição farmacêutica, e, método para tratar uma infecção viral em um mamífero. |
| EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
| WO2009149837A1 (fr) * | 2008-06-09 | 2009-12-17 | Bayer Schering Pharma Aktiengesellschaft | 4-(indazolyl)-1,4-dihydropyridines substituées et leurs procédés d’utilisation |
| EP2310372B1 (fr) | 2008-07-09 | 2012-05-23 | Sanofi | Composés hétérocycliques, leur procédé de préparation, médicaments les contenant et leur utilisation |
| AU2009296820B2 (en) * | 2008-09-26 | 2014-03-20 | Merck Sharp & Dohme Llc | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| EP2348857B1 (fr) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Nouveaux dérivés de benzimidazole cycliques utiles comme agents anti-diabétiques |
| AU2009309037A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| EP2362775B1 (fr) | 2008-11-20 | 2015-08-05 | GlaxoSmithKline LLC | Composés chimiques |
| WO2010068601A1 (fr) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant |
| JP2013501792A (ja) * | 2009-08-10 | 2013-01-17 | サミュメッド リミテッド ライアビリティ カンパニー | Ｗｎｔ／ｂ−カテニンシグナル伝達経路阻害剤としてのインダゾールおよびその治療的使用 |
| HRP20151425T1 (hr) * | 2009-08-10 | 2016-01-29 | Samumed, Llc | Inhibitori indazola wnt signalnog puta i njihove terapeutske uporabe |
| ES2443016T3 (es) | 2009-08-26 | 2014-02-17 | Sanofi | Nuevos hidratos cristalinos de fluoroglicósidos heteroaromáticos, productos farmacéuticos que comprenden estos compuestos, y su empleo |
| HUE035612T2 (en) | 2009-12-21 | 2018-05-28 | Samumed Llc | 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
| EP2582709B1 (fr) | 2010-06-18 | 2018-01-24 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| EP3915367A1 (fr) | 2010-08-18 | 2021-12-01 | BioSplice Therapeutics, Inc. | Dicétones et hydroxydicétones utiles en tant qu'activateurs de la voie de signalisation de la caténine |
| WO2012078777A1 (fr) * | 2010-12-09 | 2012-06-14 | Amgen Inc. | Composés bicycliques en tant qu'inhibiteurs de pim |
| EP2766349B1 (fr) | 2011-03-08 | 2016-06-01 | Sanofi | Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation |
| EP2683705B1 (fr) | 2011-03-08 | 2015-04-22 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
| US8809325B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof |
| EP2683699B1 (fr) | 2011-03-08 | 2015-06-24 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
| WO2012120057A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Nouveaux dérivés phényl-oxathiazine substitués, procédé pour leur préparation, agent pharmaceutique contenant ces composés et leur utilisation |
| US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
| US8846666B2 (en) | 2011-03-08 | 2014-09-30 | Sanofi | Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683700B1 (fr) | 2011-03-08 | 2015-02-18 | Sanofi | Dérivés d'oxathiazine tétra-substitués, leur procédé de fabrication, leur utilisation comme médicament ainsi que médicaments en étant pourvu et leur utilisation |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012129338A1 (fr) | 2011-03-22 | 2012-09-27 | Amgen Inc. | Composés d'azole utilisés en tant qu'inhibiteurs des pim |
| WO2013037390A1 (fr) | 2011-09-12 | 2013-03-21 | Sanofi | Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
| RU2627693C2 (ru) | 2011-09-14 | 2017-08-10 | СЭМЬЮМЕД, ЭлЭлСи | ИНДАЗОЛ-3-КАРБОКСАМИДЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ СИГНАЛЬНОГО ПУТИ WNT/b-КАТЕНИНА |
| EP2760862B1 (fr) | 2011-09-27 | 2015-10-21 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
| US9469606B2 (en) | 2011-10-25 | 2016-10-18 | The General Hospital Corporation | Wnt/b-catenin inhibitors and methods of use |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| SG10201710585UA (en) | 2012-05-04 | 2018-02-27 | Samumed Llc | 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| MX370487B (es) | 2013-01-08 | 2019-12-16 | Samumed Llc | Inhibidores de 3-(benzo-imidazol-2-il)-indazol de la senda de señalización de wnt y usos terapéuticos de los mismos. |
| JP6401189B2 (ja) | 2013-02-22 | 2018-10-03 | サミュメッド リミテッド ライアビリティ カンパニー | Ｗｎｔ／β−カテニンシグナル伝達経路活性化剤としてのγ−ジケトン |
| HRP20192161T1 (hr) | 2014-08-20 | 2020-02-21 | Samumed, Llc | Gama-diketoni za liječenje i prevenciju starenja kože i bora |
| WO2016040182A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine et ses utilisations thérapeutiques |
| WO2016040190A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques |
| WO2016040185A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine et ses utilisations thérapeutiques |
| WO2016040184A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques |
| WO2016040193A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques |
| WO2016040188A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques |
| WO2016040181A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques |
| WO2016040180A1 (fr) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques |
| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| WO2017023984A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines et leurs utilisations thérapeutiques |
| WO2017023986A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-indol-2-yl)-1h-indazoles et leurs utilisations thérapeutiques |
| US10383861B2 (en) | 2015-08-03 | 2019-08-20 | Sammumed, LLC | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
| US10519169B2 (en) | 2015-08-03 | 2019-12-31 | Samumed, Llc | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10329309B2 (en) | 2015-08-03 | 2019-06-25 | Samumed, Llc | 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017023996A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines et leurs utilisations thérapeutiques |
| US10195185B2 (en) | 2015-08-03 | 2019-02-05 | Samumed, Llc | 3-(1H-imidazo[4,5-C]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10463651B2 (en) | 2015-08-03 | 2019-11-05 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof |
| US10231956B2 (en) | 2015-08-03 | 2019-03-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10392383B2 (en) | 2015-08-03 | 2019-08-27 | Samumed, Llc | 3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10226453B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017024026A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines et leurs utilisations thérapeutiques |
| US10226448B2 (en) | 2015-08-03 | 2019-03-12 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof |
| WO2017024021A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles et leurs utilisations thérapeutiques |
| WO2017023980A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines et leurs utilisations thérapeutiques |
| WO2017024004A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques |
| WO2017023988A1 (fr) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines et leurs utilisations thérapeutiques |
| CA2997556C (fr) * | 2015-09-03 | 2020-12-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Petites molecules inhibitrices de dyrk1a et leurs utilisations |
| MX389958B (es) | 2015-11-06 | 2025-03-20 | Samumed Llc | 2- (1h-indazol-3-il) -3h-imidazo[4,5-c] piridinas y usos antiinflamatorios de las mismas. |
| AR108325A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| AR108326A1 (es) | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| RS63813B1 (sr) | 2016-06-01 | 2023-01-31 | Biosplice Therapeutics Inc | Postupak pripreme n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida |
| WO2018013430A2 (fr) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Composés hétérocycliques pour le traitement d'une infection à arenavirus |
| BR112019008061A2 (pt) | 2016-10-21 | 2019-09-17 | Samumed Llc | métodos de uso de indazol-3-carboxamidas e seu uso como inibidores da via de sinalização de wnt/b-catenina |
| MA46696A (fr) | 2016-11-07 | 2019-09-11 | Samumed Llc | Formulations injectables à dose unique prêtes à l'emploi |
| WO2019079626A1 (fr) | 2017-10-19 | 2019-04-25 | Samumed, Llc | 6-(hétéroaryle à 5 chaînons)isoquinolin-3-yl carboxamides, leur préparation et leur utilisation |
| WO2019084497A1 (fr) | 2017-10-27 | 2019-05-02 | Samumed, Llc | 6-(hétéroaryle et aryle à 6 chaînons)isoquinolin-3-yl carboxamides, leur préparation et leur utilisation |
| US10413537B2 (en) | 2017-10-27 | 2019-09-17 | Samumed, Llc | 6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof |
| US10703748B2 (en) | 2017-10-31 | 2020-07-07 | Samumed, Llc | Diazanaphthalen-3-yl carboxamides and preparation and use thereof |
| AU2019224075A1 (en) | 2018-02-23 | 2020-09-10 | Samumed, Llc | 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof |
| US12528810B2 (en) | 2018-03-01 | 2026-01-20 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of DYRK/CLK and uses thereof |
| US10759799B2 (en) | 2018-06-15 | 2020-09-01 | Samumed, Llc | Indazole containing macrocycles and therapeutic uses thereof |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| WO2020150545A1 (fr) | 2019-01-17 | 2020-07-23 | Samumed, Llc | DÉRIVÉS DE PYRAZOLE UTILISÉS COMME MODULATEURS DE LA VOIE DE SIGNALISATION WNT/β-CATÉNINE |
| WO2021168341A1 (fr) | 2020-02-21 | 2021-08-26 | Samumed, Llc | Formes solides de 1-(5-(3-(7-(3-fluorophényl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-n,n-diméthylméthanamine |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1376600A (en) | 1971-02-15 | 1974-12-04 | Agfa Gevaert | Photographic developer compositions |
| FR2265739B1 (fr) | 1974-03-29 | 1976-12-17 | Ugine Kuhlmann | |
| JPS5615287A (en) | 1979-07-16 | 1981-02-14 | Chugai Pharmaceut Co Ltd | Pyrazoloindazole derivative and its preparation |
| JPS57109787A (en) | 1980-12-26 | 1982-07-08 | Chugai Pharmaceut Co Ltd | Pyrazoloindazole derivative |
| JPS59228248A (ja) | 1983-06-08 | 1984-12-21 | Konishiroku Photo Ind Co Ltd | 直接ポジ用ハロゲン化銀写真感光材料 |
| JPS604184A (ja) | 1983-06-23 | 1985-01-10 | Chugai Pharmaceut Co Ltd | ピラゾロインダゾ−ル誘導体 |
| US4978603A (en) | 1987-12-14 | 1990-12-18 | Fuji Photo Film Co., Ltd. | Image forming process comprising developing fine grain silver halide emulsion with a hydroquinone developer |
| US5208248A (en) | 1991-01-11 | 1993-05-04 | Merck Sharpe & Dohme, Ltd. | Indazole-substituted five-membered heteroaromatic compounds |
| EP0494774A1 (fr) | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Composés hétéroaromatiques à 5 chaînons substitués par l'indazole |
| NZ243065A (en) | 1991-06-13 | 1995-07-26 | Lundbeck & Co As H | Piperidine derivatives and pharmaceutical compositions |
| ZA951822B (en) | 1994-12-23 | 1996-09-26 | Glaxo Group Ltd | Chemical compounds |
| PT780386E (pt) | 1995-12-20 | 2003-02-28 | Hoffmann La Roche | Inibidores de metaloprotease de matriz |
| EP0818442A3 (fr) | 1996-07-12 | 1998-12-30 | Pfizer Inc. | Dérivés cycliques de sulfones comme inhibiteurs de métalloprotéinase et de la production du facteur de nécrose des tumeurs |
| HRP970371A2 (en) | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
| AU6870098A (en) | 1997-03-31 | 1998-10-22 | Du Pont Merck Pharmaceutical Company, The | Indazoles of cyclic ureas useful as hiv protease inhibitors |
| FR2767475A1 (fr) | 1997-08-25 | 1999-02-26 | Oreal | Compositions de teinture des fibres keratiniques contenant des derives d'indazoles et procede |
| WO2000038719A1 (fr) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | Techniques permettant d'utiliser un inhibiteur matriciel de la metalloproteinase et un antagoniste de l'integrine pour traiter les maladies neoplasiques |
| GB2345486A (en) | 1999-01-11 | 2000-07-12 | Glaxo Group Ltd | Heteroaromatic protein tyrosine kinase inhibitors |
| YU54202A (sh) | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
| KR100423899B1 (ko) | 2000-05-10 | 2004-03-24 | 주식회사 엘지생명과학 | 세포 증식 억제제로 유용한 1,1-디옥소이소티아졸리딘을갖는 인다졸 |
| US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
| US7064215B2 (en) | 2001-07-03 | 2006-06-20 | Chiron Corporation | Indazole benzimidazole compounds |
| FR2831536A1 (fr) | 2001-10-26 | 2003-05-02 | Aventis Pharma Sa | Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr |
| US7008953B2 (en) * | 2003-07-30 | 2006-03-07 | Agouron Pharmaceuticals, Inc. | 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
-
2004
- 2004-06-10 US US10/866,059 patent/US7008953B2/en not_active Expired - Fee Related
- 2004-07-19 WO PCT/IB2004/002441 patent/WO2005009997A1/fr not_active Ceased
- 2004-07-19 JP JP2006521699A patent/JP3920914B2/ja not_active Expired - Fee Related
- 2004-07-19 KR KR1020067001916A patent/KR20060030914A/ko not_active Abandoned
- 2004-07-19 EP EP04744094A patent/EP1658284A1/fr not_active Withdrawn
- 2004-07-19 EA EA200600123A patent/EA200600123A1/ru unknown
- 2004-07-19 BR BRPI0413051-0A patent/BRPI0413051A/pt not_active IP Right Cessation
- 2004-07-19 AU AU2004259531A patent/AU2004259531A1/en not_active Abandoned
- 2004-07-19 MX MXPA06001193A patent/MXPA06001193A/es unknown
- 2004-07-19 CA CA002532908A patent/CA2532908A1/fr not_active Abandoned
- 2004-07-19 OA OA1200600024A patent/OA13196A/fr unknown
- 2004-07-23 PE PE2004000713A patent/PE20050330A1/es not_active Application Discontinuation
- 2004-07-27 PA PA20048608201A patent/PA8608201A1/es unknown
- 2004-07-27 UY UY28442A patent/UY28442A1/es not_active Application Discontinuation
- 2004-07-28 AR ARP040102681A patent/AR045143A1/es unknown
- 2004-07-29 TW TW093122761A patent/TW200521124A/zh unknown
- 2004-07-30 NL NL1026761A patent/NL1026761C2/nl not_active IP Right Cessation
-
2005
- 2005-09-26 US US11/237,446 patent/US20060142345A1/en not_active Abandoned
- 2005-12-29 IL IL172924A patent/IL172924A0/en unknown
- 2005-12-29 CO CO05130968A patent/CO5650247A2/es not_active Application Discontinuation
- 2005-12-30 IS IS8214A patent/IS8214A/is unknown
-
2006
- 2006-01-20 NO NO20060319A patent/NO20060319L/no not_active Application Discontinuation
- 2006-01-30 EC EC2006006335A patent/ECSP066335A/es unknown
- 2006-01-30 TN TNP2006000038A patent/TNSN06038A1/fr unknown
- 2006-01-30 MA MA28762A patent/MA27937A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP066335A (es) | 2006-07-28 |
| MXPA06001193A (es) | 2006-04-11 |
| CO5650247A2 (es) | 2006-06-30 |
| AR045143A1 (es) | 2005-10-19 |
| US7008953B2 (en) | 2006-03-07 |
| KR20060030914A (ko) | 2006-04-11 |
| EP1658284A1 (fr) | 2006-05-24 |
| MA27937A1 (fr) | 2006-06-01 |
| NL1026761A1 (nl) | 2005-02-01 |
| CA2532908A1 (fr) | 2005-02-03 |
| TNSN06038A1 (fr) | 2007-10-03 |
| US20060142345A1 (en) | 2006-06-29 |
| TW200521124A (en) | 2005-07-01 |
| EA200600123A1 (ru) | 2006-06-30 |
| JP3920914B2 (ja) | 2007-05-30 |
| PA8608201A1 (es) | 2005-03-03 |
| BRPI0413051A (pt) | 2006-10-17 |
| NL1026761C2 (nl) | 2005-10-18 |
| PE20050330A1 (es) | 2005-05-16 |
| US20050026960A1 (en) | 2005-02-03 |
| WO2005009997A1 (fr) | 2005-02-03 |
| AU2004259531A1 (en) | 2005-02-03 |
| JP2007500183A (ja) | 2007-01-11 |
| IS8214A (is) | 2005-12-30 |
| OA13196A (en) | 2006-12-13 |
| UY28442A1 (es) | 2005-02-28 |
| IL172924A0 (en) | 2006-06-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO20060319L (no) | 3,5-disubstituerte indazolforbindelser, farmasoytiske blandinger og fremgangsmater for a mediere eller inhibere celleproliferasjon | |
| WO2001053268A3 (fr) | Composes d'indazole, compositions pharmaceutiques, et methodes destines a la mediation ou a l'inhibition de la proliferation cellulaire | |
| TWI262914B (en) | Compounds and pharmaceutical compositions for inhibiting protein kinases | |
| AP1486A (en) | Indazole Compounds And Pharmaceutical Compositions For Inhibiting Protein Kinases, And Methods For Their Use. | |
| WO2003093297A3 (fr) | Modulateurs de proteine kinase et procedes d'utilisation | |
| EA200500811A1 (ru) | 2-(1h-индазол-6-иламино)бензамидные соединения как ингибиторы протеинкиназ, полезные для лечения офтальмологических заболеваний | |
| Chiusaroli et al. | Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis | |
| AP2001002341A0 (en) | Diaminothiazoles and their use for inhibiting protein kinases. | |
| WO2006120573A3 (fr) | N-oxydes heterocycliques utilises comme inhibiteurs de la proteine kinase lors d'une reduction selective dans un environnement hypoxique | |
| NO20045677L (no) | Inhibitorer av JAK- og CDK2-proteinkinaser | |
| BRPI0509172A (pt) | pelo menos uma entidade quìmica, composição farmacêutica, métodos para tratar um paciente, para inibir pelo menos uma enzima que utiliza atp, e para tratar pelo menos uma doença, uso de pelo menos uma entidade quìmica, e, método para a fabricação de um medicamento | |
| NO20073615L (no) | 3, 5-disubstituert og 3, 5, 7-trisubstituert-3H-oksazolo og 3H-tiazolo [4,5-d]pyrimidin-2-on forbindelser og prodrug derav | |
| DE60333387D1 (de) | Triazolopyridazine als proteinkinase-inhibitoren | |
| NO20052028L (no) | Pyridinderivater som CB2 reseptor modulatorer | |
| Cherdtrakulkiat et al. | Discovery of novel halogenated 8‐hydroxyquinoline‐based anti‐MRSA agents: In vitro and QSAR studies | |
| NO330888B1 (no) | Benzensylfonamidderivater, fremgangsmate for fremstilling av slike, terapeutisk preparatinneholdende slike samt anvendelse av slike for fremstilling av preparat for behandling av sykdom | |
| Abdalla et al. | Insight Study For Repurposing Of Certain Anti‐Inflammatory Drugs Based On Aspirin and Salicylic Acid Scaffolds For The Treatment of Cancer as CDKs Inhibitors: Cheminformatics and Anticancer Studies | |
| WO2006057945A3 (fr) | Derives pyridyle 2,3,4,6-substitues utiles comme inhibiteurs de la beta-secretase pour le traitement de la maladie d'alzheimer | |
| BR0314783A (pt) | Pirróis 3,4-dissubstituìdos e seu uso no tratamento de doenças inflamatórias | |
| Kursun Aktar et al. | Discovery of Novel Pyrrolidine-Based Chalcones as Dual Inhibitors of α-Amylase and α-Glucosidase: Synthesis, Molecular Docking, ADMET Profiles, and Pharmacological Screening | |
| BR0314180A (pt) | Aminoéteres substituìdos para o tratamento da doença de alzheimer | |
| DE602004019500D1 (en) | 4-substituirte-5-cyano-1h-pyrimidin-6-(th)iones als als gsk-3-hemmer | |
| Supuran | Human carbonic anhydrase inhibitors | |
| NO20030021D0 (no) | Heterosykliske forbindelser som er inhibitorer for enzymet DPP-IV | |
| NO20051444L (no) | Medikament inneholdende disorazoler og derivater av disse for behandling av benigne og maligne tumorsykdommer. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |