NO20056178L - CCI-779 lyofiliserte formuleringer - Google Patents
CCI-779 lyofiliserte formuleringerInfo
- Publication number
- NO20056178L NO20056178L NO20056178A NO20056178A NO20056178L NO 20056178 L NO20056178 L NO 20056178L NO 20056178 A NO20056178 A NO 20056178A NO 20056178 A NO20056178 A NO 20056178A NO 20056178 L NO20056178 L NO 20056178L
- Authority
- NO
- Norway
- Prior art keywords
- cci
- formulations
- lyophilized formulations
- lyophilized
- reconstituting
- Prior art date
Links
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title abstract 5
- 229960000235 temsirolimus Drugs 0.000 title abstract 5
- 238000009472 formulation Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49029303P | 2003-07-25 | 2003-07-25 | |
| PCT/US2004/023773 WO2005011688A1 (fr) | 2003-07-25 | 2004-07-15 | Formulations de cci-779 lyophilise |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20056178L true NO20056178L (no) | 2006-02-17 |
Family
ID=34115376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20056178A NO20056178L (no) | 2003-07-25 | 2005-12-23 | CCI-779 lyofiliserte formuleringer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20050020615A1 (fr) |
| EP (1) | EP1648454A1 (fr) |
| JP (1) | JP2007500191A (fr) |
| KR (1) | KR20060052880A (fr) |
| CN (1) | CN1829514A (fr) |
| AR (1) | AR045094A1 (fr) |
| AU (1) | AU2004261163A1 (fr) |
| BR (1) | BRPI0412916A (fr) |
| CA (1) | CA2532251A1 (fr) |
| CO (1) | CO5680425A2 (fr) |
| CR (1) | CR8153A (fr) |
| EC (1) | ECSP066394A (fr) |
| IL (1) | IL172573A0 (fr) |
| MX (1) | MXPA05013865A (fr) |
| NO (1) | NO20056178L (fr) |
| RU (1) | RU2345772C2 (fr) |
| SG (1) | SG144165A1 (fr) |
| TW (1) | TW200505501A (fr) |
| WO (1) | WO2005011688A1 (fr) |
| ZA (1) | ZA200600684B (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI307277B (en) * | 2002-07-30 | 2009-03-11 | Wyeth Corp | Parenteral formulations |
| BRPI0418373A (pt) * | 2004-01-08 | 2007-05-22 | Wyeth Corp | composição farmacêutica, unidade de dosagem de cci-779 oral, método de fornecimento de cci-779 a um paciente, e, uso de cci-779 micronizado |
| DE602005024012D1 (de) | 2004-08-27 | 2010-11-18 | Cordis Corp | Lösungsmittelfreies amorphes rapamycin |
| US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| US7464012B2 (en) * | 2004-12-10 | 2008-12-09 | L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude | Simplified process simulator |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| US8158152B2 (en) | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| EP2326306A1 (fr) * | 2008-09-25 | 2011-06-01 | Cephalon, Inc. | Formulations liquides de bendamustine |
| CN102281877B (zh) * | 2009-01-15 | 2014-07-23 | 赛福伦公司 | 苯达莫司汀的游离碱形式 |
| JP2013527223A (ja) * | 2010-06-02 | 2013-06-27 | フレゼニウス・カビ・オンコロジー・リミテッド | ラパマイシンエステルの安定な医薬組成物 |
| US9872873B2 (en) | 2012-02-06 | 2018-01-23 | Fresenius Kabi Oncology Limited | Process for preparing stable pharmaceutical compositions of compounds susceptible to hydrolysis |
| CN102940630A (zh) * | 2012-11-16 | 2013-02-27 | 浙江海正药业股份有限公司 | 含有西罗莫司酯化物的药物组合物及其制备方法 |
| WO2014118696A2 (fr) * | 2013-01-29 | 2014-08-07 | Gland Pharma Limited | Compositions pharmaceutiques d'esters de rapamycine et de leurs dérivés |
| US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
| CN104510708B (zh) * | 2013-09-29 | 2018-04-24 | 正大天晴药业集团股份有限公司 | 一种米铂冻干制剂及其制备方法 |
| US10342769B2 (en) | 2014-11-14 | 2019-07-09 | Navinta Iii Inc | Carmustine pharmaceutical composition |
| WO2017129772A1 (fr) | 2016-01-29 | 2017-08-03 | Xellia Phamaceuticals Aps | Compositions pharmaceutiques stables de temsirolimus |
| CN105687132B (zh) * | 2016-03-17 | 2020-06-12 | 鲁南贝特制药有限公司 | 一种坦西莫司注射用浓溶液及其制备方法 |
| CN107773539A (zh) * | 2016-08-27 | 2018-03-09 | 鲁南制药集团股份有限公司 | 一种注射用坦西莫司及其制备方法 |
| CN111165656A (zh) * | 2020-01-09 | 2020-05-19 | 南京大学(溧水)生态环境研究院 | 一种黑水虻冻干粉高效制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1204775B (it) * | 1986-01-31 | 1989-03-10 | Rosella Silvestrini | Kit per la determinazione dell'attivita' proliferativa nei tumori umani |
| US5352783A (en) * | 1993-06-09 | 1994-10-04 | Merck & Co., Inc. | Microbial transformation product having immunosuppressive activity |
| US5362735A (en) * | 1994-02-23 | 1994-11-08 | Smithkline Beecham Corporation | Rapamycin derivatives |
| US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| CZ292233B6 (cs) * | 1995-06-09 | 2003-08-13 | Novartis Ag | Deriváty rapamycinu a jejich použití jako léčiv |
| GB9514594D0 (en) * | 1995-07-17 | 1995-09-13 | Johnson & Johnson Clin Diag | Chemiluminescent analytical method |
| US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| DE19936281C2 (de) * | 1999-08-02 | 2002-04-04 | Bayer Ag | Verfahren zur Gefriertrocknung |
| US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
| GB0008785D0 (en) * | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| WO2002013802A2 (fr) * | 2000-08-11 | 2002-02-21 | Wyeth | Procede de traitement d'un carcinome a recepteur d'oestrogene |
| US6399625B1 (en) * | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
| TWI286074B (en) * | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
| TWI307277B (en) * | 2002-07-30 | 2009-03-11 | Wyeth Corp | Parenteral formulations |
| US20040077677A1 (en) * | 2002-09-17 | 2004-04-22 | Wyeth | Oral formulations |
| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
-
2004
- 2004-07-15 RU RU2006105645/15A patent/RU2345772C2/ru not_active IP Right Cessation
- 2004-07-15 KR KR1020067001674A patent/KR20060052880A/ko not_active Withdrawn
- 2004-07-15 SG SG200804938-9A patent/SG144165A1/en unknown
- 2004-07-15 MX MXPA05013865A patent/MXPA05013865A/es unknown
- 2004-07-15 EP EP04757242A patent/EP1648454A1/fr not_active Withdrawn
- 2004-07-15 BR BRPI0412916-4A patent/BRPI0412916A/pt not_active IP Right Cessation
- 2004-07-15 CA CA002532251A patent/CA2532251A1/fr not_active Abandoned
- 2004-07-15 WO PCT/US2004/023773 patent/WO2005011688A1/fr not_active Ceased
- 2004-07-15 AU AU2004261163A patent/AU2004261163A1/en not_active Withdrawn
- 2004-07-15 JP JP2006521942A patent/JP2007500191A/ja not_active Withdrawn
- 2004-07-15 CN CNA2004800214503A patent/CN1829514A/zh active Pending
- 2004-07-19 US US10/894,210 patent/US20050020615A1/en not_active Abandoned
- 2004-07-23 TW TW093121997A patent/TW200505501A/zh unknown
- 2004-07-23 AR ARP040102625A patent/AR045094A1/es unknown
-
2005
- 2005-12-14 IL IL172573A patent/IL172573A0/en unknown
- 2005-12-15 CR CR8153A patent/CR8153A/es not_active Application Discontinuation
- 2005-12-23 NO NO20056178A patent/NO20056178L/no not_active Application Discontinuation
-
2006
- 2006-01-24 ZA ZA200600684A patent/ZA200600684B/en unknown
- 2006-02-22 CO CO06017792A patent/CO5680425A2/es unknown
- 2006-02-24 EC EC2006006394A patent/ECSP066394A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2345772C2 (ru) | 2009-02-10 |
| BRPI0412916A (pt) | 2006-09-26 |
| CR8153A (es) | 2006-05-26 |
| AU2004261163A1 (en) | 2005-02-10 |
| CO5680425A2 (es) | 2006-09-29 |
| CA2532251A1 (fr) | 2005-02-10 |
| AR045094A1 (es) | 2005-10-12 |
| JP2007500191A (ja) | 2007-01-11 |
| RU2006105645A (ru) | 2006-06-27 |
| CN1829514A (zh) | 2006-09-06 |
| SG144165A1 (en) | 2008-07-29 |
| KR20060052880A (ko) | 2006-05-19 |
| IL172573A0 (en) | 2006-04-10 |
| ZA200600684B (en) | 2008-07-30 |
| TW200505501A (en) | 2005-02-16 |
| EP1648454A1 (fr) | 2006-04-26 |
| ECSP066394A (es) | 2006-08-30 |
| WO2005011688A1 (fr) | 2005-02-10 |
| MXPA05013865A (es) | 2006-02-28 |
| US20050020615A1 (en) | 2005-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |