[go: up one dir, main page]

NO20056104L - Forbindelser, formuleringer og fremgangsmater for behandling eller forebygging av rosacea - Google Patents

Forbindelser, formuleringer og fremgangsmater for behandling eller forebygging av rosacea

Info

Publication number
NO20056104L
NO20056104L NO20056104A NO20056104A NO20056104L NO 20056104 L NO20056104 L NO 20056104L NO 20056104 A NO20056104 A NO 20056104A NO 20056104 A NO20056104 A NO 20056104A NO 20056104 L NO20056104 L NO 20056104L
Authority
NO
Norway
Prior art keywords
independently hydrogen
alkyl
compounds
alkoxy
methods
Prior art date
Application number
NO20056104A
Other languages
English (en)
Other versions
NO333468B1 (no
Inventor
Jack Dejovin
Thomas M Rossi
Original Assignee
Sansrosa Pharmaceutical Dev In
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33457481&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20056104(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sansrosa Pharmaceutical Dev In filed Critical Sansrosa Pharmaceutical Dev In
Publication of NO20056104L publication Critical patent/NO20056104L/no
Publication of NO333468B1 publication Critical patent/NO333468B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

I fremgangsmåter, forbindelser og topiske formuleringer for behandling av rosacea som inkorporerer forbindelser representert ved formlene (I) - (III) nedenfor: der hver av Ri, R2 og R3 er uavhengig hydrogen, halogen, alkyl eller alkoksy; hver av R4 og R5 er uavhengig hydrogen, alkyl eller alkoksy; og hver av Re og R7 er uavhengig hydrogen, nitro, alkyl eller alkoksy; der hver av Ai, A3 og A4 er uavhengig hydrogen eller alkyl; og A2 er uavhengig hydrogen eller hydroksy; og der hver av Bi, B2 og B3 er uavhengig hydrogen, hydroksy eller alkoksy; og hver av B4 og B5 er uavhengig hydrogen eller alkyl, og påføre slike forbindelser topisk som sprayer, tåker, aerosoler, løsninger, lotion, geler, kremer, salver, pastaer, balsamer, emulsjoner og suspensjoner for å behandle rosacea og dens symptomer.
NO20056104A 2003-05-27 2005-12-21 Anvendelse av en sammensetning for behandling eller forebygging av rosacea samt topisk sammensetning NO333468B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47361103P 2003-05-27 2003-05-27
US10/853,585 US7439241B2 (en) 2003-05-27 2004-05-25 Compounds, formulations, and methods for treating or preventing rosacea
PCT/US2004/016799 WO2004105703A2 (en) 2003-05-27 2004-05-26 Compounds, formulations, and methods for treating or preventing rosacea

Publications (2)

Publication Number Publication Date
NO20056104L true NO20056104L (no) 2006-02-03
NO333468B1 NO333468B1 (no) 2013-06-17

Family

ID=33457481

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20056104A NO333468B1 (no) 2003-05-27 2005-12-21 Anvendelse av en sammensetning for behandling eller forebygging av rosacea samt topisk sammensetning

Country Status (22)

Country Link
US (13) US7439241B2 (no)
EP (3) EP2388007B1 (no)
CN (4) CN1829518B (no)
AT (1) ATE530185T1 (no)
AU (1) AU2004242967C1 (no)
CA (1) CA2530938C (no)
CY (3) CY1112242T1 (no)
DK (3) DK2388007T3 (no)
ES (3) ES2376172T5 (no)
FR (1) FR14C0056I2 (no)
HR (1) HRP20150957T1 (no)
HU (3) HUE027616T2 (no)
IL (1) IL172612A (no)
LT (1) LT2815748T (no)
LU (1) LU92462I2 (no)
MX (1) MXPA05014107A (no)
NO (1) NO333468B1 (no)
NZ (1) NZ544300A (no)
PL (3) PL2815748T3 (no)
PT (3) PT1631293E (no)
SI (3) SI2388007T1 (no)
WO (1) WO2004105703A2 (no)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
US8410102B2 (en) * 2003-05-27 2013-04-02 Galderma Laboratories Inc. Methods and compositions for treating or preventing erythema
US7439241B2 (en) * 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
US20050020600A1 (en) * 2003-07-23 2005-01-27 Scherer Warren J. Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
CN101426502A (zh) * 2004-05-25 2009-05-06 桑斯罗萨医药发展公司 治疗或预防炎症性皮肤疾病的化合物、制剂及方法
EP1846007A1 (en) * 2005-01-31 2007-10-24 Robert D. Kross Skin-protective polymer for use in teat care compositions
DE202005002183U1 (de) 2005-02-04 2005-04-14 Beiersdorf Ag Hautverwöhnende Cremelotion
MX2007012101A (es) * 2005-03-30 2007-12-04 Revance Therapeutics Inc Composiciones y metodos para tratar acne.
CN101198362B (zh) 2005-06-17 2014-03-12 威斯康星校友研究基金会 在癌症化疗和放疗时保护细胞的局部血管收缩剂制品和方法
WO2007002447A2 (en) * 2005-06-23 2007-01-04 Bioform Medical, Inc. Compositions for treating rosacea
FR2894474B1 (fr) * 2005-12-12 2008-04-11 Galderma Res & Dev Gel depigmentant hydroalcoolique
WO2008144399A1 (en) * 2007-05-18 2008-11-27 Bausch & Lomb Incorporated COMPLEXES COMPRISING α2-ADRENERGIC RECEPTOR AGONISTS AND COMPOSITIONS
ES2463717T3 (es) 2007-07-27 2014-05-29 Galderma Laboratories Inc. Compuestos, formulaciones, y métodos para reducir las arrugas, pliegues y flacidez de la piel
US20090061020A1 (en) * 2007-08-31 2009-03-05 Theobald Klaus P Brimonidine Compositions for Treating Erythema
CA2703109C (en) 2007-11-16 2017-07-18 Vicept Therapeutics, Inc. Compositions and methods for treating purpura
EP2230910A4 (en) * 2007-12-21 2011-04-13 Galderma Lab Inc PRE-SURGICAL TREATMENT
IE20070935A1 (en) * 2007-12-21 2009-06-24 Trinity College Dublin Guanidine based compounds and their use in the treatment of mental and neurological disorders.
US20100197694A1 (en) * 2008-08-01 2010-08-05 Gerald Horn Compositions and methods for treatment of diseases and conditions with increased vascular permeability
US8338421B2 (en) 2008-08-01 2012-12-25 Alpha Synergy Development, Inc. Compositions and methods for reversing rebound hyperemia
US12246013B2 (en) 2008-08-01 2025-03-11 Eye Therapies Llc Vasoconstriction compositions and methods of use
CA2750636C (en) * 2009-01-23 2017-07-25 Jr Chem, Llc Rosacea treatments and kits for performing them
FR2942138A1 (fr) 2009-02-16 2010-08-20 Galderma Res & Dev Association de composes pour le traitement ou la prevention des affections dermatologiques
US20110021588A1 (en) * 2009-05-15 2011-01-27 Recro Pharma, Inc. Sublingual dexmeditomidine compositions and methods of use thereof
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
WO2010136594A2 (en) * 2009-05-29 2010-12-02 Symatese Injectable combination of adrenergic receptor agonists with fillers, for decreasing skin reactions due to injection
EP2493309A4 (en) * 2009-10-26 2013-05-01 Galderma Pharma Sa METHODS OF TREATING OR PREVENTING ACUTE ERYTHEMA
EP2329849B1 (en) * 2009-11-18 2015-04-29 Galderma Research & Development Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder
US8394800B2 (en) 2009-11-19 2013-03-12 Galderma Laboratories, L.P. Method for treating psoriasis
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
KR20150055082A (ko) * 2010-03-26 2015-05-20 갈데르마 리써어치 앤드 디벨로프먼트 홍반의 유효하고 안전한 치료를 위한 개선된 방법 및 조성물
CN103096894A (zh) * 2010-03-26 2013-05-08 盖尔德马研究及发展公司 用于治疗红斑的包含溴莫尼定的组合物
RU2587041C2 (ru) * 2010-06-30 2016-06-10 Галдерма Ресерч Энд Девелопмент Способ предотвращения или лечения опухоли кожи
EP2595616B1 (en) 2010-06-30 2016-04-13 Galderma Research & Development Use of alpha-adrenergic receptor agonist for preventing or treating skin tumor
EP2600832A1 (en) * 2010-08-06 2013-06-12 Galderma Research & Development Combination of compounds for treating or preventing skin diseases
US8492557B2 (en) * 2010-09-16 2013-07-23 Allergan, Inc. Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol
US20120076738A1 (en) * 2010-09-28 2012-03-29 Michael Graeber Combination treatment for dermatological conditions
US20120082625A1 (en) * 2010-09-28 2012-04-05 Michael Graeber Combination treatment for rosacea
AR083651A1 (es) * 2010-10-21 2013-03-13 Galderma Sa Composiciones de brimonidina en gel y metodos de uso
CA2814975A1 (en) * 2010-10-21 2012-04-26 Galderma S.A. Topical gel composition
FR2966366B1 (fr) * 2010-10-21 2012-11-09 Galderma Sa Composition de gel de brimonidine
FR2966365B1 (fr) * 2010-10-21 2012-11-09 Galderma Sa Composition de gel topique
US8053427B1 (en) 2010-10-21 2011-11-08 Galderma R&D SNC Brimonidine gel composition
MX340859B (es) * 2010-11-16 2016-07-28 Allergan Inc Composiciones farmaceuticas que comprenden (3-(1-(1h-imidazol-4-il )etil)-2-metilfenil)metanol.
PT2645993T (pt) * 2010-12-03 2017-03-03 Allergan Inc Composições de creme farmacêutico compreendendo oximetazolina
BR112013015572A2 (pt) 2010-12-20 2016-09-27 Colgate Palmolive Co composição para cuidado oral de gelatina encapsulada contendo hidrofílico ativo, agente de estruturação hidrofóbico e transportador de óleo
WO2012083397A1 (en) 2010-12-22 2012-06-28 Silvestre Labs Químia E Farmaceutica Ltda. Guanabenz-containing compound for the treatment of primary cutaneous amyloidosis
ES2742273T3 (es) * 2011-02-15 2020-02-13 Aclaris Therapeutics Inc Composiciones de crema farmacéuticas de oximetazolina para tratar los síntomas de la rosácea
CN102260608B (zh) * 2011-06-23 2012-07-04 江苏安惠生物科技有限公司 灵芝肥皂及其制备方法
WO2013010032A1 (en) * 2011-07-14 2013-01-17 Allergan, Inc. Gel compositions of oxymetazoline and methods of use
WO2013016072A1 (en) * 2011-07-22 2013-01-31 Allergan, Inc. Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating skin diseases
WO2013052770A1 (en) 2011-10-05 2013-04-11 Sanders Jennifer L Methods and compositions for treating foot or hand pain
KR20140091543A (ko) 2011-10-19 2014-07-21 갈데르마 소시에떼아노님 전신용인 포스포디에스터레이즈타입-5-억제제에 의한 안면홍조를 경감시키는 방법
RU2014119919A (ru) 2011-10-19 2015-11-27 Галдерма С.А. Способ лечения капиллярных гемангиом
UA109359C2 (xx) * 2011-11-10 2015-08-10 Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном
US9283217B2 (en) 2011-11-10 2016-03-15 Allergan, Inc. Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions
CA2856507C (en) 2011-11-21 2017-03-21 Allergan, Inc. Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases
EP2787970B1 (en) 2011-12-11 2018-04-11 Recro Pharma, Inc. Intranasal dexmedetomidine compositions and methods of use thereof
WO2013115844A1 (en) * 2012-02-02 2013-08-08 Alpha Synergy Development, Inc. Compositions and methods for treatment of glaucoma
FR3000397A1 (fr) 2012-12-31 2014-07-04 Galderma Res & Dev Combinaison de laropiprant et d'ivermectine pour le traitement de la rosacee
FR3000398A1 (fr) * 2012-12-31 2014-07-04 Galderma Res & Dev Combinaison de laropiprant et de brimonidine pour le traitement de la rosacee
AU2013201465B2 (en) 2012-10-24 2016-03-03 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection
MD20150056A2 (ro) * 2012-12-24 2015-09-30 Ramot At Tel-Aviv University Ltd Agenţi pentru tratarea bolilor genetice cauzate de mutaţii nonsens şi metode de identificare a acestora
US9861645B2 (en) 2012-12-28 2018-01-09 Rak Holdings Llc Anti-itch scalp treatment compositions and combinations
BR112015027984A2 (pt) 2013-05-06 2017-09-05 Allergan Inc Agonistas alfa adrenérgicos para o tratamento de lesão de tecido
KR20160055794A (ko) * 2013-07-26 2016-05-18 갈데르마 리서치 & 디벨로프먼트 피부 비후의 치료용 조성물
RU2018105761A (ru) 2013-10-07 2019-02-26 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Устройства для трансдермальной доставки дексмедетомидина и способы их применения
TWI629067B (zh) 2013-10-07 2018-07-11 美商帝國製藥美國股份有限公司 用於經皮輸送非鎮靜量右美托咪啶之方法及組成物
CN106456561B (zh) 2013-10-07 2020-02-28 帝国制药美国公司 使用右旋美托咪啶经皮组合物治疗注意力缺陷多动症、焦虑症和失眠症的方法和组合物
FR3015288B1 (fr) 2013-12-19 2016-02-12 Galderma Res & Dev Utilsation du naratriptan dans le traitement de la rosacee
AU2015274532B2 (en) 2014-06-11 2020-06-11 Epi Health, Llc Stabilized oxymetazoline formulations and their uses
US20150374686A1 (en) 2014-06-30 2015-12-31 Galderma S.A. Methods of Treating Flushing Associated with Carcinoid Tumors and Carcinoid Syndrome
RU2560698C1 (ru) * 2014-08-15 2015-08-20 Общество с ограниченной ответственностью "Уральский медико-химический центр" (ООО "УМХЦ") Средство наружной терапии больных акне
US9351945B1 (en) * 2015-02-27 2016-05-31 John Daniel Dobak, III Reduction of adipose tissue
EP3319607A4 (en) 2015-07-09 2019-04-03 Galderma S.A. METHOD FOR REDUCING HAIR LOSS IN CONNECTION WITH CHEMOTHERAPY
FR3041537B1 (fr) * 2015-09-29 2018-11-30 Galderma Research & Development Mousse chimique non rincee contenant de la brimonidine et son utilisation dans le traitement de la rosacee.
WO2017085226A1 (en) * 2015-11-17 2017-05-26 Galderma Sa Use of ivermectin and brimonidine in the treatment and/or prevention of moderate to severe rosacea
EP3434271B1 (en) * 2016-03-22 2020-08-26 Doris Maria Hexsel Use of pharmaceutical composition for the treatment of poikiloderma of civatte
EP3476393A4 (en) * 2016-06-28 2019-07-17 Doris Maria Hexsel USE OF AN ACTIVE AGENT FOR THE TREATMENT OF TELANGIEKTATISCHEM MELASMA
CA3038354C (en) 2016-10-31 2021-08-17 Teikoku Pharma Usa, Inc. Methods of managing pain using dexmedetomidine transdermal delivery devices
CN109265448B (zh) * 2018-11-15 2020-09-15 三峡大学 一类含叔丁基的n-咪唑乙酰基二氢喹喔啉类衍生物，合成方法及其作为杀菌剂上的应用
CA3130439A1 (en) * 2019-02-19 2020-08-27 Sol-Gel Technologies Ltd. Method for treatment of rosacea in patients aged 65 years and older
CN113784712A (zh) 2019-05-01 2021-12-10 克雷西奥生物科技有限公司 治疗瘙痒的方法
WO2020222192A1 (en) 2019-05-01 2020-11-05 Clexio Biosciences Ltd. Methods of treating pruritus
AU2021334325A1 (en) * 2020-08-26 2023-03-02 Oticara, Inc. Compositions devices and methods for treating nasal, otic and other tissue infection and/or inflammation
RU2766973C1 (ru) * 2021-10-05 2022-03-16 Татьяна Сергеевна Русина Способ сочетанной терапии розацеа эритематозно-телеангэктатического подтипа
WO2023130086A1 (en) * 2021-12-31 2023-07-06 Jss Research, Llc Compositions and methods for topical treatment of vascular conditions

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278447A (en) 1963-12-02 1966-10-11 Cloro Bac Products Inc Process for stabilizing chlorine dioxide solution
US3560501A (en) * 1966-09-15 1971-02-02 Ciba Geigy Corp Process for making dihydroquinazolines
BG16042A3 (bg) * 1968-11-12 1972-05-20 Nans Ott Метод за получаване на нови 2(1н)-хиназолинони
US3594380A (en) * 1969-02-18 1971-07-20 American Home Prod Isoquinolin-1(2h)-ones
BE766039A (fr) * 1971-04-21 1971-09-16 Labofina Sa Nouveaux polymeres contenant des unites de pyrazole et procede de preparation de ces polymeres.
US3740442A (en) * 1972-01-14 1973-06-19 Sandoz Ag 2-isopropylaminobenzophenones in treating inflammation
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
BE795970A (fr) 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US4164570A (en) * 1973-09-24 1979-08-14 David Clough Stabilized aqueous catecholamine solutions
US4201211A (en) * 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4285967A (en) * 1978-06-30 1981-08-25 Estee Lauder Inc. Cosmetic preparation for reducing redness of blemishes
US4254145A (en) * 1978-08-16 1981-03-03 American Cyanamid Company Topical application of prostaglandin hypotensive agents
US4256763A (en) * 1978-09-19 1981-03-17 Mchugh John E Treatment of herpes simplex infections and acne
DE2924005C2 (de) * 1979-06-13 1984-07-05 Sanol Schwarz-Monheim Gmbh, 4019 Monheim Isosorbiddinitrat enthaltendes Mittel
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4908387A (en) 1988-06-06 1990-03-13 The Regents Of The University Of California Use of beta2 antagonists in the treatment of inflammatory diseases, in particular, rheumatoid arthritis
CA2003198C (en) * 1988-11-29 1995-03-21 Anthony J. Dziabo, Jr. Aqueous ophthalmic solutions and method for preserving same
US5204347A (en) * 1989-10-12 1993-04-20 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines
US5112822A (en) * 1989-10-12 1992-05-12 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5198442A (en) * 1989-10-12 1993-03-30 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5326763A (en) * 1989-10-12 1994-07-05 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5077292A (en) * 1989-10-12 1991-12-31 Allergan, Inc. (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same
US5021416A (en) * 1989-10-31 1991-06-04 Allergan, Inc. Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
US5237072A (en) * 1990-02-06 1993-08-17 Allergan, Inc. Method for producing amino-2-imidazoline derivatives
US5130441A (en) * 1990-02-06 1992-07-14 Allergan, Inc. Method for producing amino-2-imidazoline derivatives
US5721237A (en) * 1991-05-10 1998-02-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
US5326566A (en) * 1991-05-17 1994-07-05 Bristol-Myers Squibb Company Use of dibutyl adipate and isopropyl myristate in topical and transdermal products
IT1248014B (it) * 1991-06-07 1995-01-05 Inverni Della Beffa Spa Preparazioni oftalmiche a rilascio protratto
US5292517A (en) * 1992-02-25 1994-03-08 Allergan, Inc. pH sensitive, reversible gelling, copolymeric erodible drug delivery system
US5736165A (en) * 1993-05-25 1998-04-07 Allergan In-the-eye use of chlorine dioxide-containing compositions
US6323204B1 (en) * 1993-10-13 2001-11-27 Allergan Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
DE69431880T2 (de) * 1993-10-13 2003-09-18 Allergan, Inc. Verwendung von (2-imidazolin-2-yl-amino) quinoxalinderivaten
US6117871A (en) * 1993-12-17 2000-09-12 The Procter & Gamble Company 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists
US6350781B1 (en) * 1994-01-14 2002-02-26 Lee Shahinia, Jr. Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine
WO1996013267A2 (en) 1994-10-27 1996-05-09 Allergan Combinations of prostaglandins and brimonidine or derivatives thereof for the treatment of glaucoma
US5693646A (en) * 1994-12-22 1997-12-02 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
WO1996025163A1 (en) 1995-02-14 1996-08-22 Board Of Supervisors Or Louisiana State Universityof Agricultural And Mechanical College Through Itsmedical Center Treatment of herpes simplex viruses
US5620416A (en) * 1995-06-07 1997-04-15 North Carolina State University Methods of using topical agents with systemically administered active agents
US6194415B1 (en) * 1995-06-28 2001-02-27 Allergan Sales, Inc. Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury
US5720962A (en) * 1995-10-04 1998-02-24 Au Pharmaceuticals, Inc. Analgesic lotion for hemorrhoids and method of making such lotion
US6441047B2 (en) * 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
US5910312A (en) * 1996-10-09 1999-06-08 Ideal Ideas, Inc. Acne treatment composition with vasoconstrictor
US5916574A (en) * 1996-10-09 1999-06-29 Ideal Ideas, Inc. Method of treating natural poison skin conditions
US5753637A (en) * 1996-10-09 1998-05-19 Ideal Ideas, Inc. Method of treating acne conditions
JP2001512471A (ja) 1997-02-21 2001-08-21 バイヤースドルフ・アクチエンゲゼルシヤフト しゅさの処置のための調製物
ATE297755T1 (de) * 1997-04-10 2005-07-15 Agennix Inc Verwendung von lactoferrin in der behandlung von beschwerden, die von allergenen verursacht sind
JPH1129482A (ja) 1997-05-14 1999-02-02 Taisho Pharmaceut Co Ltd 医薬組成物
US6513247B1 (en) * 1997-05-29 2003-02-04 Ariel Krasik-Geiger Calibrated angle and depth scissors
US6159944A (en) * 1998-02-27 2000-12-12 Synchroneuron, Llc Method for treating painful conditions of the anal region and compositions therefor
US6432934B1 (en) * 1998-08-06 2002-08-13 Advanced Vision Research Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease
AR020660A1 (es) 1998-09-30 2002-05-22 Alcon Lab Inc Composiciones antibioticas para el tratamiento de ojos, oidos y nariz
US20030087962A1 (en) 1998-10-20 2003-05-08 Omeros Corporation Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
WO2004073708A1 (en) * 1998-12-17 2004-09-02 Dean Thomas R Brinzolamide and brimonidine for treating ocular conditions
US6258350B1 (en) * 1999-01-20 2001-07-10 Alcon Manufacturing, Ltd. Sustained release ophthalmic formulation
IN185228B (no) 1999-02-03 2000-12-09 Bakulesh Mafatlal Dr Khamar
US20020197300A1 (en) 1999-02-22 2002-12-26 Schultz Clyde L. Drug delivery system for anti-glaucomatous medication
AU5331200A (en) 1999-06-11 2001-01-02 Ohio State University Research Foundation, The Methods and compositions for treating raynaud's phenomenon and scleroderma
US6340681B1 (en) 1999-07-16 2002-01-22 Pfizer Inc 2-benzimidazolylamine compounds as ORL-1-receptor agonists
US6147102A (en) * 1999-10-26 2000-11-14 Curatek Pharmaceuticals Holding, Inc. Clonidine preparations
US20030077301A1 (en) * 1999-12-16 2003-04-24 Maibach Howard I. Topical pharmaceutical composition for the treatment of inflammatory dermatoses
PL357555A1 (en) * 2000-01-31 2004-07-26 Pfizer Products Inc. Pyrimidine carboxamides useful as inhibitors of pde4 isozymes
US6294553B1 (en) * 2000-02-15 2001-09-25 Allergan Sales, Inc. Method for treating ocular pain
US6284765B1 (en) * 2000-04-27 2001-09-04 The University Of North Texas Health Science Center At Fort Worth (+) naloxone and epinephrine combination therapy
US6444681B1 (en) * 2000-06-09 2002-09-03 The Ohio State University Research Foundation Methods and compositions for treating Raynaud's Phenomenon and scleroderma
US6468989B1 (en) 2000-07-13 2002-10-22 Dow Pharmaceutical Sciences Gel compositions containing metronidazole
KR100757656B1 (ko) 2000-07-14 2007-09-10 알레간 인코포레이티드 알파 2-아드레날린 작용제 성분을 함유하는 조성물
US6387383B1 (en) 2000-08-03 2002-05-14 Dow Pharmaceutical Sciences Topical low-viscosity gel composition
CA2427731A1 (en) 2000-10-30 2002-05-10 University Of Zurich Gnrh analogues for treatment of urinary incontinence
US7211267B2 (en) 2001-04-05 2007-05-01 Collagenex Pharmaceuticals, Inc. Methods of treating acne
MXPA03009995A (es) * 2001-05-09 2004-06-30 Univ Michigan Uso de composiciones para tratar rosacea.
TNSN02063A1 (en) * 2001-07-07 2005-12-23 Egyptian Natural Oil Co Natoil The medical effect of jojoba oil
US7115724B2 (en) * 2001-08-22 2006-10-03 Wyeth Murine genomic polynucleotide sequence encoding a G-protein coupled receptor and methods of use therefor
US7704530B2 (en) * 2001-09-14 2010-04-27 Kenji Nakamura Antimicrobially treated material and methods of preventing coloring thereof
US6680062B2 (en) * 2001-10-05 2004-01-20 Color Access, Inc. Anti-irritating rosacea treatment
US7345065B2 (en) * 2002-05-21 2008-03-18 Allergan, Inc. Methods and compositions for alleviating pain
US20040266776A1 (en) * 2003-06-25 2004-12-30 Gil Daniel W. Methods of preventing and reducing the severity of stress-associated conditions
US20040092482A1 (en) * 2002-11-07 2004-05-13 Gupta Shyam K. Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions
US20040156873A1 (en) * 2003-02-10 2004-08-12 Gupta Shyam K. Topically Bioavailable Acne and Rosacea Treatment Compositions
US20040220259A1 (en) * 2003-04-04 2004-11-04 Yu Ruey J. Topical treatment of dermatological disorders associated with reactive or dilated blood vessels
US20040254252A1 (en) * 2003-05-15 2004-12-16 Engles Charles R. Compositions containing a combination of a pharmaceutical agent or a cosmetic agent and an oxy group-bearing aromatic aldehyde and their use in treatments
US7439241B2 (en) * 2003-05-27 2008-10-21 Galderma Laboratories, Inc. Compounds, formulations, and methods for treating or preventing rosacea
US8410102B2 (en) * 2003-05-27 2013-04-02 Galderma Laboratories Inc. Methods and compositions for treating or preventing erythema
US20050020600A1 (en) * 2003-07-23 2005-01-27 Scherer Warren J. Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists
FR2862537B1 (fr) * 2003-11-21 2006-03-03 Galderma Res & Dev Utilisation du fepradinol pour la preparation d'une composition pharmaceutique pour le traitement de la rosacee
US7812049B2 (en) * 2004-01-22 2010-10-12 Vicept Therapeutics, Inc. Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists
CN101426502A (zh) * 2004-05-25 2009-05-06 桑斯罗萨医药发展公司 治疗或预防炎症性皮肤疾病的化合物、制剂及方法
AU2007219040B2 (en) * 2006-02-20 2012-01-19 Commonwealth Scientific And Industrial Research Organisation Method and composition for priming wood and natural fibres
AU2008251836A1 (en) * 2007-05-09 2008-11-20 Salutria Pharmaceuticals, Llc Spiro compounds for treatment of inflammatory disorders
US20090061020A1 (en) * 2007-08-31 2009-03-05 Theobald Klaus P Brimonidine Compositions for Treating Erythema
US8394800B2 (en) * 2009-11-19 2013-03-12 Galderma Laboratories, L.P. Method for treating psoriasis
KR20150055082A (ko) * 2010-03-26 2015-05-20 갈데르마 리써어치 앤드 디벨로프먼트 홍반의 유효하고 안전한 치료를 위한 개선된 방법 및 조성물
US8053427B1 (en) * 2010-10-21 2011-11-08 Galderma R&D SNC Brimonidine gel composition

Also Published As

Publication number Publication date
CN1829518A (zh) 2006-09-06
LU92462I2 (fr) 2015-11-02
PL2388007T3 (pl) 2016-01-29
EP2815748A1 (en) 2014-12-24
EP2815748B1 (en) 2020-08-05
US20100021402A1 (en) 2010-01-28
WO2004105703A2 (en) 2004-12-09
PT2388007E (pt) 2015-10-14
HK1164126A1 (en) 2012-09-21
US20170216282A1 (en) 2017-08-03
IL172612A (en) 2013-03-24
CY2014028I2 (el) 2015-12-09
EP2388007B1 (en) 2015-06-24
HRP20150957T1 (hr) 2015-11-20
US20150202202A1 (en) 2015-07-23
FR14C0056I1 (no) 2014-08-22
SI1631293T1 (sl) 2012-02-29
DK1631293T4 (en) 2015-01-12
CN101380321B (zh) 2013-03-27
AU2004242967C1 (en) 2015-12-24
US20040242588A1 (en) 2004-12-02
AU2004242967A1 (en) 2004-12-09
EP1631293B1 (en) 2011-10-26
US20130172359A1 (en) 2013-07-04
CY1112242T1 (el) 2015-12-09
EP2388007A1 (en) 2011-11-23
US8993571B2 (en) 2015-03-31
LT2815748T (lt) 2020-11-25
PL2815748T3 (pl) 2020-11-16
SI2815748T1 (sl) 2020-11-30
US7838563B2 (en) 2010-11-23
CN101816793B (zh) 2012-08-15
HUS1400029I1 (hu) 2017-10-30
US20130172358A1 (en) 2013-07-04
CN101816793A (zh) 2010-09-01
EP1631293A4 (en) 2009-05-06
ES2376172T3 (es) 2012-03-09
CY1123393T1 (el) 2021-12-31
DK2388007T3 (en) 2015-09-28
WO2004105703A3 (en) 2005-03-17
PT2815748T (pt) 2020-08-31
US20060264515A1 (en) 2006-11-23
PL1631293T5 (pl) 2015-04-30
US8859551B2 (en) 2014-10-14
FR14C0056I2 (fr) 2016-12-23
HK1084591A1 (en) 2006-08-04
HK1204996A1 (en) 2015-12-11
DK1631293T3 (da) 2012-02-13
US8557817B2 (en) 2013-10-15
PL1631293T3 (pl) 2012-03-30
US20100130502A1 (en) 2010-05-27
ES2812532T3 (es) 2021-03-17
SI2388007T1 (sl) 2016-01-29
CY2014028I1 (el) 2015-12-09
US8231885B2 (en) 2012-07-31
US20050276830A1 (en) 2005-12-15
US20120277241A1 (en) 2012-11-01
MXPA05014107A (es) 2006-03-17
SI1631293T2 (sl) 2015-02-27
CN102743380A (zh) 2012-10-24
EP1631293B2 (en) 2014-10-08
ATE530185T1 (de) 2011-11-15
US20100227867A1 (en) 2010-09-09
ES2547336T3 (es) 2015-10-05
CN1829518B (zh) 2010-09-08
CA2530938C (en) 2011-12-13
CN102743380B (zh) 2015-08-12
US20160220565A1 (en) 2016-08-04
US7439241B2 (en) 2008-10-21
NO333468B1 (no) 2013-06-17
PL2388007T4 (pl) 2016-03-31
EP1631293A2 (en) 2006-03-08
CN101380321A (zh) 2009-03-11
US8426410B2 (en) 2013-04-23
US20060171974A1 (en) 2006-08-03
ES2376172T5 (es) 2015-01-08
CA2530938A1 (en) 2004-12-09
DK2815748T3 (da) 2020-08-24
NZ544300A (en) 2009-03-31
AU2004242967B2 (en) 2009-05-28
HUE027616T2 (en) 2016-11-28
PT1631293E (pt) 2012-02-01
HUE051833T2 (hu) 2021-03-29

Similar Documents

Publication Publication Date Title
NO20056104L (no) Forbindelser, formuleringer og fremgangsmater for behandling eller forebygging av rosacea
WO2005115395A3 (en) Compounds, formulations, and methods for treating or preventing inflammatory skin disorders
Tabushi et al. Duplex cyclodextrin
Clark et al. Correlations in the Ultraviolet Spectra of the Purine and Pyrimidine Bases1
NO975198L (no) Tetralinforbindeler med MDR-aktivitet
BRPI0409938A (pt) derivados de azetidinacarboxamida e seu uso em terapia
BR0214096A (pt) Inibidores da pde9 para o tratamento de distúrbios cardiovasculares
Lin et al. Oxidation and Reduction of the 5‐(2′‐Deoxyuridinyl) methyl Radical
BR9916096A (pt) Derivados de bacterioclorofila substituìdos compaládio e utilização dos mesmos
Nakamoto et al. Pyridoxine and Pyridoxal Analogs. IV. Ultraviolet Spectra and Solution Equilibria of 3-Methoxypyridine-2 (and 4-)-aldehydes and of 3-Hydroxypyridine-2 (and 4-)-aldehydes1, 2
NO20050141D0 (no) Prodrugs av imidazolderivater for anvendelse som protonpumpeinhibitorer ved behandlingen av f.eks. peptisk ulcus
BR0208499A (pt) ácido 3-heterociclilpropanohidroxâmico como inibidores de procolágeno c-proteinase
Catalan et al. Analysis of mixed solvent effects on the properties of singlet oxygen (1Δg)
BR0316763A (pt) Compostos de sais sulfÈnicos eficazes em fotoiniciadores catiÈnicos multifuncionais, composição e processo
Phillips et al. Thiazole carboxanilide fungicides: A new structure—Activity relationship for succinate dehydrogenase inhibitors
Hatamjafari et al. A New Method for Synthesis of 2, 4, 5-Triaryl-1H-Imidazole Derivatives Using SiO2-NaHSO4 under Solvent-free Conditions
NO20061045L (no) Imidazolderivater
Chien et al. 1-(2-Quinolyl)-2-naphthol: A new intra-intermolecular photoacid–photobase molecule
BR0009856A (pt) Sìntese de 3-amino-3-aril propanoatos
Kadir et al. Chemical and antibacterial data of synthesized thioureido derivatives
CY1116690T1 (el) Τοπικη συνθεση για χρηση στην θεραπεια της ερυθροτητας που επαγεται απο την ροδοχρωμη ακμη
Yang et al. Studies on the interaction of lysozyme with naringein and naringin by fluorescence spectroscopy
CARL Vibrational spectra and force fields of benzylthiocyanate, benzylselenocyanate and benzyltellurocyanate
NO20060586L (no) 7-substituerte-3-nitro-pyrazol[1,5-a]pyrimidiner
Makino et al. Isolation of formylkynurenine

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: GALDERMA PHARMA SA, CH