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NO20055535L - Makrodkonjugater med anti-inflammatorisk aktivitet - Google Patents

Makrodkonjugater med anti-inflammatorisk aktivitet

Info

Publication number
NO20055535L
NO20055535L NO20055535A NO20055535A NO20055535L NO 20055535 L NO20055535 L NO 20055535L NO 20055535 A NO20055535 A NO 20055535A NO 20055535 A NO20055535 A NO 20055535A NO 20055535 L NO20055535 L NO 20055535L
Authority
NO
Norway
Prior art keywords
macro
formula
conjugates
inflammatory activity
substructure
Prior art date
Application number
NO20055535A
Other languages
English (en)
Other versions
NO333909B1 (no
NO20055535D0 (no
Inventor
Mladen Mercep
Milan Mesic
Visnja Poljak
Boska Hrvacic
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20055535D0 publication Critical patent/NO20055535D0/no
Publication of NO20055535L publication Critical patent/NO20055535L/no
Publication of NO333909B1 publication Critical patent/NO333909B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Forehggende oppfirmelse angår nye forbindelser representert ved formel (I); hvori M representerer en makrohdundererihet med understrukturen II, formel (II); L representerer kjeden til understrukturen m, formel (III), D representerer steroid- eller ikke-steroidimderenhet avledet fra steroid eller ikke-steroid (NSAID) legemidler med anti-inflammasjonsaktivitet. Foreliggende oppfinnelse angår også farmasøytisk akseptable salter og solvater av slike fremstilte forbindelser, fremgangsmåter og intermediater for deres fremstilling, så vel som den forbedrede terapeutiske virkningen og anvendelsen ved behandling av inflanmiasjonssykdommer og tilstander hos mermesker og dyr.
NO20055535A 2003-04-24 2005-11-23 Makrolidkonjugater med anti-inflammatorisk aktivitet, farmasøytisk sammensetning og anvendelse NO333909B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HR20030324A HRP20030324A2 (en) 2003-04-24 2003-04-24 Compounds of antiinflammatory effect
PCT/IB2004/001235 WO2004094449A1 (en) 2003-04-24 2004-04-23 Macrolide-conjugates with anti-inflammatory activity

Publications (3)

Publication Number Publication Date
NO20055535D0 NO20055535D0 (no) 2005-11-23
NO20055535L true NO20055535L (no) 2006-01-16
NO333909B1 NO333909B1 (no) 2013-10-14

Family

ID=33307078

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20055535A NO333909B1 (no) 2003-04-24 2005-11-23 Makrolidkonjugater med anti-inflammatorisk aktivitet, farmasøytisk sammensetning og anvendelse
NO20130898A NO335552B1 (no) 2003-04-24 2013-06-28 Makrolidkonjugater med anti-inflammatorisk aktivitet, anvendelse derav og farmasøytisk sammensetning inneholdende en slik forbindelse

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20130898A NO335552B1 (no) 2003-04-24 2013-06-28 Makrolidkonjugater med anti-inflammatorisk aktivitet, anvendelse derav og farmasøytisk sammensetning inneholdende en slik forbindelse

Country Status (27)

Country Link
US (1) US7579334B2 (no)
EP (2) EP2070940B1 (no)
JP (1) JP4613366B2 (no)
KR (1) KR101107336B1 (no)
CN (1) CN100393741C (no)
AR (1) AR044083A1 (no)
AT (1) ATE518876T1 (no)
AU (1) AU2004232546B2 (no)
BR (1) BRPI0410490A (no)
CA (1) CA2523081C (no)
CL (1) CL2004000872A1 (no)
CY (2) CY1109491T1 (no)
DE (1) DE602004022047D1 (no)
DK (2) DK2070940T3 (no)
ES (2) ES2330109T3 (no)
HR (3) HRP20030324A2 (no)
IS (2) IS2736B (no)
ME (1) MEP34708A (no)
MX (1) MXPA05011359A (no)
NO (2) NO333909B1 (no)
PL (2) PL2070940T3 (no)
PT (2) PT1633771E (no)
RS (1) RS52621B (no)
RU (1) RU2355699C2 (no)
SI (2) SI2070940T1 (no)
WO (1) WO2004094449A1 (no)
ZA (1) ZA200508388B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect
EP2716647A3 (en) 2004-02-27 2014-08-20 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
BRPI0514254A (pt) * 2004-08-12 2008-06-03 Glaxosmithkline Zagreb uso de conjugados célula-especìficos para o tratamento de doenças inflamatórias do trato gastrintestinal
US20060183696A1 (en) * 2004-08-12 2006-08-17 Pliva-Istrazivacki Institut D.O.O. Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
ES2337915T3 (es) 2004-10-27 2010-04-30 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Conjugados con adtividad antiinflamatoria.
ES2436225T3 (es) 2005-12-22 2013-12-27 Hydra Biosciences, Inc. Inhibidores TRPA1 para tratamiento del dolor
WO2007093840A2 (en) * 2006-02-15 2007-08-23 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
CA2717456A1 (en) * 2008-03-05 2009-09-11 Panacea Biotec Limited Modified release pharmaceutical compositions comprising mycophenolate and processes thereof
CN102838660B (zh) * 2011-06-23 2016-11-02 上海市第一人民医院 一种抑制炎症免疫反应的小肽及其应用
JP2016505038A (ja) * 2013-01-23 2016-02-18 スファエラ ファーマ プライベート リミテッド ミトコンドリア生合成ならびにミトコンドリア機能不全または欠乏に関連する疾患において使用するための１１β−ヒドロキシステロイドの新規の化合物
CA2899500A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Cyclosporine a-steroid conjugates
BR112015021834A2 (pt) * 2013-03-08 2017-07-18 Allergan Inc conjugados de antibióticos ligados com drogas esteroides
CN105073140A (zh) 2013-03-08 2015-11-18 阿勒根公司 与类固醇药物直接键联的抗生素缀合物
WO2014138343A1 (en) * 2013-03-08 2014-09-12 Allergan, Inc. Antibiotic conjugates with nonsteroidal anti-inflammatory drugs
CN106714770B (zh) 2014-07-23 2024-04-19 斯法尔制药私人有限公司 羟基类固醇化合物、其中间体、制备方法、组合物及其用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3779221D1 (de) 1986-08-19 1992-06-25 Genentech Inc Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und -zytokinen.
DE3860503D1 (de) 1987-09-03 1990-10-04 Pliva Pharm & Chem Works 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
SE9100341D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
GB9225923D0 (en) 1992-12-11 1993-02-03 Rhone Poulenc Rorer Ltd New compositions of matter
HUT72442A (en) 1992-12-24 1996-04-29 Rhone Poulenc Rorer Ltd Steroids condensed with heteroring containing oxygene, pharmaceutical compositions containing them and processes for their production
CA2196879A1 (en) 1994-08-12 1996-02-22 Akihiko Hoshino Interleukin-5 production inhibitor
KR970704456A (ko) 1994-08-12 1997-09-06 우에하라 아끼라 인터류킨 5 생성 억제제(Interleukin 5 Production Inhibitor)
DE19616573C2 (de) 1996-04-25 1999-03-04 Pari Gmbh Verwendung unterkritischer Treibmittelmischungen und Aerosole für die Mikronisierung von Arzneimitteln mit Hilfe dichter Gase
JP3530004B2 (ja) 1998-02-06 2004-05-24 株式会社日立ユニシアオートモティブ 吸入式投薬器
JP2002528495A (ja) * 1998-10-30 2002-09-03 ニトロメド インコーポレーテッド ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法
IT1306205B1 (it) 1999-01-15 2001-05-30 Zambon Spa Macrolidi ad attivita' antiinfiammatoria.
HRP20000310A2 (en) 2000-05-17 2002-02-28 Pliva Farmaceutska Ind Dioniko New dibenzoazulene compounds as tumor necrosis factor inhibitors
FI110835B (fi) 2000-07-11 2003-03-31 Radiolinja Ab Menetelmä palvelunumeropuhelun tarjoamiseksi matkaviestintilaajalle ennalta määrätyllä taksalla
HRP20010018A2 (en) 2001-01-09 2002-12-31 Pliva D D Novel anti-inflammatory compounds
US20040005641A1 (en) * 2002-02-15 2004-01-08 Michael Burnet Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
US20040186063A1 (en) * 2002-02-15 2004-09-23 Hans-Jurgen Gutke Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
WO2003070174A2 (en) 2002-02-15 2003-08-28 Sympore Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
CA2489402A1 (en) * 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
JP2005536488A (ja) 2002-07-08 2005-12-02 プリヴァ−イストラジヴァキ・インスティトゥ・ディー・オー・オー 新規な非ステロイド抗炎症物質、組成物、およびその使用方法
PL375162A1 (en) * 2002-07-08 2005-11-28 Pliva-Istrazivacki Institut D.O.O. Novel compounds, compositions as carriers for steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
HRP20030324A2 (en) 2003-04-24 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. Compounds of antiinflammatory effect

Also Published As

Publication number Publication date
SI1633771T1 (sl) 2009-12-31
PL2070940T3 (pl) 2011-12-30
HRP20090551T1 (hr) 2010-01-31
EP2070940A3 (en) 2009-11-25
HRP20110763T1 (hr) 2011-11-30
EP1633771B1 (en) 2009-07-15
NO335552B1 (no) 2014-12-29
ES2330109T3 (es) 2009-12-04
BRPI0410490A (pt) 2006-06-13
PL1633771T3 (pl) 2009-12-31
NO333909B1 (no) 2013-10-14
MXPA05011359A (es) 2006-05-12
CY1111978T1 (el) 2015-11-04
CA2523081C (en) 2010-08-03
CN100393741C (zh) 2008-06-11
SI2070940T1 (sl) 2011-12-30
CY1109491T1 (el) 2014-08-13
RU2005131937A (ru) 2006-06-27
RS52621B (sr) 2013-06-28
CN1777619A (zh) 2006-05-24
EP1633771A1 (en) 2006-03-15
AR044083A1 (es) 2005-08-24
ZA200508388B (en) 2006-07-26
DK1633771T3 (da) 2009-11-16
IS2736B (is) 2011-06-15
DK2070940T3 (da) 2011-10-31
JP2006524221A (ja) 2006-10-26
IS8941A (is) 2010-12-29
RS20050873A (sr) 2007-08-03
HK1086842A1 (zh) 2006-09-29
HK1129681A1 (en) 2009-12-04
JP4613366B2 (ja) 2011-01-19
WO2004094449A8 (en) 2005-03-31
PT1633771E (pt) 2009-10-20
NO20055535D0 (no) 2005-11-23
US20050080003A1 (en) 2005-04-14
WO2004094449A1 (en) 2004-11-04
DE602004022047D1 (de) 2009-08-27
ES2370371T3 (es) 2011-12-14
NO20130898L (no) 2006-01-16
RU2355699C2 (ru) 2009-05-20
AU2004232546A1 (en) 2004-11-04
EP2070940B1 (en) 2011-08-03
US7579334B2 (en) 2009-08-25
EP2070940A1 (en) 2009-06-17
IS8141A (is) 2005-11-22
CL2004000872A1 (es) 2005-03-18
KR20060024770A (ko) 2006-03-17
KR101107336B1 (ko) 2012-01-19
CA2523081A1 (en) 2004-11-04
AU2004232546B2 (en) 2011-06-09
ATE518876T1 (de) 2011-08-15
PT2070940E (pt) 2011-11-14
MEP34708A (en) 2011-05-10
HRP20030324A2 (en) 2005-02-28

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