MEP34708A - Macrolide-conjugates with anti-inflammatory activity - Google Patents

Macrolide-conjugates with anti-inflammatory activity

Info

Publication number: MEP34708A
Authority: ME; Montenegro
Prior art keywords: steroidal; macrolide; formula; conjugates; inflammatory activity
Prior art date: 2003-04-24

Application number

MEP-347/08A

Other languages

Bosnian (bs)

English (en)

Inventor

Mladen Mercep

Milan Mesic

Linda Tomaskovic

Stribor Markovic

Boska Hrvacic

Oresta Makaruha

Visnja Poljak

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-24

Filing date

2004-04-23

Publication date

2011-05-10

2004-04-23 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2011-05-10 Publication of MEP34708A publication Critical patent/MEP34708A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Genetics & Genomics (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Dermatology (AREA)
Biotechnology (AREA)
Communicable Diseases (AREA)
Vascular Medicine (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

MEP-347/08A 2003-04-24 2004-04-23 Macrolide-conjugates with anti-inflammatory activity MEP34708A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HR20030324A HRP20030324A2 (en)	2003-04-24	2003-04-24	Compounds of antiinflammatory effect
PCT/IB2004/001235 WO2004094449A1 (en)	2003-04-24	2004-04-23	Macrolide-conjugates with anti-inflammatory activity

Publications (1)

Publication Number	Publication Date
MEP34708A true MEP34708A (en)	2011-05-10

Family

ID=33307078

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MEP-347/08A MEP34708A (en)	2003-04-24	2004-04-23	Macrolide-conjugates with anti-inflammatory activity

Country Status (27)

Country	Link
US (1)	US7579334B2 (xx)
EP (2)	EP1633771B1 (xx)
JP (1)	JP4613366B2 (xx)
KR (1)	KR101107336B1 (xx)
CN (1)	CN100393741C (xx)
AR (1)	AR044083A1 (xx)
AT (1)	ATE518876T1 (xx)
AU (1)	AU2004232546B2 (xx)
BR (1)	BRPI0410490A (xx)
CA (1)	CA2523081C (xx)
CL (1)	CL2004000872A1 (xx)
CY (2)	CY1109491T1 (xx)
DE (1)	DE602004022047D1 (xx)
DK (2)	DK1633771T3 (xx)
ES (2)	ES2370371T3 (xx)
HR (3)	HRP20030324A2 (xx)
IS (2)	IS2736B (xx)
ME (1)	MEP34708A (xx)
MX (1)	MXPA05011359A (xx)
NO (2)	NO333909B1 (xx)
PL (2)	PL2070940T3 (xx)
PT (2)	PT1633771E (xx)
RS (1)	RS52621B (xx)
RU (1)	RU2355699C2 (xx)
SI (2)	SI1633771T1 (xx)
WO (1)	WO2004094449A1 (xx)
ZA (1)	ZA200508388B (xx)

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HRP20030324A2 (en)	2003-04-24	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	Compounds of antiinflammatory effect
WO2005085266A2 (en)	2004-02-27	2005-09-15	Rib-X Pharmaceuticals, Inc.	Macrocyclic compounds and methods of making and using the same
US20060183696A1 (en) *	2004-08-12	2006-08-17	Pliva-Istrazivacki Institut D.O.O.	Use of immune cell specific conjugates for treatment of inflammatory diseases of gastrointestinal tract
RU2007108544A (ru) *	2004-08-12	2008-09-20	Глаксосмитклайн Истраживацки Центар Загреб Д.О.О.(Hr)	Применение клеточно-специфических конъюгатов для лечения воспалительных заболеваний желудочно-кишечного тракта
CN101090908A (zh) *	2004-10-27	2007-12-19	葛兰素伊斯特拉齐瓦基森塔萨格勒布公司	具有抗炎活性的共轭物
JP5858557B2 (ja) *	2005-12-22	2016-02-10	ハイドラバイオサイエンシズインコーポレイテッドＨｙｄｒａＢｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ．	疼痛を処置するためのｔｒｐａ１阻害剤
WO2007093840A2 (en) *	2006-02-15	2007-08-23	Glaxosmithkline Istrazivacki Centar Zagreb D.O.O.	Use of cell-specific conjugates for treatment of inflammatory diseases of the gastrointestinal tract
AU2009220779A1 (en) *	2008-03-05	2009-09-11	Panacea Biotec Limited	Modified release pharmaceutical compositions comprising mycophenolate and processes thereof
CN102838660B (zh) *	2011-06-23	2016-11-02	上海市第一人民医院	一种抑制炎症免疫反应的小肽及其应用
CN112552364A (zh) *	2013-01-23	2021-03-26	司菲埃拉制药私人有限公司	用于线粒体生物发生和与线粒体功能障碍或耗竭相关的疾病的新颖11β-羟基类固醇化合物
EP2964266A1 (en)	2013-03-08	2016-01-13	Allergan, Inc.	Antibiotic conjugates directly linked with steroid drugs
MX2015011847A (es) *	2013-03-08	2016-01-08	Allergan Inc	Conjugados antibioticos vinculados con farmacos esteorides.
EP2964265A1 (en) *	2013-03-08	2016-01-13	Allergan, Inc.	Antibiotic conjugates with nonsteroidal anti-inflammatory drugs
RU2015135145A (ru)	2013-03-08	2017-04-13	Аллерган, Инк.	Циклоспорин а-стероидные конъюгаты
CN106714770B (zh)	2014-07-23	2024-04-19	斯法尔制药私人有限公司	羟基类固醇化合物、其中间体、制备方法、组合物及其用途

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BR0312634A (pt)	2002-07-08	2005-05-10	Pliva Istrazivacki Inst D O O	Novos compostos, composições e métodos para tratamento de doenças e condições inflamatórias
HRP20030324A2 (en)	2003-04-24	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	Compounds of antiinflammatory effect

2003
- 2003-04-24 HR HR20030324A patent/HRP20030324A2/hr not_active Application Discontinuation
2004
- 2004-04-22 US US10/830,858 patent/US7579334B2/en not_active Expired - Fee Related
- 2004-04-23 AU AU2004232546A patent/AU2004232546B2/en not_active Ceased
- 2004-04-23 ES ES09075145T patent/ES2370371T3/es not_active Expired - Lifetime
- 2004-04-23 HR HR20090551T patent/HRP20090551T1/hr unknown
- 2004-04-23 PL PL09075145T patent/PL2070940T3/pl unknown
- 2004-04-23 AT AT09075145T patent/ATE518876T1/de active
- 2004-04-23 PL PL04729157T patent/PL1633771T3/pl unknown
- 2004-04-23 DK DK04729157T patent/DK1633771T3/da active
- 2004-04-23 CL CL200400872A patent/CL2004000872A1/es unknown
- 2004-04-23 ES ES04729157T patent/ES2330109T3/es not_active Expired - Lifetime
- 2004-04-23 ME MEP-347/08A patent/MEP34708A/xx unknown
- 2004-04-23 JP JP2006506511A patent/JP4613366B2/ja not_active Expired - Fee Related
- 2004-04-23 MX MXPA05011359A patent/MXPA05011359A/es active IP Right Grant
- 2004-04-23 EP EP04729157A patent/EP1633771B1/en not_active Expired - Lifetime
- 2004-04-23 SI SI200431253T patent/SI1633771T1/sl unknown
- 2004-04-23 PT PT04729157T patent/PT1633771E/pt unknown
- 2004-04-23 SI SI200431768T patent/SI2070940T1/sl unknown
- 2004-04-23 EP EP09075145A patent/EP2070940B1/en not_active Expired - Lifetime
- 2004-04-23 WO PCT/IB2004/001235 patent/WO2004094449A1/en not_active Ceased
- 2004-04-23 DK DK09075145.4T patent/DK2070940T3/da active
- 2004-04-23 AR ARP040101400A patent/AR044083A1/es unknown
- 2004-04-23 PT PT09075145T patent/PT2070940E/pt unknown
- 2004-04-23 CN CNB2004800110487A patent/CN100393741C/zh not_active Expired - Fee Related
- 2004-04-23 RS YU20050873A patent/RS52621B/sr unknown
- 2004-04-23 DE DE602004022047T patent/DE602004022047D1/de not_active Expired - Lifetime
- 2004-04-23 RU RU2005131937/04A patent/RU2355699C2/ru not_active IP Right Cessation
- 2004-04-23 KR KR1020057020252A patent/KR101107336B1/ko not_active Expired - Fee Related
- 2004-04-23 BR BRPI0410490-0A patent/BRPI0410490A/pt not_active Application Discontinuation
- 2004-04-23 CA CA2523081A patent/CA2523081C/en not_active Expired - Lifetime
2005
- 2005-10-17 ZA ZA200508388A patent/ZA200508388B/xx unknown
- 2005-11-22 IS IS8141A patent/IS2736B/is unknown
- 2005-11-23 NO NO20055535A patent/NO333909B1/no not_active IP Right Cessation
2009
- 2009-10-14 CY CY20091101070T patent/CY1109491T1/el unknown
2010
- 2010-12-29 IS IS8941A patent/IS8941A/is unknown
2011
- 2011-10-19 HR HR20110763T patent/HRP20110763T1/hr unknown
- 2011-10-25 CY CY20111101008T patent/CY1111978T1/el unknown
2013
- 2013-06-28 NO NO20130898A patent/NO335552B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL1633771T3 (pl)	2009-12-31
HRP20110763T1 (hr)	2011-11-30
CL2004000872A1 (es)	2005-03-18
SI2070940T1 (sl)	2011-12-30
MXPA05011359A (es)	2006-05-12
CN100393741C (zh)	2008-06-11
KR101107336B1 (ko)	2012-01-19
US20050080003A1 (en)	2005-04-14
ATE518876T1 (de)	2011-08-15
IS8141A (is)	2005-11-22
NO20130898L (no)	2006-01-16
JP2006524221A (ja)	2006-10-26
AR044083A1 (es)	2005-08-24
RU2005131937A (ru)	2006-06-27
ES2370371T3 (es)	2011-12-14
US7579334B2 (en)	2009-08-25
NO335552B1 (no)	2014-12-29
EP2070940A1 (en)	2009-06-17
PT2070940E (pt)	2011-11-14
NO20055535L (no)	2006-01-16
WO2004094449A1 (en)	2004-11-04
RS20050873A (sr)	2007-08-03
ZA200508388B (en)	2006-07-26
AU2004232546A1 (en)	2004-11-04
CA2523081C (en)	2010-08-03
EP1633771A1 (en)	2006-03-15
RS52621B (sr)	2013-06-28
EP1633771B1 (en)	2009-07-15
DE602004022047D1 (de)	2009-08-27
PT1633771E (pt)	2009-10-20
NO20055535D0 (no)	2005-11-23
EP2070940B1 (en)	2011-08-03
SI1633771T1 (sl)	2009-12-31
HK1086842A1 (zh)	2006-09-29
PL2070940T3 (pl)	2011-12-30
HRP20030324A2 (en)	2005-02-28
KR20060024770A (ko)	2006-03-17
EP2070940A3 (en)	2009-11-25
DK2070940T3 (da)	2011-10-31
JP4613366B2 (ja)	2011-01-19
HK1129681A1 (en)	2009-12-04
RU2355699C2 (ru)	2009-05-20
CY1111978T1 (el)	2015-11-04
CY1109491T1 (el)	2014-08-13
CN1777619A (zh)	2006-05-24
ES2330109T3 (es)	2009-12-04
HRP20090551T1 (hr)	2010-01-31
IS2736B (is)	2011-06-15
WO2004094449A8 (en)	2005-03-31
NO333909B1 (no)	2013-10-14
DK1633771T3 (da)	2009-11-16
IS8941A (is)	2010-12-29
BRPI0410490A (pt)	2006-06-13
AU2004232546B2 (en)	2011-06-09
CA2523081A1 (en)	2004-11-04

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EA201001566A1 (ru)	2011-04-29	Новый класс спиропиперидинов для лечения нейродегенеративных заболеваний
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