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NO20054855L - Preventiv/hjelpemiddel for retinal nervesykdommer inneholdende alkyleterderivater eller salter derav - Google Patents

Preventiv/hjelpemiddel for retinal nervesykdommer inneholdende alkyleterderivater eller salter derav

Info

Publication number
NO20054855L
NO20054855L NO20054855A NO20054855A NO20054855L NO 20054855 L NO20054855 L NO 20054855L NO 20054855 A NO20054855 A NO 20054855A NO 20054855 A NO20054855 A NO 20054855A NO 20054855 L NO20054855 L NO 20054855L
Authority
NO
Norway
Prior art keywords
alkyl ether
retinal
retinal nerve
contraceptive
remedy
Prior art date
Application number
NO20054855A
Other languages
English (en)
Other versions
NO334062B1 (no
NO20054855D0 (no
Inventor
Akihito Saitoh
Noboru Iwakami
Tatsuo Kimura
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of NO20054855D0 publication Critical patent/NO20054855D0/no
Publication of NO20054855L publication Critical patent/NO20054855L/no
Publication of NO334062B1 publication Critical patent/NO334062B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Et alkyleterderivat representert ved den generelle formel [1] eller dens salt: hvor R1 og R2 hver representerer en substituent så som hydrogen, halogen eller alkyl; R3 representerer alkylamino, amino eller hydroksyl; ringen A representerer en 5- eller 6-leddet aromatisk heterosyklisk gruppe eller en benzenring; m og n er hver et helt tall på fra 1 til 6; og p er et helt tall på fra 1 til 3; viser en effekt ved å beskytte retinale nerveceller og er derfor anvendelige som et forebyggende og/eller behandlende middel for retinale nervesykdommer så som glaukom, diabetisk retinopati, retinal arterie-obstruksjon, retinal venøs obstruksjon, makuladegenerasjon og retinopati ved prematuritet.
NO20054855A 2003-04-17 2005-10-20 Alkyleterderivater eller salter derav for behandling og/eller forebygging av retinale nervesykdommer NO334062B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003112539 2003-04-17
PCT/JP2004/005355 WO2004091605A1 (ja) 2003-04-17 2004-04-15 アルキルエーテル誘導体またはその塩を含有する網膜神経疾患の予防・治療剤

Publications (3)

Publication Number Publication Date
NO20054855D0 NO20054855D0 (no) 2005-10-20
NO20054855L true NO20054855L (no) 2006-01-09
NO334062B1 NO334062B1 (no) 2013-12-02

Family

ID=33296058

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054855A NO334062B1 (no) 2003-04-17 2005-10-20 Alkyleterderivater eller salter derav for behandling og/eller forebygging av retinale nervesykdommer

Country Status (20)

Country Link
US (3) US20060205709A1 (no)
EP (1) EP1614419B1 (no)
JP (1) JP4642657B2 (no)
KR (1) KR101096528B1 (no)
CN (1) CN100353942C (no)
AU (1) AU2004229283B2 (no)
BR (1) BRPI0409398A (no)
CA (1) CA2521648C (no)
CY (1) CY1113248T1 (no)
DK (1) DK1614419T3 (no)
ES (1) ES2391273T3 (no)
IL (1) IL171388A (no)
MX (1) MXPA05011125A (no)
NO (1) NO334062B1 (no)
NZ (1) NZ543100A (no)
PL (1) PL1614419T3 (no)
PT (1) PT1614419E (no)
SI (1) SI1614419T1 (no)
WO (1) WO2004091605A1 (no)
ZA (1) ZA200508166B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1437353B1 (en) 2001-10-19 2007-06-13 Toyama Chemical Co., Ltd. Alkyl ether derivatives or salts thereof
EP2389937B1 (en) 2002-06-14 2018-08-15 Toyama Chemical Co., Ltd. Medicinal composition for improving brain function
RU2397169C2 (ru) * 2005-03-28 2010-08-20 Тояма Кемикал Ко., Лтд. Способ получения 1-(3-(2-(1-бензотиофен-5-ил)этокси) пропил)азетидин-3-ола или его солей
SI2210884T1 (sl) * 2005-03-28 2012-06-29 Toyama Chemical Co Ltd Postopek izdelave 1-(3-(2-(1-benzotiofen-5-il)-etoksi)propionske kisline ali soli le-te
SI2011796T1 (sl) * 2006-04-26 2015-02-27 Toyama Chemical Co., Ltd. Induktor nevrogeneze ali terapevtska uäśinkovina proti nevropatiji, vsebujoäśa derivat alkilnega etra ali sol le-tega
US8119625B2 (en) 2006-04-26 2012-02-21 Toyama Chemical Co., Ltd. Neurogenesis inducer or neuropathy therapeutic agent comprising alkyl ether derivative or salt thereof
EP2048145B9 (en) * 2006-08-04 2011-05-04 Toyama Chemical Co., Ltd. Protein kinase c activity enhancer containing alkyl ether derivative or salt thereof
WO2010007626A1 (en) * 2008-07-14 2010-01-21 Biocon Limited A method of synthesizing a substantially monodispersed mixture of oligomers
WO2013125617A1 (ja) 2012-02-22 2013-08-29 富山化学工業株式会社 １－（３－（２－（１－ベンゾチオフェン－５－イル）エトキシ）プロピル）アゼチジン－３－オールまたはその塩を含有する固形医薬組成物
CN106061478B (zh) 2014-01-31 2019-04-30 富士胶片富山化学株式会社 含有烷基醚衍生物或其盐的神经损伤后的康复效果促进剂
WO2016199878A1 (ja) * 2015-06-11 2016-12-15 富山化学工業株式会社 シグマ受容体結合剤
WO2017111005A1 (ja) 2015-12-25 2017-06-29 富山化学工業株式会社 １－（３－（２－（１－ベンゾチオフェン－５－イル）エトキシ）プロピル）アゼチジン－３－オールまたはその塩を含む錠剤
US20190343796A1 (en) 2016-12-28 2019-11-14 Fujifilm Toyama Chemical Co., Ltd. Composition for external use
RU2019138538A (ru) 2017-06-02 2021-07-09 ФУДЖИФИЛМ Тояма Кемикал Ко., Лтд. СРЕДСТВО ДЛЯ УМЕНЬШЕНИЯ КОЛИЧЕСТВА АМИЛОИДНОГО β-БЕЛКА
BR112019024881A2 (pt) 2017-06-02 2020-06-16 Fujifilm Toyama Chemical Co., Ltd. Agente para evitar ou tratar ataxia espinocerebelar
WO2018221728A1 (ja) 2017-06-02 2018-12-06 富山化学工業株式会社 アルツハイマー型認知症予防または治療剤
EP3632431A4 (en) 2017-06-02 2020-06-03 FUJIFILM Toyama Chemical Co., Ltd. AGENTS FOR PREVENTING OR TREATING BRAIN ATROPHY
US11548878B2 (en) 2017-10-30 2023-01-10 Fujifilm Toyama Chemical Co., Ltd. Emopamil binding protein binding agent and use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2521136A1 (fr) * 1982-02-05 1983-08-12 Synthelabo Derives de piperidine, leur preparation et leur application en therapeutique
US5922773A (en) 1992-12-04 1999-07-13 The Children's Medical Center Corp. Glaucoma treatment
DK74693D0 (da) 1993-06-23 1993-06-23 Novo Nordisk As Novel heterocyclic chemistry
TW281667B (no) * 1994-02-03 1996-07-21 Synthelabo
WO1997011054A1 (fr) * 1995-09-22 1997-03-27 Yoshitomi Pharmaceutical Industries, Ltd. Composes d'acide benzoique et leur emploi medical
JP4549452B2 (ja) * 1997-12-12 2010-09-22 富山化学工業株式会社 アルキルエーテル誘導体またはその塩並びにそれらを含有するカルシウム拮抗剤
AU9235101A (en) * 2000-10-10 2002-04-22 Toyama Chemical Co Ltd Remedies for retinal nerve diseases containing 1,2-ethanediol derivatives or salts thereof
WO2002100833A1 (en) * 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
EP1437353B1 (en) * 2001-10-19 2007-06-13 Toyama Chemical Co., Ltd. Alkyl ether derivatives or salts thereof
EP2389937B1 (en) * 2002-06-14 2018-08-15 Toyama Chemical Co., Ltd. Medicinal composition for improving brain function

Also Published As

Publication number Publication date
ZA200508166B (en) 2007-03-28
JPWO2004091605A1 (ja) 2006-07-06
SI1614419T1 (sl) 2012-12-31
IL171388A (en) 2010-12-30
CA2521648C (en) 2012-07-03
EP1614419A4 (en) 2010-08-18
NO334062B1 (no) 2013-12-02
EP1614419B1 (en) 2012-08-08
CN1774245A (zh) 2006-05-17
NZ543100A (en) 2008-07-31
JP4642657B2 (ja) 2011-03-02
PL1614419T3 (pl) 2013-01-31
CA2521648A1 (en) 2004-10-28
PT1614419E (pt) 2012-10-22
CY1113248T1 (el) 2016-04-13
US20100075941A1 (en) 2010-03-25
EP1614419A1 (en) 2006-01-11
CN100353942C (zh) 2007-12-12
US20060205709A1 (en) 2006-09-14
WO2004091605A1 (ja) 2004-10-28
DK1614419T3 (da) 2012-11-19
NO20054855D0 (no) 2005-10-20
ES2391273T3 (es) 2012-11-23
BRPI0409398A (pt) 2006-04-18
KR20050123167A (ko) 2005-12-29
AU2004229283A1 (en) 2004-10-28
KR101096528B1 (ko) 2011-12-20
US20110112066A1 (en) 2011-05-12
MXPA05011125A (es) 2005-12-14
US7897594B2 (en) 2011-03-01
AU2004229283B2 (en) 2009-02-05
US8067406B2 (en) 2011-11-29

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