NO20052244L - Enantioselektiv fremgangsmate for fremstilling av begge enantiomerene av 10,11- dihydro-10-hydroksy-5H-dibenzo[b,f]- azepin-5-karboksamid og nye krystallformer derav - Google Patents
Enantioselektiv fremgangsmate for fremstilling av begge enantiomerene av 10,11- dihydro-10-hydroksy-5H-dibenzo[b,f]- azepin-5-karboksamid og nye krystallformer deravInfo
- Publication number
- NO20052244L NO20052244L NO20052244A NO20052244A NO20052244L NO 20052244 L NO20052244 L NO 20052244L NO 20052244 A NO20052244 A NO 20052244A NO 20052244 A NO20052244 A NO 20052244A NO 20052244 L NO20052244 L NO 20052244L
- Authority
- NO
- Norway
- Prior art keywords
- hydroxy
- crystal forms
- carboxamide
- enantiomers
- dihydro
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 2
- BMPDWHIDQYTSHX-UHFFFAOYSA-N licarbazepine Chemical compound C1C(O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 BMPDWHIDQYTSHX-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052741 iridium Inorganic materials 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 229910052707 ruthenium Inorganic materials 0.000 abstract 1
- 238000009901 transfer hydrogenation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C07F15/0053—Ruthenium compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0223224.7A GB0223224D0 (en) | 2002-10-07 | 2002-10-07 | Organic compounds |
| PCT/EP2003/011034 WO2004031155A1 (fr) | 2002-10-07 | 2003-10-06 | Procede enantioselectif destine a la preparation d'enantiomeres de 10,11-dihydro-10-hydroxy-5h-dibenz [b,f]azepine-5-carboxamide et de nouvelles formes cristallines de ceux-ci |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20052244D0 NO20052244D0 (no) | 2005-05-06 |
| NO20052244L true NO20052244L (no) | 2005-07-07 |
Family
ID=9945425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20052244A NO20052244L (no) | 2002-10-07 | 2005-05-06 | Enantioselektiv fremgangsmate for fremstilling av begge enantiomerene av 10,11- dihydro-10-hydroksy-5H-dibenzo[b,f]- azepin-5-karboksamid og nye krystallformer derav |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20060142566A1 (fr) |
| EP (1) | EP1551808A1 (fr) |
| JP (1) | JP2006504710A (fr) |
| KR (1) | KR20050071549A (fr) |
| CN (2) | CN101062932A (fr) |
| AR (1) | AR041544A1 (fr) |
| AU (1) | AU2003276055B2 (fr) |
| BR (1) | BR0315113A (fr) |
| CA (1) | CA2501237A1 (fr) |
| EC (1) | ECSP055738A (fr) |
| GB (1) | GB0223224D0 (fr) |
| HK (1) | HK1079790A1 (fr) |
| MX (1) | MXPA05003737A (fr) |
| NO (1) | NO20052244L (fr) |
| PE (1) | PE20040686A1 (fr) |
| PL (1) | PL376379A1 (fr) |
| RU (1) | RU2005114350A (fr) |
| TW (1) | TW200413324A (fr) |
| WO (1) | WO2004031155A1 (fr) |
| ZA (1) | ZA200502561B (fr) |
Families Citing this family (65)
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|---|---|---|---|---|
| GB0303615D0 (en) * | 2003-02-17 | 2003-03-19 | Novartis Ag | Use of organic compounds |
| GB0425320D0 (en) | 2004-11-17 | 2004-12-22 | Johnson Matthey Plc | Diamines |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| GB0515690D0 (en) * | 2005-07-29 | 2005-09-07 | Portela & Ca Sa | Asymmetric catalytic reduction |
| GB2437078A (en) | 2006-04-11 | 2007-10-17 | Portela & Ca Sa | 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives |
| JP5172124B2 (ja) * | 2006-09-29 | 2013-03-27 | 関東化学株式会社 | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| WO2011045648A2 (fr) * | 2009-10-12 | 2011-04-21 | Matrix Laboratories Limited | Procédé de préparation de (s)-(-)-10-acétoxy-10,11-dihydro-5h-dibenz[b,f]azépine-5-carboxamide et ses esters |
| EP2383261B1 (fr) | 2010-04-23 | 2013-09-04 | Euticals GmbH | Procédé d'hydrogénation asymétrique de cétones |
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| ES2687678T3 (es) | 2011-03-08 | 2018-10-26 | Jubilant Life Sciences Limited | Procedimiento para la preparación de (S)-(+)-10,11-dihidro-10-hidroxi-5H-dibenzo[b,f]azepina-5-carboxamida y ésteres de la misma mediante reducción enantioselectiva de 10,11-dihidro-10-oxo-5H-dibenzo[b,f]azepina-5-carboxamida |
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| EP3064490A1 (fr) | 2015-03-06 | 2016-09-07 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Procédé amélioré pour la préparation d'eslicarbazépine et d'acétate d'eslicarbazépine |
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Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT101732B (pt) * | 1995-06-30 | 1997-12-31 | Portela & Ca Sa | Novas di-hidrodibenzo<b,f>azepinas substituidas processo para a sua preparacao composicoes farmaceuticas que as contem e utilizacao dos novos compostos na preparacao de composicoes farmaceuticas empregues em doencas do sistema nervoso |
| JP2003502296A (ja) * | 1999-06-15 | 2003-01-21 | ロディア・シミ | スルホニルアミド及びカルボキサミド並びに不斉触媒作用におけるそれらの使用 |
| WO2002064557A2 (fr) * | 2001-02-12 | 2002-08-22 | Teva Pharmaceutical Industries Ltd. | Nouveaux facies cristallins d'oxcarbazepine et leurs procedes de preparation |
-
2002
- 2002-10-07 GB GBGB0223224.7A patent/GB0223224D0/en not_active Ceased
-
2003
- 2003-10-06 CN CNA2007101126346A patent/CN101062932A/zh active Pending
- 2003-10-06 EP EP03798930A patent/EP1551808A1/fr not_active Withdrawn
- 2003-10-06 BR BR0315113-1A patent/BR0315113A/pt not_active IP Right Cessation
- 2003-10-06 AU AU2003276055A patent/AU2003276055B2/en not_active Expired - Fee Related
- 2003-10-06 CN CNA2003801013117A patent/CN1703404A/zh active Pending
- 2003-10-06 CA CA002501237A patent/CA2501237A1/fr not_active Abandoned
- 2003-10-06 PL PL03376379A patent/PL376379A1/xx unknown
- 2003-10-06 US US10/530,617 patent/US20060142566A1/en not_active Abandoned
- 2003-10-06 RU RU2005114350/04A patent/RU2005114350A/ru not_active Application Discontinuation
- 2003-10-06 JP JP2004540788A patent/JP2006504710A/ja active Pending
- 2003-10-06 HK HK05112208.8A patent/HK1079790A1/zh unknown
- 2003-10-06 WO PCT/EP2003/011034 patent/WO2004031155A1/fr not_active Ceased
- 2003-10-06 MX MXPA05003737A patent/MXPA05003737A/es not_active Application Discontinuation
- 2003-10-06 KR KR1020057005920A patent/KR20050071549A/ko not_active Withdrawn
- 2003-10-07 PE PE2003001022A patent/PE20040686A1/es not_active Application Discontinuation
- 2003-10-07 AR ARP030103648A patent/AR041544A1/es not_active Application Discontinuation
- 2003-10-07 TW TW092127799A patent/TW200413324A/zh unknown
-
2005
- 2005-03-30 ZA ZA200502561A patent/ZA200502561B/en unknown
- 2005-04-06 EC EC2005005738A patent/ECSP055738A/es unknown
- 2005-05-06 NO NO20052244A patent/NO20052244L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200502561B (en) | 2006-02-22 |
| CN101062932A (zh) | 2007-10-31 |
| AU2003276055B2 (en) | 2008-01-03 |
| TW200413324A (en) | 2004-08-01 |
| EP1551808A1 (fr) | 2005-07-13 |
| MXPA05003737A (es) | 2005-06-17 |
| PL376379A1 (en) | 2005-12-27 |
| US20060142566A1 (en) | 2006-06-29 |
| BR0315113A (pt) | 2005-08-23 |
| HK1079790A1 (zh) | 2006-04-13 |
| WO2004031155A1 (fr) | 2004-04-15 |
| ECSP055738A (es) | 2005-07-06 |
| KR20050071549A (ko) | 2005-07-07 |
| AR041544A1 (es) | 2005-05-18 |
| PE20040686A1 (es) | 2004-10-29 |
| CA2501237A1 (fr) | 2004-04-15 |
| AU2003276055A1 (en) | 2004-04-23 |
| NO20052244D0 (no) | 2005-05-06 |
| RU2005114350A (ru) | 2006-01-20 |
| CN1703404A (zh) | 2005-11-30 |
| GB0223224D0 (en) | 2002-11-13 |
| JP2006504710A (ja) | 2006-02-09 |
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