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NO20050074L - Modulatorer for glukocorticoidreseptoren og metode - Google Patents

Modulatorer for glukocorticoidreseptoren og metode

Info

Publication number
NO20050074L
NO20050074L NO20050074A NO20050074A NO20050074L NO 20050074 L NO20050074 L NO 20050074L NO 20050074 A NO20050074 A NO 20050074A NO 20050074 A NO20050074 A NO 20050074A NO 20050074 L NO20050074 L NO 20050074L
Authority
NO
Norway
Prior art keywords
glucocorticoid receptor
modulators
obesity
diabetes
inflammatory
Prior art date
Application number
NO20050074A
Other languages
English (en)
Inventor
David R Tortolani
Soong-Hoon Kim
Arthur M Doweyko
Wenying Li
Wayne D Vaccaro
Bingwei Vera Yang
Tram Huynh
Kenneth J Leavitt
Lidia Doweyko
Xiao-Tao Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20050074L publication Critical patent/NO20050074L/no

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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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Abstract

Nye ikke-steroidforbindelser tilveiebringes som er glukokortikoidreseptormodulatorer som er anvendelige for behandling av sykdommer som krever glukokortikoidreseptor-agonist eller -antagonist-terapi så som overvekt, diabetes, inflammatoriske og immunforstyrrelser og har strukturformelen (1)
NO20050074A 2002-07-18 2005-01-06 Modulatorer for glukocorticoidreseptoren og metode NO20050074L (no)

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PCT/US2003/022300 WO2004009017A2 (en) 2002-07-18 2003-07-17 Modulators of the glucocorticoid receptor and method

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JP (1) JP2006508042A (no)
AU (1) AU2003251970A1 (no)
IS (1) IS7645A (no)
NO (1) NO20050074L (no)
PL (1) PL375442A1 (no)
WO (1) WO2004009017A2 (no)

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