NO20050620L - Nye 2-aryltiazol-forbindelser som PPARALPHA og PPARGAMA agonister - Google Patents

Nye 2-aryltiazol-forbindelser som PPARALPHA og PPARGAMA agonister

Info

Publication number: NO20050620L
Authority: NO; Norway
Prior art keywords: ppargama; pparalpha; agonists; new; arylthiazole compounds
Prior art date: 2002-08-30

Application number

NO20050620A

Other languages

English (en)

Other versions

NO329777B1 (no

Inventor

Georges Hirth

Peter Mohr

Alfred Binggeli

Hans Hilpert

Markus Meyer

Hans-Peter Maerki

Grether Uwe

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-30

Filing date

2005-02-03

Publication date

2005-03-03

2005-02-03 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-03-03 Publication of NO20050620L publication Critical patent/NO20050620L/no

2010-12-13 Publication of NO329777B1 publication Critical patent/NO329777B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Cardiology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Rheumatology (AREA)
Pregnancy & Childbirth (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Gynecology & Obstetrics (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

NO20050620A 2002-08-30 2005-02-03 2-aryltiazol-forbindelser, fremgangsmate for fremstilling av slike, farmasoytiske preparater inneholdende slike, slike forbindelser som terapeutisk aktive substanser samt anvendelse av slike for behandling av sykdom NO329777B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02019146		2002-08-30
PCT/EP2003/009281 WO2004020420A1 (en)	2002-08-30	2003-08-21	Novel 2-arylthiazole compounds as pparalpha and ppargama agonists

Publications (2)

Publication Number	Publication Date
NO20050620L true NO20050620L (no)	2005-03-03
NO329777B1 NO329777B1 (no)	2010-12-13

Family

ID=31970267

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20050620A NO329777B1 (no)	2002-08-30	2005-02-03	2-aryltiazol-forbindelser, fremgangsmate for fremstilling av slike, farmasoytiske preparater inneholdende slike, slike forbindelser som terapeutisk aktive substanser samt anvendelse av slike for behandling av sykdom

Country Status (29)

Country	Link
US (1)	US6809110B2 (no)
EP (1)	EP1537091B1 (no)
JP (2)	JP4533141B2 (no)
KR (1)	KR100736955B1 (no)
CN (1)	CN100475810C (no)
AR (1)	AR041079A1 (no)
AT (1)	ATE483699T1 (no)
BR (1)	BR0313946A (no)
CA (1)	CA2495942C (no)
DE (1)	DE60334461D1 (no)
DK (1)	DK1537091T3 (no)
ES (1)	ES2350340T3 (no)
GT (1)	GT200300183A (no)
HR (1)	HRP20050158A2 (no)
IL (1)	IL166833A (no)
MX (1)	MXPA05002115A (no)
MY (1)	MY141020A (no)
NO (1)	NO329777B1 (no)
NZ (1)	NZ537897A (no)
PA (1)	PA8581201A1 (no)
PE (1)	PE20040982A1 (no)
PL (1)	PL375779A1 (no)
PT (1)	PT1537091E (no)
RU (1)	RU2296754C2 (no)
SI (1)	SI1537091T1 (no)
TW (1)	TWI338686B (no)
UY (1)	UY27959A1 (no)
WO (1)	WO2004020420A1 (no)
ZA (1)	ZA200501097B (no)

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US7105551B2 (en) *	2000-12-20	2006-09-12	Smithkline Beecham Corporation	Thiazole derivatives for treating PPAR related disorders
RU2296754C2 (ru) *	2002-08-30	2007-04-10	Ф.Хоффманн-Ля Рош Аг	НОВЫЕ СОЕДИНЕНИЯ 2-АРИЛТИАЗОЛА В КАЧЕСТВЕ АГОНИСТОВ PPAR α И PPAR γ
GB0405033D0 (en) *	2004-03-05	2004-04-07	Karobio Ab	Novel pharmaceutical compositions
JP2009084156A (ja) *	2006-01-18	2009-04-23	Nissan Chem Ind Ltd	チアゾール置換アセトニトリルの製造方法
NZ572268A (en) *	2006-04-18	2011-09-30	Nippon Chemiphar Co	Activating agent for peroxisome proliferator activated receptor delta (ppar)
WO2008108602A1 (en) *	2007-03-07	2008-09-12	Dong-A Pharm. Co., Ltd.	Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
AU2008221718A1 (en) *	2007-03-07	2008-09-12	Dong-A Pharm. Co., Ltd.	Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
DE102007038251A1 (de) *	2007-08-13	2009-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neues Herstellverfahren
CN101928259B (zh) *	2009-06-18	2012-10-03	南京海辰药业有限公司	2-芳基噻唑衍生物及其药物组合物
CN102285933B (zh) *	2010-06-18	2016-03-09	浙江海正药业股份有限公司	一种对亚型过氧化物酶增殖物激活受体具有激动作用的化合物、其制备方法和应用
CN102351852B (zh) *	2011-08-23	2014-06-18	上海交通大学	苯并呋喃类化合物及其制备方法、用途
EP2758041B1 (de)	2011-09-20	2021-01-13	Basf Se	Niedermolekulare modulatoren des kälte-menthol-rezeptors trpm8 und deren verwendung
US20190350955A1 (en)	2016-06-30	2019-11-21	Inserm (Institut National De La Sante Et De La Recherche Medicale	Methods and pharmaceutical compositions for the treatment of cardiomyopathies
US20200172530A1 (en) *	2017-03-14	2020-06-04	Dana-Farber Cancer Institute, Inc.	Small Molecule Sensitization of BAX Activation for Induction of Cell Death
WO2020201263A1 (en)	2019-04-01	2020-10-08	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling
CN115894379B (zh) *	2022-01-20	2025-06-27	哈尔滨三联药业股份有限公司	海因类化合物及其医药用途

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JP2001261612A (ja) *	2000-03-22	2001-09-26	Mitsui Chemicals Inc	カテコールプロピオン酸誘導体およびそれを有効成分として含有する核内レセプター作動薬
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KR100654516B1 (ko) *	2001-05-15	2006-12-05	에프. 호프만-라 로슈 아게	당뇨병 치료에서 ｐｐａｒ-알파 및 -감마 활성제로서사용하기 위한 카복실산 치환된 옥사졸 유도체
ES2316736T3 (es) *	2002-02-25	2009-04-16	Eli Lilly And Company	Moduladores de receptores activados por proliferador de peroxisoma.
RU2296754C2 (ru) *	2002-08-30	2007-04-10	Ф.Хоффманн-Ля Рош Аг	НОВЫЕ СОЕДИНЕНИЯ 2-АРИЛТИАЗОЛА В КАЧЕСТВЕ АГОНИСТОВ PPAR α И PPAR γ

2003
- 2003-08-21 RU RU2005109163/04A patent/RU2296754C2/ru not_active IP Right Cessation
- 2003-08-21 HR HR20050158A patent/HRP20050158A2/xx not_active Application Discontinuation
- 2003-08-21 AT AT03757762T patent/ATE483699T1/de active
- 2003-08-21 MX MXPA05002115A patent/MXPA05002115A/es active IP Right Grant
- 2003-08-21 WO PCT/EP2003/009281 patent/WO2004020420A1/en not_active Ceased
- 2003-08-21 PL PL03375779A patent/PL375779A1/xx not_active Application Discontinuation
- 2003-08-21 KR KR1020057003571A patent/KR100736955B1/ko not_active Expired - Fee Related
- 2003-08-21 CN CNB038205432A patent/CN100475810C/zh not_active Expired - Fee Related
- 2003-08-21 EP EP03757762A patent/EP1537091B1/en not_active Expired - Lifetime
- 2003-08-21 BR BR0313946-8A patent/BR0313946A/pt not_active IP Right Cessation
- 2003-08-21 ES ES03757762T patent/ES2350340T3/es not_active Expired - Lifetime
- 2003-08-21 JP JP2004532104A patent/JP4533141B2/ja not_active Expired - Fee Related
- 2003-08-21 NZ NZ537897A patent/NZ537897A/en not_active IP Right Cessation
- 2003-08-21 DK DK03757762.4T patent/DK1537091T3/da active
- 2003-08-21 PT PT03757762T patent/PT1537091E/pt unknown
- 2003-08-21 DE DE60334461T patent/DE60334461D1/de not_active Expired - Lifetime
- 2003-08-21 CA CA2495942A patent/CA2495942C/en not_active Expired - Fee Related
- 2003-08-21 SI SI200331904T patent/SI1537091T1/sl unknown
- 2003-08-26 PA PA20038581201A patent/PA8581201A1/es unknown
- 2003-08-26 PE PE2003000873A patent/PE20040982A1/es not_active Application Discontinuation
- 2003-08-26 TW TW092123445A patent/TWI338686B/zh not_active IP Right Cessation
- 2003-08-27 UY UY27959A patent/UY27959A1/es not_active Application Discontinuation
- 2003-08-27 GT GT200300183A patent/GT200300183A/es unknown
- 2003-08-28 AR ARP030103120A patent/AR041079A1/es active IP Right Grant
- 2003-08-28 MY MYPI20033266A patent/MY141020A/en unknown
- 2003-08-28 US US10/650,434 patent/US6809110B2/en not_active Expired - Fee Related
2005
- 2005-02-03 NO NO20050620A patent/NO329777B1/no not_active IP Right Cessation
- 2005-02-07 ZA ZA200501097A patent/ZA200501097B/en unknown
- 2005-02-10 IL IL166833A patent/IL166833A/en not_active IP Right Cessation
2010
- 2010-01-14 JP JP2010006072A patent/JP2010132671A/ja active Pending

Also Published As

Publication number	Publication date
RU2296754C2 (ru)	2007-04-10
JP2006502151A (ja)	2006-01-19
EP1537091B1 (en)	2010-10-06
RU2005109163A (ru)	2006-01-20
AU2003273801A1 (en)	2004-03-19
KR20050057083A (ko)	2005-06-16
SI1537091T1 (sl)	2010-12-31
CA2495942A1 (en)	2004-03-11
UY27959A1 (es)	2004-02-27
DK1537091T3 (da)	2010-11-08
CA2495942C (en)	2010-03-23
KR100736955B1 (ko)	2007-07-09
DE60334461D1 (de)	2010-11-18
WO2004020420A1 (en)	2004-03-11
GT200300183A (es)	2004-04-15
IL166833A (en)	2010-12-30
EP1537091A1 (en)	2005-06-08
TW200407133A (en)	2004-05-16
ES2350340T3 (es)	2011-01-21
TWI338686B (en)	2011-03-11
AR041079A1 (es)	2005-04-27
BR0313946A (pt)	2005-07-12
US6809110B2 (en)	2004-10-26
MXPA05002115A (es)	2005-05-23
ATE483699T1 (de)	2010-10-15
ZA200501097B (en)	2006-11-29
HRP20050158A2 (en)	2006-11-30
PL375779A1 (en)	2005-12-12
HK1082504A1 (zh)	2006-06-09
JP2010132671A (ja)	2010-06-17
CN1678596A (zh)	2005-10-05
NO329777B1 (no)	2010-12-13
PT1537091E (pt)	2010-11-11
JP4533141B2 (ja)	2010-09-01
CN100475810C (zh)	2009-04-08
US20040110807A1 (en)	2004-06-10
MY141020A (en)	2010-02-25
PE20040982A1 (es)	2004-12-30
NZ537897A (en)	2007-08-31
PA8581201A1 (es)	2004-09-16

Publication	Publication Date	Title
NO20044654L (no)	2004-10-28	Piperidinoylpiperidiner som 5-HTIF-agonister
DK1499311T3 (da)	2010-03-08	Substituerede benzaboler og anvendelse deraf som RAF-kinaseinhibitorer
DK1501826T3 (da)	2007-01-29	Substituerede indoler som alpha-1-agonister
NO20040933L (no)	2004-03-03	Nye gamma-sekretaseinhibitorer.
DK1492785T3 (da)	2009-03-02	2-hydroxy-3-heteroarylindol-derivater som GSK3-inhibitorer
NO20034308D0 (no)	2003-09-26	Nye tyrokinase-inhibitorer
DK1648426T3 (da)	2014-02-10	Benzimidazolderivater og anvendelse heraf som proteinkinaseinhibitorer
EP1484563A4 (en)	2005-12-07	COOLER
NO20035848L (no)	2004-02-27	Nye vevsfaktorrettede antistoffer som antikoagulanter
NO20050620L (no)	2005-03-03	Nye 2-aryltiazol-forbindelser som PPARALPHA og PPARGAMA agonister
NO20040996L (no)	2004-05-12	Nye forbindelser og sammensetninger som catepsin-inhibitorer
IS7793A (is)	2005-04-11	Nýtt efnasamband
NO20035328D0 (no)	2003-11-28	Nye forbindelser og preparater som katepsinhibitorer
DK1663971T3 (da)	2012-03-19	Substituerede 2-carbonylamino-6-piperidinaminopyridiner og substituerede 1-carbonylamino-3-piperidinamino-,benzener som 5-HT1F agonister
ITTO20020117A0 (it)	2002-02-08	Apparecchiatura per prove tribologiche.
DE60334519D1 (de)	2010-11-25	Kühlvorrichtung
DE60324018D1 (de)	2008-11-20	Agonisten
DE60300163D1 (de)	2004-12-30	Testhalterung
DK1499622T3 (da)	2009-06-08	Meterotricyclyl-6-alkylidenpenemer som beta-lactamaseinhibitorer
DE60330175D1 (de)	2009-12-31	Kühlvorrichtung
PL363840A1 (pl)	2004-11-29	Inhibitor absorpcji monoaminy
NO20043610L (no)	2004-10-05	Fenylpyrimidinaminer som IgE inhibitorer
NO20044140D0 (no)	2004-09-29	New Composition
NO20053511D0 (no)	2005-07-18	Nye fibrillin-liknende polypeptider
ATE491683T1 (de)	2011-01-15	Muskarine agonisten

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