NO20043580L - Quinazolinonderivater og deres bruk som CB agonister - Google Patents

Quinazolinonderivater og deres bruk som CB agonister

Info

Publication number: NO20043580L
Authority: NO; Norway
Prior art keywords: agonists; quinazolinone derivatives; quinazolinone; derivatives
Prior art date: 2002-02-06

Application number

NO20043580A

Other languages

English (en)

Other versions

NO328305B1 (no

NO20043580D0 (no

Inventor

Christopher Thomas Brain

Edward Karol Dziadulewicz

Terance William Hart

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-06

Filing date

2004-08-27

Publication date

2004-09-21

2002-02-06 Priority claimed from GB0202755A external-priority patent/GB0202755D0/en

2002-06-10 Priority claimed from GB0213285A external-priority patent/GB0213285D0/en

2002-09-16 Priority claimed from GB0221459A external-priority patent/GB0221459D0/en

2002-09-16 Priority claimed from GB0221460A external-priority patent/GB0221460D0/en

2004-08-27 Application filed by Novartis Ag filed Critical Novartis Ag

2004-08-27 Publication of NO20043580D0 publication Critical patent/NO20043580D0/no

2004-09-21 Publication of NO20043580L publication Critical patent/NO20043580L/no

2010-01-25 Publication of NO328305B1 publication Critical patent/NO328305B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20043580A 2002-02-06 2004-08-27 Kinazolinonderivater, fremgangsmate for fremstilling og en farmasoytisk sammensetning omfattende disse NO328305B1 (no)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB0202755A GB0202755D0 (en)	2002-02-06	2002-02-06	Organic compounds
GB0213285A GB0213285D0 (en)	2002-06-10	2002-06-10	Organic compound
GB0221459A GB0221459D0 (en)	2002-09-16	2002-09-16	Organic compound
GB0221460A GB0221460D0 (en)	2002-09-16	2002-09-16	Organic compound
PCT/EP2003/001140 WO2003066603A1 (en)	2002-02-06	2003-02-05	Quinazolinone derivatives and their use as cb agonists

Publications (3)

Publication Number	Publication Date
NO20043580D0 NO20043580D0 (no)	2004-08-27
NO20043580L true NO20043580L (no)	2004-09-21
NO328305B1 NO328305B1 (no)	2010-01-25

Family

ID=27739227

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20043580A NO328305B1 (no)	2002-02-06	2004-08-27	Kinazolinonderivater, fremgangsmate for fremstilling og en farmasoytisk sammensetning omfattende disse

Country Status (21)

Country	Link
US (2)	US20050085493A1 (no)
EP (2)	EP1472234B1 (no)
JP (2)	JP4428479B2 (no)
KR (1)	KR100954626B1 (no)
CN (1)	CN100579968C (no)
AR (1)	AR038483A1 (no)
AT (1)	ATE551329T1 (no)
AU (1)	AU2003210212A1 (no)
BR (1)	BR0307461A (no)
CA (1)	CA2471974C (no)
CO (1)	CO5601021A2 (no)
EC (1)	ECSP045219A (no)
ES (1)	ES2384967T3 (no)
MX (1)	MXPA04007641A (no)
MY (1)	MY143958A (no)
NO (1)	NO328305B1 (no)
NZ (1)	NZ571615A (no)
PE (1)	PE20030867A1 (no)
PL (1)	PL370657A1 (no)
TW (1)	TW200306839A (no)
WO (1)	WO2003066603A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL200804B1 (pl)	1999-03-17	2009-02-27	Astrazeneca Ab	Pochodne amidowe, sposoby ich wytwarzania, ich kompozycje farmaceutyczne oraz ich zastosowanie
TW200306839A (en)	2002-02-06	2003-12-01	Novartis Ag	Quinazolinone derivatives and their use as CB agonists
GB0324790D0 (en) *	2003-10-24	2003-11-26	Astrazeneca Ab	Amide derivatives
WO2005047285A1 (en)	2003-11-04	2005-05-26	Merck & Co., Inc.	Substituted naphthyridinone derivatives
SE0303491D0 (sv) *	2003-12-19	2003-12-19	Astrazeneca Ab	New use VI
CN100506802C (zh) *	2004-06-04	2009-07-01	中国科学院上海药物研究所	一类甲酰肽样受体-1调节剂、其制备方法和用途
GB0413618D0 (en) *	2004-06-17	2004-07-21	Novartis Ag	Organic compounds
WO2007006732A1 (en) *	2005-07-11	2007-01-18	N.V. Organon	Synergistic combination for the treatment of pain (cannabioid receptor agonist and opiod receptor agonist)
GB0525068D0 (en)	2005-12-08	2006-01-18	Novartis Ag	Organic compounds
WO2008157500A1 (en) *	2007-06-17	2008-12-24	Kalypsys, Inc.	Aminoquinazoline cannabinoid receptor modulators for treatment of disease
US8349852B2 (en)	2009-01-13	2013-01-08	Novartis Ag	Quinazolinone derivatives useful as vanilloid antagonists
FR2944013B1 (fr) *	2009-04-07	2011-07-15	Sanofi Aventis	Derives de 1-alkyl-cinnolin-4(1h)-one substitues,leur preparation et leur application en therapeutique.
AR080055A1 (es)	2010-02-01	2012-03-07	Novartis Ag	Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1
WO2011092293A2 (en)	2010-02-01	2011-08-04	Novartis Ag	Cyclohexyl amide derivatives as crf receptor antagonists
WO2011095450A1 (en)	2010-02-02	2011-08-11	Novartis Ag	Cyclohexyl amide derivatives as crf receptor antagonists
US8546416B2 (en)	2011-05-27	2013-10-01	Novartis Ag	3-spirocyclic piperidine derivatives as ghrelin receptor agonists
CA2867043A1 (en)	2012-05-03	2013-11-07	Novartis Ag	L-malate salt of 2,7-diaza-spiro[4.5]dec-7-yle derivatives and crystalline forms thereof as ghrelin receptor agonists
UY35675A (es)	2013-07-24	2015-02-27	Novartis Ag	Derivados sustituidos de quinazolin-4-ona
CN106146414A (zh) *	2016-07-07	2016-11-23	浙江大学	喹唑啉二酮类衍生物及其制备方法和用途
CN106831502A (zh) *	2017-03-13	2017-06-13	苏州市泽宸贸易有限公司	邻硝基苯磺酰氯、其合成方法及应用
CN109796360B (zh) *	2019-01-30	2022-03-18	上海阿拉丁生化科技股份有限公司	一种3-氨基-2-萘甲酸类化合物的制备工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR6200M (no)	1967-04-18	1968-07-22
DE1803210A1 (de)	1968-10-16	1970-05-14	Troponwerke Dinklage & Co	2-Methyl-3-(3-[4-phenylpiperazinyl-(1)]-2-hydroxypropyl)-chinazolinon-(4) und Verfahren zu seiner Herstellung
NZ192392A (en) *	1978-12-19	1983-02-15	M Ishikawa	3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones
JPS5657768A (en) *	1979-10-18	1981-05-20	Masayuki Ishikawa	Novel 4-quinazolone derivative substituted by aromatic residue at 3-position
JPS57118570A (en) *	1981-01-16	1982-07-23	Masayuki Ishikawa	Novel 3-phenyl-4-quinazolone derivative
AU543928B2 (en) *	1981-01-16	1985-05-09	Masayuki Ishikawa	4(311)-quinazolinone derivatives
WO1993023082A1 (en) *	1992-05-13	1993-11-25	Alcon Laboratories, Inc.	Topical ophthalmic compositions comprising a combination of calcium antagonists with known antiglaucoma agents
CA2245586A1 (en)	1996-02-06	1997-08-14	Japan Tobacco Inc.	Novel compounds and pharmaceutical use thereof
TW200306839A (en) *	2002-02-06	2003-12-01	Novartis Ag	Quinazolinone derivatives and their use as CB agonists
SE0303491D0 (sv)	2003-12-19	2003-12-19	Astrazeneca Ab	New use VI
GB0413618D0 (en) *	2004-06-17	2004-07-21	Novartis Ag	Organic compounds

2003
- 2003-01-30 TW TW092102105A patent/TW200306839A/zh unknown
- 2003-02-04 AR ARP030100347A patent/AR038483A1/es unknown
- 2003-02-04 PE PE2003000129A patent/PE20030867A1/es not_active Application Discontinuation
- 2003-02-05 EP EP03737316A patent/EP1472234B1/en not_active Expired - Lifetime
- 2003-02-05 EP EP10175740A patent/EP2319839A1/en not_active Withdrawn
- 2003-02-05 PL PL03370657A patent/PL370657A1/xx unknown
- 2003-02-05 NZ NZ571615A patent/NZ571615A/en not_active IP Right Cessation
- 2003-02-05 AU AU2003210212A patent/AU2003210212A1/en not_active Abandoned
- 2003-02-05 CN CN03803448A patent/CN100579968C/zh not_active Expired - Fee Related
- 2003-02-05 AT AT03737316T patent/ATE551329T1/de active
- 2003-02-05 MY MYPI20030387A patent/MY143958A/en unknown
- 2003-02-05 JP JP2003565977A patent/JP4428479B2/ja not_active Expired - Fee Related
- 2003-02-05 MX MXPA04007641A patent/MXPA04007641A/es unknown
- 2003-02-05 ES ES03737316T patent/ES2384967T3/es not_active Expired - Lifetime
- 2003-02-05 BR BR0307461-7A patent/BR0307461A/pt active Search and Examination
- 2003-02-05 WO PCT/EP2003/001140 patent/WO2003066603A1/en not_active Ceased
- 2003-02-05 KR KR1020047012147A patent/KR100954626B1/ko not_active Expired - Fee Related
- 2003-02-05 CA CA2471974A patent/CA2471974C/en not_active Expired - Fee Related
- 2003-02-05 US US10/503,779 patent/US20050085493A1/en not_active Abandoned
2004
- 2004-08-04 EC EC2004005219A patent/ECSP045219A/es unknown
- 2004-08-25 CO CO04083224A patent/CO5601021A2/es not_active Application Discontinuation
- 2004-08-27 NO NO20043580A patent/NO328305B1/no not_active IP Right Cessation
2007
- 2007-06-26 US US11/823,315 patent/US8552015B2/en not_active Expired - Fee Related
2009
- 2009-01-22 JP JP2009012064A patent/JP2009149658A/ja active Pending

Also Published As

Publication number	Publication date
WO2003066603A1 (en)	2003-08-14
MXPA04007641A (es)	2004-11-10
CA2471974C (en)	2011-11-22
US20070265285A1 (en)	2007-11-15
JP2009149658A (ja)	2009-07-09
CA2471974A1 (en)	2003-08-14
AR038483A1 (es)	2005-01-19
NZ571615A (en)	2010-01-29
CO5601021A2 (es)	2006-01-31
TW200306839A (en)	2003-12-01
ATE551329T1 (de)	2012-04-15
EP1472234B1 (en)	2012-03-28
PE20030867A1 (es)	2003-12-04
ES2384967T3 (es)	2012-07-16
CN100579968C (zh)	2010-01-13
EP2319839A1 (en)	2011-05-11
US8552015B2 (en)	2013-10-08
KR20040083501A (ko)	2004-10-02
HK1079518A1 (zh)	2006-04-07
BR0307461A (pt)	2004-11-09
EP1472234A1 (en)	2004-11-03
AU2003210212A1 (en)	2003-09-02
ECSP045219A (es)	2004-09-28
NO328305B1 (no)	2010-01-25
CN1628104A (zh)	2005-06-15
JP2005522439A (ja)	2005-07-28
NO20043580D0 (no)	2004-08-27
PL370657A1 (en)	2005-05-30
KR100954626B1 (ko)	2010-04-27
US20050085493A1 (en)	2005-04-21
MY143958A (en)	2011-07-29
JP4428479B2 (ja)	2010-03-10

Publication	Publication Date	Title
NO20026010D0 (no)	2002-12-13	Substituerte quinazolinderivater og deres anvendelse som inhibitorer
NO20043580L (no)	2004-09-21	Quinazolinonderivater og deres bruk som CB agonister
DK1478629T3 (da)	2007-01-29	N-aryl-2-oxazolidinon-5-carboxamider og deres derivater og deres anvendelse som antibakterielle midler
NO20053356L (no)	2005-07-11	Aminindazolderivater og anvendelse derav som kinaseinhibitorer.
DK1956004T3 (da)	2012-08-06	Quinolinderivater og deres anvendelse som 5-HT6-ligander
DK1480955T3 (da)	2007-10-29	O-cyclopropyl-carboxanilider og deres anvendelse som fungicider
DK1527050T3 (da)	2010-07-19	Quinolin-derivater og deres anvendelse som mycobakterielle inhibitorer
DK1578755T3 (da)	2007-11-12	Phosphonooxyguinalinderivater og deres farmaceutiske anvendelse
IS6934A (is)	2003-08-29	Nýjar spírótrísýklískar afleiður og notkun þeirrasem fosfódíesterasa-7-hindrar
DK1499311T3 (da)	2010-03-08	Substituerede benzaboler og anvendelse deraf som RAF-kinaseinhibitorer
DK1558615T3 (da)	2007-12-03	Purin-forbindelser og deres anvendelse som cannabinoid receptor ligander
NO20044137L (no)	2004-11-25	Aminoindazolderivater, deres fremstilling og anvendelse samt mellomprodukter
DK1368349T3 (da)	2007-05-21	Xanthinderivater, deres fremstilling og deres anvendelse som lægemidler
DK1581532T3 (da)	2010-08-16	Pyrazolo-3,4-B pyridinforbindelser og deres anvendelse som phosphodiesterase inhibitorer
DK1761529T3 (da)	2008-03-25	Pyrrolopyridinderivater og deres anvendelse som CRTh2-antagonister
DK1539712T3 (da)	2008-03-17	Pyrimidinderivater og deres anvendelse som CB2-modulatorer
DK1133477T3 (da)	2004-06-21	Substituerede benzimidazoler og deres anvendelse som parpinhibitorer
DK1455785T3 (da)	2009-06-08	Substituerede 2-thio-3,5-dicyano-4-phenyl-6-aminopyridiner og deres anvendelse
NO20031952L (no)	2003-07-22	3-aroylinderivater og deres anvendelse som CB2 reseptoragonister
NO20042719L (no)	2004-06-28	Substituerte 2-amino-cykloalkankarboksamider og deres anvendelse som protease-inhibitorer
NO20050665L (no)	2005-04-18	Pyrrolidonderivater som MAOE inhibitoere
DK1581518T3 (da)	2011-06-06	Substituerede 1-piperidin-4-yl-4-pyrrolidin-3-yl-piperazin-derivater og deres anvendelse som neurokinin antagonister
NO20043349L (no)	2004-10-05	Kumarinderivater, fremgangsmate for deres framstilling og anvendelse derav
DK1387838T3 (da)	2006-08-14	Cyanoanthranylamid-derivater og deres anvendelse som lægemidler
NO20034434L (no)	2003-10-03	Indolinoner substituert i 6-stilling og deres anvendelse som kinase-inhibitorer

Legal Events

Date	Code	Title	Description
2012-10-01	MM1K	Lapsed by not paying the annual fees