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NO20030301L - Nye heteroarylderivater og anvendelse derav som farmasöytika - Google Patents

Nye heteroarylderivater og anvendelse derav som farmasöytika

Info

Publication number
NO20030301L
NO20030301L NO20030301A NO20030301A NO20030301L NO 20030301 L NO20030301 L NO 20030301L NO 20030301 A NO20030301 A NO 20030301A NO 20030301 A NO20030301 A NO 20030301A NO 20030301 L NO20030301 L NO 20030301L
Authority
NO
Norway
Prior art keywords
pharmaceuticals
heteroaryl derivatives
new heteroaryl
new
derivatives
Prior art date
Application number
NO20030301A
Other languages
English (en)
Other versions
NO324939B1 (no
NO20030301D0 (no
Inventor
Peter Emig
Eckhard Guenther
Silke Baasner
Gerald Bacher
Thomas Beckers
Beate Aue
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of NO20030301D0 publication Critical patent/NO20030301D0/no
Publication of NO20030301L publication Critical patent/NO20030301L/no
Publication of NO324939B1 publication Critical patent/NO324939B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye akridinderivater av generell formel (1). fremgangsmåte for deres fremstilling og anvendelsen derav som farmasøytika, spesielt for behandling av tumorer.
NO20030301A 2000-07-21 2003-01-20 Akridinderivater, anvendelse derav, fremgangsmate for fremstilling derav samt medikament inneholdende minst ett akridinderivat NO324939B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10035927A DE10035927A1 (de) 2000-07-21 2000-07-21 Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
PCT/EP2001/008263 WO2002008194A1 (de) 2000-07-21 2001-07-18 Acridin-derivate und deren verwendung als arzneimittel

Publications (3)

Publication Number Publication Date
NO20030301D0 NO20030301D0 (no) 2003-01-20
NO20030301L true NO20030301L (no) 2003-03-11
NO324939B1 NO324939B1 (no) 2008-01-07

Family

ID=7649979

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20030301A NO324939B1 (no) 2000-07-21 2003-01-20 Akridinderivater, anvendelse derav, fremgangsmate for fremstilling derav samt medikament inneholdende minst ett akridinderivat

Country Status (28)

Country Link
US (1) US6706722B2 (no)
EP (1) EP1301485B1 (no)
JP (1) JP2004504382A (no)
KR (1) KR20030022296A (no)
CN (1) CN1296359C (no)
AR (1) AR033383A1 (no)
AT (1) ATE365717T1 (no)
AU (2) AU2001289675B2 (no)
BG (1) BG107507A (no)
BR (1) BR0112591A (no)
CA (1) CA2353360A1 (no)
CY (1) CY1106890T1 (no)
CZ (1) CZ2003427A3 (no)
DE (2) DE10035927A1 (no)
DK (1) DK1301485T3 (no)
ES (1) ES2291349T3 (no)
HU (1) HUP0303729A3 (no)
IL (1) IL153476A0 (no)
MX (1) MXPA02012564A (no)
NO (1) NO324939B1 (no)
NZ (1) NZ524155A (no)
PL (1) PL358808A1 (no)
PT (1) PT1301485E (no)
RU (1) RU2267488C2 (no)
SK (1) SK1932003A3 (no)
UA (1) UA75085C2 (no)
WO (1) WO2002008194A1 (no)
ZA (1) ZA200210411B (no)

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DE10035928A1 (de) * 2000-07-21 2002-03-07 Asta Medica Ag Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
BR0312294A (pt) * 2002-06-29 2005-04-12 Zentaris Gmbh Arilcarbonil piperazinas e hteroarilcarbonilpiperazinas e o uso das mesmas para tratamento de doenças benignas e malignas
MXPA05000487A (es) * 2002-07-17 2005-03-23 Zentaris Gmbh Nuevos derivados de antraceno y su uso como un medicamento.
US7125461B2 (en) * 2003-05-07 2006-10-24 L & L Products, Inc. Activatable material for sealing, baffling or reinforcing and method of forming same
AR044586A1 (es) * 2003-06-04 2005-09-21 Aventis Pharma Sa Productos aril - heteroaromaticos, composiciones que los contienen y su utilizacion
FR2855825B1 (fr) * 2003-06-04 2008-08-22 Aventis Pharma Sa Produits aryl-heteroaromatiques, compositions les contenant et utilisation
US7249415B2 (en) * 2003-06-26 2007-07-31 Zephyros, Inc. Method of forming members for sealing or baffling
DE10331500A1 (de) * 2003-07-11 2005-02-24 Zentaris Gmbh Neue Acridin-Derivate und deren Verwendung als Arzneimittel
JP2008528573A (ja) * 2005-01-27 2008-07-31 アルマ マテル ストゥディオルム−ウニヴェルシタ ディ ボローニャ アルツハイマー病の処置に有用な有機化合物、それらの使用及び調製の方法
US20070299093A1 (en) * 2005-01-27 2007-12-27 Alma Mater Studiorum-Universitá Di Bologna Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation
WO2008106128A2 (en) * 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
ES2395081T3 (es) * 2007-07-26 2013-02-08 Vitae Pharmaceuticals, Inc. Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1
AR069207A1 (es) * 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
US8592409B2 (en) * 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
CA2714532A1 (en) * 2008-02-11 2009-08-20 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
CA2715290A1 (en) * 2008-02-15 2009-08-20 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2718264A1 (en) * 2008-03-18 2009-09-24 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
CA2723032A1 (en) * 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2291371B1 (en) 2008-05-01 2015-06-10 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2009134400A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
TW201016691A (en) 2008-07-25 2010-05-01 Boehringer Ingelheim Int Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010011314A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
TW201039034A (en) * 2009-04-27 2010-11-01 Chunghwa Picture Tubes Ltd Pixel structure and the method of forming the same
UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
KR20120061771A (ko) * 2009-04-30 2012-06-13 비타이 파마슈티컬즈, 인코포레이티드 11베타-하이드록시스테로이드 탈수소효소 1의 고리형 억제제
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
JP5749263B2 (ja) 2009-07-01 2015-07-15 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
BR112013010021A2 (pt) 2010-11-02 2019-09-24 Boehringer Ingelheim Int combinações farmacêuticas para o tratamento de distúrbios metabólicos.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
EP0318235A3 (en) * 1987-11-25 1991-05-02 Takeda Chemical Industries, Ltd. Paf antagonist, 1,4-disubstituted piperazine compounds and production thereof
US5030631A (en) * 1989-11-27 1991-07-09 Schering Corporation Tricylclic arylsulfonamides
RU2126001C1 (ru) * 1995-01-10 1999-02-10 Самдзин Фармасьютикал Ко., Лтд Производные пиперазина и фармацевтическая композиция на их основе
AU713171B2 (en) * 1996-06-29 1999-11-25 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and process for the preparation thereof
US5861395A (en) 1996-09-13 1999-01-19 Schering Corporation Compounds useful for inhibition of farnesyl proteins transferase
FR2753706B1 (fr) 1996-09-20 1998-10-30 Nouvelles amines cycliques n-substituees, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE19743435A1 (de) 1997-10-01 1999-04-08 Merck Patent Gmbh Benzamidinderivate
BR9913654A (pt) 1998-08-28 2001-11-27 Scios Inc Inibidores de p-38alfa quinase
EP1165084A4 (en) 1999-03-03 2002-05-15 Merck & Co Inc INHIBITORS OF PRENYL PROTEIN TRANSFERASES

Also Published As

Publication number Publication date
AU2001289675B2 (en) 2005-04-07
US6706722B2 (en) 2004-03-16
SK1932003A3 (en) 2003-10-07
DK1301485T3 (da) 2007-11-05
PL358808A1 (en) 2004-08-23
ZA200210411B (en) 2003-02-26
NZ524155A (en) 2005-04-29
BR0112591A (pt) 2003-07-22
DE50112669D1 (de) 2007-08-09
MXPA02012564A (es) 2003-09-22
KR20030022296A (ko) 2003-03-15
WO2002008194A8 (de) 2003-05-08
UA75085C2 (en) 2006-03-15
PT1301485E (pt) 2007-08-30
RU2267488C2 (ru) 2006-01-10
HK1057549A1 (en) 2004-04-08
ES2291349T3 (es) 2008-03-01
BG107507A (bg) 2003-09-30
US20020132821A1 (en) 2002-09-19
HUP0303729A2 (hu) 2004-03-01
CZ2003427A3 (cs) 2003-06-18
DE10035927A1 (de) 2002-03-07
HUP0303729A3 (en) 2009-01-28
NO324939B1 (no) 2008-01-07
EP1301485A1 (de) 2003-04-16
CN1296359C (zh) 2007-01-24
EP1301485B1 (de) 2007-06-27
NO20030301D0 (no) 2003-01-20
AR033383A1 (es) 2003-12-17
CY1106890T1 (el) 2012-09-26
IL153476A0 (en) 2003-07-06
WO2002008194A1 (de) 2002-01-31
AU8967501A (en) 2002-02-05
CA2353360A1 (en) 2002-01-21
JP2004504382A (ja) 2004-02-12
ATE365717T1 (de) 2007-07-15
CN1443172A (zh) 2003-09-17

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