NO20030675D0 - Nye amidinoderivater og deres anvendelse som trombininhibitorer - Google Patents
Nye amidinoderivater og deres anvendelse som trombininhibitorerInfo
- Publication number
- NO20030675D0 NO20030675D0 NO20030675A NO20030675A NO20030675D0 NO 20030675 D0 NO20030675 D0 NO 20030675D0 NO 20030675 A NO20030675 A NO 20030675A NO 20030675 A NO20030675 A NO 20030675A NO 20030675 D0 NO20030675 D0 NO 20030675D0
- Authority
- NO
- Norway
- Prior art keywords
- thrombin inhibitors
- derivatives
- amidino derivatives
- thrombin
- novel amidino
- Prior art date
Links
- 229940122388 Thrombin inhibitor Drugs 0.000 title 1
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 title 1
- 239000003868 thrombin inhibitor Substances 0.000 title 1
- 108090000190 Thrombin Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229960004072 thrombin Drugs 0.000 abstract 2
- 102100027612 Kallikrein-11 Human genes 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 101710152431 Trypsin-like protease Proteins 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 230000002860 competitive effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0002921A SE0002921D0 (sv) | 2000-08-16 | 2000-08-16 | Pharmaceutically useful compounds |
| SE0002922A SE0002922D0 (sv) | 2000-08-16 | 2000-08-16 | Pharmaceutically useful compounds |
| US09/900,903 US6433186B1 (en) | 2000-08-16 | 2001-07-10 | Amidino derivatives and their use as thormbin inhibitors |
| PCT/SE2001/001751 WO2002014270A1 (en) | 2000-08-16 | 2001-08-13 | New amidino derivatives and their use as thrombin inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20030675D0 true NO20030675D0 (no) | 2003-02-11 |
| NO20030675L NO20030675L (no) | 2003-02-11 |
| NO325242B1 NO325242B1 (no) | 2008-03-03 |
Family
ID=27354584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030675A NO325242B1 (no) | 2000-08-16 | 2003-02-11 | Nye amidinoderivater, anvendelse og fremstilling derav, samt farmasoytisk preparat |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1311480B1 (no) |
| JP (1) | JP2004506039A (no) |
| CN (1) | CN1205183C (no) |
| AT (1) | ATE407116T1 (no) |
| AU (2) | AU2001280395B2 (no) |
| BR (1) | BR0113212A (no) |
| CA (1) | CA2415383C (no) |
| DE (1) | DE60135665D1 (no) |
| DK (1) | DK1311480T3 (no) |
| ES (1) | ES2311538T3 (no) |
| IL (1) | IL154077A0 (no) |
| MX (1) | MXPA03000643A (no) |
| NO (1) | NO325242B1 (no) |
| NZ (1) | NZ523598A (no) |
| PT (1) | PT1311480E (no) |
| SI (1) | SI1311480T1 (no) |
| WO (1) | WO2002014270A1 (no) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102921D0 (sv) | 2001-08-30 | 2001-08-30 | Astrazeneca Ab | Pharmaceutically useful compounds |
| US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| JP2004528356A (ja) | 2001-04-27 | 2004-09-16 | ザ プロクター アンド ギャンブル カンパニー | バイオフィルムを制御する化合物、組成物、及び方法 |
| SE0201658D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Immediate release pharmaceutical formulation |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| GB0503672D0 (en) * | 2005-02-23 | 2005-03-30 | Astrazeneca Ab | New process |
| US9206123B2 (en) | 2009-12-18 | 2015-12-08 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| CA2783801A1 (en) | 2009-12-18 | 2011-06-23 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
| EP2697196A1 (en) * | 2011-04-13 | 2014-02-19 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| SE9602263D0 (sv) * | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| TR200102037T2 (tr) * | 1999-01-13 | 2001-10-22 | Astrazeneca Ab | Yeni amidinobenzilamin türevleri ve trombin engelleyiciler olarak kullanılmaları. |
-
2001
- 2001-08-13 IL IL15407701A patent/IL154077A0/xx unknown
- 2001-08-13 WO PCT/SE2001/001751 patent/WO2002014270A1/en not_active Ceased
- 2001-08-13 CA CA002415383A patent/CA2415383C/en not_active Expired - Fee Related
- 2001-08-13 MX MXPA03000643A patent/MXPA03000643A/es active IP Right Grant
- 2001-08-13 SI SI200130875T patent/SI1311480T1/sl unknown
- 2001-08-13 AU AU2001280395A patent/AU2001280395B2/en not_active Ceased
- 2001-08-13 AT AT01958778T patent/ATE407116T1/de not_active IP Right Cessation
- 2001-08-13 BR BR0113212-1A patent/BR0113212A/pt not_active IP Right Cessation
- 2001-08-13 NZ NZ523598A patent/NZ523598A/en unknown
- 2001-08-13 DE DE60135665T patent/DE60135665D1/de not_active Expired - Lifetime
- 2001-08-13 AU AU8039501A patent/AU8039501A/xx active Pending
- 2001-08-13 PT PT01958778T patent/PT1311480E/pt unknown
- 2001-08-13 JP JP2002519415A patent/JP2004506039A/ja active Pending
- 2001-08-13 ES ES01958778T patent/ES2311538T3/es not_active Expired - Lifetime
- 2001-08-13 CN CNB018141250A patent/CN1205183C/zh not_active Expired - Fee Related
- 2001-08-13 EP EP01958778A patent/EP1311480B1/en not_active Expired - Lifetime
- 2001-08-13 DK DK01958778T patent/DK1311480T3/da active
-
2003
- 2003-02-11 NO NO20030675A patent/NO325242B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03000643A (es) | 2003-06-06 |
| AU2001280395B2 (en) | 2005-11-24 |
| CN1205183C (zh) | 2005-06-08 |
| EP1311480B1 (en) | 2008-09-03 |
| CN1446199A (zh) | 2003-10-01 |
| DK1311480T3 (da) | 2008-12-01 |
| EP1311480A1 (en) | 2003-05-21 |
| AU8039501A (en) | 2002-02-25 |
| BR0113212A (pt) | 2003-07-08 |
| CA2415383A1 (en) | 2002-02-21 |
| DE60135665D1 (de) | 2008-10-16 |
| WO2002014270A1 (en) | 2002-02-21 |
| IL154077A0 (en) | 2003-07-31 |
| ES2311538T3 (es) | 2009-02-16 |
| CA2415383C (en) | 2009-11-24 |
| NO20030675L (no) | 2003-02-11 |
| ATE407116T1 (de) | 2008-09-15 |
| PT1311480E (pt) | 2008-11-11 |
| SI1311480T1 (sl) | 2008-12-31 |
| NZ523598A (en) | 2004-10-29 |
| NO325242B1 (no) | 2008-03-03 |
| JP2004506039A (ja) | 2004-02-26 |
| HK1053121A1 (en) | 2003-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |