TWI264434B - New mandelic acid derivatives and their use as thrombin inhibitors - Google Patents
New mandelic acid derivatives and their use as thrombin inhibitorsInfo
- Publication number
- TWI264434B TWI264434B TW91132920A TW91132920A TWI264434B TW I264434 B TWI264434 B TW I264434B TW 91132920 A TW91132920 A TW 91132920A TW 91132920 A TW91132920 A TW 91132920A TW I264434 B TWI264434 B TW I264434B
- Authority
- TW
- Taiwan
- Prior art keywords
- acid derivatives
- mandelic acid
- thrombin inhibitors
- thrombin
- new
- Prior art date
Links
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical class O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 title 1
- 229940122388 Thrombin inhibitor Drugs 0.000 title 1
- 239000003868 thrombin inhibitor Substances 0.000 title 1
- 108090000190 Thrombin Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 229960004072 thrombin Drugs 0.000 abstract 2
- 102100027612 Kallikrein-11 Human genes 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 101710152431 Trypsin-like protease Proteins 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127219 anticoagulant drug Drugs 0.000 abstract 1
- 230000002860 competitive effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
There is provided a compound of formula I, wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW91132920A TWI264434B (en) | 2001-11-26 | 2002-11-08 | New mandelic acid derivatives and their use as thrombin inhibitors |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW90129207 | 2001-11-26 | ||
| TW91132920A TWI264434B (en) | 2001-11-26 | 2002-11-08 | New mandelic acid derivatives and their use as thrombin inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200306975A TW200306975A (en) | 2003-12-01 |
| TWI264434B true TWI264434B (en) | 2006-10-21 |
Family
ID=37969346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW91132920A TWI264434B (en) | 2001-11-26 | 2002-11-08 | New mandelic acid derivatives and their use as thrombin inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TWI264434B (en) |
-
2002
- 2002-11-08 TW TW91132920A patent/TWI264434B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200306975A (en) | 2003-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |