NO20024808L - FremgangsmÕte ved syntesen av perindopril og farmasöytisk akseptable salter derav - Google Patents

FremgangsmÕte ved syntesen av perindopril og farmasöytisk akseptable salter derav

Info

Publication number: NO20024808L
Authority: NO; Norway
Prior art keywords: perindopril; synthesis; pharmaceutically acceptable; acceptable salts; salts
Prior art date: 2000-04-06

Application number

NO20024808A

Other languages

English (en)

Other versions

NO20024808D0 (no

NO324174B1 (no

Inventor

Pascal Langlois

Hugues Turbe

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-06

Filing date

2002-10-04

Publication date

2002-10-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8848925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20024808(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-10-04 Application filed by Servier Lab filed Critical Servier Lab

2002-10-04 Publication of NO20024808D0 publication Critical patent/NO20024808D0/no

2002-10-04 Publication of NO20024808L publication Critical patent/NO20024808L/no

2007-09-03 Publication of NO324174B1 publication Critical patent/NO324174B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20024808A 2000-04-06 2002-10-04 Fremgangsmate ved syntesen av perindopril og farmasoytisk akseptable salter derav NO324174B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0004379A FR2807431B1 (fr)	2000-04-06	2000-04-06	Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2001/001026 WO2001058868A1 (fr)	2000-04-06	2001-04-05	Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (3)

Publication Number	Publication Date
NO20024808D0 NO20024808D0 (no)	2002-10-04
NO20024808L true NO20024808L (no)	2002-10-04
NO324174B1 NO324174B1 (no)	2007-09-03

Family

ID=8848925

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20024808A NO324174B1 (no)	2000-04-06	2002-10-04	Fremgangsmate ved syntesen av perindopril og farmasoytisk akseptable salter derav

Country Status (34)

Country	Link
US (1)	US6835843B2 (no)
EP (1)	EP1268424B1 (no)
JP (1)	JP3939553B2 (no)
KR (1)	KR100507616B1 (no)
CN (1)	CN1296355C (no)
AP (1)	AP1385A (no)
AT (1)	ATE369338T1 (no)
AU (2)	AU2001248470B2 (no)
BG (1)	BG65984B1 (no)
BR (1)	BRPI0109836B1 (no)
CA (1)	CA2405486C (no)
CY (1)	CY1108522T1 (no)
CZ (1)	CZ302575B6 (no)
DE (1)	DE60129800T2 (no)
DK (1)	DK1268424T3 (no)
EA (1)	EA005079B1 (no)
EE (1)	EE05032B1 (no)
ES (1)	ES2291307T3 (no)
FR (1)	FR2807431B1 (no)
GE (1)	GEP20063797B (no)
HR (1)	HRP20020876B1 (no)
HU (1)	HU227674B1 (no)
ME (1)	ME00441B (no)
MX (1)	MXPA02009706A (no)
NO (1)	NO324174B1 (no)
NZ (1)	NZ521454A (no)
OA (1)	OA12242A (no)
PL (1)	PL204471B1 (no)
PT (1)	PT1268424E (no)
RS (1)	RS50808B (no)
SK (1)	SK286921B6 (no)
UA (1)	UA75070C2 (no)
WO (1)	WO2001058868A1 (no)
ZA (1)	ZA200207419B (no)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2827860B1 (fr)	2001-07-24	2004-12-10	Servier Lab	Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
ATE365714T1 (de) *	2002-01-30	2007-07-15	Servier Lab	Verfahren zur herstellung von hochreinem perindopril und zwischenverbindungen nützlich in der synthese
JP2005256847A (ja) *	2002-02-28	2005-09-22	Nsk Ltd	車輪用軸受ユニット
GB2395195A (en) *	2002-11-18	2004-05-19	Cipla Ltd	Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
DE60301774T2 (de) *	2003-02-28	2006-07-20	Les Laboratoires Servier	Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
CA2517205C (en)	2003-02-28	2010-08-24	Lupin Limited	Process for preparation of perindopril and salts thereof
ATE307139T1 (de) *	2003-02-28	2005-11-15	Servier Lab	Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salze
SI1338591T1 (sl) *	2003-02-28	2006-02-28	Servier Lab	NOV POSTOPEK ZA SINTEZO (2S,3aS,7aS)-PERHIDROINDOL-2-KARBOKSILNE KISLINE IN NJENIH ESTROV TER UPORABA PRI SINTEZI PERINDOPRILA
DK1321471T3 (da) *	2003-03-12	2005-08-29	Servier Lab	Ny syntesefremgangsmåde til perindopril og farmaceutisk acceptable salte heraf
ES2231760T3 (es) *	2003-03-12	2005-05-16	Les Laboratoires Servier	Nuevo procedimiento de sintesis del acido(2s, 3as,7as)perhidroindol-2-carboxilico y de sus esteres, y su aplicacion a la sintesis de perindopril.
PT1319668E (pt) *	2003-03-12	2005-02-28	Servier Lab	Novo processo de sintese de derivados do acido (2s,3as,7as)-1-[(s)-alanil]-octa-hidro-1h-indole-2-carboxilico e aplicacao a sintese de perindopril
WO2004099138A2 (en) *	2003-05-12	2004-11-18	Cipla Limited	Process for the preparation of perindopril
ATE540924T1 (de)	2003-06-24	2012-01-15	Servier Lab	Neue kristalline formen von perindopril erbumine
SI1367063T1 (sl) *	2003-07-31	2006-10-31	Servier Lab	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
DK1367062T3 (da) *	2003-07-31	2007-01-02	Servier Lab	Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
AU2003300689B2 (en) *	2003-10-21	2009-01-29	Les Laboratoires Servier	Novel method for preparation of crystalline perindopril erbumine
ES2300555T3 (es) *	2003-12-10	2008-06-16	Les Laboratoires Servier	Procedimiento de sintesis de perindopril y de sus sales farmaceuticamente aceptables.
HRP20161602T1 (hr) *	2004-03-29	2016-12-30	Les Laboratoires Servier	Postupak priprave čvrstog farmaceutskog pripravka
GB2413128A (en) *	2004-04-13	2005-10-19	Neopharma Ltd	Process for the preparation of perindopril
SI21800A (sl)	2004-05-14	2005-12-31	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze perindoprila
ES2255872B1 (es) *	2004-12-31	2007-08-16	Quimica Sintetica, S.A.	Procedimiento para la preparacion de perindopril erbumina.
EP1987828A1 (en)	2005-01-06	2008-11-05	IPCA Laboratories Limited	salts of perindopril and their use in the therapy of hypertension
US7291745B2 (en) *	2005-03-21	2007-11-06	Glenmark Pharmaceuticals Limited	Process for the preparation of perindopril
JP2006290825A (ja) *	2005-04-13	2006-10-26	Shiono Chemical Co Ltd	アルファ型ペリンドプリルエルブミンの製造法
DE102005058166A1 (de) *	2005-12-05	2007-06-06	Hexal Ag	Matrixkontrolliertes transdermales System mit Amin-Salzen der ACE-Hemmer-Dicarbonsäuren
WO2007085933A2 (en) *	2006-01-25	2007-08-02	Glenmark Pharmaceuticals Limited	Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril
WO2008114270A1 (en) *	2007-03-22	2008-09-25	Aarti Healthcare Limited	Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
FR2961105B1 (fr) *	2010-06-15	2013-02-08	Servier Lab	Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
AU2013328352A1 (en) *	2012-10-10	2015-05-14	Piramal Enterprises Limited	An improved process for preparation of Perindopril intermediate
WO2016178591A2 (en)	2015-05-05	2016-11-10	Gene Predit, Sa	Genetic markers and treatment of male obesity
PH12018502155B1 (en)	2016-04-20	2024-03-27	Servier Lab	Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
CN107098949B (zh) *	2017-04-20	2021-03-16	上药东英（江苏）药业有限公司	一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2503155A2 (fr) *	1980-10-02	1982-10-08	Science Union & Cie	Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
DE3302125A1 (de) *	1983-01-22	1984-07-26	Boehringer Ingelheim KG, 6507 Ingelheim	Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
FR2620700B1 (fr) *	1987-09-17	1990-06-01	Adir	Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) *	1987-09-17	1990-09-07	Adir	Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese

2000
- 2000-04-06 FR FR0004379A patent/FR2807431B1/fr not_active Expired - Fee Related
2001
- 2001-03-20 PL PL346555A patent/PL204471B1/pl unknown
- 2001-03-30 HU HU0101336A patent/HU227674B1/hu not_active IP Right Cessation
- 2001-04-05 JP JP2001558419A patent/JP3939553B2/ja not_active Expired - Fee Related
- 2001-04-05 DE DE60129800T patent/DE60129800T2/de not_active Expired - Lifetime
- 2001-04-05 MX MXPA02009706A patent/MXPA02009706A/es active IP Right Grant
- 2001-04-05 CN CNB018073727A patent/CN1296355C/zh not_active Expired - Fee Related
- 2001-04-05 AT AT01921486T patent/ATE369338T1/de active
- 2001-04-05 EP EP01921486A patent/EP1268424B1/fr not_active Expired - Lifetime
- 2001-04-05 OA OA1200200306A patent/OA12242A/en unknown
- 2001-04-05 EE EEP200200575A patent/EE05032B1/xx not_active IP Right Cessation
- 2001-04-05 SK SK1418-2002A patent/SK286921B6/sk not_active IP Right Cessation
- 2001-04-05 AP APAP/P/2002/002630A patent/AP1385A/en active
- 2001-04-05 EA EA200201057A patent/EA005079B1/ru not_active IP Right Cessation
- 2001-04-05 US US10/239,129 patent/US6835843B2/en not_active Expired - Lifetime
- 2001-04-05 WO PCT/FR2001/001026 patent/WO2001058868A1/fr not_active Ceased
- 2001-04-05 BR BRPI0109836-5A patent/BRPI0109836B1/pt not_active IP Right Cessation
- 2001-04-05 HR HR20020876A patent/HRP20020876B1/xx not_active IP Right Cessation
- 2001-04-05 KR KR10-2002-7013376A patent/KR100507616B1/ko not_active Expired - Fee Related
- 2001-04-05 CA CA002405486A patent/CA2405486C/fr not_active Expired - Fee Related
- 2001-04-05 GE GEAP20016679A patent/GEP20063797B/en unknown
- 2001-04-05 DK DK01921486T patent/DK1268424T3/da active
- 2001-04-05 ES ES01921486T patent/ES2291307T3/es not_active Expired - Lifetime
- 2001-04-05 CZ CZ20023291A patent/CZ302575B6/cs not_active IP Right Cessation
- 2001-04-05 AU AU2001248470A patent/AU2001248470B2/en not_active Ceased
- 2001-04-05 ME MEP-2008-670A patent/ME00441B/me unknown
- 2001-04-05 PT PT01921486T patent/PT1268424E/pt unknown
- 2001-04-05 NZ NZ52145401A patent/NZ521454A/en not_active IP Right Cessation
- 2001-04-05 AU AU4847001A patent/AU4847001A/xx active Pending
- 2001-04-05 RS YUP-738/02A patent/RS50808B/sr unknown
- 2001-05-04 UA UA2002118786A patent/UA75070C2/uk unknown
2002
- 2002-09-16 ZA ZA200207419A patent/ZA200207419B/en unknown
- 2002-10-04 NO NO20024808A patent/NO324174B1/no not_active IP Right Cessation
- 2002-11-04 BG BG107249A patent/BG65984B1/bg unknown
2007
- 2007-10-16 CY CY20071101338T patent/CY1108522T1/el unknown

Also Published As

Publication number	Publication date
ES2291307T3 (es)	2008-03-01
CN1420867A (zh)	2003-05-28
AP1385A (en)	2005-04-08
HUP0101336A2 (hu)	2002-02-28
ATE369338T1 (de)	2007-08-15
EP1268424B1 (fr)	2007-08-08
KR100507616B1 (ko)	2005-08-10
PL204471B1 (pl)	2010-01-29
GEP20063797B (en)	2006-04-25
US6835843B2 (en)	2004-12-28
NO20024808D0 (no)	2002-10-04
SK14182002A3 (sk)	2003-02-04
MXPA02009706A (es)	2004-09-06
ME00441B (me)	2011-10-10
DE60129800D1 (de)	2007-09-20
EA005079B1 (ru)	2004-10-28
BG65984B1 (bg)	2010-08-31
CZ302575B6 (cs)	2011-07-20
EE200200575A (et)	2004-04-15
CA2405486A1 (fr)	2001-08-16
NZ521454A (en)	2004-03-26
RS50808B (sr)	2010-08-31
JP3939553B2 (ja)	2007-07-04
HK1053309A1 (en)	2003-10-17
CZ20023291A3 (cs)	2003-02-12
DK1268424T3 (da)	2007-12-17
FR2807431A1 (fr)	2001-10-12
SK286921B6 (sk)	2009-07-06
US20030069431A1 (en)	2003-04-10
HRP20020876B1 (en)	2010-10-31
JP2003531825A (ja)	2003-10-28
NO324174B1 (no)	2007-09-03
HU0101336D0 (en)	2001-06-28
DE60129800T2 (de)	2008-06-05
PL346555A1 (en)	2001-09-10
EP1268424A1 (fr)	2003-01-02
AU2001248470B2 (en)	2005-01-20
PT1268424E (pt)	2007-10-16
AU4847001A (en)	2001-08-20
EA200201057A1 (ru)	2003-06-26
HRP20020876A2 (en)	2004-02-29
FR2807431B1 (fr)	2002-07-19
BG107249A (bg)	2003-07-31
KR20030013381A (ko)	2003-02-14
BRPI0109836B1 (pt)	2015-08-04
CN1296355C (zh)	2007-01-24
CY1108522T1 (el)	2014-04-09
OA12242A (en)	2003-12-08
YU73802A (sh)	2006-01-16
UA75070C2 (uk)	2006-03-15
HU227674B1 (hu)	2011-11-28
CA2405486C (fr)	2008-07-29
HUP0101336A3 (en)	2003-03-28
ZA200207419B (en)	2003-09-16
WO2001058868A1 (fr)	2001-08-16
AP2002002630A0 (en)	2002-09-30
EE05032B1 (et)	2008-06-16
BR0109836A (pt)	2003-06-24

Publication	Publication Date	Title
NO20024808L (no)	2002-10-04	FremgangsmÕte ved syntesen av perindopril og farmasöytisk akseptable salter derav
AU2001248470A1 (en)	2001-11-01	Method for synthesis of perindopril and its pharmaceutically acceptable salts
NO20041994L (no)	2004-05-14	Nye beta-fenyl-alfa-oksysubstituerte propion derivater: Fremgangsmate for deres fremstilling og deres anvendelse ved fremstilling av farmasoytisk riktige forbindelser
NO20030844L (no)	2003-02-25	Fremgangsmåte for fremstilling av N-aryl-antranilinsyrer og derivater derav
NO20025377L (no)	2003-01-07	Fremgangsmate for fremstilling av dihydroksyestere og derivater derav
NO20040278L (no)	2004-01-21	Fremgangsmate for fremstilling av perindopril
IL160043A0 (en)	2004-06-20	Process for the preparation of indole derivatives
IL152580A0 (en)	2003-05-29	Process for the preparation of indole derivatives and intermediates of the process
ZA200510324B (en)	2007-03-28	Novel method for the synthesis of perindopril and the pharmaceutically acceptable salts thereof
NO20062599L (no)	2006-06-06	Fremgangsmate for syntese av perindopril og farmasoytisk akseptable salter derav
SI1367061T1 (sl)	2006-04-30	Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
ITMI20000026A0 (it)	2000-01-13	Procedimento per la produzione di gas di sintesi
SI1371659T1 (sl)	2006-02-28	Nov postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
NO20026005L (no)	2002-12-13	Indolderivater nyttige for behandlingen av CNS-forstyrrelser
SI1380590T1 (sl)	2006-12-31	Postopek za sintezo perindoprila in njenih farmacevtsko sprejemljivih soli
PL357106A1 (en)	2004-07-12	Novel process for the preparation of alpha-(2-4-disulfophenyl)-n-tert-butylnitrone and pharmaceutically acceptable salts thereof
NO20030127L (no)	2003-01-10	Indolderivater nyttige for behandling av CNS-forstyrrelser
SI1420029T1 (sl)	2008-08-31	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1380591T1 (sl)	2006-02-28	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
SI1403275T1 (sl)	2006-02-28	Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli
NO20026029D0 (no)	2002-12-16	Indolderivater nyttige for behandlingen av CNS-forstyrrelser
PL379631A1 (pl)	2006-10-30	Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
PL379625A1 (pl)	2006-10-30	Nowy sposób syntezy perindoprilu i jego farmaceutycznie dopuszczalnych soli
NO20026028L (no)	2002-12-16	Indolderivater nyttige for behandlingen av CNS-forstyrrelser
SI1422236T1 (sl)	2007-06-30	Postopek za sintezo perindoprila in njegovih farmacevtsko sprejemljivih soli

Legal Events

Date	Code	Title	Description
2019-11-25	MM1K	Lapsed by not paying the annual fees