NO20023172D0 - 10, 11-difluormetylendioksycamptothecin-forbindelser med topoisomerase I inhibering - Google Patents

10, 11-difluormetylendioksycamptothecin-forbindelser med topoisomerase I inhibering

Info

Publication number: NO20023172D0
Authority: NO; Norway
Prior art keywords: difluoromethylenedioxyamptothecin; topoisomerase; inhibition; compounds; difluoromethylenedioxyamptothecin compounds
Prior art date: 1999-12-29

Application number

NO20023172A

Other languages

English (en)

Other versions

NO20023172L (no

Inventor

Monroe E Wall

Mansukh C Wani

Govindarajan Manikumar

Neelakantan Balasubramanian

Dolatrai Vyas

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-29

Filing date

2002-06-28

Publication date

2002-06-28

2002-06-28 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2002-06-28 Publication of NO20023172D0 publication Critical patent/NO20023172D0/no

2002-08-29 Publication of NO20023172L publication Critical patent/NO20023172L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20023172A 1999-12-29 2002-06-28 10, 11-difluormetylendioksykamptoteciner med topoisomerase I inhibering NO20023172L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/474,758 US6268375B1 (en)	1999-12-29	1999-12-29	10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition
PCT/US2000/015034 WO2001049291A1 (en)	1999-12-29	2000-06-14	10,11-difluoromethylenedioxycamptothecin compounds with topoisomerase i inhibition

Publications (2)

Publication Number	Publication Date
NO20023172D0 true NO20023172D0 (no)	2002-06-28
NO20023172L NO20023172L (no)	2002-08-29

Family

ID=23884821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20023172A NO20023172L (no)	1999-12-29	2002-06-28	10, 11-difluormetylendioksykamptoteciner med topoisomerase I inhibering

Country Status (8)

Country	Link
US (1)	US6268375B1 (no)
EP (1)	EP1274431A4 (no)
JP (1)	JP2003523326A (no)
KR (2)	KR100780991B1 (no)
AU (1)	AU784647B2 (no)
CA (1)	CA2395980C (no)
NO (1)	NO20023172L (no)
WO (1)	WO2001049291A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7595400B2 (en) *	2003-02-21	2009-09-29	Chugai Seiyaku Kabushiki Kaisha	Process for the preparation of hexacyclic compounds
US7071204B2 (en) *	2003-06-30	2006-07-04	Research Triangle Institute	Camptothecin analogs having an E-ring ketone
EP1757609B1 (en) *	2004-04-09	2013-10-16	Chugai Seiyaku Kabushiki Kaisha	Novel water-soluble prodrug
JP4271086B2 (ja) *	2004-06-08	2009-06-03	株式会社東芝	免疫分析方法
TWI375678B (en)	2005-06-09	2012-11-01	Yakult Honsha Kk	A method of preparation of a tricyclic ketone
TW200744603A (en)	2005-08-22	2007-12-16	Chugai Pharmaceutical Co Ltd	Novel anticancer concomitant drug
CN104672202B (zh)	2010-08-18	2017-07-28	萨穆梅德有限公司	作为联蛋白信号通路激活剂的二酮与羟基酮
SG11201506592SA (en)	2013-02-22	2015-09-29	Samumed Llc	Gamma-diketones as wnt/beta -catenin signaling pathway activators
ES2762559T3 (es)	2014-08-20	2020-05-25	Samumed Llc	Gamma-dicetonas para tratamiento y prevención de envejecimiento de la piel y arrugas
CN108690036B (zh) *	2018-05-22	2021-05-25	北京海步医药科技股份有限公司	一种10-二氟甲基喜树碱类化合物及其制备方法和应用
CN109810114A (zh) *	2019-02-01	2019-05-28	浙江工业大学	一种微波常压合成喜树碱类化合物的方法
AU2020263231A1 (en)	2019-04-26	2021-11-18	Immunogen, Inc.	Camptothecin derivatives
CN117777153A (zh) *	2023-12-19	2024-03-29	浙江工业大学	20(s)-10,11-二氟亚甲二氧基喜树碱衍生物及其制备方法和应用
WO2025153054A1 (en) *	2024-01-18	2025-07-24	Nona Biosciences (Suzhou) Co., Ltd.	Camptothecin analogues, conjugates and methods of use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5227380A (en)	1987-03-31	1993-07-13	Research Triangle Institute	Pharmaceutical compositions and methods employing camptothecins
US5122526A (en)	1987-03-31	1992-06-16	Research Triangle Institute	Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US5053512A (en)	1987-04-14	1991-10-01	Research Triangle Institute	Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5364858A (en)	1987-03-31	1994-11-15	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
US5106742A (en)	1987-03-31	1992-04-21	Wall Monroe E	Camptothecin analogs as potent inhibitors of topoisomerase I
US4894456A (en)	1987-03-31	1990-01-16	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US4981968A (en)	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US5049668A (en)	1989-09-15	1991-09-17	Research Triangle Institute	10,11-methylenedioxy-20(RS)-camptothecin analogs
US5122606A (en)	1987-04-14	1992-06-16	Research Triangle Institute	10,11-methylenedioxy camptothecins
US5180722A (en)	1987-04-14	1993-01-19	Research Triangle Institute	10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5340817A (en)	1987-04-14	1994-08-23	Research Triangle Institute	Method of treating tumors with anti-tumor effective camptothecin compounds
DE4119981C1 (no)	1991-06-18	1993-01-21	Fa. Carl Freudenberg, 6940 Weinheim, De
US5646159A (en)	1994-07-20	1997-07-08	Research Triangle Institute	Water-soluble esters of camptothecin compounds
US5496830A (en)	1994-09-14	1996-03-05	Johns Hopkins University	Inhibition of hemoflagellates by camptothecin compounds
US5614529A (en)	1994-09-22	1997-03-25	Research Triangle Institute	Inhibition of plasmodia parasites by camptothecin compounds
AU7732996A (en)	1995-11-22	1997-06-11	Research Triangle Institute	Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties

1999
- 1999-12-29 US US09/474,758 patent/US6268375B1/en not_active Expired - Fee Related
2000
- 2000-06-14 KR KR1020027008492A patent/KR100780991B1/ko not_active Expired - Fee Related
- 2000-06-14 EP EP00939455A patent/EP1274431A4/en not_active Withdrawn
- 2000-06-14 AU AU54539/00A patent/AU784647B2/en not_active Ceased
- 2000-06-14 WO PCT/US2000/015034 patent/WO2001049291A1/en not_active Ceased
- 2000-06-14 CA CA2395980A patent/CA2395980C/en not_active Expired - Fee Related
- 2000-06-14 KR KR1020077020141A patent/KR100794417B1/ko not_active Expired - Fee Related
- 2000-06-14 JP JP2001549659A patent/JP2003523326A/ja not_active Withdrawn
2002
- 2002-06-28 NO NO20023172A patent/NO20023172L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU784647B2 (en)	2006-05-18
CA2395980A1 (en)	2001-07-12
WO2001049291A1 (en)	2001-07-12
JP2003523326A (ja)	2003-08-05
US6268375B1 (en)	2001-07-31
KR100780991B1 (ko)	2007-11-29
NO20023172L (no)	2002-08-29
KR20020084082A (ko)	2002-11-04
KR100794417B1 (ko)	2008-01-16
KR20070100911A (ko)	2007-10-12
EP1274431A1 (en)	2003-01-15
EP1274431A4 (en)	2003-05-02
CA2395980C (en)	2010-08-10
AU5453900A (en)	2001-07-16

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NO20023172D0 (no)	2002-06-28	10, 11-difluormetylendioksycamptothecin-forbindelser med topoisomerase I inhibering
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DE50011611D1 (de)	2005-12-22	Bohrwerkzeug
NO20020466L (no)	2002-03-20	Kalsilytiske forbindelser
IS6141A (is)	2001-11-01	Ný efnasambönd
NO20014262D0 (no)	2001-09-03	Tiazoloindolinon-forbindelser
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ID29984A (id)	2001-10-25	Senyawa-senyawa bis-stirilbifenil
ATE259816T1 (de)	2004-03-15	Tricyclische benzoylcyclohexandion-derivate

Legal Events

Date	Code	Title	Description
2010-04-06	FC2A	Withdrawal, rejection or dismissal of laid open patent application