NO20022976D0 - 2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet - Google Patents

2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet

Info

Publication number: NO20022976D0
Authority: NO; Norway
Prior art keywords: indol; antitumor activity; oxoacetamides; acetamides; colon
Prior art date: 1999-12-23

Application number

NO20022976A

Other languages

English (en)

Other versions

NO323312B1 (no

NO20022976L (no

Inventor

Ernesto Menta

Nicoletta Pescalli

Original Assignee

Novuspharma Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-23

Filing date

2002-06-20

Publication date

2002-06-20

2002-06-20 Application filed by Novuspharma Spa filed Critical Novuspharma Spa

2002-06-20 Publication of NO20022976D0 publication Critical patent/NO20022976D0/no

2002-06-20 Publication of NO20022976L publication Critical patent/NO20022976L/no

2007-03-12 Publication of NO323312B1 publication Critical patent/NO323312B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

NO20022976A 1999-12-23 2002-06-20 2-(1H-indol-3yl)-2-okso-acetamider, sammensetninger inneholdende disse og deres anvendelse NO323312B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI002693A IT1315267B1 (it)	1999-12-23	1999-12-23	Derivati di 2-(1h-indol-3-il)-2-oxo-acetammidi ad attivita'antitumorale
PCT/EP2000/013068 WO2001047916A1 (en)	1999-12-23	2000-12-21	2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity

Publications (3)

Publication Number	Publication Date
NO20022976D0 true NO20022976D0 (no)	2002-06-20
NO20022976L NO20022976L (no)	2002-06-20
NO323312B1 NO323312B1 (no)	2007-03-12

Family

ID=11384182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20022976A NO323312B1 (no)	1999-12-23	2002-06-20	2-(1H-indol-3yl)-2-okso-acetamider, sammensetninger inneholdende disse og deres anvendelse

Country Status (24)

Country	Link
US (1)	US6753342B2 (no)
EP (1)	EP1244652B1 (no)
JP (1)	JP2003519140A (no)
KR (1)	KR100795533B1 (no)
CN (1)	CN1250542C (no)
AT (1)	ATE302772T1 (no)
AU (1)	AU776332B2 (no)
BR (1)	BR0016553A (no)
CA (1)	CA2395205A1 (no)
CZ (1)	CZ20022170A3 (no)
DE (1)	DE60022227T2 (no)
EA (1)	EA004925B1 (no)
ES (1)	ES2246918T3 (no)
HU (1)	HUP0203524A3 (no)
IL (2)	IL150329A0 (no)
IT (1)	IT1315267B1 (no)
MX (1)	MXPA02006217A (no)
NO (1)	NO323312B1 (no)
NZ (1)	NZ519689A (no)
PL (1)	PL356541A1 (no)
SK (1)	SK285682B6 (no)
TR (1)	TR200201613T2 (no)
WO (1)	WO2001047916A1 (no)
ZA (1)	ZA200204964B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE330955T1 (de)	1998-04-28	2006-07-15	Elbion Ag	Indolderivate und deren verwendung als inhibitoren der phosphodiesterase 4.
IT1318641B1 (it) *	2000-07-25	2003-08-27	Novuspharma Spa	Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale.
DE10037310A1 (de) *	2000-07-28	2002-02-07	Asta Medica Ag	Neue Indolderivate und deren Verwendung als Arzneimittel
CN101602756B (zh) *	2002-07-09	2014-11-12	法斯根公司	化合物、含该化合物的药物组合物以及该化合物的应用方法
BRPI0414313A (pt)	2003-09-11	2006-11-07	Kemia Inc	inibidores de citocinas
WO2005094816A1 (en) *	2004-03-11	2005-10-13	Actelion Pharmaceuticals Ltd	Indol-1-yl-acetic acid derivatives
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
SI2007756T1 (sl)	2006-04-07	2015-11-30	Vertex Pharmaceuticals Incorporated	Modulatorji prenašalcev z atp-vezavno kaseto
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
EP2049520A4 (en) *	2006-08-07	2011-01-05	Ironwood Pharmaceuticals Inc	indole compounds
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
MX2012012204A (es)	2010-04-22	2012-12-05	Vertex Pharma	Proceso para producir compuestos de cicloalquilcarboxamido-indol.
AR084433A1 (es)	2010-12-22	2013-05-15	Ironwood Pharmaceuticals Inc	Inhibidores de la faah y composiciones farmaceuticas que los contienen
WO2012135027A2 (en) *	2011-03-25	2012-10-04	The Research Foundation Of State University Of New York	Thiolactone antibiotics
HK1209318A1 (en)	2012-07-16	2016-04-01	Vertex Pharmaceuticals Incorporated	Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
DK3925607T3 (da)	2014-04-15	2023-08-21	Vertex Pharma	Farmaceutiske sammensætninger til behandlingen af cystisk fibrosetransmembrankonduktansregulator-medierede sygdomme
CN115785079B (zh) *	2022-11-28	2024-02-13	沈阳药科大学	4-(1h-吲哚-5-基)氨基呋喃-2(5h)-酮类化合物及其制备和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2225465A1 (en) *	1995-08-02	1997-02-13	Newcastle University Ventures Limited	Benzimidazole compounds
CO4970714A1 (es)	1997-09-05	2000-11-07	Boehringer Mannheim Gmbh	Derivados ureido y tioureido de 4-amino-2(5h)-furanonas y 4-amino-2(5h) tiofenonas como agentes antitumorales
DE19814838C2 (de)	1998-04-02	2001-01-18	Asta Medica Ag	Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
ATE330955T1 (de) *	1998-04-28	2006-07-15	Elbion Ag	Indolderivate und deren verwendung als inhibitoren der phosphodiesterase 4.

1999
- 1999-12-23 IT IT1999MI002693A patent/IT1315267B1/it active
2000
- 2000-12-21 ES ES00985225T patent/ES2246918T3/es not_active Expired - Lifetime
- 2000-12-21 JP JP2001549386A patent/JP2003519140A/ja active Pending
- 2000-12-21 NZ NZ519689A patent/NZ519689A/en unknown
- 2000-12-21 EA EA200200558A patent/EA004925B1/ru not_active IP Right Cessation
- 2000-12-21 MX MXPA02006217A patent/MXPA02006217A/es active IP Right Grant
- 2000-12-21 KR KR1020027007960A patent/KR100795533B1/ko not_active Expired - Fee Related
- 2000-12-21 CZ CZ20022170A patent/CZ20022170A3/cs unknown
- 2000-12-21 PL PL00356541A patent/PL356541A1/xx not_active IP Right Cessation
- 2000-12-21 AT AT00985225T patent/ATE302772T1/de not_active IP Right Cessation
- 2000-12-21 AU AU21704/01A patent/AU776332B2/en not_active Ceased
- 2000-12-21 US US10/149,406 patent/US6753342B2/en not_active Expired - Fee Related
- 2000-12-21 CN CNB00817492XA patent/CN1250542C/zh not_active Expired - Fee Related
- 2000-12-21 EP EP00985225A patent/EP1244652B1/en not_active Expired - Lifetime
- 2000-12-21 HU HU0203524A patent/HUP0203524A3/hu unknown
- 2000-12-21 CA CA002395205A patent/CA2395205A1/en not_active Abandoned
- 2000-12-21 TR TR2002/01613T patent/TR200201613T2/xx unknown
- 2000-12-21 WO PCT/EP2000/013068 patent/WO2001047916A1/en not_active Ceased
- 2000-12-21 DE DE60022227T patent/DE60022227T2/de not_active Expired - Fee Related
- 2000-12-21 IL IL15032900A patent/IL150329A0/xx active IP Right Grant
- 2000-12-21 SK SK896-2002A patent/SK285682B6/sk not_active IP Right Cessation
- 2000-12-21 BR BR0016553-0A patent/BR0016553A/pt not_active Application Discontinuation
2002
- 2002-06-19 IL IL150329A patent/IL150329A/en not_active IP Right Cessation
- 2002-06-20 ZA ZA200204964A patent/ZA200204964B/en unknown
- 2002-06-20 NO NO20022976A patent/NO323312B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
BR0016553A (pt)	2002-09-17
TR200201613T2 (tr)	2002-10-21
AU2170401A (en)	2001-07-09
AU776332B2 (en)	2004-09-02
NO323312B1 (no)	2007-03-12
ZA200204964B (en)	2004-01-29
CA2395205A1 (en)	2001-07-05
WO2001047916A1 (en)	2001-07-05
DE60022227D1 (de)	2005-09-29
HUP0203524A3 (en)	2008-01-28
NZ519689A (en)	2004-02-27
EP1244652B1 (en)	2005-08-24
PL356541A1 (en)	2004-06-28
US20030158153A1 (en)	2003-08-21
CN1413205A (zh)	2003-04-23
DE60022227T2 (de)	2006-06-22
ES2246918T3 (es)	2006-03-01
IT1315267B1 (it)	2003-02-03
KR20020063247A (ko)	2002-08-01
HUP0203524A2 (hu)	2003-03-28
ATE302772T1 (de)	2005-09-15
KR100795533B1 (ko)	2008-01-16
IL150329A (en)	2006-07-05
IL150329A0 (en)	2002-12-01
EA200200558A1 (ru)	2002-12-26
NO20022976L (no)	2002-06-20
JP2003519140A (ja)	2003-06-17
EP1244652A1 (en)	2002-10-02
MXPA02006217A (es)	2004-02-26
CN1250542C (zh)	2006-04-12
CZ20022170A3 (cs)	2002-09-11
US6753342B2 (en)	2004-06-22
SK285682B6 (sk)	2007-06-07
ITMI992693A0 (it)	1999-12-23
ITMI992693A1 (it)	2001-06-23
SK8962002A3 (en)	2002-11-06
EA004925B1 (ru)	2004-10-28

Publication	Publication Date	Title
NO20022976D0 (no)	2002-06-20	2-(1H-indol-3yl)-2-okso-acetamider med antitumoraktivitet
DE69918422D1 (de)	2004-08-05	Phthalazinone pde iii/iv hemmer
TR200000059T2 (tr)	2000-06-21	Piridin türevleri
ATE258930T1 (de)	2004-02-15	Dihydrobenzifurane
PT1086096E (pt)	2003-12-31	Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
DE60005689D1 (de)	2003-11-06	Neue aminobenzophenone
SE9903290D0 (sv)	1999-09-15	Novel compounds
ATE330958T1 (de)	2006-07-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
DK1377574T3 (da)	2005-04-25	6-phenylbenzonaphtyridiner
BG106937A (en)	2003-04-30	Novel indole derivatives
ATE286887T1 (de)	2005-01-15	Antibakterielle mittel
MA24197A1 (fr)	1997-12-31	Nouvelles fungarrestines
ATE213236T1 (de)	2002-02-15	Substituierte benzyloxyimino-verbindungen
DE59901563D1 (de)	2002-07-04	N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung
ES2166710A1 (es)	2003-12-01	Nuevos compuestos heterociclicos con actividad antiinflamatoria.

Legal Events

Date	Code	Title	Description
2010-07-19	MM1K	Lapsed by not paying the annual fees