NO20020913L - Androgenreseptor-modulatorforbindelser og fremgangsmåter - Google Patents

Androgenreseptor-modulatorforbindelser og fremgangsmåter

Info

Publication number: NO20020913L
Authority: NO; Norway
Prior art keywords: methods; androgen receptor; receptor modulator; modulator compounds; compounds
Prior art date: 1999-08-27

Application number

NO20020913A

Other languages

English (en)

Other versions

NO20020913D0 (no

Inventor

Robert Higuchi

Kristen L Arienti

Mani S Neelakandha

Barbara Pio

Lin Zhi

Penghui Chen

Thomas R Caferro

Original Assignee

Ligand Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-27

Filing date

2002-02-25

Publication date

2002-04-29

2002-02-25 Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc

2002-02-25 Publication of NO20020913D0 publication Critical patent/NO20020913D0/no

2002-04-29 Publication of NO20020913L publication Critical patent/NO20020913L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Gynecology & Obstetrics (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20020913A 1999-08-27 2002-02-25 Androgenreseptor-modulatorforbindelser og fremgangsmåter NO20020913L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US15098899P	1999-08-27	1999-08-27
PCT/US2000/023520 WO2001016139A1 (en)	1999-08-27	2000-08-25	Androgen receptor modulator compounds and methods

Publications (2)

Publication Number	Publication Date
NO20020913D0 NO20020913D0 (no)	2002-02-25
NO20020913L true NO20020913L (no)	2002-04-29

Family

ID=22536855

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20020913A NO20020913L (no)	1999-08-27	2002-02-25	Androgenreseptor-modulatorforbindelser og fremgangsmåter

Country Status (21)

Country	Link
US (3)	US6462038B1 (no)
EP (1)	EP1212330B1 (no)
JP (1)	JP2003508402A (no)
KR (1)	KR20020038741A (no)
CN (1)	CN1391576A (no)
AT (1)	ATE323709T1 (no)
AU (1)	AU778655B2 (no)
BG (1)	BG106550A (no)
BR (1)	BR0013597A (no)
CA (1)	CA2383077A1 (no)
CZ (1)	CZ2002711A3 (no)
DE (1)	DE60027443D1 (no)
HU (1)	HUP0202814A3 (no)
IL (1)	IL148045A0 (no)
MX (1)	MXPA02002032A (no)
NO (1)	NO20020913L (no)
PL (1)	PL353792A1 (no)
SK (1)	SK2732002A3 (no)
TR (1)	TR200200507T2 (no)
WO (1)	WO2001016139A1 (no)
ZA (1)	ZA200201056B (no)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6566372B1 (en)	1999-08-27	2003-05-20	Ligand Pharmaceuticals Incorporated	Bicyclic androgen and progesterone receptor modulator compounds and methods
CN1391576A (zh) *	1999-08-27	2003-01-15	利甘德药品公司	雄激素受体调节剂化合物及方法
US7001911B2 (en)	2000-06-28	2006-02-21	Bristol-Myers Squibb Company	Fused cyclic modulators of nuclear hormone receptor function
HUP0303172A3 (en)	2000-06-28	2006-05-29	Bristol Myers Squibb Co	Selective androgen receptor modulators and methods for their identification, desing and use
US20040077605A1 (en)	2001-06-20	2004-04-22	Salvati Mark E.	Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6953679B2 (en)	2000-09-19	2005-10-11	Bristol-Myers Squibb Company	Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US7214690B2 (en) *	2001-02-23	2007-05-08	Ligand Pharmaceuticals Incorporated	Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
US7026484B2 (en)	2001-02-23	2006-04-11	Ligand Pharmaceuticals Incorporated	Tricyclic androgen receptor modulator compounds and methods
US6670386B2 (en)	2001-07-31	2003-12-30	Bristol-Myers Squibb Company	Bicyclic modulators of androgen receptor function
AU2002364082A1 (en)	2001-12-19	2003-07-09	Bristol-Myers Squibb Company	Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function
US6858621B2 (en)	2002-04-26	2005-02-22	Ortho-Mcneil Pharmaceutical, Inc.	2-(quinolonyl)-fused heterocycles as androgen receptor modulators
US7405234B2 (en)	2002-05-17	2008-07-29	Bristol-Myers Squibb Company	Bicyclic modulators of androgen receptor function
CN1665510A (zh) *	2002-06-25	2005-09-07	惠氏公司	作为pr调节剂的环硫代氨基甲酸酯衍生物的衍生物和其用于治疗皮肤病的用途
US7632858B2 (en)	2002-11-15	2009-12-15	Bristol-Myers Squibb Company	Open chain prolyl urea-related modulators of androgen receptor function
EP1587804A1 (en)	2003-01-17	2005-10-26	Warner-Lambert Company LLC	Androgen receptor antagonists
BRPI0406805A (pt)	2003-01-17	2005-12-27	Warner Lambert Co	Antagonistas de receptores de androgênio
EP1597233A1 (en)	2003-02-11	2005-11-23	Warner-Lambert Company LLC	Benzyl urea and thiourea derivatives useful as androgen antagonists
EP1603882A2 (en)	2003-02-11	2005-12-14	Warner-Lambert Company LLC	Urea and thiourea derivatives
US7009052B2 (en)	2003-03-20	2006-03-07	Warner Lambert Company Llc	Sulfonamide derivatives
US7098340B2 (en)	2003-05-14	2006-08-29	Warner Lambert Company Llc	Benzyl sulfonamide derivatives
WO2005000795A2 (en) *	2003-06-10	2005-01-06	Smithkline Beecham Corporation	Aniline derivatived androgen-, glucocorticoid-, mineralcorticoid- and progesterone- receptor modulators
EP1656142A4 (en)	2003-08-22	2011-06-22	Ligand Pharm Inc	6-CYCLOAMINO-2-QUINOLINONE DERIVATIVES AS MODULATORS ANDROGEN RECEPTOR COMPOUNDS
CA2546601A1 (en)	2003-11-19	2005-06-09	Metabasis Therapeutics, Inc.	Novel phosphorus-containing thyromimetics
EP1698478A1 (en) *	2003-12-26	2006-09-06	Mitsubishi Chemical Corporation	Optical recording medium and dye
US7820702B2 (en)	2004-02-04	2010-10-26	Bristol-Myers Squibb Company	Sulfonylpyrrolidine modulators of androgen receptor function and method
US7696241B2 (en)	2004-03-04	2010-04-13	Bristol-Myers Squibb Company	Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en)	2004-03-04	2009-12-01	Bristol-Myers Squibb Company	Bicyclic modulators of androgen receptor function
US8519158B2 (en) *	2004-03-12	2013-08-27	Ligand Pharmaceuticals Incorporated	Androgen receptor modulator compounds and methods
WO2005111042A1 (en) *	2004-05-03	2005-11-24	Janssen Pharmaceutica N.V.	Novel indole derivatives as selective androgen receptor modulators (sarms)
EP1753749B1 (en) *	2004-05-03	2014-07-30	Janssen Pharmaceutica NV	Novel indole derivatives as selective androgen receptor modulators (sarms)
BRPI0513020A (pt) *	2004-07-08	2008-04-22	Warner Lambert Co	moduladores de andrÈgenio, seus usos, composição farmacêutica, formulação farmacêutica tópica e artigo de fabricação
US7280723B2 (en) *	2005-05-06	2007-10-09	Schott Corporation	Illumination assembly including a rigid light-guiding element incorporating a numerical-aperture alteration taper
CA2598216C (en) *	2005-06-17	2014-04-08	Ligand Pharmaceuticals Incorporated	Androgen receptor modulator compounds and methods
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
EP2258358A3 (en)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
JP2009506077A (ja) *	2005-08-26	2009-02-12	ザリージェンツオブザユニバーシティオブカリフォルニア	非ステロイド性抗アンドロゲン剤
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7790745B2 (en)	2005-10-21	2010-09-07	Bristol-Myers Squibb Company	Tetrahydroisoquinoline LXR Modulators
JP2009512711A (ja)	2005-10-21	2009-03-26	ブレインセルス，インコーポレイティド	Ｐｄｅ阻害による神経新生の調節
JP2009513672A (ja)	2005-10-31	2009-04-02	ブレインセルス，インコーポレイティド	神経発生のｇａｂａ受容体媒介調節
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
ES2382009T3 (es)	2006-12-01	2012-06-04	Bristol-Myers Squibb Company	Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
PL2222636T3 (pl)	2007-12-21	2014-04-30	Ligand Pharm Inc	Selektywne modulatory receptorów androgenowych (SARM) i ich zastosowania
EP2130831A1 (en)	2008-06-06	2009-12-09	InterMed Discovery GmbH	CDC25 inhibitors
US20120046364A1 (en)	2009-02-10	2012-02-23	Metabasis Therapeutics, Inc.	Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
US20190375732A1 (en)	2018-05-14	2019-12-12	David Hung	Anti-cancer nuclear hormone receptor-targeting compounds
CN108659219B (zh) *	2018-06-08	2021-02-09	扬州大学	一种聚苯胺的制备方法
AU2020257397A1 (en)	2019-04-19	2021-12-16	Ligand Pharmaceuticals Inc.	Crystalline forms and methods of producing crystalline forms of a compound
JP2022532342A (ja)	2019-05-14	2022-07-14	ニューベイション・バイオ・インコーポレイテッド	抗がん核内ホルモン受容体標的化化合物
WO2021097046A1 (en)	2019-11-13	2021-05-20	Nuvation Bio Inc.	Anti-cancer nuclear hormone receptor-targeting compounds
CA3214408A1 (en)	2021-03-23	2022-09-29	Nuvation Bio Inc.	Anti-cancer nuclear hormone receptor-targeting compounds
WO2022235585A1 (en)	2021-05-03	2022-11-10	Nuvation Bio Inc.	Anti-cancer nuclear hormone receptor-targeting compounds

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH590275A5 (no)	1970-03-16	1977-07-29	Hoffmann La Roche
US3979394A (en)	1970-12-11	1976-09-07	Agfa-Gevaert N.V.	Duplo quinoline compounds
GB1379387A (en)	1970-12-11	1975-01-02	Agfa Gevaert	Photoconductive recording materials
US3755332A (en) *	1971-07-01	1973-08-28	Ciba Geigy Corp	Substituted 4 indazolaminoquinolines
GB1400993A (en)	1971-11-10	1975-07-16	Agfa Gevaert	Electrophotographic material
BE795696A (nl)	1972-02-28	1973-08-21	Agfa Gevaert Nv	Voor warmte gevoelige materialen
US3936461A (en) *	1973-09-24	1976-02-03	Warner-Lambert Company	Substituted 4-benzylquinolines
US3993656A (en)	1974-11-19	1976-11-23	Merck & Co., Inc.	1,8-Naphthyridine compounds
IE43079B1 (en)	1975-03-20	1980-12-17	Ici Ltd	Quinolone derivatives
US4138490A (en) *	1975-03-20	1979-02-06	Imperial Chemical Industries Limited	Analgesic compositions containing 1,2-dihydro-2-oxoquinol-4-ylpropionic acid derivatives
SU555119A1 (ru)	1975-05-19	1977-04-25	Предприятие П/Я Г-4913	Вулканизуема резинова смесь на основе полиизопренового каучука
LU77254A1 (no)	1977-05-04	1979-01-18
US4579134A (en) *	1977-09-08	1986-04-01	The Bridgeport Metal Goods Manufacturing Co.	Lipstick container
US4326055A (en)	1977-12-22	1982-04-20	Hoffmann-La Roche Inc.	Stilbene derivatives
JPS54154797A (en) *	1978-05-25	1979-12-06	Eisai Co Ltd	Benzimidazoquinolizine derivative and antibacterials comprising it
US4234589A (en)	1979-09-24	1980-11-18	E. R. Squibb & Sons, Inc.	Imidazolylethoxymethyl derivatives of 1,3-dioxolo quinolines
JPS5777676A (en)	1980-10-31	1982-05-15	Otsuka Pharmaceut Co Ltd	Carbostyril derivative
DE3202100A1 (de)	1982-01-23	1983-08-04	Basf Ag, 6700 Ludwigshafen	Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
US4534979A (en)	1982-06-28	1985-08-13	Usv Pharmaceutical Corp.	Polyene compounds useful in the treatment of psoriasis and allergic responses
US4427654A (en)	1982-07-27	1984-01-24	University Of Delaware	Wound healing compositions and formulations
US4505852A (en)	1982-11-29	1985-03-19	Enzyme Systems Products	7-Amino-4-trifluoromethylquinolone derived substrates and method for determining enzymes and inhibitors
US4539134A (en)	1982-12-02	1985-09-03	Halliburton Company	Methods and cleaning compositions for removing organic materials from metallic surfaces
JPS6056985A (ja) *	1983-09-08	1985-04-02	Sankyo Co Ltd	クマリン誘導体
PT79699B (en)	1983-12-22	1986-12-10	Pfizer	Process for preparing quinolone inotropic agents
GR851296B (no)	1984-05-29	1985-11-25	Pfizer
CH667868A5 (fr)	1984-09-05	1988-11-15	Oreal	Derives du benzonorbornene, leurs procedes de preparation et compositions medicamenteuse et cosmetique les contenant.
DE3434944A1 (de)	1984-09-22	1986-04-03	Basf Ag, 6700 Ludwigshafen	L-substituierte tetralinderivate, ihre herstellung und verwendung
FR2580277B1 (fr)	1985-04-15	1988-06-10	Oreal	Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant
LU86022A1 (fr)	1985-07-25	1987-02-04	Cird	Derives aromatiques polycyliques,leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique
JPS62215581A (ja)	1986-03-18	1987-09-22	Koichi Shiyudo	フラボンカルボン酸誘導体
FR2601670B1 (fr)	1986-07-17	1988-10-07	Cird	Nouveaux derives bicycliques aromatiques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire et en cosmetique
US5071773A (en)	1986-10-24	1991-12-10	The Salk Institute For Biological Studies	Hormone receptor-related bioassays
FR2605626B1 (fr)	1986-10-27	1989-06-02	Oreal	Nouveaux derives aromatiques bicycliques, leur procede de preparation et leur utilisation en cosmetique et en medecine humaine et veterinaire
US5081242A (en)	1986-12-22	1992-01-14	Ortho Pharmaceutical Corporation	6-benzoxazinyl- and 6-benzothiazinyl 2,3,4,5-tetrahydropyridazin-3-ones
GB8630702D0 (en)	1986-12-23	1987-02-04	Wellcome Found	Quinoline compound
FR2614618B1 (fr)	1987-04-30	1989-07-07	Cird	Derives heterocycliques polycycliques, leur procede de preparation et leur utilisation en medecine humaine et veterinaire
EP0303418A3 (en)	1987-08-11	1990-11-07	Smithkline Beecham Laboratoires Pharmaceutiques	Substituted indolones, useful in the treatment of heart or asthmatic diseases
LU87040A1 (fr)	1987-11-04	1989-06-14	Oreal	Esters aromatiques polycycliques d'antibiotiques macrolidiques et lincosamidiques,leur procede de preparation et compositions pharmaceutiques et cosmetiques les contenant
US4981784A (en)	1987-12-02	1991-01-01	The Salk Institute For Biological Studies	Retinoic acid receptor method
WO1989007441A1 (en)	1988-02-10	1989-08-24	The Regents Of The University Of California	6-amino-1,2-benzopyrone antitumorigenic agents and method
DE3810706A1 (de)	1988-03-25	1989-10-05	Schering Ag	Substituierte cumarinderivate, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung
EP0347960B1 (en)	1988-06-23	1994-07-06	Agfa-Gevaert N.V.	Photosensitive recording material suited for use in electrophotography
GB8820174D0 (en)	1988-08-25	1988-09-28	Wellcome Found	Quinoline compound
US5108486A (en) *	1990-02-09	1992-04-28	Kanagawa Chemical Laboratory, Ltd.	Herbicidal substituted-phenyl-1,2,4-triazol-5(1H)-thiones and -ones
US5091528A (en)	1990-09-12	1992-02-25	Allergan, Inc.	6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
DE4036779A1 (de)	1990-11-17	1992-05-21	Basf Ag	Verwendung von arylpolyencarbonsaeuren und ihren derivaten als lichtschutzmittel in kosmetischen zubereitungen
JPH0570464A (ja) *	1991-02-18	1993-03-23	Yamanouchi Pharmaceut Co Ltd	オキサジノベンズアゾール化合物
US5147844A (en)	1991-06-14	1992-09-15	Eastman Kodak Company	Mixture on cyan and yellow dyes to form a green hue for color filter array element
FR2683818B1 (fr) *	1991-11-14	1993-12-31	Adir Cie	Nouveaux derives de 3-sulfonylamino-2-(1h)-quinoleinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES2149814T3 (es)	1992-04-22	2000-11-16	Ligand Pharm Inc	Compuestos que tienen selectividad para los receptores de retinoides x.
CA2093577C (en)	1992-05-07	2006-01-03	Michael Klaus	Alkyl or alkoxy substituted s-heterocyclic retinoids
US5391569A (en)	1992-09-29	1995-02-21	Adir Et Compagnie	New chromene compounds having a triene side chain
JPH08506323A (ja)	1992-11-25	1996-07-09	ラホヤキャンサーリサーチファウンデーション	Ｒｘｒホモダイマー形成ならびに架橋二環式芳香族化合物および調節遺伝子発現におけるそれらの使用
WO1994015901A1 (en)	1993-01-11	1994-07-21	Ligand Pharmaceuticals Inc.	Compounds having selectivity for retinoid x receptors
JPH08505852A (ja)	1993-01-11	1996-06-25	リガンド・ファーマシューティカルズ・インコーポレーテッド	レチノイドｘレセプターに対する選択性を有する化合物
US5455265A (en)	1993-02-11	1995-10-03	Allergan, Inc.	Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors
US5399586A (en)	1993-03-11	1995-03-21	Allergan, Inc.	Treatment of mammals afflicted with tumors with compounds having RXR retinoid receptor agonist activity
US5677336A (en) *	1993-10-21	1997-10-14	Ligand Pharmaceuticals Incorporated	Non-steroid androgen receptor antagonist compounds and methods
WO1995024394A1 (en) *	1994-03-08	1995-09-14	Takeda Chemical Industries, Ltd.	Quinoline or quinazoline derivatives as anti-inflammatory agents, in particular for treating arthritis
FR2719041B1 (fr)	1994-04-26	1996-05-31	Cird Galderma	Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
AU696501B2 (en)	1994-08-10	1998-09-10	F. Hoffmann-La Roche Ag	Retinoic acid x-receptor ligands
US5977125A (en)	1994-10-31	1999-11-02	Eisai Co., Ltd.	Mono-or polyenic carboxylic acid derivatives
US5968908A (en)	1994-12-19	1999-10-19	American Cyanamid Company	Restricted 9-cis retinoids
IL116259A (en)	1994-12-19	2000-07-16	American Cyanamid Co	Analogs of 9-cis retinoic acid and their use
US5693646A (en)	1994-12-22	1997-12-02	Ligand Pharmaceuticals Incorporated	Steroid receptor modulator compounds and methods
CA2208347A1 (en)	1994-12-22	1996-06-27	Ligand Pharmaceuticals Incorporated	Steroid receptor modulator compounds and methods
US6696459B1 (en) *	1994-12-22	2004-02-24	Ligand Pharmaceuticals Inc.	Steroid receptor modulator compounds and methods
US6083977A (en)	1994-12-30	2000-07-04	Ligand Pharmaceuticals Incorporated	Trienoic retinoid compounds and methods
AU712187B2 (en)	1994-12-30	1999-10-28	Ligand Pharmaceuticals Incorporated	Novel trienoic retinoid compounds and methods
RU2164515C2 (ru)	1995-06-21	2001-03-27	Сосьете де Консей де Решерш э Д'Аппликасьон Сьентифик (СКРАС)	Соединения камптотецина, способы их получения, промежуточные соединения и терапевтические композиции
JP3964478B2 (ja)	1995-06-30	2007-08-22	エーザイ・アール・アンド・ディー・マネジメント株式会社	ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬
WO1997007120A1 (en) *	1995-08-11	1997-02-27	Smithkline Beecham Plc	Biphenyl(thio)amide and biphenylethan(thi)one derivatives, their preparation and their use as 5-ht1d receptor antagonists
US5776699A (en)	1995-09-01	1998-07-07	Allergan, Inc.	Method of identifying negative hormone and/or antagonist activities
CA2233888A1 (en)	1995-10-06	1997-04-10	Ligand Pharmaceuticals Incorporated	Dimer-selective rxr modulators and methods for their use
US6017924A (en) *	1996-06-27	2000-01-25	Ligand Pharmaceuticals Incorporated	Androgen receptor modulator compounds and methods
DK0918774T3 (da)	1996-06-27	2002-05-21	Ligand Pharm Inc	Androgenreceptormodulatorforbindelser og fremgangsmåder
FR2752837B1 (fr)	1996-09-02	1999-11-12	Cird Galderma	Nouveaux composes modulateurs des recepteurs hormonaux, les compositions les comprenant et leur utilisation en therapie
JP2858002B2 (ja) *	1997-01-06	1999-02-17	大塚製薬株式会社	医薬組成物
ES2270537T3 (es)	1997-11-12	2007-04-01	F. Hoffmann-La Roche Ag	Tratamiento de enfermedades inmunes mediadas por celulas t ayudantes de tipo 2.
US6001846A (en) *	1998-02-17	1999-12-14	Ligand Pharmaceuticals Incorporated	Process for the preparation of 1,2-dihydroquinolines
JPH11242304A (ja) *	1998-02-26	1999-09-07	Konica Corp	熱現像感光材料
AU3247799A (en)	1998-02-27	1999-09-15	Novo Nordisk A/S	Glp-1 derivatives of glp-1 and exendin with protracted profile of action
AU3595099A (en)	1998-05-11	1999-11-29	Novo Nordisk A/S	New compounds, their preparation and use
US6093826A (en) *	1998-06-08	2000-07-25	Ligand Pharmaceuticals Incorporated	Process for the preparation of C(5)-substituted 1,2-dihydro-5H-chromeno[3,4-f] quinolines
US6147224A (en)	1998-10-01	2000-11-14	Allergan Sales, Inc.	2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors
BR9917205A (pt)	1999-03-08	2001-12-26	Basilea Pharmaceutica Ag	Antagonistas de retinóides e seu uso
AT407876B (de)	1999-04-30	2001-07-25	Georg Dr Uray	Lumineszierende 4-trifluormethyl-2-chinolinone mit langwelliger uv-absorption und ihre verwendung
WO2001016133A2 (en) *	1999-08-27	2001-03-08	Ligand Pharmaceuticals Incorporated	8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators
CN1391576A (zh) *	1999-08-27	2003-01-15	利甘德药品公司	雄激素受体调节剂化合物及方法
US6566372B1 (en) *	1999-08-27	2003-05-20	Ligand Pharmaceuticals Incorporated	Bicyclic androgen and progesterone receptor modulator compounds and methods
US6172241B1 (en) *	1999-10-15	2001-01-09	Ligand Pharmaceuticals Incorporated	Process for the preparation of 1,2-dihydroquinolines
US7214690B2 (en) *	2001-02-23	2007-05-08	Ligand Pharmaceuticals Incorporated	Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
US7026484B2 (en) *	2001-02-23	2006-04-11	Ligand Pharmaceuticals Incorporated	Tricyclic androgen receptor modulator compounds and methods
US6670386B2 (en) *	2001-07-31	2003-12-30	Bristol-Myers Squibb Company	Bicyclic modulators of androgen receptor function

2000
- 2000-08-25 CN CN00814951A patent/CN1391576A/zh active Pending
- 2000-08-25 DE DE60027443T patent/DE60027443D1/de not_active Expired - Lifetime
- 2000-08-25 PL PL00353792A patent/PL353792A1/xx not_active Application Discontinuation
- 2000-08-25 KR KR1020027002613A patent/KR20020038741A/ko not_active Withdrawn
- 2000-08-25 SK SK273-2002A patent/SK2732002A3/sk unknown
- 2000-08-25 IL IL14804500A patent/IL148045A0/xx unknown
- 2000-08-25 US US09/648,684 patent/US6462038B1/en not_active Expired - Lifetime
- 2000-08-25 HU HU0202814A patent/HUP0202814A3/hu unknown
- 2000-08-25 AU AU69414/00A patent/AU778655B2/en not_active Ceased
- 2000-08-25 TR TR2002/00507T patent/TR200200507T2/xx unknown
- 2000-08-25 BR BR0013597-6A patent/BR0013597A/pt not_active Application Discontinuation
- 2000-08-25 EP EP00957854A patent/EP1212330B1/en not_active Expired - Lifetime
- 2000-08-25 AT AT00957854T patent/ATE323709T1/de not_active IP Right Cessation
- 2000-08-25 CZ CZ2002711A patent/CZ2002711A3/cs unknown
- 2000-08-25 JP JP2001519705A patent/JP2003508402A/ja active Pending
- 2000-08-25 MX MXPA02002032A patent/MXPA02002032A/es active IP Right Grant
- 2000-08-25 WO PCT/US2000/023520 patent/WO2001016139A1/en not_active Ceased
- 2000-08-25 CA CA002383077A patent/CA2383077A1/en not_active Abandoned
2002
- 2002-02-06 ZA ZA200201056A patent/ZA200201056B/xx unknown
- 2002-02-25 NO NO20020913A patent/NO20020913L/no unknown
- 2002-03-25 BG BG106550A patent/BG106550A/xx unknown
- 2002-09-09 US US10/238,363 patent/US20030186970A1/en not_active Abandoned
2006
- 2006-01-25 US US11/340,282 patent/US20070167445A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1212330A1 (en)	2002-06-12
NO20020913D0 (no)	2002-02-25
EP1212330B1 (en)	2006-04-19
KR20020038741A (ko)	2002-05-23
AU6941400A (en)	2001-03-26
US6462038B1 (en)	2002-10-08
BR0013597A (pt)	2002-07-16
CN1391576A (zh)	2003-01-15
IL148045A0 (en)	2002-09-12
WO2001016139A9 (en)	2002-09-19
US20070167445A1 (en)	2007-07-19
DE60027443D1 (de)	2006-05-24
ATE323709T1 (de)	2006-05-15
SK2732002A3 (en)	2002-07-02
HUP0202814A2 (hu)	2002-12-28
US20030186970A1 (en)	2003-10-02
TR200200507T2 (tr)	2002-10-21
CZ2002711A3 (cs)	2003-11-12
JP2003508402A (ja)	2003-03-04
HUP0202814A3 (en)	2003-11-28
MXPA02002032A (es)	2003-05-19
WO2001016139A1 (en)	2001-03-08
PL353792A1 (en)	2003-12-01
BG106550A (en)	2002-10-31
CA2383077A1 (en)	2001-03-08
ZA200201056B (en)	2003-07-30
AU778655B2 (en)	2004-12-16

Publication	Publication Date	Title
NO20020913L (no)	2002-04-29	Androgenreseptor-modulatorforbindelser og fremgangsmåter
NO986100L (no)	1998-12-23	Androgene reseptormodulerende forbindelser og fremgangsmÕter
AU2003228283A1 (en)	2003-09-22	Quinazolinone modulators of nuclear receptors
BR9510486A (pt)	1998-06-02	Compostos moduladores de receptores de esteróide e métodos
BG106539A (en)	2002-10-31	Bicyclic androgen and progesterone receptor modulator compounds and methods
CR6478A (es)	2004-02-02	Moduladores del receptor glucocorticoide
AU2002367060A8 (en)	2003-07-30	Heterocyclic modulators of nuclear receptors
YU7797A (sh)	2000-10-30	Kombinovana terapija za osteoporozu
WO2001016133A3 (en)	2001-06-14	8-substituted-6-trifluoromethyl-9-pyrido[3,2-g]quinoline compounds as androgen receptor modulators
HN1998000157A (es)	1999-06-02	Agonistas de prostaglandinas
ATE245993T1 (de)	2003-08-15	Allosterische modulatoren des nmda-rezeptors
BR0104836A (pt)	2002-10-15	Processo para a preparação de moduladores de receptores de glucocorticóides não-esteroidais
ATE437853T1 (de)	2009-08-15	Glucocorticoid-rezeptoren-modulatoren
BR0011741A (pt)	2002-03-19	Compostos de organossilila tendo atividade de modulação do receptor de hormÈnio nuclear
MXPA03001610A (es)	2003-09-10	Derivados de acido oxazolil-arilpropionico y su uso como agonistas de los receptores activados por proliferadores de peroxisomas.
WO2006047269A3 (en)	2006-07-20	Pharmaceutical compositions
DE69916932T2 (de)	2005-04-21	Kombinationstherapeutika, enthaltend einen selektiven Östrogenrezeptormodulator und Prostaglandin E2
WO2005010202A3 (en)	2005-04-21	PHENYL ACETIC ACID DERIVATIVES AS HEPATOCYTE NUCLEAR FACTOR 4α (HNF-4α) MODULATOR COMPOUNDS
DE60040764D1 (de)	2008-12-18	Mesoprogestinen (progesteron-rezeptor-modulatoren) als bestandteil von zusammensetzungen für die hormonersatztherapie
ATE408144T1 (de)	2008-09-15	Assays
MX9301870A (es)	1994-05-31	Antagonistas receptores de angiotensina ii
ECSP993230A (es)	2000-06-19	Antagonistas iii del receptor ccr-3