NO20014648L - Forbindelser og metoder for behandling av astma, allergi og inflammatoriske sykdommer - Google Patents

Forbindelser og metoder for behandling av astma, allergi og inflammatoriske sykdommer

Info

Publication number: NO20014648L
Authority: NO; Norway
Prior art keywords: allergies; asthma; compounds; treatment; methods
Prior art date: 1999-03-26

Application number

NO20014648A

Other languages

English (en)

Other versions

NO20014648D0 (no

Inventor

Ralph Scannell

Pierre Chatelain

Anna Toy-Palmer

Edmond Differding

James Ellis

Marie-Agnes Lassoie

Michelle Young

Xiong Cai

Sajjat Hussoin

Gurmit Grewal

Timothy Lewis

Original Assignee

Ucb Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-26

Filing date

2001-09-25

Publication date

2001-11-22

2001-09-25 Application filed by Ucb Sa filed Critical Ucb Sa

2001-09-25 Publication of NO20014648D0 publication Critical patent/NO20014648D0/no

2001-11-22 Publication of NO20014648L publication Critical patent/NO20014648L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Immunology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Toxicology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Otolaryngology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Furan Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20014648A 1999-03-26 2001-09-25 Forbindelser og metoder for behandling av astma, allergi og inflammatoriske sykdommer NO20014648L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12652199P	1999-03-26	1999-03-26
PCT/BE2000/000026 WO2000058295A2 (en)	1999-03-26	2000-03-23	Compounds and methods for treatment of asthma, allergy and inflammatory disorders

Publications (2)

Publication Number	Publication Date
NO20014648D0 NO20014648D0 (no)	2001-09-25
NO20014648L true NO20014648L (no)	2001-11-22

Family

ID=22425273

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO20014648A NO20014648L (no)	1999-03-26	2001-09-25	Forbindelser og metoder for behandling av astma, allergi og inflammatoriske sykdommer
NO20042861A NO20042861L (no)	1999-03-26	2004-07-06	N-(3-butyn-1-yl)-N-hydroksyurea

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO20042861A NO20042861L (no)	1999-03-26	2004-07-06	N-(3-butyn-1-yl)-N-hydroksyurea

Country Status (37)

Country	Link
US (3)	US6451801B1 (no)
EP (1)	EP1165533B1 (no)
JP (2)	JP2002540198A (no)
KR (1)	KR20020005635A (no)
CN (3)	CN1160344C (no)
AR (2)	AR020026A1 (no)
AT (1)	ATE279401T1 (no)
AU (1)	AU761422B2 (no)
BG (1)	BG105909A (no)
BR (1)	BR0009341A (no)
CA (1)	CA2368090A1 (no)
CO (1)	CO5180543A1 (no)
CZ (1)	CZ20013471A3 (no)
DE (1)	DE60014876T2 (no)
DZ (1)	DZ3027A1 (no)
EE (2)	EE200100498A (no)
ES (1)	ES2231164T3 (no)
GT (1)	GT200000034A (no)
HK (1)	HK1041880B (no)
HU (1)	HUP0200613A2 (no)
ID (1)	ID30430A (no)
IL (1)	IL145481A0 (no)
IS (2)	IS6077A (no)
JO (1)	JO2250B1 (no)
MX (1)	MXPA01009664A (no)
NO (2)	NO20014648L (no)
NZ (1)	NZ514291A (no)
PA (1)	PA8493101A1 (no)
PE (1)	PE20001566A1 (no)
PL (1)	PL350845A1 (no)
RU (1)	RU2241707C2 (no)
SK (1)	SK13272001A3 (no)
TR (2)	TR200401779T2 (no)
UA (1)	UA69449C2 (no)
WO (1)	WO2000058295A2 (no)
YU (1)	YU68601A (no)
ZA (1)	ZA200107642B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6686502B1 (en) *	1999-03-26	2004-02-03	Ucb S.A.	Compounds and methods for treatment of asthma, allergy and inflammatory disorders
PE20001566A1 (es) *	1999-03-26	2001-02-05	Ucb Sa	Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
US6894059B1 (en) *	1999-03-26	2005-05-17	Ucb S.A.	Compounds and methods for treatment of asthma, allergy and inflammatory disorders
BR0107624A (pt)	2000-01-17	2002-11-12	Bayer Ag	Arilcetonas substituìdas
US6440994B1 (en) *	2000-03-29	2002-08-27	Richard J. Sanders, Jr.	Method of treating acne
GB0009479D0 (en) *	2000-04-17	2000-06-07	Cipla Limited	Antihistaminic compounds
PL375439A1 (en)	2002-03-27	2005-11-28	Sun Pharmaceutical Industries Limited	4-(diarylmethyl)-1-piperazinyl derivatives
CA2514145A1 (en)	2003-01-23	2004-08-05	Ucb Farchim Sa	Piperazine derivatives and their use as synthesis intermediates
EP1457485A1 (en) *	2003-03-14	2004-09-15	Dompé S.P.A.	Sulfonic acids, their derivatives and pharmaceutical compositions containing them
WO2006010283A1 (en) *	2004-07-28	2006-02-02	Universität Zürich	Prevention and treatment of thrombus formation
KR100658436B1 (ko) *	2005-12-09	2006-12-27	한국화학연구원	아데노실코발라민 함유 피부질환 치료용 외용제 조성물
EP2035573B1 (en) *	2006-06-27	2010-08-18	Biolipox AB	Methods for identifying modulators of eoxin formation
RS20090154A (sr)	2006-10-18	2010-10-31	Pfizer Products Inc.	Jedinjenja biaril etra uree
AU2008335788B2 (en) *	2007-12-12	2012-11-29	Amgen Inc.	Glycine transporter-1 inhibitors
BRPI0821302A8 (pt) *	2007-12-18	2015-12-08	Meiji Seika Kaisha	Composição farmacêutica, método para prevenir ou tratar doenças do intestino inflamatórias, e, uso de um composto
WO2010046908A2 (en)	2008-09-17	2010-04-29	Calyx Chemicals And Pharmaceuticals Pvt. Ltd.	Novel water based process for the preparation of substituted diphenylmethyl piperazines
CN102924406B (zh) *	2012-11-07	2014-11-05	南京医科大学	取代芳氧乙基哌嗪类衍生物及其制备方法和应用
CN107602534B (zh) *	2017-09-05	2020-04-24	合肥医工医药股份有限公司	具有抗组胺和抗炎活性的化合物及其制备方法和应用
CN115215800B (zh) *	2021-04-21	2023-07-18	赣江中药创新中心	一种二苯并环基-环胺基醚衍生物或盐及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2898339A (en)	1957-07-29	1959-08-04	Wm S Merrell Co	N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine
GB1574822A (en)	1976-03-23	1980-09-10	Lafon Labor	Acetohydroxamic acid derivatives and pharmaceutical compositions thereof
US4282233B1 (en) *	1980-06-19	2000-09-05	Schering Corp	Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
DK154078C (da) *	1981-02-06	1989-05-22	Ucb Sa	Analogifremgangsmaade til fremstilling af 2-(2-(4-(diphenyl-methyl)-1-piperazinyl)ethoxy)-acetamider eller syreadditionssalte heraf
US4826853A (en)	1986-10-31	1989-05-02	Schering Corporation	6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5438062A (en) *	1986-10-31	1995-08-01	Schering Corporation	Benzo(5,6)cycloheptapyridines, compositions and methods of use
US5066658A (en) *	1988-11-10	1991-11-19	Ortho Pharmaceutical Corporation	Substituted hydroxyureas
US5288751A (en) *	1992-11-06	1994-02-22	Abbott Laboratories	[(Substituted) phenyalkyl]furylalkynyl-and [substituted) phenyalkyl] thienylalkynyl-N-hydroxyurea inhibitors or leukotriene biosynthesis
GB9305282D0 (en) *	1993-03-15	1993-05-05	Ucb Sa	Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
DE69429438T2 (de)	1993-10-15	2002-08-08	Schering Corp., Kenilworth	Tricyclische carbamat-derivate zur inhibierung der g-protein funktion und für die behandlung von proliferativen erkrankungen
US5719148A (en)	1993-10-15	1998-02-17	Schering Corporation	Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
WO1995013264A1 (en)	1993-11-08	1995-05-18	Terumo Kabushiki Kaisha	Hydroxamic acid derivative and medicinal preparation containing the same
US5877177A (en)	1997-06-17	1999-03-02	Schering Corporation	Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US6686502B1 (en) *	1999-03-26	2004-02-03	Ucb S.A.	Compounds and methods for treatment of asthma, allergy and inflammatory disorders
US6894059B1 (en) *	1999-03-26	2005-05-17	Ucb S.A.	Compounds and methods for treatment of asthma, allergy and inflammatory disorders
PE20001566A1 (es) *	1999-03-26	2001-02-05	Ucb Sa	Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas

2000
- 2000-03-17 PE PE2000000236A patent/PE20001566A1/es not_active Application Discontinuation
- 2000-03-22 GT GT200000034A patent/GT200000034A/es unknown
- 2000-03-23 KR KR1020017012282A patent/KR20020005635A/ko not_active Ceased
- 2000-03-23 PL PL00350845A patent/PL350845A1/xx not_active Application Discontinuation
- 2000-03-23 YU YU68601A patent/YU68601A/sh unknown
- 2000-03-23 HU HU0200613A patent/HUP0200613A2/hu unknown
- 2000-03-23 CN CNB008068216A patent/CN1160344C/zh not_active Expired - Fee Related
- 2000-03-23 SK SK1327-2001A patent/SK13272001A3/sk unknown
- 2000-03-23 HK HK02103566.6A patent/HK1041880B/en not_active IP Right Cessation
- 2000-03-23 AT AT00912274T patent/ATE279401T1/de not_active IP Right Cessation
- 2000-03-23 IL IL14548100A patent/IL145481A0/xx unknown
- 2000-03-23 BR BR0009341-6A patent/BR0009341A/pt not_active IP Right Cessation
- 2000-03-23 NZ NZ514291A patent/NZ514291A/en unknown
- 2000-03-23 UA UA2001107287A patent/UA69449C2/uk unknown
- 2000-03-23 CN CNA2004100495405A patent/CN1560041A/zh active Pending
- 2000-03-23 DE DE60014876T patent/DE60014876T2/de not_active Expired - Fee Related
- 2000-03-23 MX MXPA01009664A patent/MXPA01009664A/es active IP Right Grant
- 2000-03-23 EE EEP200100498A patent/EE200100498A/xx unknown
- 2000-03-23 AU AU34105/00A patent/AU761422B2/en not_active Ceased
- 2000-03-23 CN CNA2004100282269A patent/CN1528742A/zh active Pending
- 2000-03-23 JP JP2000607998A patent/JP2002540198A/ja not_active Withdrawn
- 2000-03-23 EP EP00912274A patent/EP1165533B1/en not_active Expired - Lifetime
- 2000-03-23 CA CA002368090A patent/CA2368090A1/en not_active Abandoned
- 2000-03-23 ES ES00912274T patent/ES2231164T3/es not_active Expired - Lifetime
- 2000-03-23 TR TR2004/01779T patent/TR200401779T2/xx unknown
- 2000-03-23 WO PCT/BE2000/000026 patent/WO2000058295A2/en not_active Ceased
- 2000-03-23 TR TR2001/02717T patent/TR200102717T2/xx unknown
- 2000-03-23 RU RU2001129098/04A patent/RU2241707C2/ru not_active IP Right Cessation
- 2000-03-23 AR ARP000101298A patent/AR020026A1/es not_active Application Discontinuation
- 2000-03-23 CZ CZ20013471A patent/CZ20013471A3/cs unknown
- 2000-03-23 EE EEP200400104A patent/EE200400104A/xx unknown
- 2000-03-23 ID IDW00200102070A patent/ID30430A/id unknown
- 2000-03-24 PA PA20008493101A patent/PA8493101A1/es unknown
- 2000-03-24 US US09/534,947 patent/US6451801B1/en not_active Expired - Fee Related
- 2000-03-24 CO CO00021428A patent/CO5180543A1/es not_active Application Discontinuation
- 2000-03-25 DZ DZ000053A patent/DZ3027A1/xx active
- 2000-03-27 JO JO200026A patent/JO2250B1/en active
2001
- 2001-09-17 ZA ZA200107642A patent/ZA200107642B/en unknown
- 2001-09-18 BG BG105909A patent/BG105909A/bg unknown
- 2001-09-18 IS IS6077A patent/IS6077A/is unknown
- 2001-09-25 NO NO20014648A patent/NO20014648L/no not_active Application Discontinuation
2002
- 2002-09-12 US US10/242,346 patent/US6797713B2/en not_active Expired - Fee Related
2003
- 2003-08-08 US US10/637,163 patent/US20040048875A1/en not_active Abandoned
2004
- 2004-07-05 IS IS7343A patent/IS7343A/is unknown
- 2004-07-06 NO NO20042861A patent/NO20042861L/no not_active Application Discontinuation
- 2004-07-12 JP JP2004204939A patent/JP2005002118A/ja not_active Withdrawn
- 2004-07-14 AR ARP040102477A patent/AR045991A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
ID30430A (id)	2001-12-06
NO20014648D0 (no)	2001-09-25
EP1165533B1 (en)	2004-10-13
DE60014876D1 (de)	2004-11-18
IL145481A0 (en)	2002-06-30
PA8493101A1 (es)	2002-08-26
ZA200107642B (en)	2002-09-17
PE20001566A1 (es)	2001-02-05
AR020026A1 (es)	2002-03-27
CN1528742A (zh)	2004-09-15
MXPA01009664A (es)	2002-08-12
PL350845A1 (en)	2003-02-10
DE60014876T2 (de)	2005-10-20
AU761422B2 (en)	2003-06-05
CN1560041A (zh)	2005-01-05
UA69449C2 (uk)	2004-09-15
WO2000058295A3 (en)	2001-02-08
EE200100498A (et)	2002-12-16
US6797713B2 (en)	2004-09-28
NO20042861L (no)	2001-11-22
US20030220347A1 (en)	2003-11-27
EE200400104A (et)	2004-10-15
CN1349521A (zh)	2002-05-15
TR200102717T2 (tr)	2002-04-22
GT200000034A (es)	2001-09-13
BR0009341A (pt)	2002-02-19
DZ3027A1 (fr)	2004-03-27
ES2231164T3 (es)	2005-05-16
IS6077A (is)	2001-09-18
CA2368090A1 (en)	2000-10-05
IS7343A (is)	2004-07-05
JP2002540198A (ja)	2002-11-26
HK1041880B (en)	2005-02-18
WO2000058295A2 (en)	2000-10-05
ATE279401T1 (de)	2004-10-15
TR200401779T2 (tr)	2005-01-24
CO5180543A1 (es)	2002-07-30
HUP0200613A2 (en)	2002-06-29
HK1041880A1 (en)	2002-07-26
NZ514291A (en)	2003-07-25
US6451801B1 (en)	2002-09-17
AU3410500A (en)	2000-10-16
CZ20013471A3 (cs)	2002-06-12
CN1160344C (zh)	2004-08-04
YU68601A (sh)	2004-07-15
RU2241707C2 (ru)	2004-12-10
JP2005002118A (ja)	2005-01-06
US20040048875A1 (en)	2004-03-11
BG105909A (bg)	2002-05-31
KR20020005635A (ko)	2002-01-17
JO2250B1 (en)	2004-10-07
EP1165533A2 (en)	2002-01-02
SK13272001A3 (sk)	2002-05-09
AR045991A2 (es)	2005-11-23

Publication	Publication Date	Title
NO20050570L (no)	2005-03-04	Nye forbindelser, preparater og fremgangsmater for behandling av inflammasjonssykdommer og -tilstander
NO20014648L (no)	2001-11-22	Forbindelser og metoder for behandling av astma, allergi og inflammatoriske sykdommer
NO20041277L (no)	2004-03-26	Farmasoytiske preparater for behandling av astma.
CY2019030I2 (el)	2020-05-29	Παραγωγο ραπαμυκινης για την θεραπευτικη αντιμετωπιση του καρκινου του πνευμονα
NO20031442L (no)	2003-05-26	Morfolin-acetamidderivater for behandling av inflammatoriske sykdommer
NO20040097L (no)	2004-03-01	Kombinasjoner for behandling av inflammatoriske forstyrrelser
NO20033594D0 (no)	2003-08-13	Fenetanolamin-derivater for behandling av luftveissykdommer
NO20041216L (no)	2004-05-05	Imidazol-4-karboksamidderivater, fremstilling og anvendelse derav for behandling av overvekt
NO20053077D0 (no)	2005-06-23	Terapeutiske formuleringer for behandling av beta-amyloid-relaterte sykdommer.
NO20040072L (no)	2005-03-08	Nye substituerte benzimidazol-doseringsformer og fremgangsmate for anvendelse av samme
DE60034155D1 (de)	2007-05-10	Adamantanderivate zur Behandlung von entzündlichen, immunologischen und kardiovaskulären Erkrankungen
NO20031443L (no)	2003-05-26	Forbindelser nyttige for behandling av inflammatoriske sykdommer
NO993847D0 (no)	1999-08-10	Fremgangsmåter og sammensetninger for behandling av allergisk astma og andre sykdommer som anvender deskarboetoksyloratadin
NO20026008L (no)	2002-12-13	Fremgangsmåte for behandling av cardiovaskul¶re sykdommer
NO20043085L (no)	2004-07-13	Fremgangsmater og sammensetninger for behandling av forstyrrelser i sentralnervesystemet
NO20015542L (no)	2002-01-14	Fremgangsmåte for fremstilling og anvendelse av N- desmetylzopikloner
PT1487828E (pt)	2009-01-06	Derivados de morfolinil-ureia para utilização no tratamento de doenças inflamatórias
AU2001249262A1 (en)	2001-10-03	Therapeutic compounds for the treatment of asthma and allergy, and methods of use thereof
DK1478438T3 (da)	2012-08-27	Fremgangsmåder og sammensætninger til behandling af astma
EP1611120A4 (en)	2008-04-23	NEW M THODES FOR THE TREATMENT OF INFLAMMATORY DISEASES
NO20015772L (no)	2002-01-22	Forbindelser og fremgangsmåter for behandling av post- traumatisk stress-syndrom
IS7163A (is)	2004-02-26	Aðferðir til meðhöndlunar á lungnasjúkdómi
NO20020784D0 (no)	2002-02-18	Medikament for behandling av brudd
NO20023737L (no)	2002-09-27	Fremgangsmåte og preparater for behandling av en inflammatorisk lidelse
NO20033120D0 (no)	2003-07-08	2-arylimino-2,3-dihydrotiazolderivater, fremgangsmater for fremstilling derav og terapeutisk anvendelse derav

Legal Events

Date	Code	Title	Description
2006-03-13	FC2A	Withdrawal, rejection or dismissal of laid open patent application