[go: up one dir, main page]

NO20012983D0 - Nye malonsyrederivater, fremgangsmåter for fremstilling derav, og farmasöytiske preparater inneholdende disse (inhiberingav faktor Xa-aktivitet) - Google Patents

Nye malonsyrederivater, fremgangsmåter for fremstilling derav, og farmasöytiske preparater inneholdende disse (inhiberingav faktor Xa-aktivitet)

Info

Publication number
NO20012983D0
NO20012983D0 NO20012983A NO20012983A NO20012983D0 NO 20012983 D0 NO20012983 D0 NO 20012983D0 NO 20012983 A NO20012983 A NO 20012983A NO 20012983 A NO20012983 A NO 20012983A NO 20012983 D0 NO20012983 D0 NO 20012983D0
Authority
NO
Norway
Prior art keywords
inhibition
factor
activity
preparation
methods
Prior art date
Application number
NO20012983A
Other languages
English (en)
Norwegian (no)
Other versions
NO20012983L (no
Inventor
Elisabeth Defossa
Uwe Heinelt
Otmar Klingler
Gerhard Zoller
Hans Matter
Fahad A Al-Obeidi
Armin Walser
Peter Wildgoose
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP99100002A external-priority patent/EP1016663A1/fr
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20012983L publication Critical patent/NO20012983L/no
Publication of NO20012983D0 publication Critical patent/NO20012983D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
NO20012983A 1999-01-02 2001-06-15 Nye malonsyrederivater, fremgangsmåter for fremstilling derav, og farmasöytiske preparater inneholdende disse (inhiberingav faktor Xa-aktivitet) NO20012983D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99100002A EP1016663A1 (fr) 1999-01-02 1999-01-02 Dérivés de l'acide malonique, procédé pour leur préparation, leur utilisation comme médicaments et compositions les contenant (inhibiteurs du facteur Xa )
EP99119537 1999-10-01
PCT/EP1999/010340 WO2000040571A1 (fr) 1999-01-02 1999-12-23 Nouveaux derives d'acide malonique, procedes de preparation de ces derives, leur utilisation et compositions pharmaceutiques les contenant (inhibition de l'activite du facteur xa)

Publications (2)

Publication Number Publication Date
NO20012983L NO20012983L (no) 2001-06-15
NO20012983D0 true NO20012983D0 (no) 2001-06-15

Family

ID=26152843

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20012983A NO20012983D0 (no) 1999-01-02 2001-06-15 Nye malonsyrederivater, fremgangsmåter for fremstilling derav, og farmasöytiske preparater inneholdende disse (inhiberingav faktor Xa-aktivitet)

Country Status (17)

Country Link
US (1) US6395737B1 (fr)
EP (1) EP1140878A1 (fr)
JP (1) JP2002534420A (fr)
KR (1) KR20010101355A (fr)
CN (1) CN1332734A (fr)
AU (1) AU3043100A (fr)
BR (1) BR9916732A (fr)
CA (1) CA2358578A1 (fr)
CZ (1) CZ20012379A3 (fr)
HK (1) HK1041700A1 (fr)
HU (1) HUP0105437A3 (fr)
ID (1) ID29979A (fr)
IL (1) IL144096A0 (fr)
NO (1) NO20012983D0 (fr)
PL (1) PL349343A1 (fr)
TR (1) TR200101903T2 (fr)
WO (1) WO2000040571A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010089753A (ko) 1999-01-02 2001-10-08 로버트 흐라이탁, 미쉘 베스트 아릴알카노일 유도체, 이의 제조방법, 이의 용도 및 이를함유하는 약제학적 조성물
EP1127884A1 (fr) * 2000-02-26 2001-08-29 Aventis Pharma Deutschland GmbH Dérivés de l'acide malonique, procédés pour leur préparation, leur utilisation comme inhibiteur du facteur XA et compositions les contenants
FR2812635B1 (fr) * 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
US20050232995A1 (en) * 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
HUE025683T2 (hu) 2002-12-03 2016-04-28 Pharmacyclics Llc VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok
WO2012054633A2 (fr) 2010-10-20 2012-04-26 Bioformix, Llc Synthèse de malonates de méthylène par récupération rapide en présence d'un agent de transfert d'énergie
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
SI2766346T1 (sl) 2011-10-14 2017-05-31 Bristol-Myers Squibb Company Substituirane tetrahidroizokinolinske spojine kot faktor xia inhibitorji
ES2579832T3 (es) 2011-10-14 2016-08-17 Bristol-Myers Squibb Company Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa
EP2766345B1 (fr) 2011-10-14 2016-03-16 Bristol-Myers Squibb Company Composés tétrahydroisoquinolines substitués en tant qu'inhibiteurs du facteur xia
EP3339301A3 (fr) 2011-10-19 2018-08-08 Sirrus, Inc. Procédés de préparation de monomères bêta-cétoester de méthylène
JP6188252B2 (ja) 2012-03-30 2017-08-30 シラス・インコーポレイテッド 重合性組成物の活性化方法、重合系およびこれにより形成される製品
CA2869115A1 (fr) 2012-03-30 2013-10-03 Bioformix Inc. Formulations d'encre et de revetement et systemes polymerisables pour la production desdites formulations
CA2869112A1 (fr) 2012-03-30 2013-10-03 Bioformix Inc. Articles stratifies et composites et systemes polymerisables pour les produire
WO2013181600A2 (fr) 2012-06-01 2013-12-05 Bioformix Inc. Matériau optique et objets formés à partir de celui-ci
EP2906552B1 (fr) 2012-10-12 2017-11-22 Bristol-Myers Squibb Company Composés de tetrahydroisoquinoline substitués par guanidine en tant qu'inhibiteurs de factor xia
US9403774B2 (en) 2012-10-12 2016-08-02 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
WO2014059203A1 (fr) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Formes cristallines d'un inhibiteur de facteur xia
CN105008438B (zh) 2012-11-16 2019-10-22 拜奥福米克斯公司 塑料粘结体系及方法
EP3712928A1 (fr) 2012-11-30 2020-09-23 Sirrus, Inc. Compositions composites pour applications électroniques
EP2943462B1 (fr) 2013-01-11 2018-06-27 Sirrus, Inc. Procédé d'obtention de malonate de méthylène par l'intermédiaire de la voie du bis(hydroxyméthyl)malonate
WO2014160668A1 (fr) 2013-03-25 2014-10-02 Bristol-Myers Squibb Company Tétrahydroisoquinolines comprenant des azoles substitués en tant qu'inhibiteurs du facteur xia
NO2760821T3 (fr) 2014-01-31 2018-03-10
ES2893251T3 (es) 2014-01-31 2022-02-08 Bristol Myers Squibb Co Macrociclos con grupos P2’ heterocíclicos como inhibidores del factor XIa
CA2952968A1 (fr) 2014-07-01 2016-01-07 Rempex Pharmaceuticals, Inc. Derives d'acide boronique et leurs utilisations therapeutiques
CN107074821B (zh) 2014-09-04 2020-05-22 百时美施贵宝公司 为fxia抑制剂的二酰胺大环化合物
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE235866C (fr)
DE242404C (fr)
AU8866882A (en) * 1981-09-25 1983-03-31 Wellcome Foundation Limited, The 2-(n-hydroxycarbamoyl)phenylpropanoyl amino acids
JPH05503300A (ja) 1990-11-15 1993-06-03 ペンタファルム　アクチェンゲゼルシャフト メタ置換フェニルアラニン誘導体
IT1254883B (it) * 1992-04-16 1995-10-11 Italfarmaco Spa Tetrapeptidi parzialmente modificati e retroinvertiti, analoghi di frammenti della proteina c-reattiva.
HUT68042A (en) 1993-02-10 1995-03-22 Pentapharm Ag Piperazides of substituted phenylalanine derivates as thrombin inhibitors
US5977074A (en) * 1993-10-01 1999-11-02 Merrell Pharmaceuticals, Inc. Inhibitors of β-amyloid protein production
HUT76346A (en) * 1994-04-26 1997-08-28 Selectide Corp Factor xa inhibitors
WO1996005189A1 (fr) * 1994-08-09 1996-02-22 Pentapharm Ag Nouveaux inhibiteurs de type benzamidine
GB9420763D0 (en) * 1994-10-14 1994-11-30 Glaxo Inc Acetamide derivatives
RU2170764C2 (ru) * 1995-12-20 2001-07-20 Авентис Фармасьютикалз Инк. НОВЫЙ СПОСОБ ПОЛУЧЕНИЯ N-АЦЕТИЛ-(L)-4-ЦИАНОФЕНИЛАЛАНИНА АС-(L)-PHE(4-CN)-OH И N-АЦЕТИЛ-(L)-N-АМИДИНОФЕНИЛАЛАНИН-ЦИКЛОГЕКСИЛ-ГЛИЦИН-β-(3-N-МЕТИЛПИРИДИН ИЯ)-АЛАНИНА АС-(L)-PАPH-СHG-РAL МE(3)-NH2
JP2001524117A (ja) 1997-05-02 2001-11-27 アクゾ・ノベル・エヌ・ベー セリンプロテアーゼ阻害剤
HU227568B1 (en) 1997-12-24 2011-08-29 Sanofi Aventis Deutschland Indole derivatives, as inhibitors os factor xa
EP1016663A1 (fr) 1999-01-02 2000-07-05 Aventis Pharma Deutschland GmbH Dérivés de l'acide malonique, procédé pour leur préparation, leur utilisation comme médicaments et compositions les contenant (inhibiteurs du facteur Xa )

Also Published As

Publication number Publication date
CA2358578A1 (fr) 2000-07-13
NO20012983L (no) 2001-06-15
CN1332734A (zh) 2002-01-23
HK1041700A1 (zh) 2002-07-19
KR20010101355A (ko) 2001-11-14
EP1140878A1 (fr) 2001-10-10
TR200101903T2 (tr) 2001-11-21
HUP0105437A3 (en) 2003-03-28
IL144096A0 (en) 2002-05-23
CZ20012379A3 (cs) 2001-09-12
WO2000040571A1 (fr) 2000-07-13
HUP0105437A2 (hu) 2002-05-29
JP2002534420A (ja) 2002-10-15
ID29979A (id) 2001-10-25
BR9916732A (pt) 2001-09-25
AU3043100A (en) 2000-07-24
US6395737B1 (en) 2002-05-28
PL349343A1 (en) 2002-07-15

Similar Documents

Publication Publication Date Title
NO20012983L (no) Nye malonsyrederivater, fremgangsmåter for fremstilling derav, og farmasöytiske preparater inneholdende disse (inhiberingav faktor Xa-aktivitet)
IL151459A0 (en) Novel malonic acid derivatives, processes for their preparation, their use as inhibitors of factor xa activity and pharmaceutical compositions containing them
IL162105A (en) INDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS FOR INHIBITION OF FACTOR Xa
NO20032726D0 (no) Kinazolinderivater, medikamenter inneholdende disse forbindelser, deres anvendelse og fremgangsmåte for fremstilling derav
NO982590L (no) Metalloproteinase-inhibitorer, farmas°ytiske blandinger inneholdende dem og deres farmas°ytiske anvendelser, og fremgangsmÕter og mellomprodukter anvendelige for deres fremstilling
NO996433D0 (no) Nye formuleringer av legemidler, fremgangsmåter for fremstilling derav og fremgangsmåter for anvendelse derav
NO20051695L (no) Nye spirokondenserte kinazolinoner og deres anvendelse som fosfodiestereaseinbibitorer
NO20010277D0 (no) Benzocykloheptener, fremgangsmåte for fremstilling derav, farmasöytiske preparater inneholdende disse, og deres anvendelse for fremstilling av medikamenter
NO20020374L (no) Karboksylsyreamider, medikamenter inneholdende disse forbindelser, deres anvendelse og fremstilling
NO994620D0 (no) Nye 2-(iminometyl)amino-fenyl-derivater, fremstilling, anvendelse som medisiner og farmasöytiske blandinger inneholdende disse
HUP0202934A3 (en) Arylsulfonamido-substituted hydroxamic acid derivatives, process for their preparation, pharmaceutical compositions containing them and use thereof
NO20015659D0 (no) Purinderivater, fremstillingsmetode og farmasöytiske preparater inneholdende disse
NO20023662L (no) Nye heterocykliske derivater, fremgangsmåte ved fremstilling og farmasöytiske sammensetninger inneholdende det samme
NO20022828D0 (no) Nye forgrenede substituerte aminoderivater av 3-amino-1-fenyl- 1H[1,2,4]triazol, fremgangsmåter for fremstilling av disse, ogfarmasöytiske preparater inneholdende disse
NO20014632L (no) Nye morfolinderivater, fremgangsmåte for fremstilling derav og farmasöytiske preparater inneholdende de nevnte derivater
NO20013878L (no) (1-fenacy-3-fenyl-3-piperidylety)piperidinderivater, fremgangsmåte for fremstilling derav og farmasöytiske preparaterinneholdende de samme
NO20020777L (no) Farmasöytiske preparater inneholdende derivater og fremgangsmåte for fremstilling derav
NO20024802D0 (no) Terapeutisk anvendbare nye salter av CCK-inhibitorer, fremgangsmåte for fremstilling derav og farmasöytiske preparaterinneholdende disse
HUP0203270A3 (en) Hydroxamic acid derivative as inhibitor of the formation of human cd23, process for its preparation and pharmaceutical compositions containing the same
NO994908D0 (no) Nye 4-halogenerte steroider, fremstillingsmetode og mellomprodukter, anvendelse som medisin, og farmasöytiske preparater inneholdende disse
NO20002483L (no) Nye 19-norsteroider substituert i posisjon 11B, fremstillingsfremgangsmÕte og intermediater, anvendelse som medisiner og farmasøytiske preparater som inneholder dem
NO986045L (no) Nye heterocykliske forbindelser, en fremgangsmÕte ved deres fremstilling og farmas°ytiske sammensetninger inneholdende disse
NO20006573L (no) Nye 17-halogenerte 19-nor-steroider, metode og mellomprodukter for fremstilling av disse, anvendelse som medisiner og farmasöytiske preparater inneholdende disse
HU0100751D0 (en) New aryl or heteroaryl quinolinylphosphonic acid derivatives, process for their preparation and pharmaceutical compositions containing them
NO991481D0 (no) Nye heteroaryloksyetylaminer, fremgangsmÕte for fremstilling av, anvendelse som medisin og farmas°ytiske blandinger inneholdende disse

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application