HUP0105437A3 - Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them - Google Patents
Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing themInfo
- Publication number
- HUP0105437A3 HUP0105437A3 HU0105437A HUP0105437A HUP0105437A3 HU P0105437 A3 HUP0105437 A3 HU P0105437A3 HU 0105437 A HU0105437 A HU 0105437A HU P0105437 A HUP0105437 A HU P0105437A HU P0105437 A3 HUP0105437 A3 HU P0105437A3
- Authority
- HU
- Hungary
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- acid derivatives
- Prior art date
Links
- 150000002690 malonic acid derivatives Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100002A EP1016663A1 (en) | 1999-01-02 | 1999-01-02 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
| EP99119537 | 1999-10-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0105437A2 HUP0105437A2 (hu) | 2002-05-29 |
| HUP0105437A3 true HUP0105437A3 (en) | 2003-03-28 |
Family
ID=26152843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105437A HUP0105437A3 (en) | 1999-01-02 | 1999-12-23 | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6395737B1 (hu) |
| EP (1) | EP1140878A1 (hu) |
| JP (1) | JP2002534420A (hu) |
| KR (1) | KR20010101355A (hu) |
| CN (1) | CN1332734A (hu) |
| AU (1) | AU3043100A (hu) |
| BR (1) | BR9916732A (hu) |
| CA (1) | CA2358578A1 (hu) |
| CZ (1) | CZ20012379A3 (hu) |
| HK (1) | HK1041700A1 (hu) |
| HU (1) | HUP0105437A3 (hu) |
| ID (1) | ID29979A (hu) |
| IL (1) | IL144096A0 (hu) |
| NO (1) | NO20012983D0 (hu) |
| PL (1) | PL349343A1 (hu) |
| TR (1) | TR200101903T2 (hu) |
| WO (1) | WO2000040571A1 (hu) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69924527T2 (de) | 1999-01-02 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Arylalkanoylderivate, verfahren zu ihrer herstellung, ihre verwendung und diese enthaltende pharmazeutische zubereitungen |
| EP1127884A1 (en) * | 2000-02-26 | 2001-08-29 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them |
| FR2812635B1 (fr) * | 2000-08-01 | 2002-10-11 | Aventis Pharma Sa | Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens |
| US20050232995A1 (en) * | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
| US9279022B1 (en) | 2014-09-08 | 2016-03-08 | Sirrus, Inc. | Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions |
| US9828324B2 (en) | 2010-10-20 | 2017-11-28 | Sirrus, Inc. | Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom |
| US8884051B2 (en) | 2010-10-20 | 2014-11-11 | Bioformix Inc. | Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent |
| US10414839B2 (en) | 2010-10-20 | 2019-09-17 | Sirrus, Inc. | Polymers including a methylene beta-ketoester and products formed therefrom |
| US9249265B1 (en) | 2014-09-08 | 2016-02-02 | Sirrus, Inc. | Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions |
| TWI633091B (zh) | 2011-10-14 | 2018-08-21 | Bristol-Myers Squibb Company | 作為因子ｘｉａ抑制劑之經取代四氫異喹啉化合物 |
| US9108951B2 (en) | 2011-10-14 | 2015-08-18 | Bristol-Myers Squibb Company | Substituted 5,6,7,8-tetrahydro-1,6-naphthyridines as factor XIa inhibitors |
| IN2014CN02805A (hu) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
| EP3517523A1 (en) | 2011-10-19 | 2019-07-31 | Sirrus, Inc. | Multifunctional monomers and methods for making them |
| EP2831124B1 (en) | 2012-03-30 | 2016-10-05 | Sirrus, Inc. | Composite and laminate articles and polymerizable systems for producing the same |
| CA2869115A1 (en) | 2012-03-30 | 2013-10-03 | Bioformix Inc. | Ink and coating formulations and polymerizable systems for producing the same |
| EP2831125B1 (en) | 2012-03-30 | 2016-10-05 | Sirrus, Inc. | Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby |
| US10047192B2 (en) | 2012-06-01 | 2018-08-14 | Sirrus, Inc. | Optical material and articles formed therefrom |
| WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| EP2906552B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
| SI2906551T1 (en) | 2012-10-12 | 2018-05-31 | Bristol-Myers Squibb Company | Crystalline forms of a factor xia inhibitor |
| CN105008438B (zh) | 2012-11-16 | 2019-10-22 | 拜奥福米克斯公司 | 塑料粘结体系及方法 |
| WO2014085570A1 (en) | 2012-11-30 | 2014-06-05 | Bioformix, Inc. | Composite compositions for electronics applications |
| CN110204441A (zh) | 2013-01-11 | 2019-09-06 | 瑟拉斯公司 | 经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法 |
| US9738655B2 (en) | 2013-03-25 | 2017-08-22 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors |
| NO2760821T3 (hu) | 2014-01-31 | 2018-03-10 | ||
| BR112016015717B1 (pt) | 2014-01-31 | 2023-04-04 | Bristol-Myers Squibb Company | Compostos macrociclos com grupos p2' heterocíclicos como inibidores do fator xia, composição farmacêutica compreendendo os referidos compostos e uso dos mesmos |
| CA2952968A1 (en) | 2014-07-01 | 2016-01-07 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| JP6526796B2 (ja) | 2014-09-04 | 2019-06-05 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｆｘｉａ阻害剤であるジアミドマクロ環 |
| US9416091B1 (en) | 2015-02-04 | 2016-08-16 | Sirrus, Inc. | Catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
| US9315597B2 (en) | 2014-09-08 | 2016-04-19 | Sirrus, Inc. | Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures |
| US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
| US10501400B2 (en) | 2015-02-04 | 2019-12-10 | Sirrus, Inc. | Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
| US9334430B1 (en) | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
| US9217098B1 (en) | 2015-06-01 | 2015-12-22 | Sirrus, Inc. | Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound |
| US9518001B1 (en) | 2016-05-13 | 2016-12-13 | Sirrus, Inc. | High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation |
| US9617377B1 (en) | 2016-06-03 | 2017-04-11 | Sirrus, Inc. | Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
| US10428177B2 (en) | 2016-06-03 | 2019-10-01 | Sirrus, Inc. | Water absorbing or water soluble polymers, intermediate compounds, and methods thereof |
| US10196481B2 (en) | 2016-06-03 | 2019-02-05 | Sirrus, Inc. | Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof |
| US9567475B1 (en) | 2016-06-03 | 2017-02-14 | Sirrus, Inc. | Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE235866C (hu) | ||||
| DE242404C (hu) | ||||
| DK425382A (da) * | 1981-09-25 | 1983-03-26 | Wellcome Found | Fremgangsmaade til fremstilling af amider |
| CA2073776A1 (en) | 1990-11-15 | 1992-05-16 | Joerg Stuerzebecher | Meta-substituted phenyl alanine derivatives |
| IT1254883B (it) * | 1992-04-16 | 1995-10-11 | Italfarmaco Spa | Tetrapeptidi parzialmente modificati e retroinvertiti, analoghi di frammenti della proteina c-reattiva. |
| CZ245994A3 (en) | 1993-02-10 | 1995-10-18 | Pentapharm Ag | Piperazides of substituted phenylalanine derivatives as thrombin inhibitors |
| US5977074A (en) * | 1993-10-01 | 1999-11-02 | Merrell Pharmaceuticals, Inc. | Inhibitors of β-amyloid protein production |
| SI9520044B (sl) * | 1994-04-26 | 2004-08-31 | Aventis Pharmaceuticals Inc. | Inhibitorji Xa faktorja |
| AU3107795A (en) * | 1994-08-09 | 1996-03-07 | Pentapharm Ag | Inhibitors of the benzamidine type |
| GB9420763D0 (en) * | 1994-10-14 | 1994-11-30 | Glaxo Inc | Acetamide derivatives |
| CN1087349C (zh) * | 1995-12-20 | 2002-07-10 | 阿温蒂斯药物公司 | N－乙酰基－(L)－4－氰基苯丙氨酸Ac-(L)-Phe(4－CN)－OH与N－乙酰基－(L)－对脒基苯丙氨酸－环己基甘氨酸－β－（3－N－甲基吡啶鎓）－丙氨酸AC－（L）－PAPh－chg－PaIMe(3)-NH2的新颖的制备方法 |
| HUP0002942A3 (en) | 1997-05-02 | 2001-12-28 | Akzo Nobel Nv | Peptides having serine protease inhibiting effect pharmaceutical compositions comprising thereof and their use |
| KR100608472B1 (ko) | 1997-12-24 | 2006-08-09 | 사노피-아벤티스 도이칠란트 게엠베하 | 인자 Ｘａ의 억제제로서의 인돌 유도체 및 이를 함유하는 약제학적 조성물 |
| EP1016663A1 (en) | 1999-01-02 | 2000-07-05 | Aventis Pharma Deutschland GmbH | Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity) |
-
1999
- 1999-12-23 ID IDW00200101430A patent/ID29979A/id unknown
- 1999-12-23 BR BR9916732-8A patent/BR9916732A/pt not_active IP Right Cessation
- 1999-12-23 HK HK02103402.4A patent/HK1041700A1/zh unknown
- 1999-12-23 PL PL99349343A patent/PL349343A1/xx not_active Application Discontinuation
- 1999-12-23 TR TR2001/01903T patent/TR200101903T2/xx unknown
- 1999-12-23 AU AU30431/00A patent/AU3043100A/en not_active Abandoned
- 1999-12-23 HU HU0105437A patent/HUP0105437A3/hu unknown
- 1999-12-23 JP JP2000592279A patent/JP2002534420A/ja not_active Abandoned
- 1999-12-23 CA CA002358578A patent/CA2358578A1/en not_active Abandoned
- 1999-12-23 KR KR1020017008429A patent/KR20010101355A/ko not_active Withdrawn
- 1999-12-23 CN CN99815372A patent/CN1332734A/zh active Pending
- 1999-12-23 CZ CZ20012379A patent/CZ20012379A3/cs unknown
- 1999-12-23 EP EP99964667A patent/EP1140878A1/en not_active Withdrawn
- 1999-12-23 WO PCT/EP1999/010340 patent/WO2000040571A1/en not_active Ceased
- 1999-12-23 IL IL14409699A patent/IL144096A0/xx unknown
- 1999-12-28 US US09/473,053 patent/US6395737B1/en not_active Expired - Lifetime
-
2001
- 2001-06-15 NO NO20012983A patent/NO20012983D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20012379A3 (cs) | 2001-09-12 |
| WO2000040571A1 (en) | 2000-07-13 |
| CN1332734A (zh) | 2002-01-23 |
| PL349343A1 (en) | 2002-07-15 |
| AU3043100A (en) | 2000-07-24 |
| TR200101903T2 (tr) | 2001-11-21 |
| HK1041700A1 (zh) | 2002-07-19 |
| NO20012983L (no) | 2001-06-15 |
| KR20010101355A (ko) | 2001-11-14 |
| NO20012983D0 (no) | 2001-06-15 |
| EP1140878A1 (en) | 2001-10-10 |
| US6395737B1 (en) | 2002-05-28 |
| IL144096A0 (en) | 2002-05-23 |
| CA2358578A1 (en) | 2000-07-13 |
| HUP0105437A2 (hu) | 2002-05-29 |
| BR9916732A (pt) | 2001-09-25 |
| JP2002534420A (ja) | 2002-10-15 |
| ID29979A (id) | 2001-10-25 |
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