NO20012948D0 - Hydroksydifenylureasulfonamider som IL-8 reseptor antagonister - Google Patents
Hydroksydifenylureasulfonamider som IL-8 reseptor antagonisterInfo
- Publication number
- NO20012948D0 NO20012948D0 NO20012948A NO20012948A NO20012948D0 NO 20012948 D0 NO20012948 D0 NO 20012948D0 NO 20012948 A NO20012948 A NO 20012948A NO 20012948 A NO20012948 A NO 20012948A NO 20012948 D0 NO20012948 D0 NO 20012948D0
- Authority
- NO
- Norway
- Prior art keywords
- hydroxydiphenylureasulfonamides
- receptor antagonists
- antagonists
- receptor
- Prior art date
Links
- 102000010681 interleukin-8 receptors Human genes 0.000 title 1
- 108010038415 interleukin-8 receptors Proteins 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11248198P | 1998-12-16 | 1998-12-16 | |
| US13700399P | 1999-06-01 | 1999-06-01 | |
| PCT/US1999/029940 WO2000035442A1 (en) | 1998-12-16 | 1999-12-15 | Hydroxy diphenyl urea sulfonamides as il-8 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20012948D0 true NO20012948D0 (no) | 2001-06-14 |
| NO20012948L NO20012948L (no) | 2001-06-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20012948A NO20012948L (no) | 1998-12-16 | 2001-06-14 | Hydroksydifenylureasulfonamider som IL-8 reseptor antagonister |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US6500863B1 (no) |
| EP (1) | EP1161232B1 (no) |
| JP (1) | JP2002532419A (no) |
| KR (1) | KR20010101243A (no) |
| CN (1) | CN1334726A (no) |
| AR (1) | AR029605A1 (no) |
| AT (1) | ATE262328T1 (no) |
| AU (1) | AU748799B2 (no) |
| BG (1) | BG105661A (no) |
| BR (1) | BR9916159A (no) |
| CA (1) | CA2355890A1 (no) |
| CO (1) | CO4990929A1 (no) |
| CZ (1) | CZ20012150A3 (no) |
| DE (1) | DE69915888T2 (no) |
| DK (1) | DK1161232T3 (no) |
| DZ (1) | DZ2964A1 (no) |
| EA (1) | EA005210B1 (no) |
| ES (1) | ES2217871T3 (no) |
| HK (1) | HK1043535B (no) |
| HU (1) | HUP0104686A3 (no) |
| IL (1) | IL143507A0 (no) |
| MA (1) | MA25366A1 (no) |
| NO (1) | NO20012948L (no) |
| NZ (1) | NZ511993A (no) |
| OA (1) | OA11731A (no) |
| PE (1) | PE20001323A1 (no) |
| PL (1) | PL348179A1 (no) |
| PT (1) | PT1161232E (no) |
| SK (1) | SK8222001A3 (no) |
| TR (1) | TR200101772T2 (no) |
| UY (1) | UY25842A1 (no) |
| WO (1) | WO2000035442A1 (no) |
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| ME00275B (me) | 1999-01-13 | 2011-02-10 | Bayer Corp | ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE |
| EP1140840B1 (en) * | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| JP2002534468A (ja) | 1999-01-13 | 2002-10-15 | バイエル コーポレイション | p38キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素 |
| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| AR029637A1 (es) * | 1999-05-28 | 2003-07-10 | Smithkline Beecham Corp | Compuestos de guanidina, antagonistas de los receptores de la il-8, una composicion farmaceutica que los contiene y el uso de los mismos para la manufactura de un medicamento |
| AU2001243351A1 (en) * | 2000-03-01 | 2001-09-12 | Smith Kline Beecham Corporation | Il-8 receptor antagonists |
| EP1261329A4 (en) * | 2000-03-10 | 2005-08-17 | Smithkline Beecham Corp | IL-8 RECEPTOR ANTAGONISTS |
| AR030273A1 (es) * | 2000-03-10 | 2003-08-20 | Smithkline Beecham Corp | Compuestos de hidroxifenil urea sustituidos con sulfonamidas, composiciones farmaceuticas que los comprenden, y uso de los mismos en la fabricacion de medicamentos para tratar una enfermedad mediada por una quimioquina |
| JP2003527360A (ja) * | 2000-03-14 | 2003-09-16 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体アンタゴニスト |
| AR030689A1 (es) * | 2000-03-14 | 2003-09-03 | Smithkline Beecham Corp | Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas |
| CO5280089A1 (es) * | 2000-03-16 | 2003-05-30 | Smithkline Beecham Corp | Antagonistas del receptor il-8 |
| US6664259B2 (en) * | 2000-03-16 | 2003-12-16 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| UY26627A1 (es) * | 2000-03-24 | 2001-09-28 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
| US6653310B2 (en) | 2000-04-07 | 2003-11-25 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| WO2002012243A2 (en) * | 2000-08-09 | 2002-02-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | SYNTHESIS OF (R)-3-(4-BROMOBENZYL)-1-(3,5-DICHLOROPHENYL)-5-IODO-3-METHYL-1-H-IMIDAZO[1,2-a]IMIDAZOL-2-ONE |
| AU2002222683B9 (en) * | 2000-12-18 | 2021-12-23 | Institute Of Medicinal Molecular Design, Inc | Inflammatory cytokine release inhibitor |
| WO2002057230A1 (en) * | 2001-01-16 | 2002-07-25 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| JP2005507366A (ja) * | 2001-03-30 | 2005-03-17 | スミスクライン・ビーチャム・コーポレイション | フェノール含有化合物の合成方法 |
| TW200303742A (en) * | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| US20030207872A1 (en) * | 2002-01-11 | 2003-11-06 | Bayer Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| PT1478358E (pt) | 2002-02-11 | 2013-09-11 | Bayer Healthcare Llc | Tosilato de sorafenib para o tratamento de doenças caracterizadas por angiogénese anormal |
| TW200410671A (en) * | 2002-06-05 | 2004-07-01 | Inst Med Molecular Design Inc | Medicines for inhibiting the activation of AP-1 |
| CA2488363C (en) | 2002-06-06 | 2011-01-04 | Institute Of Medicinal Molecular Design, Inc. | O-substituted hydroxyaryl derivatives |
| TW200418812A (en) * | 2002-10-29 | 2004-10-01 | Smithkline Beecham Corp | IL-8 receptor antagonists |
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| DK1636585T3 (da) | 2003-05-20 | 2008-05-26 | Bayer Pharmaceuticals Corp | Diarylurinstoffer med kinasehæmmende aktivitet |
| PT1663978E (pt) | 2003-07-23 | 2008-02-15 | Bayer Pharmaceuticals Corp | Omega-carboxiaril difenil ureia substituída por flúor para o tratamento e a prevenção de doenças e estados patológicos |
| EP1812008A4 (en) * | 2004-10-20 | 2008-10-29 | Smithkline Beecham Corp | ANTAGONISTS OF THE IL-8 RECEPTOR |
| JP2009534420A (ja) * | 2006-04-21 | 2009-09-24 | スミスクライン・ビーチャム・コーポレイション | Il−8受容体アンタゴニスト |
| WO2007124424A2 (en) * | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| US7671058B2 (en) | 2006-06-21 | 2010-03-02 | Institute Of Medicinal Molecular Design, Inc. | N-(3,4-disubstituted phenyl) salicylamide derivatives |
| PE20080943A1 (es) | 2006-06-23 | 2008-09-27 | Smithkline Beecham Corp | Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8 |
| EP2203432A4 (en) * | 2007-09-21 | 2011-04-27 | Glaxosmithkline Llc | PROCESSING METHOD |
| EP2110019A1 (de) | 2008-04-19 | 2009-10-21 | Bayer CropScience AG | Herbizide Verbindungen auf Basis von N-Azinyl-N'-phenylsulfonylharnstoffen |
| JP6067226B2 (ja) | 2009-03-13 | 2017-01-25 | アジオス ファーマシューティカルズ, インコーポレイテッド | 細胞増殖関連疾患のための方法および組成物 |
| NZ597379A (en) | 2009-06-29 | 2014-04-30 | Agios Pharmaceuticals Inc | Therapeutic compounds and compositions |
| WO2011050210A1 (en) | 2009-10-21 | 2011-04-28 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| CA2793836C (en) | 2009-10-21 | 2020-03-24 | Agios Pharmaceuticals, Inc. | Methods and compositions for cell-proliferation-related disorders |
| US8962606B2 (en) * | 2009-10-21 | 2015-02-24 | Bayer Intellectual Property Gmbh | Substituted benzosulphonamides |
| CA2783696A1 (en) | 2009-12-17 | 2011-06-23 | Galderma Research & Development | Use of compounds in the treatment or prevention of skin disorders |
| SMT201800354T1 (it) | 2011-05-03 | 2018-09-13 | Agios Pharmaceuticals Inc | Attivatori della piruvato chinasi per uso in terapia |
| CN102827170A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| EP3984997B1 (en) | 2012-01-06 | 2025-07-30 | Les Laboratoires Servier | Therapeutically active compounds and their methods of use |
| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| CA2888360A1 (en) | 2012-10-15 | 2014-04-24 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| WO2015003355A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| CA2917671A1 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | 2,4-or 4,6-diaminopyrimidine compounds as idh2 mutants inhibitors for the treatment of cancer |
| CN105492435B (zh) | 2013-07-11 | 2018-06-29 | 安吉奥斯医药品有限公司 | 作为idh2突变体抑制剂的化合物 |
| WO2015003360A2 (en) | 2013-07-11 | 2015-01-15 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| US9579324B2 (en) | 2013-07-11 | 2017-02-28 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| US20150031627A1 (en) | 2013-07-25 | 2015-01-29 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
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| FR3030515B1 (fr) | 2014-12-23 | 2017-01-20 | Galderma Res & Dev | Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines |
| US11234976B2 (en) | 2015-06-11 | 2022-02-01 | Agios Pharmaceuticals, Inc. | Methods of using pyruvate kinase activators |
| EP3362066B1 (en) | 2015-10-15 | 2021-10-06 | Les Laboratoires Servier SAS | Combination therapy for treating malignancies |
| PT3362065T (pt) | 2015-10-15 | 2024-06-21 | Servier Lab | Terapia de combinação compreendendo ivosidenib, citarabina e daunorubicina ou idarubicina para o tratamento de leucemia mielóide aguda |
| US10980788B2 (en) | 2018-06-08 | 2021-04-20 | Agios Pharmaceuticals, Inc. | Therapy for treating malignancies |
| CN112778167A (zh) * | 2019-11-01 | 2021-05-11 | 邵阳学院 | 一种快速制备n-苯磺酰基氨基酸酯类化合物的方法 |
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| US3972886A (en) * | 1972-07-13 | 1976-08-03 | Leo Pharmaceutical Products Ltd. | Certain 4-phenoxy-3-heteroarylmethyl or ethyl sulfamyl benzoic acid derivatives |
| US4155930A (en) | 1978-07-11 | 1979-05-22 | American Cyanamid Company | Ureylene phenylene anionic naphthalenesulfonic acids |
| US4786316A (en) | 1984-07-13 | 1988-11-22 | E. I. Du Pont De Nemours And Company | Herbicidal ortho-sulfamoyl sulfonamides |
| BR9709938A (pt) * | 1996-06-27 | 1999-08-10 | Smithkline Beecham Corp | Antagonistas dos receptores de il-8 |
| WO1997049400A1 (en) * | 1996-06-27 | 1997-12-31 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| DE69826695T2 (de) * | 1997-05-23 | 2006-02-02 | Bayer Pharmaceuticals Corp., West Haven | Arylharnstoffderivate zur behandlung von inflammatorischen oder immunomodulatorischen erkrankungen |
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1999
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- 1999-12-12 DZ DZ990264A patent/DZ2964A1/xx active
- 1999-12-13 CO CO99077673A patent/CO4990929A1/es unknown
- 1999-12-14 AR ARP990106373A patent/AR029605A1/es not_active Application Discontinuation
- 1999-12-14 PE PE1999001243A patent/PE20001323A1/es not_active Application Discontinuation
- 1999-12-15 CA CA002355890A patent/CA2355890A1/en not_active Abandoned
- 1999-12-15 PT PT99965288T patent/PT1161232E/pt unknown
- 1999-12-15 KR KR1020017007504A patent/KR20010101243A/ko not_active Ceased
- 1999-12-15 ES ES99965288T patent/ES2217871T3/es not_active Expired - Lifetime
- 1999-12-15 OA OA1200100154A patent/OA11731A/en unknown
- 1999-12-15 CN CN99816125A patent/CN1334726A/zh active Pending
- 1999-12-15 AT AT99965288T patent/ATE262328T1/de active
- 1999-12-15 BR BR9916159-1A patent/BR9916159A/pt not_active IP Right Cessation
- 1999-12-15 US US09/868,165 patent/US6500863B1/en not_active Expired - Fee Related
- 1999-12-15 TR TR2001/01772T patent/TR200101772T2/xx unknown
- 1999-12-15 JP JP2000587762A patent/JP2002532419A/ja not_active Ceased
- 1999-12-15 AU AU31237/00A patent/AU748799B2/en not_active Ceased
- 1999-12-15 HU HU0104686A patent/HUP0104686A3/hu unknown
- 1999-12-15 DE DE1999615888 patent/DE69915888T2/de not_active Expired - Lifetime
- 1999-12-15 IL IL14350799A patent/IL143507A0/xx unknown
- 1999-12-15 PL PL99348179A patent/PL348179A1/xx not_active Application Discontinuation
- 1999-12-15 NZ NZ511993A patent/NZ511993A/en not_active IP Right Cessation
- 1999-12-15 EA EA200100659A patent/EA005210B1/ru not_active IP Right Cessation
- 1999-12-15 DK DK99965288T patent/DK1161232T3/da active
- 1999-12-15 CZ CZ20012150A patent/CZ20012150A3/cs unknown
- 1999-12-15 WO PCT/US1999/029940 patent/WO2000035442A1/en not_active Ceased
- 1999-12-15 SK SK822-2001A patent/SK8222001A3/sk unknown
- 1999-12-15 HK HK02103608.6A patent/HK1043535B/en not_active IP Right Cessation
- 1999-12-15 EP EP99965288A patent/EP1161232B1/en not_active Expired - Lifetime
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2001
- 2001-06-13 MA MA26236A patent/MA25366A1/fr unknown
- 2001-06-14 NO NO20012948A patent/NO20012948L/no not_active Application Discontinuation
- 2001-06-29 BG BG105661A patent/BG105661A/xx unknown
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2002
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