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NO20003514L - Hypolipidemiske benzothiazepin-forbindelser - Google Patents

Hypolipidemiske benzothiazepin-forbindelser

Info

Publication number
NO20003514L
NO20003514L NO20003514A NO20003514A NO20003514L NO 20003514 L NO20003514 L NO 20003514L NO 20003514 A NO20003514 A NO 20003514A NO 20003514 A NO20003514 A NO 20003514A NO 20003514 L NO20003514 L NO 20003514L
Authority
NO
Norway
Prior art keywords
benzothiazepine compounds
hypolipidemic benzothiazepine
compounds
hypolipidemic
solvates
Prior art date
Application number
NO20003514A
Other languages
English (en)
Other versions
NO20003514D0 (no
Inventor
Anthony Louis Handlon
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO20003514D0 publication Critical patent/NO20003514D0/no
Publication of NO20003514L publication Critical patent/NO20003514L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Det er beskrevet nye hypolipidemiske forbindelser ifølge formel (I), hvori R1 er H eller metyl og salter, solvater eller fysiologiske funksjonelle derivater derav, frem- gangsmåter og nye mellomprodukter for fremstilling derav, farmasøytiske sammen- setninger som inneholder disse og anvendelse i medisin, spesielt ved profylakse og behandling av hyperlipidemiske tilstander og assosierte sykdommer, så som athero- sklerose.
NO20003514A 1998-01-10 2000-07-07 Hypolipidemiske benzothiazepin-forbindelser NO20003514L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9800428.6A GB9800428D0 (en) 1998-01-10 1998-01-10 Chemical compounds
PCT/EP1999/000021 WO1999035135A1 (en) 1998-01-10 1999-01-07 Hypolipidemic benzothiazepine compounds

Publications (2)

Publication Number Publication Date
NO20003514D0 NO20003514D0 (no) 2000-07-07
NO20003514L true NO20003514L (no) 2000-09-07

Family

ID=10825042

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003514A NO20003514L (no) 1998-01-10 2000-07-07 Hypolipidemiske benzothiazepin-forbindelser

Country Status (27)

Country Link
US (1) US6465451B1 (no)
EP (1) EP1045840A1 (no)
JP (1) JP2002500220A (no)
KR (1) KR20010033988A (no)
CN (1) CN1292785A (no)
AP (1) AP2000001860A0 (no)
AR (1) AR014261A1 (no)
AU (1) AU2515599A (no)
BR (1) BR9906799A (no)
CA (1) CA2317651A1 (no)
CO (1) CO4820391A1 (no)
EA (1) EA200000623A1 (no)
GB (1) GB9800428D0 (no)
HR (1) HRP20000468A2 (no)
HU (1) HUP0201343A3 (no)
ID (1) ID25495A (no)
IL (1) IL137040A0 (no)
IS (1) IS5551A (no)
MA (1) MA26595A1 (no)
NO (1) NO20003514L (no)
NZ (1) NZ505453A (no)
PE (1) PE20000179A1 (no)
PL (1) PL341672A1 (no)
SK (1) SK10242000A3 (no)
TR (1) TR200001816T2 (no)
WO (1) WO1999035135A1 (no)
ZA (1) ZA9981B (no)

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GB0304194D0 (en) 2003-02-25 2003-03-26 Astrazeneca Ab Chemical compounds
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TR201810984T4 (tr) 2010-11-04 2018-09-21 Albireo Ab Karaciğer hastalıklarının tedavisi için IBAT inhibitörleri.
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CN107375291A (zh) 2011-10-28 2017-11-24 鲁美纳医药公司 用于治疗高胆血症和胆汁淤积性肝病的胆汁酸再循环抑制剂
CN105228615A (zh) 2013-03-15 2016-01-06 鲁美纳医药公司 用于治疗巴雷特食管和胃食管返流疾病的胆汁酸再循环抑制剂
MX2015013193A (es) 2013-03-15 2016-04-15 Lumena Pharmaceuticals Inc Inhibidores del reciclaje de acidos biliares para el tratamiento de colangitis esclerosante primaria y enfermedad inflamatoria intestinal.
JO3301B1 (ar) 2013-04-26 2018-09-16 Albireo Ab تعديلات بلورية على إيلوبيكسيبات
KR20220082931A (ko) 2014-06-25 2022-06-17 이에이 파마 가부시키가이샤 고형 제제 및 그의 착색 방지 또는 착색 감소 방법
EP3012252A1 (en) 2014-10-24 2016-04-27 Ferring BV Crystal modifications of elobixibat
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
JP6954927B2 (ja) 2016-02-09 2021-10-27 アルビレオ・アクチボラグ 経口コレスチラミン製剤及びその使用
US10786529B2 (en) 2016-02-09 2020-09-29 Albireo Ab Oral cholestyramine formulation and use thereof
WO2017138877A1 (en) 2016-02-09 2017-08-17 Albireo Ab Oral cholestyramine formulation and use thereof
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
WO2019032027A1 (en) 2017-08-09 2019-02-14 Albireo Ab CHOLESTYRAMINE TABLETS, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
WO2019032026A1 (en) 2017-08-09 2019-02-14 Albireo Ab CHOLESTYRAMINE GRANULES, ORAL FORMULATIONS OF CHOLESTYRAMINE AND THEIR USE
CA3100113A1 (en) 2018-06-05 2019-12-12 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US10793534B2 (en) 2018-06-05 2020-10-06 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
KR20210024033A (ko) 2018-06-20 2021-03-04 알비레오 에이비 오데빅시바트의 약학 제제
US11801226B2 (en) 2018-06-20 2023-10-31 Albireo Ab Pharmaceutical formulation of odevixibat
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US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
TWI867107B (zh) 2019-12-04 2024-12-21 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途
BR112022010505A2 (pt) 2019-12-04 2022-09-06 Albireo Ab Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar
EP4069361B1 (en) * 2019-12-04 2024-01-03 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators
PT4069360T (pt) 2019-12-04 2024-03-06 Albireo Ab Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar
EP4069362A1 (en) * 2019-12-04 2022-10-12 Albireo AB Benzothiazepine compounds and their use as bile acid modulators
WO2021110887A1 (en) 2019-12-04 2021-06-10 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
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WO2022117778A1 (en) * 2020-12-04 2022-06-09 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
JP2025524362A (ja) 2022-06-09 2025-07-30 アルビレオ・アクチボラグ 肝炎の処置
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Also Published As

Publication number Publication date
TR200001816T2 (tr) 2000-11-21
ZA9981B (en) 2000-07-06
ID25495A (id) 2000-10-05
EP1045840A1 (en) 2000-10-25
NO20003514D0 (no) 2000-07-07
CN1292785A (zh) 2001-04-25
MA26595A1 (fr) 2004-12-20
PE20000179A1 (es) 2000-03-16
HUP0201343A2 (hu) 2003-06-28
US6465451B1 (en) 2002-10-15
SK10242000A3 (sk) 2001-02-12
NZ505453A (en) 2002-11-26
CA2317651A1 (en) 1999-07-15
WO1999035135A1 (en) 1999-07-15
CO4820391A1 (es) 1999-07-28
IL137040A0 (en) 2001-06-14
AP2000001860A0 (en) 2000-09-30
BR9906799A (pt) 2000-10-10
HUP0201343A3 (en) 2003-08-28
JP2002500220A (ja) 2002-01-08
PL341672A1 (en) 2001-04-23
KR20010033988A (ko) 2001-04-25
AR014261A1 (es) 2001-02-07
GB9800428D0 (en) 1998-03-04
AU2515599A (en) 1999-07-26
EA200000623A1 (ru) 2001-04-23
HRP20000468A2 (en) 2000-10-31
IS5551A (is) 2000-06-27

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