NO20000722D0 - 2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater - Google Patents

2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater

Info

Publication number: NO20000722D0
Authority: NO; Norway
Prior art keywords: piperazin; ylmethyl; heteroaryl; aryl; indole derivatives
Prior art date: 1997-08-15

Application number

NO20000722A

Other languages

English (en)

Norwegian (no)

Other versions

NO20000722L (no

Inventor

Anton Franz Josef Fliri

Marc J Majchrzak

Patricia Ann Seymour

Stevin Howard Zorn

Hans Rollema

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-15

Filing date

2000-02-14

Publication date

2000-02-14

2000-02-14 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2000-02-14 Publication of NO20000722L publication Critical patent/NO20000722L/no

2000-02-14 Publication of NO20000722D0 publication Critical patent/NO20000722D0/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

NO20000722A 1997-08-15 2000-02-14 2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater NO20000722D0 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5576497P	1997-08-15	1997-08-15
PCT/IB1998/001198 WO1999009025A2 (en)	1997-08-15	1998-08-05	2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor

Publications (2)

Publication Number	Publication Date
NO20000722L NO20000722L (no)	2000-02-14
NO20000722D0 true NO20000722D0 (no)	2000-02-14

Family

ID=22000003

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20000722A NO20000722D0 (no)	1997-08-15	2000-02-14	2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater

Country Status (30)

Country	Link
EP (1)	EP1003739A2 (xx)
JP (1)	JP2002536291A (xx)
KR (1)	KR20010022507A (xx)
CN (1)	CN1265660A (xx)
AP (1)	AP9801321A0 (xx)
AR (1)	AR017019A1 (xx)
AU (1)	AU8457298A (xx)
BG (1)	BG104069A (xx)
BR (1)	BR9811557A (xx)
CA (1)	CA2297486C (xx)
CO (1)	CO4960656A1 (xx)
DZ (1)	DZ2583A1 (xx)
EA (1)	EA200000023A1 (xx)
HR (1)	HRP980441A2 (xx)
HU (1)	HUP0003425A3 (xx)
ID (1)	ID23803A (xx)
IL (1)	IL133960A0 (xx)
IS (1)	IS5336A (xx)
MA (1)	MA24632A1 (xx)
NO (1)	NO20000722D0 (xx)
OA (1)	OA11286A (xx)
PA (1)	PA8457001A1 (xx)
PE (1)	PE106299A1 (xx)
PL (1)	PL338947A1 (xx)
SK (1)	SK1352000A3 (xx)
TN (1)	TNSN98151A1 (xx)
TR (1)	TR200000414T2 (xx)
UY (1)	UY25144A1 (xx)
WO (1)	WO1999009025A2 (xx)
ZA (1)	ZA987304B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU226859B1 (en) *	1997-10-27	2009-12-28	Neurosearch As	Phenyl- or heteroaryl-homopiperazines, their use and medicaments containing them
EP0953567A3 (en) *	1998-04-29	2003-04-02	Pfizer Products Inc.	Bicyclic substituted piperazine-, piperidine- and tetrahydropyridine derivatives, their preparation and their use as agents with central dopaminergic (dopamine D4 receptor) activity
HRP20020567A2 (en)	1999-12-30	2005-04-30	H. Lundbeck A/S	4-phenyl-1-piperazinyl, -piperidinyl and -tetrahydropyridyl derivatives
GB0017952D0 (en) *	2000-07-22	2000-09-13	Univ Manchester	Treatment of dyskinesia
EP1177792A3 (en)	2000-07-27	2002-10-23	Pfizer Products Inc.	Dopamine D4 Ligands for the treatment of novelty-seeking disorders
AU2002336273A1 (en)	2001-03-09	2002-09-24	Ortho-Mcneil Pharmaceutical, Inc.	Heterocyclic compounds and their use as histamine h4 ligands.
PL377087A1 (pl)	2002-09-06	2006-01-23	Janssen Pharmaceutica, N.V.	Związki heterocykliczne
WO2004108671A1 (en) *	2003-06-06	2004-12-16	Suven Life Sciences Limited	Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them
JP4859665B2 (ja)	2004-03-30	2012-01-25	武田薬品工業株式会社	アルコキシフェニルプロパン酸誘導体
US7618980B2 (en)	2004-07-14	2009-11-17	Bristol-Myers Squibb Company	Pyrrolo(oxo)quinolines as 5HT ligands
US7572805B2 (en)	2004-07-14	2009-08-11	Bristol-Myers Squibb Company	Pyrrolo(oxo)isoquinolines as 5HT ligands
JO2769B1 (en)	2005-10-26	2014-03-15	جانسين فارماسوتيكا ان. في	Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en)	2006-12-08	2012-06-17	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) *	2007-02-13	2015-03-15	جانسين فارماسوتيكا ان. في	Dopamine 2 receptor antagonists are rapidly hydrolyzed
ES2400710T3 (es)	2007-04-23	2013-04-11	Janssen Pharmaceutica, N.V.	Tia(dia)zoles como antagonistas del receptor de dopamina 2 de disociación rápida
JP5431305B2 (ja)	2007-04-23	2014-03-05	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
ES2398625T3 (es)	2008-07-03	2013-03-20	Janssen Pharmaceutica N.V.	6-(1-Piperazinil)-piritazinas sustituidas como antagonistas de receptores 5-HT6
CA2730774C (en)	2008-07-31	2016-09-13	Janssen Pharmaceutica Nv	Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists
EP3686196B1 (en) *	2017-09-20	2024-06-12	Hangzhou Innogate Pharma Co., Ltd.	Polycyclic compound acting as ido inhibitor and/or ido-hdac dual inhibitor
WO2021216665A1 (en) *	2020-04-22	2021-10-28	Anima Biotech Inc.	Collagen 1 translation inhibitors and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB944443A (xx) *	1959-09-25	1900-01-01
WO1993001181A1 (en) *	1991-07-03	1993-01-21	The Upjohn Company	Substituted indoles as anti-aids pharmaceuticals
JPH05255089A (ja) *	1991-12-18	1993-10-05	Sanwa Kagaku Kenkyusho Co Ltd	抗ウイルス剤
CA2146018A1 (en) *	1992-10-23	1994-05-11	Paul David Leeson	Dopamine receptor subtype ligands
GB9305644D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
AU6215594A (en) *	1993-03-18	1994-10-11	Merck Sharp & Dohme Limited	Indole derivatives as dopamine d4 antagonists
AU6435594A (en) *	1993-04-15	1994-11-08	Merck Sharp & Dohme Limited	Indole derivatives as dopamine d4 antagonists
DE4414113A1 (de) *	1994-04-22	1995-10-26	Merck Patent Gmbh	3-Indolylpiperidine
TW406075B (en) *	1994-12-13	2000-09-21	Upjohn Co	Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) *	1995-11-17	1998-04-14	Upjohn Co	Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) *	1996-05-10	2002-10-01	Janssen Pharmaceutica Nv	2,4-diaminopyrimidine derivatives

1998
- 1998-08-05 IL IL13396098A patent/IL133960A0/xx unknown
- 1998-08-05 KR KR1020007001093A patent/KR20010022507A/ko not_active Ceased
- 1998-08-05 AU AU84572/98A patent/AU8457298A/en not_active Abandoned
- 1998-08-05 PL PL98338947A patent/PL338947A1/xx unknown
- 1998-08-05 EA EA200000023A patent/EA200000023A1/ru unknown
- 1998-08-05 CN CN98807831A patent/CN1265660A/zh active Pending
- 1998-08-05 EP EP98935229A patent/EP1003739A2/en not_active Withdrawn
- 1998-08-05 AP APAP/P/1998/001321A patent/AP9801321A0/en unknown
- 1998-08-05 TR TR2000/00414T patent/TR200000414T2/xx unknown
- 1998-08-05 BR BR9811557-0A patent/BR9811557A/pt not_active IP Right Cessation
- 1998-08-05 SK SK135-2000A patent/SK1352000A3/sk unknown
- 1998-08-05 CA CA002297486A patent/CA2297486C/en not_active Expired - Fee Related
- 1998-08-05 ID IDW20000197A patent/ID23803A/id unknown
- 1998-08-05 JP JP2000509706A patent/JP2002536291A/ja active Pending
- 1998-08-05 WO PCT/IB1998/001198 patent/WO1999009025A2/en not_active Ceased
- 1998-08-05 HU HU0003425A patent/HUP0003425A3/hu unknown
- 1998-08-10 PA PA19988457001A patent/PA8457001A1/es unknown
- 1998-08-10 PE PE1998000717A patent/PE106299A1/es not_active Application Discontinuation
- 1998-08-12 TN TNTNSN98151A patent/TNSN98151A1/fr unknown
- 1998-08-12 DZ DZ980193A patent/DZ2583A1/xx active
- 1998-08-12 MA MA25210A patent/MA24632A1/fr unknown
- 1998-08-13 AR ARP980104021A patent/AR017019A1/es unknown
- 1998-08-14 ZA ZA9807304A patent/ZA987304B/xx unknown
- 1998-08-14 CO CO98046788A patent/CO4960656A1/es unknown
- 1998-08-14 HR HR60/055,764A patent/HRP980441A2/hr not_active Application Discontinuation
- 1998-08-17 UY UY25144A patent/UY25144A1/es not_active Application Discontinuation
2000
- 2000-01-10 BG BG104069A patent/BG104069A/xx unknown
- 2000-01-11 IS IS5336A patent/IS5336A/is unknown
- 2000-02-08 OA OA1200000030A patent/OA11286A/en unknown
- 2000-02-14 NO NO20000722A patent/NO20000722D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
PA8457001A1 (es)	2000-09-29
WO1999009025A3 (en)	1999-04-15
CN1265660A (zh)	2000-09-06
CO4960656A1 (es)	2000-09-25
EA200000023A1 (ru)	2000-08-28
NO20000722L (no)	2000-02-14
MA24632A1 (fr)	1999-04-01
PE106299A1 (es)	1999-11-02
BR9811557A (pt)	2000-08-22
AU8457298A (en)	1999-03-08
IS5336A (is)	2000-01-11
ZA987304B (en)	2000-02-14
HUP0003425A3 (en)	2002-02-28
BG104069A (en)	2001-05-31
WO1999009025A2 (en)	1999-02-25
UY25144A1 (es)	2000-12-29
DZ2583A1 (fr)	2003-02-22
KR20010022507A (ko)	2001-03-15
IL133960A0 (en)	2001-04-30
HUP0003425A2 (hu)	2001-10-28
TNSN98151A1 (fr)	2005-03-15
AP9801321A0 (en)	2000-02-14
EP1003739A2 (en)	2000-05-31
CA2297486C (en)	2005-05-03
AR017019A1 (es)	2001-08-22
HRP980441A2 (en)	1999-04-30
ID23803A (id)	2000-05-11
JP2002536291A (ja)	2002-10-29
PL338947A1 (en)	2000-12-04
SK1352000A3 (en)	2000-08-14
OA11286A (en)	2003-10-22
TR200000414T2 (tr)	2000-08-21
CA2297486A1 (en)	1999-02-25

Publication	Publication Date	Title
NO20000722D0 (no)	2000-02-14	2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater
ATE246700T1 (de)	2003-08-15	Benzimidazolderivate
MA26542A1 (fr)	2004-12-20	Derives oxindole substitues.
DK1005446T3 (da)	2004-06-07	N-aroylphenylalaninderivater
ATE235220T1 (de)	2003-04-15	Resorcinderivate
ID22781A (id)	1999-12-09	Turunan-turunan nikotinamida
DE69817186D1 (de)	2003-09-18	Diaminorhodamin-derivate
DK0958291T3 (da)	2009-05-04	3-heteroxyclyl-substituerede benzoylderivater
DK0915088T3 (da)	2003-01-27	D-prolinderivater
ATE278695T1 (de)	2004-10-15	Piperidinderivate
ATE255098T1 (de)	2003-12-15	Substituierte chromanderivate
PT1003719E (pt)	2002-10-31	Derivados microbicidas de n-sulfonil-glicinalquiniloxifenemetilamida
ATE440854T1 (de)	2009-09-15	5-deoxy-cytidin-derivate
PT869121E (pt)	2004-10-29	Derivados de propanolamina hipolipidemicos
PT1027362E (pt)	2005-08-31	Derivados de cetolidos 2-halogeno-6-o-substituidos
ATE255099T1 (de)	2003-12-15	Substituierte chromanderivate
DK0966437T3 (da)	2002-10-07	5-Aroylnaphthalenderivater
DE69829682D1 (de)	2005-05-12	Cis-disubstituierte aminocycloalkyl-pyrrolidin-derivate
DE69828780D1 (de)	2005-03-03	Amidinocamptpthecin-derivate
NO981495D0 (no)	1998-04-02	Phenoxymetylpiperidin-derivater
DK1030850T3 (da)	2008-01-07	Azolinderivater
FI974024A0 (fi)	1997-10-22	Foerfarande foer framstaellning av en ifyllnings- och/eller toemningsoeppning foer en vaetskefoerpackning
FI974001A0 (fi)	1997-10-20	Nya metylenbisfosfonsyraderivat
DK1015447T3 (da)	2002-06-17	Piperidinylmethyloxazolidinonderivat
DK1091875T3 (da)	2005-12-19	Pillesikkert eller pillemodstandsdygtigt lukke

Legal Events

Date	Code	Title	Description
2002-05-06	FC2A	Withdrawal, rejection or dismissal of laid open patent application