NO150838C - Analogifremgangsmaate for fremstilling av nye klavulansyreforbindelser med antibakterielle og beta-laktamase-inhiberende egenskaper - Google Patents

Analogifremgangsmaate for fremstilling av nye klavulansyreforbindelser med antibakterielle og beta-laktamase-inhiberende egenskaper

Info

Publication number: NO150838C
Authority: NO; Norway
Prior art keywords: lactamase; antibacterial; beta; preparation; new
Prior art date: 1974-04-20

Application number

NO791956A

Other languages

English (en)

Other versions

NO150838B (no

NO791956L (no

Inventor

Martin Cole

Thomas Trevor Howarth

Christopher Reading

Original Assignee

Beecham Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-04-20

Filing date

1979-06-12

Publication date

1985-01-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27448389&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO150838(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1974-04-20 Priority claimed from GB17410/74A external-priority patent/GB1508977A/en

1975-10-21 Publication of NO791956L publication Critical patent/NO791956L/no

1979-06-12 Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd

1984-09-17 Publication of NO150838B publication Critical patent/NO150838B/no

1985-01-09 Publication of NO150838C publication Critical patent/NO150838C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Tropical Medicine & Parasitology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NO791956A 1974-04-20 1979-06-12 Analogifremgangsmaate for fremstilling av nye klavulansyreforbindelser med antibakterielle og beta-laktamase-inhiberende egenskaper NO150838C (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB17410/74A GB1508977A (en)	1974-04-20	1974-04-20	Beta-lactam antibiotic from streptomyces clavuligerus
GB2771574		1974-06-21
GB4365174		1974-10-09
GB5352574		1974-12-11

Publications (3)

Publication Number	Publication Date
NO791956L NO791956L (no)	1975-10-21
NO150838B NO150838B (no)	1984-09-17
NO150838C true NO150838C (no)	1985-01-09

Family

ID=27448389

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO751407A NO145247C (no)	1974-04-20	1975-04-18	Fremgangsmaate for fremstilling av clavulansyre
NO791956A NO150838C (no)	1974-04-20	1979-06-12	Analogifremgangsmaate for fremstilling av nye klavulansyreforbindelser med antibakterielle og beta-laktamase-inhiberende egenskaper
NO801852A NO801852L (no)	1974-04-20	1980-06-20	Farmasoeytisk clavulansyrepreparat.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
NO751407A NO145247C (no)	1974-04-20	1975-04-18	Fremgangsmaate for fremstilling av clavulansyre

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO801852A NO801852L (no)	1974-04-20	1980-06-20	Farmasoeytisk clavulansyrepreparat.

Country Status (26)

Country	Link
US (5)	US4427690A (no)
JP (7)	JPS521996B2 (no)
AR (3)	AR206627A1 (no)
CA (1)	CA1059050A (no)
CH (2)	CH629252A5 (no)
CY (1)	CY1078A (no)
DD (2)	DD132297A5 (no)
DE (4)	DE2517316C2 (no)
DK (1)	DK141254B (no)
FI (1)	FI54144C (no)
FR (1)	FR2267778B1 (no)
HK (1)	HK54780A (no)
IE (1)	IE41109B1 (no)
IL (1)	IL47087A (no)
IN (1)	IN140042B (no)
KE (1)	KE3076A (no)
LU (1)	LU72322A1 (no)
MY (1)	MY8100195A (no)
NL (1)	NL163824C (no)
NO (3)	NO145247C (no)
NZ (1)	NZ177159A (no)
OA (1)	OA05203A (no)
PH (1)	PH16474A (no)
RO (2)	RO77320A (no)
SE (8)	SE422063B (no)
YU (3)	YU39941B (no)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE41109B1 (en) *	1974-04-20	1979-10-24	Beecham Group Ltd	Novel -lactam antibiotic from streptomyces clavuligerus
FR2368276A1 (fr) *	1975-02-07	1978-05-19	Glaxo Lab Ltd	Nouvel antibiotique provenant de streptomyces clavuligerus et son procede de preparation
JPS596796Y2 (ja) *	1975-04-04	1984-03-01	株式会社東芝	脱水兼用洗濯機
US6031093C1 (en) *	1975-04-17	2001-10-16	Smithkline Beecham Plc	Solid salts of clavulanic acid
US6218380B1 (en) *	1975-04-17	2001-04-17	Smithkline Beecham P.L.C.	Pharmaceutical compositions
GB1563103A (en) *	1975-10-13	1980-03-19	Beecham Group Ltd	Process for the preparation of clavulanic acid
US4230622A (en) *	1975-12-17	1980-10-28	Glaxo Laboratories Limited	Halogen derivatives of clavulaic acid
GB1515241A (en) *	1976-01-27	1978-06-21	Beecham Group Ltd	Beta-lactam antibiotics
NL7706242A (nl) *	1976-06-08	1977-12-12	Glaxo Lab Ltd	Werkwijze voor de bereiding van clavamderivaten.
GB1562802A (en) *	1976-06-26	1980-03-19	Beecham Group Ltd	Pharmaceutical compositions containing containing clavulanic acid
GB1562902A (en) *	1976-06-30	1980-03-19	Beecham Group Ltd	Pharmaceutical compositions containing clavulanic acid
GB1578739A (en) *	1976-07-23	1980-11-05	Beecham Group Ltd	Amine salts of clavulanic acid methods for their preparation and compositions containing them
GB1594001A (en) *	1977-03-16	1981-07-30	Beecham Group Ltd	Pellets suitable for use in the testing of microorganisms
GB1582884A (en) *	1977-05-19	1981-01-14	Beecham Group Ltd	Clavulanic acid derivatives their preparation and use
DE2912511C2 (de) *	1977-06-07	1982-06-24	Pfizer Inc., 10017 New York, N.Y.	Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
JO984B1 (en) *	1977-10-11	1979-12-01	بيتشام غروب ليمتد	A dry pharmaceutical compound with a suitable dosage unit for oral administration
JPS54126735A (en) *	1978-03-24	1979-10-02	Toyama Chem Co Ltd	Bactericidal composition for medical use
EP0008905B1 (en) *	1978-09-06	1983-02-16	Beecham Group Plc	Pharmaceutical compositions containing two beta-lactam derivatives
JPS5545906U (no) *	1978-09-21	1980-03-26
US4202819A (en) *	1979-05-04	1980-05-13	Hoffman-La Roche Inc.	2-(3-Alanyl)clavam antibiotic
ZA804670B (en) *	1979-08-03	1981-07-29	Beecham Group Ltd	Derivatives of clavulanic acid, a process for their preparation and their use
DE3063683D1 (en) *	1979-08-24	1983-07-14	Beecham Group Plc	Amine salt of clavulanic acid, its preparation and use
EP0053893B1 (en) *	1980-12-09	1985-03-20	Beecham Group Plc	Derivatives of clavulanic acid, their preparation and their use
US4562182A (en) *	1980-12-23	1985-12-31	Beecham Group P.L.C.	Compounds containing beta-lactams
US4533542A (en) *	1983-08-22	1985-08-06	Eli Lilly And Company	Pharmaceutical compositions for storage in plastic containers and process therefor
US4684643A (en) *	1983-08-22	1987-08-04	Eli Lilly And Company	Pharmaceutical compositions for storage in plastic containers and process therefor
IT1207982B (it) *	1983-10-07	1989-06-01	Lisapharma Spa	Composizioni farmaceutiche adattivita' antibiotica.
JPS6155889A (ja) *	1984-08-28	1986-03-20	松下電器産業株式会社	高周波加熱装置
US4757066A (en) *	1984-10-15	1988-07-12	Sankyo Company Limited	Composition containing a penem or carbapenem antibiotic and the use of the same
DE3725375A1 (de) *	1987-07-31	1989-02-09	Bayer Ag	Stabile oxapenem-3-carbonsaeuren
GB9009446D0 (en) *	1990-04-26	1990-06-20	Beecham Group Plc	Veterinary composition
DE4027928A1 (de) *	1990-09-04	1992-03-05	Bayer Ag	Neue 2-tert.substituierte methyl-oxapenem-3-carbonsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung
DE4030706A1 (de) *	1990-09-28	1992-04-02	Bayer Ag	Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9201639D0 (en) *	1992-01-25	1992-03-11	Smithkline Beecham Plc	Pharmaceutical formulations
AT400033B (de) *	1992-03-10	1995-09-25	Biochemie Gmbh	Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT399155B (de) *	1992-03-26	1995-03-27	Lek Tovarna Farmacevtskih	Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
DE69425131T2 (de) *	1993-01-22	2001-03-15	Smithkline Beecham P.L.C., Brentford	Verwendung von clavulansäure und einem antibiotikum zur behandlung von infektionen
US5760218A (en) *	1993-03-26	1998-06-02	Gist-Brocades N.V.	Diamine salts of clavulanic acid
NZ263564A (en) *	1993-03-26	1995-12-21	Gist Brocades Nv	Tertiary, tertiary diamine mono and di salts of clavulanic acid; purification of clavulanic acid
US5821364A (en) *	1993-03-26	1998-10-13	Gist-Brocades N.V.	Diamine salts of clavulanic acid
US5741903A (en) *	1993-03-26	1998-04-21	Gist-Brocades N.V.	Diamine salts for purification of clavulanic acid
GB9315393D0 (en) *	1993-07-24	1993-09-08	Smithkline Beecham Plc	Novel product
US20030219867A1 (en) *	1993-07-24	2003-11-27	Smithkline Beecham Plc	Clavulanic acid dehydrogenase, preparation and use for the production of clavulanic acid
SI9400107A (en) *	1994-03-02	1995-10-31	Lek Tovarna Farmacevtskih	New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
US20030109503A1 (en) *	1995-06-06	2003-06-12	Smithkline Beecham P.L.C.	Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
GB9515809D0 (en) *	1995-08-02	1995-10-04	Smithkline Beecham Plc	Process
SI9500265A1 (en) *	1995-08-28	1997-02-28	Lek Tovarna Farmacevtskih	Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
ATE208618T1 (de) *	1995-09-07	2001-11-15	Smithkline Beecham Corp	Verwendung einer amoxicillin und clavulanat enthaltenden paediatrischen pharmazeutischen formulierung
AT403375B (de) *	1995-11-15	1998-01-26	Biochemie Gmbh	Verfahren zur fällung von alkalisalzen der clavulansäure
US20030124187A1 (en) *	1997-02-14	2003-07-03	Smithkline Beecham Laboratoires Pharmaceutiques,	Pharmaceutical formulations comprising amoxycillin and clavulanate
BR9807362A (pt) *	1997-02-20	2000-04-18	Dsm Nv	Produção fermentativa de compostos úteis em escala industrial usando meios quimicamente definidos
AR015825A1 (es) *	1997-05-28	2001-05-30	Gist Brocades Bv	Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
CN1308682A (zh) *	1998-07-03	2001-08-15	Dsm公司	在低浓度游离氨基酸下生产棒酸的发酵工艺
US7250176B1 (en) *	1999-04-13	2007-07-31	Beecham Pharmaceuticals (Pte) Limited	Method of treating a bacterial infection
US6878386B1 (en)	1999-04-13	2005-04-12	Beecham Pharmaceuticals (Pte) Limited	Method of treating a bacterial infection comprising amoxycillin and potassium clavulanate
US6294199B1 (en) *	1999-04-13	2001-09-25	Beecham Pharmaceuticals (Pte) Limited	Method of treating a bacterial infection comprising administering amoxycillin
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
US6756057B2 (en)	2000-10-12	2004-06-29	Beecham Pharmaceuticals (Pte) Limited	Amoxicillin and potassium clavulanate dosage form
WO2002030392A2 (en)	2000-10-12	2002-04-18	Beecham Pharmaceuticals (Pte) Limited	Formulation containing amoxicillin
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
IL150907A (en) *	2002-07-25	2007-07-04	Stephan Cherkez	Process for the preparation of stable amorphous calcium pseudomonate
US8313775B2 (en)	2003-07-21	2012-11-20	Shionogi Inc.	Antibiotic product, use and formulation thereof
CA2533178C (en)	2003-07-21	2014-03-11	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
US8425936B2 (en)	2003-07-21	2013-04-23	Shionogi Inc.	Antibiotic product, use and formulation thereof
JP2007502296A (ja)	2003-08-11	2007-02-08	アドバンシスファーマスーティカルコーポレイション	ロバストペレット
CA2535398C (en)	2003-08-12	2013-11-12	Advancis Pharmaceuticals Corporation	Antibiotic product, use and formulation thereof
AU2004270170B2 (en)	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
WO2005027877A1 (en)	2003-09-15	2005-03-31	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
WO2006014427A1 (en)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
US20060194285A1 (en) *	2005-02-08	2006-08-31	Wei Lian	Biological production of clavulanic acid and related compounds
DE102005009277B4 (de) *	2005-02-25	2008-07-31	Johnson Controls Interiors Gmbh & Co. Kg	Halterung für eine Komponente
DK1965798T3 (da) *	2005-12-07	2011-11-28	Basilea Pharmaceutica Ag	Nyttige monobactam-antibiotika
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US20070218038A1 (en)	2006-03-17	2007-09-20	Pegasus Biologics, Inc.	Stabilized, sterilized collagen scaffolds with active adjuncts attached
US8299052B2 (en) *	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
EP2575781A1 (en)	2010-06-03	2013-04-10	Mahmut Bilgic	Production method for the effervescent formulation comprising cephalosporin and potassium clavulanate
CN105026407B (zh)	2012-12-07	2017-09-08	维纳拓尔斯制药公司	β‑内酰胺酶抑制剂
US9403850B2 (en)	2013-01-10	2016-08-02	VenatoRx Pharmaceuticals, Inc.	Beta-lactamase inhibitors
EP2970340B1 (en)	2013-03-14	2020-02-12	Venatorx Pharmaceuticals, Inc.	Beta-lactamase inhibitors
US20150361108A1 (en) *	2014-06-11	2015-12-17	VenatoRx Pharmaceuticals, Inc.	Orally bioavailable beta-lactamase inhibitors
US9511142B2 (en)	2014-06-11	2016-12-06	VenatoRx Pharmaceuticals, Inc.	Beta-lactamase inhibitors
RU2686740C2 (ru)	2014-06-11	2019-04-30	Венаторкс Фармасьютикалс, Инк.	Ингибиторы бета-лактамазы
CN108472284A (zh)	2015-09-11	2018-08-31	维纳拓尔斯制药公司	β-内酰胺酶抑制剂
WO2017100537A1 (en)	2015-12-10	2017-06-15	VenatoRx Pharmaceuticals, Inc.	Beta-lactamase inhibitors
AU2017295866A1 (en)	2016-07-14	2019-01-17	Achaogen, Inc.	Combination of ceftibuten and clavulanic acid for use in the treatment of bacterial infections
EP3494121B1 (en)	2016-08-04	2021-10-06	Venatorx Pharmaceuticals, Inc.	Boron-containing compounds
US11267826B2 (en)	2017-05-26	2022-03-08	VenatoRx Pharmaceuticals, Inc.	Penicillin-binding protein inhibitors
US11332485B2 (en)	2017-05-26	2022-05-17	VenatoRx Pharmaceuticals, Inc.	Penicillin-binding protein inhibitors
US12173018B2 (en)	2018-05-25	2024-12-24	VenatoRx Pharmaceuticals, Inc.	Penicillin-binding protein inhibitors
AU2019386849B2 (en)	2018-11-29	2025-07-24	VenatoRx Pharmaceuticals, Inc.	Combination compositions comprising a beta-lactamase inhibitor and uses thereof
US12139741B2 (en)	2019-10-25	2024-11-12	Instrumentation Laboratory Company	Biocide compositions compatible with enzyme biosensors and methods of use thereof
WO2021080598A1 (en)	2019-10-25	2021-04-29	Instrumentation Laboratory Company	Biocide compositions compatible with enzyme biosensors and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3801464A (en)	1972-02-09	1974-04-02	Lilly Co Eli	Antibiotic a16886 and process for production thereof
IE41109B1 (en) *	1974-04-20	1979-10-24	Beecham Group Ltd	Novel -lactam antibiotic from streptomyces clavuligerus
US4140764A (en) *	1974-12-18	1979-02-20	Beecham Group Limited	β-Lactamase inhibitors and process for their preparation
US4123540A (en) *	1974-12-18	1978-10-31	Beecham Group Limited	Isoclavulanic acid as an antibacterial and a β-lactamase inhibitor
US4144242A (en) *	1975-02-07	1979-03-13	Glaxo Laboratories Limited	Process for the purification of clavulanic acid
FR2368276A1 (fr) *	1975-02-07	1978-05-19	Glaxo Lab Ltd	Nouvel antibiotique provenant de streptomyces clavuligerus et son procede de preparation
JO984B1 (en) *	1977-10-11	1979-12-01	بيتشام غروب ليمتد	A dry pharmaceutical compound with a suitable dosage unit for oral administration

1975
- 1975-04-08 IE IE792/75A patent/IE41109B1/xx not_active IP Right Cessation
- 1975-04-08 NZ NZ177159A patent/NZ177159A/xx unknown
- 1975-04-09 YU YU908/75A patent/YU39941B/xx unknown
- 1975-04-11 FR FR7511344A patent/FR2267778B1/fr not_active Expired
- 1975-04-11 CY CY1078A patent/CY1078A/xx unknown
- 1975-04-14 IL IL47087A patent/IL47087A/xx unknown
- 1975-04-14 IN IN743/CAL/75A patent/IN140042B/en unknown
- 1975-04-16 FI FI751133A patent/FI54144C/fi not_active IP Right Cessation
- 1975-04-18 DD DD7500193531A patent/DD132297A5/xx unknown
- 1975-04-18 DK DK167275AA patent/DK141254B/da not_active IP Right Cessation
- 1975-04-18 NO NO751407A patent/NO145247C/no unknown
- 1975-04-18 DD DD185542A patent/DD121799A5/xx unknown
- 1975-04-18 DE DE2517316A patent/DE2517316C2/de not_active Expired
- 1975-04-18 NL NL7504621.A patent/NL163824C/xx not_active IP Right Cessation
- 1975-04-18 SE SE7504541A patent/SE422063B/xx not_active IP Right Cessation
- 1975-04-18 AR AR258435A patent/AR206627A1/es active
- 1975-04-18 DE DE2560074A patent/DE2560074C2/de not_active Expired
- 1975-04-18 LU LU72322A patent/LU72322A1/xx unknown
- 1975-04-18 DE DE2559411A patent/DE2559411C2/de not_active Expired
- 1975-04-18 CA CA224,970A patent/CA1059050A/en not_active Expired
- 1975-04-18 DE DE19752559410 patent/DE2559410A1/de not_active Ceased
- 1975-04-19 JP JP50048086A patent/JPS521996B2/ja not_active Expired
- 1975-04-19 RO RO7595311A patent/RO77320A/ro unknown
- 1975-04-19 JP JP50048087A patent/JPS5246957B2/ja not_active Expired
- 1975-04-19 RO RO7582037A patent/RO69984A/ro unknown
- 1975-04-19 OA OA55480A patent/OA05203A/xx unknown
- 1975-04-21 PH PH17082A patent/PH16474A/en unknown
- 1975-04-21 CH CH506075A patent/CH629252A5/de not_active IP Right Cessation
- 1975-11-28 AR AR261404A patent/AR219050A1/es active
- 1975-11-28 AR AR261403A patent/AR216430A1/es active
1976
- 1976-09-24 US US06/726,224 patent/US4427690A/en not_active Expired - Lifetime
1977
- 1977-04-05 JP JP4026077A patent/JPS533589A/ja active Granted
- 1977-04-05 JP JP4025877A patent/JPS532495A/ja active Granted
- 1977-04-05 JP JP4026177A patent/JPS533590A/ja active Pending
- 1977-04-05 JP JP4025777A patent/JPS532494A/ja active Granted
- 1977-04-05 JP JP4025977A patent/JPS533588A/ja active Granted
1978
- 1978-07-13 US US05/924,174 patent/US4556559A/en not_active Expired - Lifetime
- 1978-10-27 SE SE7811203A patent/SE443562B/sv not_active IP Right Cessation
- 1978-10-27 SE SE7811200A patent/SE435286B/sv not_active IP Right Cessation
- 1978-10-27 SE SE7811201A patent/SE446687B/sv not_active IP Right Cessation
- 1978-10-27 SE SE7811202A patent/SE435287B/sv not_active IP Right Cessation
1979
- 1979-06-12 NO NO791956A patent/NO150838C/no unknown
1980
- 1980-06-20 NO NO801852A patent/NO801852L/no unknown
- 1980-08-29 KE KE3076A patent/KE3076A/xx unknown
- 1980-09-25 HK HK547/80A patent/HK54780A/xx unknown
- 1980-12-22 CH CH947280A patent/CH630631A5/de not_active IP Right Cessation
1981
- 1981-06-09 US US06/272,030 patent/US4526783A/en not_active Expired - Lifetime
- 1981-10-02 SE SE8105829A patent/SE453600B/sv not_active IP Right Cessation
- 1981-11-23 YU YU2744/81A patent/YU42745B/xx unknown
- 1981-11-23 YU YU2743/81A patent/YU42744B/xx unknown
- 1981-12-03 US US06/327,253 patent/US4525352A/en not_active Expired - Lifetime
- 1981-12-14 US US06330456 patent/US4560552C1/en not_active Expired - Lifetime
- 1981-12-30 MY MY195/81A patent/MY8100195A/xx unknown
1983
- 1983-11-16 SE SE8306328A patent/SE8306328D0/xx unknown
1986
- 1986-12-16 SE SE8605405A patent/SE8605405D0/xx unknown

Also Published As

Publication number	Publication date
YU39941B (en)	1985-06-30
SE422063B (sv)	1982-02-15
JPS532494A (en)	1978-01-11
MY8100195A (en)	1981-12-31
US4427690A (en)	1984-01-24
FI54144B (fi)	1978-06-30
DD132297A5 (de)	1978-09-20
JPS50142591A (no)	1975-11-17
SE8605405L (sv)	1986-12-16
NZ177159A (en)	1978-03-06
OA05203A (fr)	1981-02-28
NO145247C (no)	1982-02-10
DE2560074C2 (de)	1985-03-28
NL163824C (nl)	1980-10-15
YU274481A (en)	1983-06-30
AR206627A1 (es)	1976-08-06
SE453600B (sv)	1988-02-15
JPS521996B2 (no)	1977-01-19
SE7811202L (sv)	1978-10-27
SE7504541L (no)	1975-12-19
DE2559410A1 (de)	1976-09-23
SE8605405D0 (sv)	1986-12-16
RO77320A (ro)	1981-08-17
NO751407L (no)	1975-10-21
FI751133A7 (no)	1975-10-21
SE8306328L (sv)	1983-11-16
JPS50142789A (no)	1975-11-17
IE41109B1 (en)	1979-10-24
JPS5549833B2 (no)	1980-12-15
HK54780A (en)	1980-10-03
US4525352A (en)	1985-06-25
SE8306328D0 (sv)	1983-11-16
LU72322A1 (no)	1975-08-20
JPS533588A (en)	1978-01-13
DE2559411C2 (de)	1982-07-01
PH16474A (en)	1983-10-25
FI54144C (fi)	1978-10-10
IE41109L (en)	1975-10-20
JPS5549831B2 (no)	1980-12-15
JPS533589A (en)	1978-01-13
NO150838B (no)	1984-09-17
JPS5246957B2 (no)	1977-11-29
US4556559A (en)	1985-12-03
FR2267778A1 (no)	1975-11-14
CH629252A5 (de)	1982-04-15
CH630631A5 (de)	1982-06-30
DK167275A (no)	1975-10-21
JPS5549830B2 (no)	1980-12-15
YU274381A (en)	1983-06-30
SE435287B (sv)	1984-09-17
FR2267778B1 (no)	1978-11-17
JPS532495A (en)	1978-01-11
DE2517316A1 (de)	1975-10-23
YU42745B (en)	1988-12-31
US4560552A (en)	1985-12-24
AR216430A1 (es)	1979-12-28
JPS5549832B2 (no)	1980-12-15
NO791956L (no)	1975-10-21
DK141254C (no)	1980-08-11
SE7811201L (sv)	1978-10-27
CA1059050A (en)	1979-07-24
SE7811203L (sv)	1978-10-27
AR219050A1 (es)	1980-07-31
YU42744B (en)	1988-12-31
YU90875A (en)	1982-05-31
US4526783A (en)	1985-07-02
RO69984A (ro)	1980-12-30
NL7504621A (nl)	1975-10-22
SE446687B (sv)	1986-10-06
DD121799A5 (no)	1976-08-20
KE3076A (en)	1980-10-03
DK141254B (da)	1980-02-11
SE7811200L (sv)	1978-10-27
DE2517316C2 (de)	1985-03-07
NL163824B (nl)	1980-05-16
IL47087A0 (en)	1975-06-25
IL47087A (en)	1979-07-25
NO145247B (no)	1981-11-02
US4560552C1 (en)	2001-10-16
CY1078A (en)	1980-12-27
IN140042B (no)	1976-09-04
DE2559411A1 (de)	1976-10-21
SE443562B (sv)	1986-03-03
JPS533590A (en)	1978-01-13
SE8105829L (sv)	1981-10-02
SE435286B (sv)	1984-09-17
NO801852L (no)	1975-10-21

Publication	Publication Date	Title
NO150838C (no)	1985-01-09	Analogifremgangsmaate for fremstilling av nye klavulansyreforbindelser med antibakterielle og beta-laktamase-inhiberende egenskaper
NO145342C (no)	1982-03-10	Fremgangsmaate til fremstilling av nye fosfoglykolipid- og glykopeptidantibiotika
SE393800B (sv)	1977-05-23	Forfarande for framstellning av bensoylamino-alkyl-fenoxi-alkylkarbonsyraderivat med lipidsenkande effekt
SE418966B (sv)	1981-07-06	Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
FI53718C (fi)	1978-07-10	Foerfarande foer framstaellning av antibiotikumet tienamycin
SE403630B (sv)	1978-08-28	Forfarande vid framstellning av flortyg
SE401087B (sv)	1978-04-24	Forfarande for framstellning av ett antibakteriellt preparat innehallande penicillinderivat
SE424966B (sv)	1982-08-23	Forfarande for framstellning av axelhus med axeltappar
SE425733B (sv)	1982-11-01	Forfarande for framstellning av vissa angivna triglyucerider med antiinflammatoriska egenskaper
SE421209B (sv)	1981-12-07	Analogiforfarande for framstellning av tienobensodiazepiner
NO141472C (no)	1980-03-19	Fremgangsmaate for fremstilling av polysakkarider og derivater derav
SE7900773L (sv)	1979-01-29	Nytt forfarande for framstellning av foreningen amoxycillin
SE7512968L (sv)	1976-05-19	Forfarande for framstellning av kiselstal med hog permeabilitet ii
NO143625C (no)	1981-03-18	Analogifremgangsmaate for fremstilling av 2-metoksy-benzamider
SE421315B (sv)	1981-12-14	Forfarande for framstellning av vinkamin och derivat derav
SE406243B (sv)	1979-01-29	Forfarande for framstellning av ferromagnetisk kromdioxid
SE417318B (sv)	1981-03-09	Forfarande for framstellning av oxofurylesterderivat av penicillin
SE7510681L (sv)	1976-03-26	Framstellning av beta-laktamantibiotika
SE7509657L (sv)	1976-03-08	Forfarande for framstellning och anvendning av nya organiska foreningar
AT320658B (de)	1975-02-25	Verfahren zur Herstellung von neuen Phthalazonderivaten und von ihren Salzen
SE431547B (sv)	1984-02-13	Forfarande for framstellning av 3-metylencefamsulfoxider
IL47797A0 (en)	1975-10-15	New derivatives of penicillanic acid and cephalosporanic acid and their preparation
FI55245C (fi)	1979-06-11	Anordning foer reglering av matningskraften vid bergborraggregat
NO146636C (no)	1982-11-10	Analogifremgangsmaate for fremstilling av nye propionsyrederivater.
JPS51131891A (en)	1976-11-16	Production of 133dinitrogenn heterocyclic compound with 122condensed 5 or 6 membered ring