NO157620C - Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazo -diazepiner. - Google Patents
Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazo -diazepiner.Info
- Publication number
- NO157620C NO157620C NO820622A NO820622A NO157620C NO 157620 C NO157620 C NO 157620C NO 820622 A NO820622 A NO 820622A NO 820622 A NO820622 A NO 820622A NO 157620 C NO157620 C NO 157620C
- Authority
- NO
- Norway
- Prior art keywords
- diazepines
- preparation
- therapeutically active
- analogue procedure
- active imidazo
- Prior art date
Links
- 150000004908 diazepines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH133881 | 1981-02-27 | ||
| CH134281 | 1981-02-27 | ||
| CH133981 | 1981-02-27 | ||
| CH134181 | 1981-02-27 | ||
| CH367581 | 1981-06-04 | ||
| CH793481 | 1981-12-11 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO820622L NO820622L (no) | 1982-08-30 |
| NO157620B NO157620B (no) | 1988-01-11 |
| NO157620C true NO157620C (no) | 1988-04-20 |
Family
ID=27543637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO820622A NO157620C (no) | 1981-02-27 | 1982-02-26 | Analogifremgangsmaate til fremstilling av terapeutisk aktive imidazo -diazepiner. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4353827A (fr) |
| EP (1) | EP0059391B1 (fr) |
| KR (1) | KR890002624B1 (fr) |
| AU (1) | AU551891B2 (fr) |
| BR (1) | BR8201024A (fr) |
| CA (1) | CA1185602A (fr) |
| CS (1) | CS247064B2 (fr) |
| DE (1) | DE3263633D1 (fr) |
| DK (1) | DK168073B1 (fr) |
| FI (1) | FI73430C (fr) |
| HK (1) | HK23288A (fr) |
| IE (1) | IE52543B1 (fr) |
| IL (1) | IL65056A0 (fr) |
| MC (1) | MC1442A1 (fr) |
| NO (1) | NO157620C (fr) |
| NZ (1) | NZ199793A (fr) |
| PH (1) | PH19881A (fr) |
| PT (1) | PT74504B (fr) |
| YU (1) | YU45860B (fr) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC1528A1 (fr) * | 1982-07-21 | 1984-04-13 | Hoffmann La Roche | Imidazobenzodiazepines |
| CS249146B2 (en) * | 1984-01-19 | 1987-03-12 | Hoffmann La Roche | Method of new imidazodiazepine's derivatives production |
| DK174086D0 (da) * | 1986-04-16 | 1986-04-16 | Ferrosan As | Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme |
| CA1327008C (fr) * | 1988-01-15 | 1994-02-15 | Walter Merz | Imidazobenzodiazepine, neuroleptique |
| CA1312825C (fr) * | 1988-01-27 | 1993-01-19 | F. Hoffmann-La Roche Ag | Prevention ou interruption des etats de pannique avec une imidazobenzodiazepine |
| CA2015336A1 (fr) * | 1989-05-19 | 1990-11-19 | F. Hoffmann-La Roche Ag | Imidazodiazepines pour le traitement des symptomes neurologiques |
| CA2055308A1 (fr) * | 1990-11-29 | 1992-05-30 | Roman Amrein | Imidazobenzodiazepine servant au traitement de troubles du sommeil |
| JO2259B1 (en) * | 1999-05-12 | 2004-10-07 | اف. هوفمان- لاروش أيه جي | Method for the manufacture of diazapine derivatives |
| US7678818B2 (en) * | 2006-02-07 | 2010-03-16 | Hoffmann-La Roche Inc. | Anthranilamide and 2-amino-heteroarene-carboxamide compounds |
| US20090054412A1 (en) * | 2007-08-20 | 2009-02-26 | John Alan Kemp | Treatment of Sleep Disorders |
| US20100234359A1 (en) * | 2007-08-20 | 2010-09-16 | Evotec Neurosciences Gmbh | Treatment of sleep disorders |
| BR112012026410B8 (pt) | 2010-04-15 | 2023-01-31 | Spirogen Dev Sarl | Composto e conjugado de pirrolobenzodiazepinas e usos dos mesmos |
| CN107019804A (zh) | 2010-04-15 | 2017-08-08 | 西雅图基因公司 | 靶向吡咯并苯并二氮杂卓结合物 |
| CN103987718A (zh) | 2011-09-20 | 2014-08-13 | 斯皮罗根有限公司 | 作为非对称二聚体pbd化合物用于内含在靶向结合物中的吡咯并苯并二氮杂卓 |
| AU2012322932B2 (en) | 2011-10-14 | 2016-11-10 | Medimmune Limited | Pyrrolobenzodiazepines |
| KR101961976B1 (ko) | 2011-10-14 | 2019-03-25 | 시애틀 지네틱스, 인크. | 피롤로벤조디아제핀 및 표적 접합체 |
| CA2850103C (fr) | 2011-10-14 | 2019-09-10 | Spirogen Sarl | Pyrrolobenzodiazepines |
| CN103987384A (zh) | 2011-10-14 | 2014-08-13 | 西雅图基因公司 | 吡咯并苯并二氮杂卓和靶向结合物 |
| CN103374000B (zh) * | 2012-04-13 | 2015-11-11 | 中国科学院广州生物医药与健康研究院 | 嘧啶并二氮杂卓类化合物及其药用组合物和应用 |
| SMT202100265T1 (it) | 2012-10-12 | 2021-07-12 | Medimmune Ltd | Pirrolobenzodiazepine e loro coniugati |
| PL2906251T3 (pl) | 2012-10-12 | 2018-02-28 | Adc Therapeutics Sa | Koniugaty pirolobenzodiazepina-przeciwciało anty-CD22 |
| WO2014057114A1 (fr) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Conjugués pyrrolobenzodiazepine-anticorps anti-psma |
| JP6367204B2 (ja) | 2012-10-12 | 2018-08-01 | メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ | 結合用のピロロベンゾジアゼピン誘導体の合成および中間体 |
| KR101995619B1 (ko) | 2012-10-12 | 2019-07-03 | 에이디씨 테라퓨틱스 에스에이 | 피롤로벤조디아제핀-항체 컨주게이트 |
| SMT201800346T1 (it) | 2012-10-12 | 2018-09-13 | Medimmune Ltd | Coniugati pirrolobenzodiazepina-anticorpo |
| WO2014057120A1 (fr) | 2012-10-12 | 2014-04-17 | Adc Therapeutics Sàrl | Conjugués anticorps - pyrrolobenzodiazépine |
| RS57694B1 (sr) | 2012-10-12 | 2018-11-30 | Adc Therapeutics Sa | Pirolobenzodiazepin - anti-psma konjugati antitela |
| EP2839860B1 (fr) | 2012-10-12 | 2019-05-01 | MedImmune Limited | Pyrrolobenzodiazépines et ses conjugués |
| GB201317981D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| US9950078B2 (en) | 2013-10-11 | 2018-04-24 | Medimmune Limited | Pyrrolobenzodiazepine-antibody conjugates |
| EP3054983B1 (fr) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Conjugués anticorps-pyrrolobenzodiazépines |
| EP3054986B1 (fr) | 2013-10-11 | 2019-03-20 | Medimmune Limited | Conjugués anticorps-pyrrolobenzodiazépine |
| GB201317982D0 (en) | 2013-10-11 | 2013-11-27 | Spirogen Sarl | Pyrrolobenzodiazepines and conjugates thereof |
| GB201416112D0 (en) | 2014-09-12 | 2014-10-29 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| CN107148285B (zh) | 2014-11-25 | 2022-01-04 | Adc治疗股份有限公司 | 吡咯并苯并二氮杂䓬-抗体缀合物 |
| GB201506402D0 (en) | 2015-04-15 | 2015-05-27 | Berkel Patricius H C Van And Howard Philip W | Site-specific antibody-drug conjugates |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| GB201601431D0 (en) | 2016-01-26 | 2016-03-09 | Medimmune Ltd | Pyrrolobenzodiazepines |
| GB201602356D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201602359D0 (en) | 2016-02-10 | 2016-03-23 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201607478D0 (en) | 2016-04-29 | 2016-06-15 | Medimmune Ltd | Pyrrolobenzodiazepine Conjugates |
| GB201617466D0 (en) | 2016-10-14 | 2016-11-30 | Medimmune Ltd | Pyrrolobenzodiazepine conjugates |
| GB201702031D0 (en) | 2017-02-08 | 2017-03-22 | Medlmmune Ltd | Pyrrolobenzodiazepine-antibody conjugates |
| JP6671555B2 (ja) | 2017-02-08 | 2020-03-25 | アーデーセー セラピューティクス ソシエテ アノニム | ピロロベンゾジアゼピン抗体複合体 |
| CN110582505B (zh) | 2017-04-18 | 2021-04-02 | 免疫医疗有限公司 | 吡咯并苯并二氮杂*缀合物 |
| MX2019012464A (es) | 2017-04-20 | 2019-12-11 | Adc Therapeutics Sa | Terapia combinada con un conjugado de anticuerpo y farmaco anti-axl. |
| AU2018285562B2 (en) | 2017-06-14 | 2024-01-18 | Adc Therapeutics Sa | Dosage regimes for the administration of an anti-CD19 ADC |
| ES2906965T3 (es) | 2017-08-18 | 2022-04-21 | Medimmune Ltd | Conjugados de pirrolobenzodiazepina |
| GB201803342D0 (en) | 2018-03-01 | 2018-04-18 | Medimmune Ltd | Methods |
| GB201806022D0 (en) | 2018-04-12 | 2018-05-30 | Medimmune Ltd | Pyrrolobenzodiazepines and conjugates thereof |
| ES2967878T3 (es) | 2019-03-15 | 2024-05-06 | Medimmune Ltd | Dímeros de azetidobenzodiazepina y conjugados que los comprenden para uso en el tratamiento del cáncer |
| WO2021113492A1 (fr) * | 2019-12-06 | 2021-06-10 | Schrödinger, Inc. | Composés cycliques et leurs procédés d'utilisation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3933794A (en) * | 1971-08-04 | 1976-01-20 | The Upjohn Company | 2-(2-Alkynylamino)-3H-1,4-benzodiazepines |
| GB1600600A (en) * | 1977-03-10 | 1981-10-21 | Diamond Shamrock Chem | Plasticiser compositions for use with synthetic resin polymers |
| US4118386A (en) * | 1977-04-04 | 1978-10-03 | Hoffmann-La Roche Inc. | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates |
| CA1143728A (fr) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Derives d'imidazodiazepine |
-
1982
- 1982-01-21 CA CA000394685A patent/CA1185602A/fr not_active Expired
- 1982-02-10 PH PH26851A patent/PH19881A/en unknown
- 1982-02-17 CS CS821081A patent/CS247064B2/cs unknown
- 1982-02-18 US US06/349,801 patent/US4353827A/en not_active Expired - Lifetime
- 1982-02-19 DK DK074282A patent/DK168073B1/da not_active IP Right Cessation
- 1982-02-19 DE DE8282101273T patent/DE3263633D1/de not_active Expired
- 1982-02-19 EP EP82101273A patent/EP0059391B1/fr not_active Expired
- 1982-02-19 IL IL65056A patent/IL65056A0/xx not_active IP Right Cessation
- 1982-02-22 NZ NZ199793A patent/NZ199793A/en unknown
- 1982-02-22 AU AU80669/82A patent/AU551891B2/en not_active Expired
- 1982-02-25 FI FI820647A patent/FI73430C/fi not_active IP Right Cessation
- 1982-02-25 MC MC821577A patent/MC1442A1/fr unknown
- 1982-02-26 KR KR8200862A patent/KR890002624B1/ko not_active Expired
- 1982-02-26 NO NO820622A patent/NO157620C/no unknown
- 1982-02-26 PT PT74504A patent/PT74504B/pt unknown
- 1982-02-26 BR BR8201024A patent/BR8201024A/pt unknown
- 1982-02-26 IE IE421/82A patent/IE52543B1/en not_active IP Right Cessation
- 1982-02-26 YU YU43682A patent/YU45860B/sh unknown
-
1988
- 1988-03-30 HK HK232/88A patent/HK23288A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU551891B2 (en) | 1986-05-15 |
| KR890002624B1 (ko) | 1989-07-20 |
| MC1442A1 (fr) | 1982-12-06 |
| KR830009105A (ko) | 1983-12-17 |
| FI73430B (fi) | 1987-06-30 |
| DK168073B1 (da) | 1994-01-31 |
| IE820421L (en) | 1982-08-27 |
| EP0059391B1 (fr) | 1985-05-08 |
| FI73430C (fi) | 1987-10-09 |
| CA1185602A (fr) | 1985-04-16 |
| PT74504A (en) | 1982-03-01 |
| PT74504B (en) | 1984-11-26 |
| NO820622L (no) | 1982-08-30 |
| DE3263633D1 (en) | 1985-06-13 |
| NO157620B (no) | 1988-01-11 |
| IE52543B1 (en) | 1987-12-09 |
| EP0059391A1 (fr) | 1982-09-08 |
| US4353827A (en) | 1982-10-12 |
| DK74282A (da) | 1982-08-28 |
| BR8201024A (pt) | 1983-01-04 |
| YU45860B (sh) | 1992-09-07 |
| CS247064B2 (en) | 1986-11-13 |
| HK23288A (en) | 1988-04-08 |
| IL65056A0 (en) | 1982-04-30 |
| YU43682A (en) | 1988-08-31 |
| PH19881A (en) | 1986-08-13 |
| AU8066982A (en) | 1982-09-02 |
| FI820647L (fi) | 1982-08-28 |
| NZ199793A (en) | 1985-08-30 |
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