NL8301996A - Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. - Google Patents
Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. Download PDFInfo
- Publication number
- NL8301996A NL8301996A NL8301996A NL8301996A NL8301996A NL 8301996 A NL8301996 A NL 8301996A NL 8301996 A NL8301996 A NL 8301996A NL 8301996 A NL8301996 A NL 8301996A NL 8301996 A NL8301996 A NL 8301996A
- Authority
- NL
- Netherlands
- Prior art keywords
- vaccine
- live
- vaccines
- preparing
- emulsion
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title claims abstract description 11
- 239000007764 o/w emulsion Substances 0.000 claims abstract description 8
- 241001465754 Metazoa Species 0.000 claims description 12
- 229960003971 influenza vaccine Drugs 0.000 claims description 3
- 230000002238 attenuated effect Effects 0.000 abstract description 4
- 229940124590 live attenuated vaccine Drugs 0.000 abstract 3
- 229940023012 live-attenuated vaccine Drugs 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000000605 viral structure Anatomy 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 description 17
- 239000000839 emulsion Substances 0.000 description 10
- 241000700605 Viruses Species 0.000 description 8
- 230000008774 maternal effect Effects 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 238000009472 formulation Methods 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 230000002163 immunogen Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 4
- 230000000405 serological effect Effects 0.000 description 4
- 206010022000 influenza Diseases 0.000 description 3
- 208000009305 pseudorabies Diseases 0.000 description 3
- 241000282887 Suidae Species 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000009589 serological test Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/813—Viral vaccine for bovine species, e.g. cattle
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/815—Viral vaccine for porcine species, e.g. swine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compounds Of Unknown Constitution (AREA)
- Stereophonic System (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8301996A NL8301996A (nl) | 1983-06-06 | 1983-06-06 | Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. |
| FI842215A FI79787C (fi) | 1983-06-06 | 1984-06-01 | Foerfarande foer framstaellning av ett levande virusvaccin. |
| DK273384A DK273384A (da) | 1983-06-06 | 1984-06-01 | Levende adjuvansholdige vacciner og fremgangsmaader til fremstilling af saadanne vacciner |
| US06/616,144 US4650677A (en) | 1983-06-06 | 1984-06-01 | Method of preparing adjuvanted live attenuated vaccines and adjuvanted live attenuated vaccines thus obtained |
| ES533111A ES8502870A1 (es) | 1983-06-06 | 1984-06-04 | Un metodo de preparar una vacuna viva |
| JP11398984A JPH0639386B2 (ja) | 1983-06-06 | 1984-06-05 | アジュバント生ワクチンの製造方法 |
| AT84200796T ATE36956T1 (de) | 1983-06-06 | 1984-06-05 | Verfahren zu herstellung von lebenden, adjuvierten impfstoffen und so erhaltende lebende, adjuvierte impfstoffe. |
| EP19840200796 EP0129923B1 (en) | 1983-06-06 | 1984-06-05 | Method of preparing adjuvanted live vaccines and adjuvanted live vaccines thus obtained |
| IE1388/84A IE57927B1 (en) | 1983-06-06 | 1984-06-05 | Method of preparing adjuvanted live vaccines and adjuvanted live vaccines thus obtained |
| DE8484200796T DE3473825D1 (en) | 1983-06-06 | 1984-06-05 | Method of preparing adjuvanted live vaccines and adjuvanted live vaccines thus obtained |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL8301996 | 1983-06-06 | ||
| NL8301996A NL8301996A (nl) | 1983-06-06 | 1983-06-06 | Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8301996A true NL8301996A (nl) | 1985-01-02 |
Family
ID=19841956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8301996A NL8301996A (nl) | 1983-06-06 | 1983-06-06 | Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4650677A (es) |
| EP (1) | EP0129923B1 (es) |
| JP (1) | JPH0639386B2 (es) |
| AT (1) | ATE36956T1 (es) |
| DE (1) | DE3473825D1 (es) |
| DK (1) | DK273384A (es) |
| ES (1) | ES8502870A1 (es) |
| FI (1) | FI79787C (es) |
| IE (1) | IE57927B1 (es) |
| NL (1) | NL8301996A (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8301996A (nl) * | 1983-06-06 | 1985-01-02 | Duphar Int Res | Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. |
| IL74289A (en) * | 1985-02-10 | 1989-02-28 | Israel State | Vaccine system comprising a live-non-virulent vaccine and an adjuvant |
| US4790987A (en) * | 1985-11-15 | 1988-12-13 | Research Corporation | Viral glycoprotein subunit vaccine |
| US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
| ZA872532B (en) * | 1986-04-21 | 1987-11-25 | Akzo Nv | Combined vaccine |
| EP0382271B1 (en) * | 1989-02-04 | 1994-12-21 | Akzo Nobel N.V. | Tocols as adjuvant in vaccine |
| DE4040246A1 (de) * | 1990-02-20 | 1991-08-22 | Avt Anlagen Verfahrenstech | Wanderbettreaktor, insbesondere zur behandlung von rauchgasen |
| US5688761A (en) * | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
| JPH06507172A (ja) * | 1991-04-19 | 1994-08-11 | アフィニティー バイオテック,インコーポレイテッド | 転換可能なミクロエマルジョン処方剤 |
| WO1993024147A1 (en) * | 1992-05-29 | 1993-12-09 | Smithkline Beecham Corporation | Lecithin adjuvanted modified live virus vaccines |
| US5738854A (en) * | 1992-10-06 | 1998-04-14 | Akzo Nobel N.V. | Pseudorabies virus vaccine |
| ES2053402B1 (es) * | 1993-01-15 | 1995-02-01 | Hipra Lab Sa | Metodo de preparacion de vacunas inactivadas y vacunas vivas adyuvantadas asi como las vacunas obtenidas por dicho metodo. |
| FR2700957B1 (fr) * | 1993-01-29 | 1995-03-03 | Seppic Sa | Composition de vaccin sous-unitaire recombinant vivant et procédé de préparation. |
| NZ285324A (en) * | 1994-05-10 | 1998-08-26 | American Home Prod | Vaccine containing modified live bovine respiratory syncytial virus (brsv) with an adjuvant and pharmaceutically acceptable carrier |
| RU2123331C1 (ru) * | 1996-03-28 | 1998-12-20 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Способ получения живой коревой вакцины |
| RU2140288C1 (ru) * | 1998-04-09 | 1999-10-27 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Способ получения живой коревой вакцины |
| US9839685B2 (en) | 2006-04-13 | 2017-12-12 | The Regents Of The University Of Michigan | Methods of inducing human immunodeficiency virus-specific immune responses in a host comprising nasally administering compositions comprising a naonemulsion and recombinant GP120 immunogen |
| CA2765511C (en) * | 2009-06-16 | 2015-05-12 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
| FR2957803B1 (fr) * | 2010-03-24 | 2012-06-01 | Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic | Diluants adjuvants de vaccins vivants pour maladies porcines |
| FR2957933B1 (fr) * | 2010-03-24 | 2012-04-27 | Seppic Sa | Vaccin vivant pour maladies aviaires |
| DK3116541T3 (da) | 2014-03-12 | 2020-02-24 | Bavarian Nordic As | Anvendelse af olie-og-vand-emulsioner til forøgelse af b-celleresponser med modificerede vaccinia-ankara-virus |
| US9457540B2 (en) | 2014-07-29 | 2016-10-04 | The Boeing Company | Panel-insert assembly and method |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB888180A (es) * | 1900-01-01 | |||
| GB425406A (en) * | 1933-06-07 | 1935-03-07 | Vincent Gregory Walsh | Improvements in or relating to the manufacture of medical preparations of bacterial toxins |
| US3083142A (en) * | 1958-02-27 | 1963-03-26 | Glaxo Group Ltd | Improved swine erysipelas vaccine |
| US3149036A (en) * | 1961-10-16 | 1964-09-15 | Merck & Co Inc | Adjuvant vaccine with aluminum monostearate, mannide monooleate, vegetable oil, and an aqueous phase immunolgical agent |
| GB1015251A (en) * | 1963-03-12 | 1965-12-31 | Glaxo Lab Ltd | Aqueous pharmaceutical compositions in capsule form |
| GB1080994A (en) * | 1963-10-25 | 1967-08-31 | Nat Res Dev | Injectable emulsions containing antigens |
| US3399263A (en) * | 1965-04-12 | 1968-08-27 | American Cyanamid Co | Stable adjuvant emulsion compositions comprising the hydrated reaction products of a methallic cation and a fatty acid |
| US3492399A (en) * | 1965-09-27 | 1970-01-27 | Samuel J Prigal | Emulsion compositions and methods |
| US3378443A (en) * | 1966-04-05 | 1968-04-16 | American Cyanamid Co | Anhydrous liquid suspensions of biologics |
| US3435112A (en) * | 1966-06-21 | 1969-03-25 | Norden Lab Inc | Repository vaccine and method of preparing the same |
| GB1163470A (en) * | 1967-11-13 | 1969-09-04 | Cecil Arthur Clark | Improvements in or relating to Adjuvant Vaccines |
| US3790665A (en) * | 1968-02-23 | 1974-02-05 | Haver Lockhart Labor Inc | Injectable adjuvant,method of preparing same and compositions including such adjuvant |
| ZA695759B (en) * | 1968-09-19 | 1971-03-31 | Merck & Co Inc | Stimulation of antibody response |
| LU57465A1 (es) * | 1968-12-04 | 1970-06-04 | ||
| US3678149A (en) * | 1970-01-26 | 1972-07-18 | Samuel J Prigal | Method of enhancing the action of a medicament |
| US3919411A (en) * | 1972-01-31 | 1975-11-11 | Bayvet Corp | Injectable adjuvant and compositions including such adjuvant |
| US3983228A (en) * | 1973-08-28 | 1976-09-28 | Merck & Co., Inc. | Water-in-oil adjuvant composition |
| US4069313A (en) * | 1974-11-19 | 1978-01-17 | Merck & Co., Inc. | Water-in-oil adjuvant composition |
| FR2313078A1 (fr) * | 1975-02-07 | 1976-12-31 | Anvar | Composition a base d'huile vegetale metabolisable et d'eau, utilisable notamment pour la constitution de preparations adjuvantes, ces preparations adjuvantes et leur procede d'obtention |
| US4073743A (en) * | 1975-04-17 | 1978-02-14 | Merck & Co., Inc. | Process for preparing an emulsion |
| NL7801060A (nl) * | 1977-02-09 | 1978-08-11 | Merck & Co Inc | Werkwijze voor het bereiden van een afgezwakt syncytiaal ademhalingsvirus, alsmede prepara- ten en vaccins die dit virus bevatten. |
| US4160024A (en) | 1978-05-01 | 1979-07-03 | Cornell Research Foundation, Inc. | Marek's disease vaccine |
| NL8102786A (nl) * | 1981-06-10 | 1983-01-03 | Duphar Int Res | Werkwijze voor het immuniseren van varkens tegen de ziekte van aujeszky. |
| EP0073856A1 (en) * | 1981-08-28 | 1983-03-16 | Gist-Brocades N.V. | Infectious-bronchitis vaccines for poultry, combined infectious-bronchitis vaccines, process for preparing such vaccines, process for preventing infectious bronchitis and infectious-bronchitis virus strain |
| NL8301996A (nl) * | 1983-06-06 | 1985-01-02 | Duphar Int Res | Werkwijze ter bereiding van geadjuveerde levende vaccins en aldus verkregen geadjuveerde levende vaccins. |
-
1983
- 1983-06-06 NL NL8301996A patent/NL8301996A/nl not_active Application Discontinuation
-
1984
- 1984-06-01 DK DK273384A patent/DK273384A/da not_active Application Discontinuation
- 1984-06-01 FI FI842215A patent/FI79787C/fi not_active IP Right Cessation
- 1984-06-01 US US06/616,144 patent/US4650677A/en not_active Expired - Lifetime
- 1984-06-04 ES ES533111A patent/ES8502870A1/es not_active Expired
- 1984-06-05 AT AT84200796T patent/ATE36956T1/de not_active IP Right Cessation
- 1984-06-05 IE IE1388/84A patent/IE57927B1/en not_active IP Right Cessation
- 1984-06-05 EP EP19840200796 patent/EP0129923B1/en not_active Expired
- 1984-06-05 DE DE8484200796T patent/DE3473825D1/de not_active Expired
- 1984-06-05 JP JP11398984A patent/JPH0639386B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US4650677A (en) | 1987-03-17 |
| FI79787B (fi) | 1989-11-30 |
| IE841388L (en) | 1984-12-06 |
| DE3473825D1 (en) | 1988-10-13 |
| JPS6011429A (ja) | 1985-01-21 |
| FI79787C (fi) | 1990-03-12 |
| ES533111A0 (es) | 1985-02-01 |
| FI842215A0 (fi) | 1984-06-01 |
| EP0129923B1 (en) | 1988-09-07 |
| IE57927B1 (en) | 1993-05-19 |
| ES8502870A1 (es) | 1985-02-01 |
| FI842215L (fi) | 1984-12-07 |
| DK273384A (da) | 1984-12-07 |
| EP0129923A1 (en) | 1985-01-02 |
| ATE36956T1 (de) | 1988-09-15 |
| JPH0639386B2 (ja) | 1994-05-25 |
| DK273384D0 (da) | 1984-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1B | A search report has been drawn up | ||
| BV | The patent application has lapsed |